Publications

High-precision targeting workflow for volume electron microscopy.

Ronchi P, Mizzon G, Machado P, D'Imprima E, Best BT, Cassella L, Schnorrenberg S, Montero MG, Jechlinger M, Ephrussi A, Leptin M, Mahamid J, Schwab Y

The Journal of cell biology 2021

34160561. doi:10.1083/jcb.202104069.

The 3D architecture and molecular foundations of de novo centriole assembly via bicentrioles.

Gomes Pereira S, Sousa AL, Nabais C, Paixão T, Holmes AJ, Schorb M, Goshima G, Tranfield EM, Becker JD, Bettencourt-Dias M

Current biology : CB 2021

34433076. doi:10.1016/j.cub.2021.07.063.

Whole-body integration of gene expression and single-cell morphology.

Vergara HM, Pape C, Meechan KI, Zinchenko V, Genoud C, Wanner AA, Mutemi KN, Titze B, Templin RM, Bertucci PY, Simakov O, Dürichen W, Machado P, Savage EL, Schermelleh L, Schwab Y, Friedrich RW, Kreshuk A, Tischer C, Arendt D

Cell 2021

34380046. doi:10.1016/j.cell.2021.07.017.

Cytoklepty in the plankton: a host strategy to optimize the bioenergetic machinery of endosymbiotic algae.

Uwizeye C, Mars Brisbin M, Gallet B, Chevalier F, LeKieffre C, Schieber NL, Falconet D, Wangpraseurt D, Schertel L, Stryhanyuk H, Musat N, Mitarai S, Schwab Y, Finazzi G, Decelle J

Proceedings of the National Academy of Sciences of the United States of America 2021

34215695. doi:10.1073/pnas.2025252118.

Recapitulating actin module organization in the Drosophila reveals new roles for bristle-actin-modulating proteins.

Krishnan RK, Baskar R, Anna B, Elia N, Boermel M, Bausch AR, Abdu U

International journal of molecular sciences 2021

33924532. doi:10.3390/ijms22084006.

Strategies for optimization of cryogenic electron tomography data acquisition.

Weis F, Hagen WJH, Schorb M, Mattei S

Journal of visualized experiments : JoVE 2021

33818563. doi:10.3791/62383.

Morphological bases of phytoplankton energy management and physiological responses unveiled by 3D subcellular imaging.

Uwizeye C, Decelle J, Jouneau PH, Flori S, Gallet B, Keck JB, Bo DD, Moriscot C, Seydoux C, Chevalier F, Schieber NL, Templin R, Allorent G, Courtois F, Curien G, Schwab Y, Schoehn G, Zeeman SC, Falconet D, Finazzi G

Nature communications 2021

33594064. doi:10.1038/s41467-021-21314-0.

A high throughput SEC23 functional interaction screen reveals a role for focal adhesion and extracellular matrix signalling in the regulation of COPII subunit SEC23A

Jung J, Khan MM, Landry J, Halavatyi A, Machado P, Reiss M, Pepperkok R

2021

doi:10.1101/2021.03.16.435679.

Fluorescence-based 3D targeting of FIB-SEM acquisition of small volumes in large samples.

Ronchi P, Machado P, D’Imprima E, Mizzon G, Best BT, Cassella L, Schnorrenberg S, Montero MG, Jechlinger M, Ephrussi A, Leptin M, Mahamid J, Schwab Y

2021

doi:10.1101/2021.01.18.427072.

Mesopolysaccharides: the extracellular surface layer of visceral organs.

Wagner WL, Zheng Y, Pierce A, Ackermann M, Horstmann H, Kuner T, Ronchi P, Schwab Y, Konietzke P, Wünnemann F, Wielpütz MO, Kauczor HU, Mentzer SJ

PloS one 2020

32941441. doi:10.1371/journal.pone.0238798.

Photonic-chip assisted correlative light and electron microscopy.

Tinguely JC, Steyer AM, Øie CI, Helle ØI, Dullo FT, Olsen R, McCourt P, Schwab Y, Ahluwalia BS

Communications biology 2020

33288833. doi:10.1038/s42003-020-01473-4.

