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EMBO Practical Course

Integrative analysis of multi-omics data

Overview

Funded by EMBO for excellence in the life sciences

Course overview

Biological and biomedical research frequently employs multiple ‘omics methods
(“multi-omics”) to investigate biological systems comprehensively. This approach simultaneously examines various molecular layers (DNA, RNAs, proteins, metabolites) and helps to overcome limitations inherent in individual technologies. These modalities are increasingly profiled at single-cell and/or spatial resolutions. Integrating and analysing these complex datasets poses significant challenges. How can we interpret perturbation effects, establish associations between molecular profiles and study variables, or detect latent variables representing key biological elements like cell types or states? Crucially, how can we achieve these goals with statistical robustness and scientific rigor, facilitating clear and convincing reporting?

This course addresses those essential questions, providing participants with foundational mathematical and conceptual understanding of integrative multi-modal data analysis methods. Through hands-on sessions using state-of-the-art datasets, attendees will explore different software tools, assess data quality and results, identify potential pitfalls, evaluate performance, optimize model parameters, interpret outcomes effectively, and embrace open-science practices. Methods covered include factor analysis, multi-table ordination and dimensionality reduction techniques, notably the widely utilised Multi-Omics Factor Analysis (MOFA) and more recent approaches, developed by the course faculty.

Audience

This course is aimed at bioinformatics scientists, PhD students and post-docs aiming to improve their skills in multi-omics data integration methodologies. Scientists who themselves have a training role are particularly encouraged to apply. Experience with R and/or Python and willingness to work with both is a prerequisite for this course.

Modules

  • Multi-table integration: motivation, concepts and theory
  • Multi-omics case studies, single cell multi-omics, spatial omics
  • Data management and open science related topics in multi-modal data integration
  • Visualisation and interactive data analysis

Learning outcomes

The course will provide researchers with an overview and the theoretical foundations of state-of-the-art methods for multi-modal integration, with a focus on omics data. In practical sessions on relevant real-world examples from single-cell and bulk multi-omics studies, participants will gain familiarity with software implementations and learn about practical aspects, including quality assessment of inputs and outputs, method performance assessment, choice of tuning parameters, interpretation of the model fit and potential pitfalls.

What past participants say about the course

The course was a fantastic overview of the state-of-the-art in multi-omics integration with exposure to the top methods and researchers in the field. Getting to discuss open problems with the speakers and other participants was invaluable and I’ve made some great connections with other attendees which I hope to continue to develop.” – Eleanor Williams, Wellcome-MRC Cambridge Stem Cell Institute, UK

The course provides a comprehensive overview of different multiomics data integration techniques with real-life applications and an excellent opportunity to network with fellow participants, speakers, and method developers.” – Adhideb Ghosh, ETH Zurich, Switzerland

