Predicting evolution

Time (Europe/Berlin)	Speaker
11:30 – 13:00	Registration and light refreshments
13:00 – 13:15	Opening remarks
	Session 1: Predicting the evolution of molecules, part 1 Chairs: Patricia Wittkopp, Frank Albert
13:15 – 13:40	Meiotic drive and satellite DNA in Drosophila Amanda Larracuente – University of Rochester, USA
13:40 – 14:05	Epistasis between promoter activity and coding mutations shapes gene evolvability Christian Landry – Institute of Integrative and Systems Biology, Canada Not available on demand
14:05 – 14:30	Towards a mechanistic basis of evolvability Tzachi Pilpel – Weizmann Institute of Science, Israel
14:30 – 14:45	Evolutionary playgrounds and how to find them Alexandra Dallaire – Royal Botanic Gardens Kew, UK
14:45 – 15:00	Mutational hotspots of T→G in bacteria can be constructed by manipulating local nucleotide context James Horton – University of Bath, UK
15:00 – 15:30	Coffee Break and meet the speakers
15:30 – 15:55	Clustering structures at the scale of the known protein universe to study protein evolution Pedro Beltrao – ETH Zurich, Switzerland
15:55 – 16:10	Epistasis facilitates functional evolution in an ancient transcription factor Brian Metzger – Purdue University, USA
16:10 – 16:25	B. subtilis underground metabolic richness hinders evolutionary predictability Lianet Noda-García – The Hebrew University of Jerusalem, Israel
16:25 – 16:50	The evolution of transcription-factor binding specificity: a role for disordered regions Naama Barkai – Weizmann Institute of Science, Israel
16:50 – 17:15	Antagonistic coevolution preserves genome integrity Mia Levine – University of Pennsylvania, USA Not available on demand
17:15 – 17:30	Flash talks 1
17:30 – 19:00	Dinner in canteen
19:00 – 21:00	Pub quiz & after dinner drinks in canteen

Time (Europe/Berlin)	Speaker
	Session 2: Predicting regulatory network evolution Chairs: Joshua Payne, Tamar Friedlander
09:15 – 09:40	Evolutionary changes in gene regulatory networks inferred from patterns of co-expression Patricia Wittkopp – University of Michigan, USA
09:40 – 09:55	Predictive genotype-phenotype-fitness mapping of tetracycline resistance Mato Lagator – University of Manchester, UK
09:55 – 10:10	The contribution of alternative splicing to adaptation in threespine stickleback Carlos Ramirez – University of Bern, Switzerland
10:10 – 10:35	Predicting the evolution of Sars-CoV-2 Michael Lässig – University of Cologne, Germany
10:35 – 11:05	Coffee break and meet the speakers
11:05 – 11:30	Predicting cis-regulatory evolution using a deep learning oracle Carl de Boer – University of British Columbia, Canada
11:30 – 11:45	Towards interpretable genomic predictions: effect propagation in gene regulatory networks Natalia Ruzickova – Institute of Science and Technology, Austria
11:45 – 12:00	Origin and evolution of dynamic properties of gene regulatory circuits in fluctuating environments Mariana Gómez-Schiavon – Universidad Nacional Autónoma de México, Mexico
12:00 – 12:25	Does lab yeast evolution predict wild yeast evolution? Maitreya Dunham – University of Washington Seattle, USA
12:25 – 14:00	Lunch
	Session 3: Predicting cellular evolution Chairs: Gautam Dey, Tim Fuqua
14:00 – 14:25	A foray into convergent mechanisms of embryo implantation Camille Berthelot – Institut Pasteur, France
14:25 – 14:40	Genetic variation in the ubiquitin-proteasome system Frank Albert – University of Minnesota, USA
14:40 – 14:55	The Evolution of Biomolecular Condensates: Why is it an exciting and fundamental problem? Pouria Dasmeh – University of Marburg, Germany
14:55 – 15:10	Simple rules govern metabolome evolution in animals Balazs Papp – Biological Research Centre Szeged, Hungary
15:10 – 15:40	Coffee break and meet the speakers
15:40 – 15:55	Acquired antimicrobial resistance affects the evolvability of resistance to further antibiotic exposure Maria Rosa Domingo Sananes – Nottingham Trent University, UK
15:55 – 16:10	Bacterial evolved resistance against host-targeting drugs culminates in predictable antibiotic cross-resistance Amir Mitchell – University of Massachusetts Medical School, USA Not available on demand
16:10 – 16:35	Predicting experimental evolution in Pseudomonas Peter Lind – Umeå University, Sweden Not available on demand
16:35 – 17:00	A tail of tales: convergent phenotypes driven by divergent genotypes Hopi E. Hoekstra – Harvard University/HHMI Cambridge, USA (remote talk)
17:00 – 17:15	Flash talks 2
17:15 – 19:00	Poster session 1 (odd numbers)
19:00	Free evening

