Cellular timing heterogeneity regulates phase transitions in living matter

Schindler-Johnson M, Vangheel J, Aguirre-Tamaral A, Belpaire TER, Smeets B, Corominas-Murtra B, Petridou NI.

2026

doi:10.64898/2026.06.16.732542.

Adhesion-driven rigidity transition decoupled from density-driven jamming triggers epithelial organization in embryonic tissues.

Rustarazo-Calvo L, Pallares-Cartes C, Aguirre-Tamaral A, Floris E, Hingerl M, Autorino C, Khan AUM, Corominas-Murtra B, Petridou NI.

Nature physics, 2026

doi:10.1038/s41567-026-03276-6.

Tissue rigidity phase transition shapes morphogen gradients.

Autorino C, Khoromskaia D, Harari L, Floris E, Booth H, Pallares-Cartes C, Petrasiunaite V, Dorrity M, Corominas-Murtra B, Hadjivasiliou Z, Petridou NI.

Nature cell biology, 2026

doi:10.1038/s41556-026-01954-4.

Tissue phase transitions in development: more than just mechanics.

Rustarazo-Calvo L, Soans KG, Petridou NI.

Development (Cambridge, England), 2026

doi:10.1242/dev.205219.

Adhesion-driven tissue rigidification triggers epithelial cell polarity

Rustarazo-Calvo L, Pallares-Cartes C, Aguirre-Tamaral A, Floris E, Hingerl M, Autorino C, Khan AUM, Corominas-Murtra B, Petridou NI.

2025

doi:10.1101/2025.03.18.644006.

Flow, sense and divide.

Petridou NI.

Nature cell biology, 2025

doi:10.1038/s41556-024-01591-9.

Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions.

Petridou NI, Corominas-Murtra B, Heisenberg CP, Hannezo E.

Cell, 2021

doi:10.1016/j.cell.2021.02.017.

Tissue rheology in embryonic organization.

Petridou NI, Heisenberg CP.

The EMBO journal, 2019

doi:10.15252/embj.2019102497.

Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical Wnt signalling.

Petridou NI, Grigolon S, Salbreux G, Hannezo E, Heisenberg CP.

Nature cell biology, 2018

doi:10.1038/s41556-018-0247-4.

Multiscale force sensing in development.

Petridou NI, Spiró Z, Heisenberg CP.

Nature cell biology, 2017

doi:10.1038/ncb3524.

A ligand-independent integrin β1 mechanosensory complex guides spindle orientation.

Petridou NI, Skourides PA.

Nature communications, 2016

doi:10.1038/ncomms10899.

FAK transduces extracellular forces that orient the mitotic spindle and control tissue morphogenesis.

Petridou NI, Skourides PA.

Nature communications, 2014

doi:10.1038/ncomms6240.

A dominant-negative provides new insights into FAK regulation and function in early embryonic morphogenesis.

Petridou NI, Stylianou P, Skourides PA.

Development (Cambridge, England), 2013

doi:10.1242/dev.096073.

Activation of endogenous FAK via expression of its amino terminal domain in Xenopus embryos.

Petridou NI, Stylianou P, Christodoulou N, Rhoads D, Guan JL, Skourides PA.

PloS one, 2012

doi:10.1371/journal.pone.0042577.