The Chemical Biology Core Facility (CBCF) offers the infrastructure and expertise for assay development, small-molecule screening and use of medicinal chemistry to optimise compounds against novel targets for ‘biotool’ or early drug development.
The facility is set up as a collaboration between EMBL and German Cancer Research Center (DKFZ) to provide the infrastructure and expertise to open up small molecule development to research groups at these institutions.
High Throughput Screening (HTS) allows a researcher to quickly conduct thousands of tests against a biological target through the use of automation (robotics, liquid handling devices, sensitive detectors), data processing and control software.
Computational chemistry methods are integral to the process of active molecule identification and optimisation. These include: