Beamlines P12, P13 and P14 are in operation. Data collection can be performed in person or via remote or mail-in access.
Before starting the proposal, please be aware that the scientist submitting the proposal (main proposer) must hold a PhD and each co-proposer needs to have created an account.
After you have logged in, the proposal submission is divided in three stages:
You must VALIDATE the proposal while working in the tab “Proposals in progress”. The list of proposals to be validated appears under the section titled “These proposals have not been completed and/or submitted”. Validation of a proposal includes a check for completeness and assignment of a tracking number. You will receive confirmation and the number by email. If you have successfully validated your proposal but have not received the confirmation, please contact us at firstname.lastname@example.org.
After you have validated the proposal and prior to the evaluation process, the beamline responsible will check the technical feasibility and finalise the proposal. At this stage, the proposal is allocated a final number (MX NN or SAXS NN). Please note that finalising the proposals is performed by the EMBL staff – no action from you is required.
If you are a current SMIS user (i.e. you have submitted a proposal to EMBL after 2012), you may use the existing credentials, numbers and use previous proposals as templates (duplicate) in the “Proposals with Final Number/Previous proposals” section. For the pre-2012 proposals filed in the old system (not SMIS) this is unfortunately not possible. Please register as a new user.
We now offer the possibility to submit a BAG (Block Allocation Group) proposal for beam time. BAG proposals allow groups of users (eg. local, regional or national research consortia) to submit their projects in one proposal and share the resulting beam time. Beam time awarded to BAG proposals will normally be allocated in regular blocks across the year in order to optimise and accelerate access to beam time.
Investigators are strongly encouraged to file joint BAG proposals with other colleagues. Moreover, individual groups with three or more projects must submit them within a BAG proposal and not as multiple single proposals from the same group.
To submit a BAG proposal, please complete the online beam time application form on the EMBL user portal. Before submission, you will need to complete the BAG Description, with a list of the projects which will be worked on by each Principle Investigator within the BAG, and the sample sheets, listing the samples related to the different projects.
You can restore your draft version by clicking on a proposal type (MX or SAXS) as if you were initiating a new proposal. A pop-up window will then advise you that a draft version is stored and by clicking “Restore Draft” button, the form will be re-filled with your draft data.
EMBL Hamburg is a partner in the iNEXT-Discovery project, funded by the Horizon 2020 programme of the European Union as well as an Instruct ERIC centre. To apply for funding, please submit a proposal on the respective websites. Once the iNEXT-Discovery or Instruct proposal has been approved, please submit a beamline application proposal through the EMBL portal https://smis.embl-hamburg.de. There, you can select that the proposal is approved by either iNEXT-Discovery or Instruct and upload the body of the proposal. If needed, please contact the user office for further information.
Rolling proposals are accepted throughout the year (the evaluation usually takes about two to three months). The acceptance and scheduling of beamtime will depend on the score and on the availability of the user slots.
Yes, this is possible. Switching between the robotic and the FPLC operation takes about ten minutes.
Due to overbooking of the beamline, faster access may be achieved via the mail-in option.
For SAXS proposals, you may select the mail-in option for your project. After the beamtime for mail-in access has been allocated, the samples and matching buffers should be mailed to EMBL Hamburg with appropriate instructions for the sample handling and measurements.
Mail-in projects may be service-only (you receive the data) or collaborative projects with one of our staff (you receive the data, analysis, interpretation and modelling).
The mail-in SAXS option is mostly for standard batch measurements with fully-prepared samples which require minimum handling. However, a limited number of constructs can also be sent to P12 for in-line SEC/IEC-SAXS. The proposed FPLC/HPLC-SAXS experiments must be discussed in detail with the responsible scientist and sufficient quantities of the sample and elution buffer(s) must be provided. Both service-only (you receive the SAXS data and limited spectroscopic information) and collaborative projects (you receive the data, analysis, interpretation and modelling) are possible. However, if additional biophysical characterization is required (SEC/IE-SAXS combined with MALLS/DLS, etc) or you elect additional access to the SPC infrastructures (mass-spec, CD, FTIR, etc), the project will be considered collaborative.