Time (Europe/Berlin)	Speaker
	Session 4: Prediction developmental evolution Patricia Wittkopp, Virginie Courtier-Orgogozo
09:15 – 09:40	Multidimensional Approach to Decoding the Mysteries of Animal Development Justin Crocker – EMBL Heidelberg, Germany
09:40 – 09:55	Studying enhancer evolution in Drosophila trichome development using neural networks Tatiana Gaitan – Stowers Institute for Medical Research, USA
09:55 – 10:10	Polyploidization: can we predict its evolutionary pathway? David Peris – CSIC & University of Oslo, Spain
10:10 – 10:35	Genetic and nongenetic evolutionary determinants of cancer driver choice Duncan Odom – German Cancer Research Center, Germany
10:35 – 11:05	Coffee break and meet the speakers
11:05 – 11:30	Replaying the tape of life: how predictable is evolution Catherine Peichel – University of Bern, Switzerland
11:30 – 11:45	Exploring the mechanisms of adaptation to altered glucose homeostasis in blind Mexican cavefish Ansa Cobham – Stowers Institute for Medical Research, USA
11:45 – 12:00	Evolution of the capability for regulation of gene expression in the symbionts of reed beetles Ana Carvalho – Max-Planck Institute for Chemical Ecology, Germany
12:00 – 12:25	Diversification of duplicated genes and their cis-regulatory control in shaping natural and engineered plant phenotypes Zachary Lippman – CSHL/HHMI New York, USA Not available on demand
12:25 – 14:00	Lunch
	Session 5: Prediction population and community evolution Justin Crocker, Joe Thornton
14:00 – 14:25	The predictability of protein evolution under rewired genetic codes Joshua Payne – ETH Zurich, Switzerland Not available on demand
14:25 – 14:40	Strong environmental memory revealed by experimental evolution in static and fluctuating environments Clare Abreu – Stanford University, USA
14:40 – 14:55	Evolutionary adaptations in microbial microcosms are largely independent of the presence of coevolving species Jonathan Friedman – Hebrew University of Jerusalem, Israel
14:55 – 15:10	Developmental selection and its impact on evolutionary trajectories Paco Majic – ETH Zurich, Switzerland
15:10 – 15:40	Coffee break and meet the speakers
15:40 – 15:55	Evolving insertion sequences into promoters Timothy Fuqua – University of Zurich, Switzerland
15:55 – 16:10	The role of promiscuous molecular recognition in the evolution of RNase-based self-incompatibility Tamar Friedlander – Hebrew University of Jerusalem, Israel Not available on demand
16:10 – 16:25	The rise Patterns of recombination in snakes reveal a tug-of-war between PRDM9 and promoter-like features Carla Hoge – Columbia University New York, USA
16:25 – 16:40	Broad Explorations of SARS-CoV-2 Omicron Lineage Protein Landscapes Thomas Dupic – Harvard University, USA
16:40 – 16:55	Flash talks 3
16:55 – 19:00	Poster session 2 (even numbers)
19:00 – 21:00	Conference dinner in the canteen
21:00 – 23:00	Conference party

