Metabolite and species dynamics in microbial communities

Overview

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Course overview

Metagenomics studies are rapidly uncovering the compositional richness of microbial communities across diverse habitats, from the oceans to the human gut. While their fundamental role in our health and environment is undeniable, there is an urgent need for unravelling the molecular mechanisms underlying the dynamics of these communities. This requires a combined experimental and computational approach. Recent studies (including those from the organisers’ and speakers’ labs) have underlined the success of such integrative approaches. For example, emergence of cell subpopulations (Varahan et al. eLife 2019, 2020), and long-term stability (Blasche, Kim et al. Nat Microbiol. 2021) through metabolic cross-feeding.

As researchers worldwide map species dynamics in the ecosystems of their interest, this course will provide the necessary overview and tools for moving from cataloguing to identifying key interaction agents, especially metabolites. This will include integrating species- and metabolite-dynamics data and leveraging the power of genome-scale metabolic models to predict community interactions.

What past participants say about the course

“The course was a great blend of theoretical knowledge and practical applications. It was very dynamic, allowing for engaging discussions and networking opportunities among participants. From trainers to speakers and organizers, everyone was so helpful and approachable, making it easy to ask questions and seek guidance. The diverse facets and perspectives presented created an ideal environment for learning, hands-on exploration, and collaboration.” – Humberto Castillo González, Université de Franche-Comté, France.

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