Speakers, trainers, and staff

Annique Claringbould

Erasmus Medical Centre Rotterdam

The Netherlands

Helena Crowell

Centro Nacional de Análisis Genómico

Spain

Sascha Dietrich

Universitätsklinikum Düsseldorf

Germany

Wolfgang Huber

EMBL Heidelberg

Germany

Junyan Lu

Heidelberg University

Germany

Mor Nitzan

The Hebrew University of Jerusalem

Israel

Denis Schapiro

Heidelberg University

Germany

Oliver Stegle

EMBL Heidelberg/ DKFZ

Germany

Jonan Tanevski

Heidelberg University

Germany

Scientific organisers

Wolfgang Huber

EMBL Heidelberg

Germany

Junyan Lu

Heidelberg University

Germany

Oliver Stegle

EMBL Heidelberg/ DKFZ

Germany

Britta Velten

Heidelberg University

Germany

Course organisers

Juan Camilo Barbosa Caro

Scientific Training Officer

EMBL Heidelberg

Germany

Aline Schnieder

Course and Conference Team Lead

EMBL Heidelberg

Germany

Programme

Day 0: Date tbc
Time (Europe/Berlin)Session
Introduction to EMBLeCampus – pre-course briefing,
software package installations
Day 1: Tuesday, 28 July 2026
Time (Europe/Berlin)SessionLocation
08:40Bus to EMBL ATCISG Hotel
08:50 – 09:00RegistrationCourtyard Room A & B
09:00 – 09:15Welcome and safety instructionsCourtyard Room A & B
09:15 – 09:30Course OverviewCourtyard Room A & B
09:30 – 10:15Networking: Ice breaking activityCourtyard Room A & B
10:15 – 11:15Lecture 1: Probabilistic factor models for
integration of multi-omic data (MOFA)
Courtyard Room A & B
11:15 – 11:45Coffee break and meet the speakerCourtyard Room A & B
11:45 – 12:45LunchEMBL Canteen
12:45 – 14:15Practical 1: First steps with Multi-Omics Factor Analysis (MOFA): data setup, method calling, troubleshooting, and results interpretationCourtyard Room A & B
14:15 – 15:15Lecture 2
Oliver Stegle – EMBL Heidelberg/ German Cancer Research Center (DKFZ), Germany
Courtyard Room A & B
15:15 – 15:45Coffee break and meet the speaker – Oliver StegleCourtyard Room A & B
15:45 – 17:15Pratical 1: First steps with Multi-Omics Factor Analysis (MOFA): data setup, method calling, troubleshooting, and results interpretationCourtyard Room A & B
17:15 – 19:15Participant flash talksCourtyard Room A & B
19:15 – 20:15DinnerEMBL Canteen
20:15Bus to ISG HotelATC Entrance
Day 2: Wednesday, 29 July 2026
Time (Europe/Berlin)SessionLocation
08:40Bus to EMBL ATCISG Hotel
08:50 – 09:00Overview of the dayCourtyard Room A & B
09:00 – 10:00Lecture 3: Integrating single-cell transcriptomics and large-scale genetics to understand complex diseases
Annique Claringbould – Erasmus Medical Centre Rotterdam, The Netherlands
Courtyard Room A & B
10:00 – 10:15Coffee break and meet the speaker – Annique ClaringbouldCourtyard Room A & B
10:15 – 12:15Participants Presentations | NetworkingCourtyard Room A & B
12:15 – 12:30Group PhotoCourtyard Room A & B
12:30 – 13:15Lunch Break
13:15 – 14:45Practical 2: MOFA for single-cell multi-omics dataCourtyard Room A & B
14:45 – 15:45Lecture 4
Wolfgang Huber – EMBL Heidelberg, Germany
Courtyard Room A & B
15:45 – 16:15Coffee break and meet the speaker – Wolfgang HuberCourtyard Room A & B
16:15 – 18:15Pratical 2: Mosaic integration of multi-omics single-cell dataCourtyard Room A & B
18:15 – 18:30Bus to ISG HotelATC Entrance
18:30 – 19:30DinnerISG Hotel
19:30 – 20:30Round table discussion: Problems and challenges in data integration (including RCR principles)ISG Hotel
Day 3: Thursday, 30 July 2026
Time (Europe/Berlin)SessionLocation
08:40Bus to EMBL ATC ISG Hotel
08:50 – 09:00Overview of the dayCourtyard Room A & B
09:00 – 10:00Lecture 5: Integrative Spatial-omic data analysis
Denis Schapiro – Heidelberg University, Germany
Courtyard Room A & B
10:00 – 11:00Practical 3: Integrative analysis of spatial omics dataCourtyard Room A & B
11:00 – 11:15Coffee break and meet the speaker – Denis SchapiroCourtyard Room A & B
11:15 – 12:15Practical 3 (cont.): Integrative analysis of spatial omics dataCourtyard Room A & B
12:15 – 13:15LunchEMBL Canteen
13:15 – 14:15Lecture 6: Spatial-Resolved Transcriptomic Analysis
Helena L. Crowell – Centro Nacional de Análisis Genómico, Spain
Courtyard Room A & B
14:15 – 14:45Coffee break and meet the speaker – Helena L. CrowellCourtyard Room A & B
14:45 – 16:15Practical 3 (cont.): Integrative analysis of spatial omics dataCourtyard Room A & B
16:15 – 17:15Lecture 7: Multi-Omics for Precision Medicine
Junyan Lu – Heidelberg University, Germany
Courtyard Room A & B
17:15 – 18:00Bus transfer downtownATC Entrance
18:00 – 19:30Guided city tour
19:30 – 21:30Course dinner
Day 4: Friday, 31 July 2026
Time (Europe/Berlin)SessionLocation
08:40 – 08:50Bus to EMBL ATC ISG Hotel
08:50 – 09:00Overview of the dayCourtyard Room A & B
09:00 – 09:30Discussion: Open science and responsible conduct of research in data sciences
Wolfgang Huber – EMBL Heidelberg, Germany
Oliver Stegle – EMBL Heidelberg/ German Cancer Research Center (DKFZ), Germany
Courtyard Room A & B
09:30 – 10:30Lecture 8: AI and Multi-Modal Data Integration in Clinical Studies
Sascha Dietrich – University Clinic Düsseldorf, Germany
Courtyard Room A & B
10:30 – 10:45Coffee break and meet the speaker – Sascha Dietrich
10:45 – 11:45Lecture 9: Understanding complex and
dynamic biological systems with single-cell omic data