Time (Europe/Berlin)	Speaker
	Session 6: Predicting the evolution of molecules, part 2 Chairs: Joshua Payne and Balazs Papp
09:15 – 09:40	The evolutionary road to complexity of earth’s most important CO2 fixing enzyme Georg Hochberg – MPI Marburg, Germany
09:40 – 09:55	A rugged yet easily navigable fitness landscape of antibiotic resistance Andrei Papkou – University of Zurich, Switzerland
09:55 – 10:10	The global simplicity of protein sequence-function relationships Joe Thornton – University of Chicago, USA
10:10 – 10:35	Provisional parcels for predicting evolution Brandon Ogbunu – Yale University New Haven, USA (remote talk)
10:35 – 11:05	Coffee break and meet the speakers
11:05 – 11:30	Predicting the mutations underlying phenotypic evolution using Gephebase Virginie Courtier-Orgogozo- Institut Jacques Monod Paris, France
11:30 – 11:45	How does temperature adaptation influence the evolvability of proteins? David Schnettler – ETH Zurich, Switzerland
11:45 – 12:00	Genomic analysis predicts the emergence of de novo Oxalate Metabolism in E. coli during Lab Evolution Avihu Yona – The Hebrew University, Jerusalem, Israel
12:00 – 12:15	Closing remarks and poster prize Justin Crocker
12:15 -13:00	Packed lunch and departure
13:00	Optional: Bus to Frankfurt airport (Terminal 1)

On-site registration fees include admission, conference materials, COVID-19 safety measures, meals and coffee breaks. Participants are expected to book and pay their own accommodation and travel expenses.

Virtual registration fees include access to all of the talks (livestreamed and on demand) and facility to submit questions.

On-site Academia	€450
On-site PhD Student	€350
On-site Industry	€750
Virtual Academia	€200
Virtual PhD Student	€150
Virtual Industry	€250

NO visa support letters will be issued until payment of the registration fee is confirmed.

Accredited journalists may be eligible to register for a reduced press rate or in some cases for complimentary registration. Registrants may be required to provide accreditation or equivalent proof of press membership after registration. Please contact Inna Bösselmann for more information. Please note that we do not offer complimentary registrations for editors of scientific journals.

Confirmation and payment

Registration will be on a first-come first-served basis. Your place can only be confirmed after payment of the registration fee. If you are added to our waiting list, please consider taking advantage of our offerings to participate virtually.

On-site participants: Types of payments accepted are international bank transfers and credit card payments.

Virtual participants: We are only able to accept card payments. In exceptional cases we can accept bank transfers. Please contact events@embl.de for details.

Abstract submission

Only participants registering to attend the on-site event are eligible to submit an abstract. Abstracts will not be accepted from virtual participants.

After registration you can submit your abstract via a separate link that will be provided in the email confirmation. Alternatively, you can access the link on the confirmation page directly after registering. The same login credentials are used for both processes.

Please note:

Abstract body: The limit of 2000 characters refers to manually typed text and excludes spaces. If an error occurs try using a different web browser (preferably Google Chrome or Mozilla Firefox).

If you copy-paste the text into the form, hidden formatting might still be included which may cause the text to exceed the 2,000 character limit resulting in an error message. We recommend you clear all formatting before pasting in the text.

If you have special symbols in your text, make sure you are using Unicode characters, otherwise these will not be recognised.

Title: The title should not exceed 20 words. Only the first word of the title should start with a capital letter and the rest should be lowercase.

Authors and affiliations: Please fill in the author’s details as requested in the online form. The compulsory fields are: First Name, Last Name, Organisation Name (Affiliation or Company), Country and Email.

Kindly mark only one author in the role of First Author and please don’t forget to indicate who will be the Presenter.

Please enter your co-authors correctly via the system by adding accounts together with their organisation/institute. Do not copy-paste them into the body of the abstract text, as they will not be indexed in the abstract book.

Presentation types: When submitting your abstract, you can apply for an oral or poster presentation. A selection process will take place with the results announced 2-3 weeks after the abstract submission deadline.

For detailed instructions on how to submit a conference abstract, follow the instructions provided in this video.

Please check our FAQs pages for further information on how to submit an abstract.

Financial assistance

Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants. These are available for on-site participants at EMBL Conferences and EMBO|EMBL Symposia, and for on-site and virtual participants at EMBO Workshops. We are currently working on securing funding for all virtual participants, and ask that you please apply for financial assistance for both on-site and virtual participation. 

