Chemical Synthesis Core Facility

Analytical and organic chemistry services

The Chemical Synthesis Core Facility (CSCF) focuses on design and multi step synthesis of small molecules and molecular probes. We assist biologists to access these probes to address important biological questions in their research.


The Chemical Synthesis Core Facility specializes in small-molecule synthesis. Our mission is to support projects from groups lacking chemical synthesis expertise or infrastructure, providing services ranging from consultation, design, synthesis and characterization of small-molecule tool compounds for a variety of biological applications.

Available infrastructure and instrumentation

The Chemical Synthesis Core Facility is equipped with a state-of-the-art laboratory, fully equipped for efficient synthetic work. This includes:

Synthesis infrastructure and instrumentation

  • 10 fume hoods for chemical synthesis
  • Preparative HPLC-MS
  • Preparative HPLC
  • Flash chromatography system
  • Microwave reactor
  • H-Cube flow hydrogenator
  • Lyophilizer
  • Centrifugal evaporator
  • Parallel reaction stations

Characterisation implementation

  • Analytical UPLC-MS-ELSD system
  • Analytical Chiral HPLC
  • 400MHz NMR equipped with autosampler and enabling multinuclei measurements
  • Polarimeter

In addition, the large resources in other Core Facilities at EMBL also enable us to perform advanced characterisations including: UV-Vis, fluorescence spectroscopy, and HRMS.