Mor Nitzan – The Hebrew University of Jerusalem, Germany
Courtyard Room A & B
11:45 – 12:30Discussion in small groups + time for participants to prepare presentationsCourtyard Room A & B
12:30 – 13:15Lunch BreakCourtyard Room A & B
13:15 – 14:00Discussion in small groups + time for participants to prepare presentationsCourtyard Room A & B
14:00 – 14:30Coffee break and meet the speaker – Mor Nitzan
14:30 – 16:00Presentations/ DiscussionCourtyard Room A & B
16:00 – 16:15Coffee Break /Courtyard Room A & B
16:15 – 17:30Presentations/ DiscussionCourtyard Room A & B
17:30 – 17:45Feedback and closing remarksCourtyard Room A & B
17:45 – 00:00Bus to Heidelberg train station and city center

Practical information

Registration fees

The course is limited to 30 participants. For selection purposes, please note that your application will not be considered without a letter of motivation.

Registration fees

Your registration for the event includes:

  • Admission to the event
  • Possibility to submit an abstract (if applicable)
  • Meals and coffee breaks
  • Course materials
  • Access to the e-learning platform
  • A letter to support your visa application (for more information, check the ‘Travel and accommodation’ tab)

For this EMBO course, the fees include accommodation and transportation to and from the ISG Hotel to the venue

Academia€250
PhD Student€250
Industry€1100

Confirmation and payment

The registration fee should be paid only after acceptance to the course. The results will be announced approximately 3 weeks after the application deadline.

Cancellation policy

If you are no longer able to take part in the course, please inform your course contact responsible for this event. Your registration and the submitted motivation letter will be deleted.

Please also check our Terms and Conditions for the cancellation policy.

Submitting a motivation letter

After you have logged in and successfully registered, you will receive an email asking you to submit your motivation letter. Click on the link provided and enter your motivation letter in the text box provided. Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering.

Instructions

  1. Include your relevant skills, experience and qualifications showing why you would be suitable for the course.
  2. Explain why you would like to attend, including what you can contribute and how you think you will benefit from the course.

Please note:

  • The limit of 2,000 characters refers to manually typed text and excludes spaces. If an error occurs try using a different web browser (preferably Google Chrome or Mozilla Firefox).
  • If you copy-paste the text into the form, hidden formatting might still be included which may cause the text to exceed the 2,000 character limit resulting in an error message. We recommend you clear all formatting before pasting in the text.
  • If you have special symbols in your text, make sure you are using Unicode characters, otherwise these will not be recognised.

For detailed instructions, please watch our video on how to submit a course motivation letter.

Please note it is not possible to apply after the motivation letter deadline!

Further details

For further information about registration and motivation letter submission please refer to the FAQ page.

Financial assistance

Financial assistance

Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of travel grants, childcare grants, and accessibility grants.

Your place in the meeting is only confirmed by paying the registration fee, which is mandatory even when receiving a fee waiver.

Travel grant

The travel grant will cover the cost of travel (airfare, train, bus, taxi, and visa) and/or registration fees and is provided up to specified caps which are normally as follows:

  • up to €500 for any participant travelling to an EMBO Practical Course.
  • up to €1000 for any participant working in Chile, India, Singapore, or Taiwan travelling to an EMBO Practical Course.

The organisers may reduce the grant cap to accommodate more participants. Recipients will be notified of their travel cap amount when they are informed of the outcome of their application. Original receipts must be provided with your signature for all costs incurred within two months of completion of travel. Scanned copies cannot be accepted.

Childcare grants

There is the possibility to apply for a childcare grant to offset child care costs incurred by participants, speakers, trainers, and organisers when attending a course. Eligible costs include (but are not limited to) fees for a babysitter, child-care facility, or travel costs for a caregiver. Please note that priority will be given to early-stage researchers. There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants.