Local blood coagulation drives cancer cell arrest and brain metastasis in a mouse model.

Feinauer MJ, Schneider SW, Berghoff AS, Robador JR, Tehranian C, Karreman MA, Venkataramani V, Solecki G, Grosch JK, Gunkel K, Kovalchuk B, Mayer FT, Fischer M, O Breckwoldt M, Brune M, Schwab Y, Wick W, Bauer AT, Winkler F

Blood 2020

33270819. doi:10.1182/blood.2020005710.

Integrative imaging reveals SARS-CoV-2-induced reshaping of subcellular morphologies.

Cortese M, Lee JY, Cerikan B, Neufeldt CJ, Oorschot VMJ, Köhrer S, Hennies J, Schieber NL, Ronchi P, Mizzon G, Romero-Brey I, Santarella-Mellwig R, Schorb M, Boermel M, Mocaer K, Beckwith MS, Templin RM, Gross V, Pape C, Tischer C, Frankish J, Horvat NK, Laketa V, Stanifer M, Boulant S, Ruggieri A, Chatel-Chaix L, Schwab Y, Bartenschlager R

Cell host & microbe 2020

33245857. doi:10.1016/j.chom.2020.11.003.

Cell surface mechanics gate embryonic stem cell differentiation.

Bergert M, Lembo S, Sharma S, Russo L, Milovanović D, Gretarsson KH, Börmel M, Neveu PA, Hackett JA, Petsalaki E, Diz-Muñoz A

Cell stem cell 2020

33207217. doi:10.1016/j.stem.2020.10.017.

Efficient transmission electron microscopy characterization of cell-nanostructure interfacial interactions.

Aslanoglou S, Chen Y, Oorschot V, Trifunovic Z, Hanssen E, Suu K, Voelcker NH, Elnathan R

Journal of the American Chemical Society 2020

32869983. doi:10.1021/jacs.0c05919.

In-cell architecture of the nuclear pore and snapshots of its turnover.

Allegretti M, Zimmerli CE, Rantos V, Wilfling F, Ronchi P, Fung HKH, Lee CW, Hagen W, Turoňová B, Karius K, Börmel M, Zhang X, Müller CW, Schwab Y, Mahamid J, Pfander B, Kosinski J, Beck M

Nature 2020

32879490. doi:10.1038/s41586-020-2670-5.

Spatial control of nucleoporin condensation by fragile X-related proteins.

Agote-Aran A, Schmucker S, Jerabkova K, Jmel Boyer I, Berto A, Pacini L, Ronchi P, Kleiss C, Guerard L, Schwab Y, Moine H, Mandel JL, Jacquemont S, Bagni C, Sumara I

The EMBO journal 2020

32706158. doi:10.15252/embj.2020104467.

Transcytosis via the late endocytic pathway as a cell morphogenetic mechanism.

Mathew R, Rios-Barrera LD, Machado P, Schwab Y, Leptin M

The EMBO journal 2020

32657472. doi:10.15252/embj.2020105332.

Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis.

Choudhary V, El Atab O, Mizzon G, Prinz WA, Schneiter R

The Journal of cell biology 2020

32349126. doi:10.1083/jcb.201910177.

Selective autophagy degrades nuclear pore complexes.

Lee CW, Wilfling F, Ronchi P, Allegretti M, Mosalaganti S, Jentsch S, Beck M, Pfander B

Nature cell biology 2020

32029894. doi:10.1038/s41556-019-0459-2.

Dynamic buffering of extracellular chemokine by a dedicated scavenger pathway enables robust adaptation during directed tissue migration.

Wong M, Newton LR, Hartmann J, Hennrich ML, Wachsmuth M, Ronchi P, Guzmán-Herrera A, Schwab Y, Gavin AC, Gilmour D

Developmental cell 2020

32059773. doi:10.1016/j.devcel.2020.01.013.