Your place in the meeting is only confirmed by paying the registration fee, which is mandatory even when receiving a fee waiver.

Registration fee waiver

The fee waiver will cover the registration sum that you have paid to attend the course or conference.

Travel grant

The travel grant will cover the cost of travel to an on-site event (airfare, train, bus, taxi, accommodation, visa, and/or registration fees*) and is provided up to specified caps which are normally as follows:

–up to €400 for participants travelling to an EMBL Conference or EMBO|EMBL Symposium from within Europe.

–up to €1000 for participants travelling to an EMBL Conference or EMBO|EMBL Symposium from outside Europe.

–up to €500 for any participant travelling to an EMBO Workshop.

–up to €1000 for any participant working in Chile, India, Singapore or Taiwan travelling to an EMBO Workshop.

–up to €700 for any participant working in Croatia, Czech Republic, Estonia, Greece, Hungary, Italy, Lithuania, Luxembourg, Poland, Slovenia, and Turkey travelling to an EMBO Workshop.

*Registration fees are only covered for EMBO Workshops

The organisers may reduce the grant cap to accommodate more participants. Recipients will be notified of their travel cap amount when they are informed of the outcome of their application. Original receipts must be provided with your signature for all costs incurred within two months of completion of travel. Scanned copies cannot be accepted.

Childcare grant (EMBO Workshops only)

For EMBO Workshop participants with children, there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a conference. Eligible costs include fees for a baby-sitter or child-care facility, travel costs for a caregiver, or travel costs for taking the child to the meeting etc. Please note that priority will be given to early stage researchers. A maximum amount of €500 can be awarded per participant applying for an EMBO childcare grant. In order to apply for this grant for EMBO Workshops, you must be registered by the abstract submission deadline.

Application

On-site participants

You may apply for financial assistance when submitting your abstract. In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career. Application for financial support will not affect the outcome of your registration application.

Virtual participants

If you are attending virtually, you can apply for financial assistance in the submission portal by the abstract deadline. Read the instructions on how to apply for financial assistance. Only submissions for financial assistance will be accepted. Presentation abstracts cannot be submitted here and will be declined. 

In your application you will be asked to summarise your current work,  answer questions regarding why your lab cannot fund your attendance, and how your attendance will make a difference to your career. Application for financial support will not affect the outcome of your registration application.

Selection

The scientific organisers will select the recipients of all financial assistance during the abstract selection process. Results will be announced approximately 6 – 8 weeks before the event start date, however for some events this may be delayed. Selection results do not impact your admission to the meeting. Selection is based on scientific merit, your current work or study location, the reasons for needing financial support, and the impact this event will have on your career.

Reimbursement

Costs will be reimbursed after the meeting only once a reimbursement form and original receipts (from travel costs) have been received.

Further details

View our list of external funding opportunities and information on attending a conference as an event reporter.

For further information about financial assistance please refer to the FAQ page.

Accommodation is not included in the conference registration fee.

As further changes in our events are possible due to COVID-19, you should book flights, trains and hotels with flexible options and favourable cancellation conditions.

The hotels below have rooms on hold for participants until 13 June 2023, in some cases at special rates. Please email the hotel directly, quoting the booking code PEV23-01 to confirm the exact price of the room.

Hotel Anlage	Hotel Holländer Hof	Hotel Monpti
Hotel Bayrischer Hof	Hotel ibis Heidelberg	Premier Inn Heidelberg City
B&B Hotel	ISG Hotel	Staycity Aparthotel Heidelberg
Exzellenz Hotel	Leonardo Hotel Heidelberg City Centre	Steffi’s Hostel Heidelberg

Conference shuttle buses

Conference shuttle buses are free of charge for participants, and depart from designated bus stops near the hotels to EMBL and back, mornings and evenings.

You can find the final bus schedule here.

