The Chemical Synthesis Core Facility specializes in small-molecule synthesis. Our mission is to support projects from groups lacking chemical synthesis expertise or infrastructure, providing services ranging from consultation, design, synthesis and characterization of small-molecule tool compounds for a variety of biological applications.
Available infrastructure and instrumentation
The Chemical Synthesis Core Facility is equipped with a state-of-the-art laboratory, fully equipped for efficient synthetic work. This includes:
Synthesis infrastructure and instrumentation
- 10 fume hoods for chemical synthesis
- Preparative HPLC-MS
- Preparative HPLC
- Flash chromatography system
- Microwave reactor
- H-Cube flow hydrogenator
- Lyophilizer
- Centrifugal evaporator
- Parallel reaction stations
Characterisation implementation
- Analytical UPLC-MS-ELSD system
- Analytical Chiral HPLC
- 400MHz NMR equipped with autosampler and enabling multinuclei measurements
- Polarimeter
In addition, the large resources in other Core Facilities at EMBL also enable us to perform advanced characterisations including: UV-Vis, fluorescence spectroscopy, and HRMS.