Cell and tissue manipulation with ultrashort infrared laser pulses in light-sheet microscopy.

de Medeiros G, Kromm D, Balazs B, Norlin N, Günther S, Izquierdo E, Ronchi P, Komoto S, Krzic U, Schwab Y, Peri F, de Renzis S, Leptin M, Rauzi M, Hufnagel L

Scientific reports 2020

32029815. doi:10.1038/s41598-019-54349-x.

AMST: Alignment to median smoothed template for Focused Ion Beam Scanning Electron Microscopy image stacks.

Hennies J, Lleti JMS, Schieber NL, Templin RM, Steyer AM, Schwab Y

Scientific reports 2020

32029771. doi:10.1038/s41598-020-58736-7.

Actin assembly ruptures the nuclear envelope by prying the lamina away from nuclear pores and nuclear membranes in starfish oocytes.

Wesolowska N, Avilov I, Machado P, Geiss C, Kondo H, Mori M, Lenart P

eLife 2020

31989921. doi:10.7554/eLife.49774.

Drosophila Atg9 regulates the actin cytoskeleton via interactions with profilin and Ena.

Kiss V, Jipa A, Varga K, Takáts S, Maruzs T, Lőrincz P, Simon-Vecsei Z, Szikora S, Földi I, Bajusz C, Tóth D, Vilmos P, Gáspár I, Ronchi P, Mihály J, Juhász G

Cell death and differentiation 2019

31740789. doi:10.1038/s41418-019-0452-0.

Tunneling nanotube-mediated intercellular vesicle and protein transfer in the stroma-provided imatinib resistance in chronic myeloid leukemia cells.

Kolba MD, Dudka W, Zaręba-Kozioł M, Kominek A, Ronchi P, Turos L, Chroscicki P, Wlodarczyk J, Schwab Y, Klejman A, Cysewski D, Srpan K, Davis DM, Piwocka K

Cell death & disease 2019

31659149. doi:10.1038/s41419-019-2045-8.

Nuclear pores assemble from Nucleoporin condensates during oogenesis.

Hampoelz B, Schwarz A, Ronchi P, Bragulat-Teixidor H, Tischer C, Gaspar I, Ephrussi A, Schwab Y, Beck M

Cell 2019

31626769. doi:10.1016/j.cell.2019.09.022.

Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes.

Pasquier A, Vivot K, Erbs E, Spiegelhalter C, Zhang Z, Aubert V, Liu Z, Senkara M, Maillard E, Pinget M, Kerr-Conte J, Pattou F, Marciniak G, Ganzhorn A, Ronchi P, Schwab Y, Schieber NL, Goginashvili A, Saftig P, Ricci R

Nature communications 2019

31346174. doi:10.1038/s41467-019-11170-4.

Biopearling of interconnected outer membrane vesicle chains by a marine flavobacterium.

Fischer T, Schorb M, Reintjes G, Kolovou A, Santarella-Mellwig R, Markert S, Rhiel E, Littmann S, Becher D, Schweder T, Harder J

Applied and environmental microbiology 2019

31324630. doi:10.1128/AEM.00829-19.

Spatiotemporal coupling of the hepatitis C virus replication cycle by creating a lipid droplet-proximal membranous replication compartment.

Lee JY, Cortese M, Haselmann U, Tabata K, Romero-Brey I, Funaya C, Schieber NL, Qiang Y, Bartenschlager M, Kallis S, Ritter C, Rohr K, Schwab Y, Ruggieri A, Bartenschlager R

Cell reports 2019

31216478. doi:10.1016/j.celrep.2019.05.063.

Software tools for automated transmission electron microscopy.

Schorb M, Haberbosch I, Hagen WJH, Schwab Y, Mastronarde DN

Nature methods 2019

31086343. doi:10.1038/s41592-019-0396-9.

An ESCRT-LEM protein surveillance system is poised to directly monitor the nuclear envelope and nuclear transport system.

Thaller DJ, Allegretti M, Borah S, Ronchi P, Beck M, Lusk CP

eLife 2019

30942170. doi:10.7554/eLife.45284.

Clearance by microglia depends on packaging of phagosomes into a unique cellular compartment.

Villani A, Benjaminsen J, Moritz C, Henke K, Hartmann J, Norlin N, Richter K, Schieber NL, Franke T, Schwab Y, Peri F

Developmental cell 2019

30880002. doi:10.1016/j.devcel.2019.02.014.

Studying the fate of tumor extracellular vesicles at high spatiotemporal resolution using the zebrafish embryo.

Hyenne V, Ghoroghi S, Collot M, Bons J, Follain G, Harlepp S, Mary B, Bauer J, Mercier L, Busnelli I, Lefebvre O, Fekonja N, Garcia-Leon MJ, Machado P, Delalande F, Silva SG, López AA, van Niel G, Verweij FJ, Peinado H, Djouad F, Klymchenko AS, Carapito C, Goetz JG

Developmental cell 2019

30745140. doi:10.1016/j.devcel.2019.01.014.

Single organelle dynamics linked to 3D structure by correlative live-cell - 3D electron microscopy.

Fermie J, Liv N, Ten Brink C, van Donselaar EG, Müller WH, Schieber NL, Schwab Y, Gerritsen HC, Klumperman J

Traffic (Copenhagen, Denmark) 2018

29451726. doi:10.1111/tra.12557.

GM130 and p115 play a key role in the organisation of the early secretory pathway during skeletal muscle differentiation.

Giacomello E, Ronchi P, Pepperkok R

Journal of cell science 2019

30630895. doi:10.1242/jcs.222083.

Alpha-synuclein fibrils recruit TBK1 and OPTN to lysosomal damage sites and induce autophagy in microglial cells.

Bussi C, Peralta Ramos JM, Arroyo DS, Gallea JI, Ronchi P, Kolovou A, Wang JM, Florey O, Celej MS, Schwab Y, Ktistakis NT, Iribarren P

Journal of cell science 2018

30404831. doi:10.1242/jcs.226241.

Altered nuclear envelope structure and proteasome function of micronuclei.

Maass KK, Rosing F, Ronchi P, Willmund KV, Devens F, Hergt M, Herrmann H, Lichter P, Ernst A

Experimental cell research 2018

30149001. doi:10.1016/j.yexcr.2018.08.029.

Correlative light electron microscopy (CLEM) for tracking and imaging viral protein associated structures in cryo-immobilized cells.

Santarella-Mellwig R, Haselmann U, Schieber NL, Walther P, Schwab Y, Antony C, Bartenschlager R, Romero-Brey I

Journal of visualized experiments : JoVE 2018

30247481. doi:10.3791/58154.

Daughter-cell-specific modulation of nuclear pore complexes controls cell cycle entry during asymmetric division.

Kumar A, Sharma P, Gomar-Alba M, Shcheprova Z, Daulny A, Sanmartín T, Matucci I, Funaya C, Beato M, Mendoza M

Nature cell biology 2018

29531309. doi:10.1038/s41556-018-0056-9.

Correlated light and electron microscopy of cell division in large marine oocytes, eggs, and embryos.

Burdyniuk M, Wesolowska N, Fleszar M, Karreman MA, Machado P, Borrego-Pinto J, Ruthensteiner B, Schwab Y, Lénárt P

Methods in cell biology 2018

29957211. doi:10.1016/bs.mcb.2018.03.031.

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction.

Weinhard L, di Bartolomei G, Bolasco G, Machado P, Schieber NL, Neniskyte U, Exiga M, Vadisiute A, Raggioli A, Schertel A, Schwab Y, Gross CT

Nature communications 2018

29581545. doi:10.1038/s41467-018-03566-5.

Single cell polarity in liquid phase facilitates tumour metastasis.

