Structure and function of RNA-protein complexes
Moritz Pfleiderer, the first PhD student in the Galej group, has successfully defended his thesis last Thursday. During the PhD, Moritz studied multi-subunit Integrator complex, which is involved in transcription attenuation and snRNAs 3′-end processing. His results were recently published in…
The latest #cryoEM structure from Nagai group at MRC LMB in Cambridge identifying a new spliceosome assembly intermediate (Ci complex) is now published in Molecular Cell. The paper contains the most complete and accurate depiction of the catalytic spliceosome to date and identifies a new functional…
Our newest paper describing the structure of the catalytic core of the Integrator complex is online now in Molecular Cell. Integrator complex was discovered more than 15 years ago as a specialised endonuclease responsible for the 3’-end processing of spliceosomal snRNAs. More recent studies…
Check out our latest pre-print from the Nagai group identifying a new spliceosome assembly intermediate. The most complete and accurate depiction of the catalytic spliceosome to date; 9 datasets, 12 focused maps, 4 years in making. Fantastic effort by Max Wilkinson and Sebastian Fica.…