Boehringer Ingelheim Fonds travel grant

Applies to selected courses only. Availability will be indicated during the abstract or motivation letter submission process.

This grant covers costs related to your attendance to the course (registration, travel, and accommodation costs). The grant is restricted to PhD students and postdocs who conduct basic biomedical research.
Whether you are eligible to apply for a travel grant, depends on when you received your university entrance qualification (e.g. Abitur, A-Levels, High School Diploma, Final State Examination):

  • for PhD and MD students, as well as graduates, the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course
  • for postdocs, the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course

EMBO accessibility grant

For EMBO Practical Course participants with accessibility needs, there is the possibility to apply for an accessibility grant to offset costs incurred by participants or speakers when participating at a course. Eligible costs include costs incurred for equipment or adaptations to the course environment, or travel costs for an event companion to assist the participant or speaker during the course where necessary. While we do our best to accommodate needs, please note that extensive changes to the course environment might not be possible. Priority will be given to early-stage researchers.

A maximum amount of €500 can be awarded per participant applying for an EMBO accessibility grant. In order to apply for this grant for EMBO Practical Courses, you must be registered by the application deadline. 

Application

Whether you are attending onsite or virtually, to apply for financial assistance, please follow the steps in the application system. During the process of submitting your motivation letter to the system, you will be asked which type of grant you want to apply for.

Applications for financial support will not affect the outcome of your selection results.

Information about the grant will be sent out shortly after the motivation letter deadline.

Results

Grant allocations are announced by email to all applicants after the selection results.

Allocation results do not impact your selection to the course. Selection for financial assistance is based on scientific merit, your current work or study location, the reasons for needing financial support, and the impact this event will have on your career.

Please note that for childcare grants, priority will be given to early-stage researchers.

Further details

Check out this list of external funding opportunities

For further information about financial assistance please refer to the FAQ page.

Participant selection

The selection results will be announced by email to all applicants. We aim to announce 3 weeks (21 days) after the motivation letter submission deadline but delays may occur.

Travel and accommodation

Visa

We can send you a registration confirmation to support your visa procedure (not an official invitation letter). Please contact the Conference Officer responsible for your event. Read our FAQ for more information.

Travel

If you are travelling to Heidelberg via aeroplane, train, car, or long-distance bus, you can find useful information on our travel information page.

Accommodation

Accommodation in twin rooms, including breakfast is also part of the registration fee. Accommodation will be booked for the selected participants at the ISG Hotel for the default dates of 27 July 2026 to 1 August 2026 (5 nights).

In case you would like to have a single room, please let the hotel know and please note that you will be required to pay a surcharge per night (availability of single rooms may be limited). This should be paid by you directly to the ISG Hotel during your stay.

We recommend that all course participants stay at the ISG Hotel for the course.

Local transportation

Course shuttle buses

Shuttle buses will go from the ISG Hotel to EMBL and back, mornings and evenings. A bus schedule and location of the bus stops will be made available prior to the meeting.

Other local transportation

In addition to the shuttle busses, there is also the public bus 28 that serves the EMBL campus and taxis can be easily booked at any time. For more information, please refer to the local transportation (RNV) website.

You may also walk from the ISG Hotel to EMBL (takes up to 30 minutes)

Map to walk from ISG Hotel to EMBL

Further details

Address: EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

For more information about accommodation and travel, please refer to the FAQ page.

Onsite information

Here you will find useful information for when you are onsite at the event.

Catering

All meals and coffee breaks are included in the registration fee. Our catering staff will prepare a variety of vegetarian meals, meat and fish dishes, soups, pasta, fresh fruit and vegetables, as well as a variety of desserts.

Please wear your badge at all times when serving yourself.

No food or drinks are allowed in the computer training lab or wet labs.

Internet

Wi-Fi is available on campus using the EMBL-Events network and the event specific password, which will be provided on site. The eduroam network (secure, worldwide roaming access service developed for the international research and education community) is also available.

Photography

During the conference, an EMBL Photographer may be taking photos. If you would not like to appear in these, please inform the photographer or a member of the Course and Conference Office.

Charging stations

There are lockers available next to the stairs leading down into the Auditorium. You will find some of those equipped with sockets to charge your smartphone/tablet etc.