Lorentzen A, Becker PF, Kosla J, Saini M, Weidele K, Ronchi P, Klein C, Wolf MJ, Geist F, Seubert B, Ringelhan M, Mihic-Probst D, Esser K, Roblek M, Kuehne F, Bianco G, O'Connor T, Müller Q, Schuck K, Lange S, Hartmann D, Spaich S, Groß O, Utikal J, Haferkamp S, Sprick MR, Damle-Vartak A, Hapfelmeier A, Hüser N, Protzer U, Trumpp A, Saur D, Vartak N, Klein CA, Polzer B, Borsig L, Heikenwalder M

Nature communications 2018

29491397. doi:10.1038/s41467-018-03139-6.

Postmitotic nuclear pore assembly proceeds by radial dilation of small membrane openings

Otsuka S, Steyer AM, Schorb M, Hériché JK, Hossain MJ, Sethi S, Kueblbeck M, Schwab Y, Beck M, Ellenberg J

2017

29323269. doi:10.1038/s41594-017-0001-9.

Dynamics of in vivo ASC speck formation.

Kuri P, Schieber NL, Thumberger T, Wittbrodt J, Schwab Y, Leptin M

The Journal of cell biology 2017

28701426. doi:10.1083/jcb.201703103.

Asymmetric Centriole Numbers at Spindle Poles Cause Chromosome Missegregation in Cancer.

Cosenza MR, Cazzola A, Rossberg A, Schieber NL, Konotop G, Bausch E, Slynko A, Holland-Letz T, Raab MS, Dubash T, Glimm H, Poppelreuther S, Herold-Mende C, Schwab Y, Krämer A

Cell reports 2017

28834753. doi:10.1016/j.celrep.2017.08.005.

Exosomes purified from a single cell type have diverse morphology.

Zabeo D, Cvjetkovic A, Lässer C, Schorb M, Lötvall J, Höög JL

Journal of extracellular vesicles 2017

28717422. doi:10.1080/20013078.2017.1329476.

Find your way with X-Ray: Using microCT to correlate in vivo imaging with 3D electron microscopy.

Karreman MA, Ruthensteiner B, Mercier L, Schieber NL, Solecki G, Winkler F, Goetz JG, Schwab Y

Methods in cell biology 2017

28528637. doi:10.1016/bs.mcb.2017.03.006.

In vivo testing of gold nanoparticles using the Caenorhabditis elegans model organism.

Gonzalez-Moragas L, Berto P, Vilches C, Quidant R, Kolovou A, Santarella-Mellwig R, Schwab Y, Stürzenbaum S, Roig A, Laromaine A

Acta biomaterialia 2017

28161575. doi:10.1016/j.actbio.2017.01.080.

A new method for cryo-sectioning cell monolayers using a correlative workflow.

Kolovou A, Schorb M, Tarafder A, Sachse C, Schwab Y, Santarella-Mellwig R

Methods in cell biology 2017

28528643. doi:10.1016/bs.mcb.2017.03.011.

Minimal resin embedding of multicellular specimens for targeted FIB-SEM imaging.

Schieber NL, Machado P, Markert SM, Stigloher C, Schwab Y, Steyer AM

Methods in cell biology 2017

28528642. doi:10.1016/bs.mcb.2017.03.005.

Targeted Ablation Using Laser Nanosurgery.

Gayathri Vegesna NV, Ronchi P, Durdu S, Terjung S, Pepperkok R

Methods in molecular biology (Clifton, N.J.) 2017

28324605. doi:10.1007/978-1-4939-6810-7_8.

Ultrastructural Characterization of Zika Virus Replication Factories.

Cortese M, Goellner S, Acosta EG, Neufeldt CJ, Oleksiuk O, Lampe M, Haselmann U, Funaya C, Schieber N, Ronchi P, Schorb M, Pruunsild P, Schwab Y, Chatel-Chaix L, Ruggieri A, Bartenschlager R

Cell reports 2017

28249158. doi:10.1016/j.celrep.2017.02.014.

New hardware and workflows for semi-automated correlative cryo-fluoresence and cryo-electron microscopy/tomography.

Schorb M, Gaechter L, Avinoam O, Sieckmann F, Clarke M, Bebeacua C, Bykov YS, Sonnen AF, Lihl R, Briggs JA

Journal of structural biology 2016

27368127. doi:10.1016/j.jsb.2016.06.020.

Intravital Correlative Microscopy: Imaging Life at the Nanoscale.

Karreman MA, Hyenne V, Schwab Y, Goetz JG

Trends in cell biology 2016

27515435. doi:10.1016/j.tcb.2016.07.003.

Bio-identity and fate of albumin-coated SPIONs evaluated in cells and by the C. elegans model.

Yu SM, Gonzalez-Moragas L, Milla M, Kolovou A, Mellwig-Santarella R, Schwab Y, Laromaine A, Roig A

Acta Biomaterialia 2016

27427227. doi:10.1016/j.actbio.2016.07.024.

Nuclear pore assembly proceeds by an inside-out extrusion of the nuclear envelope

Otsuka S, Bui KH, Schorb M, Hossain MJ, Politi AZ, Koch B, Eltsov M, Beck M, Ellenberg J

eLife 2016

27630123. doi:10.7554/eLife.19071.

Dengue virus perturbs mitochondrial morphodynamics to dampen innate immune responses.

Chatel-Chaix L, Cortese M, Romero-Brey I, Bender S, Neufeldt CJ, Fischl W, Scaturro P, Schieber N, Schwab Y, Fischer B, Ruggieri A, Bartenschlager R

Cell host & microbe 2016

27545046. doi:10.1016/j.chom.2016.07.008.

Pre-assembled nuclear pores insert into the nuclear envelope during early development.

Hampoelz B, Mackmull MT, Machado P, Ronchi P, Bui KH, Schieber N, Santarella-Mellwig R, Necakov A, Andrés-Pons A, Philippe JM, Lecuit T, Schwab Y, Beck M

Cell 2016

27397507. doi:10.1016/j.cell.2016.06.015.

The Aurora-B-dependent NoCut checkpoint prevents damage of anaphase bridges after DNA replication stress.

Amaral N, Vendrell A, Funaya C, Idrissi FZ, Maier M, Kumar A, Neurohr G, Colomina N, Torres-Rosell J, Geli MI, Mendoza M

Nature cell biology 2016

27111841. doi:10.1038/ncb3343.

ESCRT-III drives the final stages of CUPS maturation for unconventional protein secretion.

Curwin AJ, Brouwers N, Adell MA, Teis D, Turacchio G, Parashuraman S, Ronchi P, Malhotra V

eLife 2016

27115345. doi:10.7554/elife.16299.

A 3-D cell culture system to study epithelia functions using microcarriers.

Jakob PH, Kehrer J, Flood P, Wiegel C, Haselmann U, Meissner M, Stelzer EH, Reynaud EG

Cytotechnology 2016

26847791. doi:10.1007/s10616-015-9935-0.

The seipin complex Fld1/Ldb16 stabilizes ER-lipid droplet contact sites.

Grippa A, Buxó L, Mora G, Funaya C, Idrissi FZ, Mancuso F, Gomez R, Muntanyà J, Sabidó E, Carvalho P

The Journal of cell biology 2015

26572621. doi:10.1083/jcb.201502070.

Endocytic membrane turnover at the leading edge is driven by a transient interaction between Cdc42 and GRAF1.

Francis MK, Holst MR, Vidal-Quadras M, Henriksson S, Santarella-Mellwig R, Sandblad L, Lundmark R

Journal of cell science 2015

26446261. doi:10.1242/jcs.174417.

Amphiphysin 2 Orchestrates Nucleus Positioning and Shape by Linking the Nuclear Envelope to the Actin and Microtubule Cytoskeleton.

D'Alessandro M, Hnia K, Gache V, Koch C, Gavriilidis C, Rodriguez D, Nicot AS, Romero NB, Schwab Y, Gomes E, Labouesse M, Laporte J

Developmental cell 2015

26506308. doi:10.1016/j.devcel.2015.09.018.

RAL-1 controls multivesicular body biogenesis and exosome secretion.