In most places the electricity is 220 volts AC (50 cycles). An adaptor and a plug that fits the German socket may be needed for your appliances/laptop (i.e. American, Japanese, etc.). A USB charging station for electronic devices is available at the registration desk.

Printing

We can help to print your boarding pass/train ticket. Please send it to events@embl.de and collect your print-outs at the registration desk.

Luggage

There are lockers available on-site to store your luggage, which require a 2 EURO coin to operate. There is another luggage room on level E0, which is free to use but remains unlocked during the course.

Lost and found

‘’Lost and Found’’ items are kept at the registration desk until the end of the course.

Nursing room

There is a nursing room available in the ATC Rooftop Lounge on level A29.

Room for prayers, meditation, and yoga

There is a room for prayer, yoga, and meditation, located on level E0 behind the Auditorium. Please be respectful of others using the room.

EMBL campus map

Health and safety notes

Please take a moment to read our health and safety policy.

  • Do not smoke in any EMBL building.
  • Eating and drinking is prohibited in the Auditorium and all laboratories.
  • Do not enter any restricted areas or the laboratories unless instructed to do so.

If first aid is required

  • The first aid room is located next to the ATC Registration Desk (room 10- 205).
  • Dial the Emergency number 222 from any EMBL internal phone only.
  • Be prepared to answer the following questions: Where is the accident? What happened? How many injured?
  • Emergency number 06221-387 7821 from mobile phones.
  • Please report all accidents to the conference officer at the registration desk.

In case of fire

  • Press the nearest fire alarm button or the Emergency number 222 from any internal phone.
  • A loud fire alarm will go off if an evacuation is required. On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points
  • Do not use the lifts.

Beyond first aid

The Heidelberg University Hospital or ‘Universitätsklinikum‘ has a 24 hour accident and emergency facility and is at ‘Im Neuenheimer Feld 672’. It is a 8km or a 20 minute taxi ride away from EMBL. In a medical emergency, the ambulance service generally transports patients to this hospital.

Please remember to bring your own medication, if needed, to the conference. Note that the next pharmacy is a 4-minute drive from the EMBL, but for many medications you will be required to see a doctor to get a prescription.

Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg.

The EMBL course and conference office team are able to advise you on where to turn for emergency or non-emergency medical treatment in Heidelberg and can assist you in making appointments and / or arranging transport to get to the pharmacy or a doctor of your choice if necessary. Please note, we are not however permitted to personally accompany you off-campus.

Sightseeing

A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing.

Technical requirements and event software

Technical requirements

Below you will find the software and technical requirements for this course. You will need admin rights to be able to install the software on your computer and we recommend you try this before the course. If you do not have admin rights, please contact your technical support team in advance to make sure the software can be installed.

Additional software

The EMBL eCampus learning platform will be used to collaborate, communicate and network with all of the course participants. All participants will receive information on how to join shortly before the course. We recommend using Chrome, Safari or Mozilla Firefox browsers for eCampus. 

Zoom will be used for the live talks and Q&A sessions. More information will be provided closer to the start of the course.

Additional information

Please find additional information including FAQs and terms and conditions on our Information for Participants page.

Sponsors

Sponsorship opportunities

We offer a variety of event sponsoring possibilities, with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget. Discounts are available for companies sponsoring multiple events at EMBL Heidelberg. View other conferences, or contact sponsorship@embl.org. for further information.

If you are interested in becoming a media partner of this event, please visit our media partnerships webpage.

Warning

EMBL advises sponsors to beware of fraudulent schemes falsely offering sponsorship opportunities. All legitimate communication about sponsorship for EMBL conferences, symposia, and courses comes directly from EMBL via official EMBL email accounts. EMBL does not use third parties for sponsorship acquisition.

– EMBL does not sell attendee lists.
– EMBL will never ask for credit card details or direct payments.
– All payments are processed by invoice only.

If you receive a suspicious message claiming to be from or on behalf of EMBL, please report it to sponsorship@embl.org.

Media kit

Want to let others know you’re attending this event? Take a look at our shareable media and feel free to use them in your social media channels or presentations.

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Date: 28 - 31 Jul 2026

Location: EMBL Heidelberg

Venue: EMBL Advanced Training Centre


Deadline(s):

Application: 21 Apr 2026


Organisers:

  • Wolfgang Huber
    EMBL Heidelberg, Germany

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