Hyenne V, Apaydin A, Rodriguez D, Spiegelhalter C, Hoff-Yoessle S, Diem M, Tak S, Lefebvre O, Schwab Y, Goetz JG, Labouesse M

The Journal of cell biology 2015

26459596. doi:10.1083/jcb.201504136.

Inflammation-induced emergency megakaryopoiesis driven by hematopoietic stem cell-like megakaryocyte progenitors.

Haas S, Hansson J, Klimmeck D, Loeffler D, Velten L, Uckelmann H, Wurzer S, Prendergast ÁM, Schnell A, Hexel K, Santarella-Mellwig R, Blaszkiewicz S, Kuck A, Geiger H, Milsom MD, Steinmetz LM, Schroeder T, Trumpp A, Krijgsveld J, Essers MA

Cell stem cell 2015

26299573. doi:10.1016/j.stem.2015.07.007.

Distinct Trafficking of Cell Surface and Endosomal TIM-1 to the Immune Synapse.

Echbarthi M, Zonca M, Mellwig R, Schwab Y, Kaplan G, DeKruyff RH, Roda-Navarro P, Casasnovas JM

Traffic (Copenhagen, Denmark) 2015

26332704. doi:10.1111/tra.12329.

ENDOCYTOSIS. Endocytic sites mature by continuous bending and remodeling of the clathrin coat.

Avinoam O, Schorb M, Beese CJ, Briggs JA, Kaksonen M

Science (New York, N.Y.) 2015

26089517. doi:10.1126/science.aaa9555.

Quantitative analysis of cytoskeletal reorganization during epithelial tissue sealing by large-volume electron tomography.

Eltsov M, Dubé N, Yu Z, Pasakarnis L, Haselmann-Weiss U, Brunner D, Frangakis AS

Nature cell biology 2015

25893916. doi:10.1038/ncb3159.

Insulin granules. Insulin secretory granules control autophagy in pancreatic β cells.

Goginashvili A, Zhang Z, Erbs E, Spiegelhalter C, Kessler P, Mihlan M, Pasquier A, Krupina K, Schieber N, Cinque L, Morvan J, Sumara I, Schwab Y, Settembre C, Ricci R

Science (New York, N.Y.) 2015

25700520. doi:10.1126/science.aaa2628.

Systems biology in 3D space - enter the morphome.

Lucocq JM, Mayhew TM, Schwab Y, Steyer AM, Hacker C

Trends in cell biology 2014

25455351. doi:10.1016/j.tcb.2014.09.008.

Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders.

Aiyar RS, Bohnert M, Duvezin-Caubet S, Voisset C, Gagneur J, Fritsch ES, Couplan E, von der Malsburg K, Funaya C, Soubigou F, Courtin F, Suresh S, Kucharczyk R, Evrard J, Antony C, St Onge RP, Blondel M, di Rago JP, van der Laan M, Steinmetz LM

Nature Communications 2014

25519239. doi:10.1038/ncomms6585.

Correlating Intravital Multi-Photon Microscopy to 3D Electron Microscopy of Invading Tumor Cells Using Anatomical Reference Points.

Karreman MA, Mercier L, Schieber NL, Shibue T, Schwab Y, Goetz JG

PloS one 2014

25479106. doi:10.1371/journal.pone.0114448.

Automated Stitching of Microtubule Centerlines across Serial Electron Tomograms.

Weber B, Tranfield EM, Höög JL, Baum D, Antony C, Hyman T, Verbavatz JM, Prohaska S

PloS one 2014

25438148. doi:10.1371/journal.pone.0113222.

Correlative Light and Electron Microscopy for a Free-Floating Spindle in Xenopus laevis Egg Extracts.

Tranfield EM, Heiligenstein X, Peristere I, Antony C

Methods in cell biology 2014

25287839. doi:10.1016/b978-0-12-801075-4.00006-9.

Quality control of inner nuclear membrane proteins by the Asi complex.

Foresti O, Rodriguez-Vaello V, Funaya C, Carvalho P

Science (New York, N.Y.) 2014

25236469. doi:10.1126/science.1255638.

Positive feedback between golgi membranes, microtubules and ER-exit sites directs golgi de novo biogenesis.

Ronchi P, Tischer C, Acehan D, Pepperkok R

Journal of cell science 2014

25189616. doi:10.1242/jcs.150474.

An arp2/3 nucleated f-actin shell fragments nuclear membranes at nuclear envelope breakdown in starfish oocytes.

Mori M, Somogyi K, Kondo H, Monnier N, Falk HJ, Machado P, Bathe M, Nédélec F, Lénárt P

Current biology : CB 2014

24909322. doi:10.1016/j.cub.2014.05.019.

A bacterial tubulovesicular network

Acehan D, Santarella-Mellwig R, Devos DP

Journal of cell science 2013

24259664. doi:10.1242/jcs.137596.

CHD4 is a RanGTP-dependent MAP that stabilizes microtubules and regulates bipolar spindle formation

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Organization of organelles within hyphae of Ashbya gossypii revealed by electron tomography

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Open membranes are the precursors for assembly of large DNA viruses

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Spindle pole body-anchored Kar3 drives the nucleus along microtubules from another nucleus in preparation for nuclear fusion during yeast karyogamy

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Facilitated aggregation of FG nucleoporins under molecular crowding conditions

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Electron tomography reveals novel microtubule lattice and microtubule organizing centre defects in +TIP mutants

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Three-dimensional reconstruction of bacteria with a complex endomembrane system

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Electron tomography of the microtubule cytoskeleton in multinucleated hyphae of Ashbya gossypii

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Internal structure of an intact Convallaria majalis pollen grain observed with X-ray Fresnel coherent diffractive imaging

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Optics express 2012

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Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells

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Heritable yeast prions have a highly organized three-dimensional architecture with interfiber structures

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BLD10/CEP135 is a microtubule-associated protein that controls the formation of the flagellum central microtubule pair

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Developmental cell 2012

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Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis

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Sm protein down-regulation leads to defects in nuclear pore complex disassembly and distribution in C. elegans embryos

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An extended γ-tubulin ring functions as a stable platform in microtubule nucleation

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Transient structure associated with the spindle pole body directs meiotic microtubule reorganization in S. pombe

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GCP6 is a substrate of Plk4 and required for centriole duplication

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Regulation of signaling at regions of cell-cell contact by endoplasmic reticulum-bound protein-tyrosine phosphatase 1B

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An amyloidogenic determinant in n-terminal pro-brain natriuretic peptide (nt-probnp): Implications for cardiac amyloidoses

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Biopolymers 2012

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Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication.

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PLoS pathogens 2012

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The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements

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Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing

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Electron tomography reveals a flared morphology on growing microtubule ends

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A novel laser nanosurgery approach supports de novo Golgi biogenesis in mammalian cells

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Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome

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NLS-mediated NPC functions of the nucleoporin Pom121

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N-terminal regions of Mps1 kinase determine functional bifurcation

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Quantitative and spatio-temporal features of protein aggregation in Escherichia coli and consequences on protein quality control and cellular ageing

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The EMBO journal 2010

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Kinetochores generate microtubules with distal plus ends: their roles and limited lifetime in mitosis

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Developmental cell 2010

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Fission yeast a cellular model well suited for electron microscopy investigations

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The fission yeast XMAP215 homolog Dis1p is involved in microtubule bundle organization

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The compartmentalized bacteria of the planctomycetes-verrucomicrobia-chlamydiae superphylum have membrane coat-like proteins

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PLoS biology 2010

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Mechanosensing in actin stress fibers revealed by a close correlation between force and protein localization

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Decreased contractility due to energy deprivation in a transgenic rat model of hypertrophic cardiomyopathy

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Performance evaluation of image processing algorithms on the GPU

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A visualization and segmentation toolbox for electron microscopy

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Classification of cryo-electron sub-tomograms using constrained correlation

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A role for gp210 in mitotic nuclear-envelope breakdown

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