The bus stops for this conference are:

• Kurfürsten-Anlage (Opposite Main Train Station)
• Hotel Premier, Kurfürsten-Anlage 23
• Leonardo Hotel (Bergheimer Str.)
• Neckarmuenzplatz
• Peterskirche
• ISG Hotel

View Conference shuttle bus stops and hotels in a larger map. Please note that not every bus stop will be used for every event. You can find the final bus schedule here.

Further details

Address: EMBL, Meyerhofstraße 1, 69117 Heidelberg, Germany. For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue. For information about accommodation and local transportation please refer to the FAQ page.

Catering

All meals and coffee breaks are included in the registration fee. Our catering staff will prepare a wide variety of vegetarian meals, meat and fish dishes, soups, pasta, fresh fruit and vegetables, as well as a variety of desserts.

Please wear your badge at all times when serving yourself.

No food or drinks are allowed in the auditorium.

Charging lockers

There are lockers available next to the stairs leading down into the Auditorium. You will find some of those equipped with sockets to charge your smartphone/tablet etc.

Electricity and charging station

In most places the electricity is 220 volts AC (50 cycles). An adaptor and a plug that fits the German socket may be needed for your appliances/laptop (i.e. American, Japanese, etc.). A USB charging station for electronic devices is available at the registration desk.

EMBL merchandise

If you are interested in purchasing an EMBL souvenir (products presented in the glass display in the registration area), please ask at the registration desk for more information.

Health and safety notes

Please read EMBL’s COVID-19 safety policy for on-site events.
Do not smoke in any EMBL building.
Eating and drinking is prohibited in the Auditorium and all laboratories.
Do not enter any restricted areas or the laboratories unless instructed to do so.

If first aid is required …

• The first aid room is located next to the ATC Registration Desk (room 10- 205).
• Dial the Emergency number 222 from any EMBL internal phone only.
• Where is the accident? What happened? How many injured?
• Emergency number 06221-387 7821 from mobile phones.
• Please report all accidents to the conference officer at the registration desk.

In case of fire …

• Press the nearest fire alarm button or the Emergency number 222 from any internal phone.
• A loud fire alarm will go off if an evacuation is required. On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points
• Do not use the lifts.

Beyond first aid…

Please remember to bring your own medication, if needed, to the conference. Note that the next pharmacy is a 4-minute drive from the EMBL, but for many medications you will be required to see a doctor to get a prescription.

Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg. In any case, the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary.

Internet

Wi-Fi is available everywhere on the premises using the EMBL-Events network and the event specific password, which will be provided on site. The eduroam network (secure, world-wide roaming access service developed for the international research and education community) is also available.

Lost and found

‘’Lost and Found’’ are kept at the registration desk until the end of the conference.

Luggage

There are lockers available on-site to store your luggage, which require a 2 EURO coin to operate. There is another luggage room on level E0, which is free to use but remains unlocked during the conference.

Nursing room

There is a nursing room available in the ATC Rooftop Lounge on level A29.

Photography

During the conference an EMBL Photographer may be taking photographs. If you would not like to appear in these, please inform the photographer or a member of the Course and Conference Office.

Printing

We can help printing your boarding passes/train ticket. Please send it to events@embl.de and collect your print-outs at the registration desk.

Room for prayer, yoga and meditation

There is a room for prayer, mediation and yoga located on level E0 behind the Auditorium. Please be respectful of other participants using the room.

Sightseeing

A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing.

Travel to and from the venue

During the event we provide conference shuttle buses to and from EMBL. In addition, there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time. Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page.

Useful German expressions

Hello	Hallo
Goodbye	Auf Wiedersehen
Good morning	Guten Morgen
Good afternoon	Guten Tag
Good evening	Guten Abend
Good night	Gute Nacht
I’m sorry	Tut mir leid
Excuse me…	Entschuldigen Sie
How are you?	Wie gehts?
I’m fine thanks. And you?	Mir geht es gut , danke, und dir/Ihnen?
What is your name	Wie heisst du? Wie heissen Sie?
My name is	Ich heisse
Do you speak English	Sprechen Sie Englisch?
I don’t understand	Ich verstehe nicht
Please speak more slowly	Können Sie bitte langsamer sprechen
Thank you	Dankeschön
Where is the toilet?	Wo ist die Toilette?
Please call me a taxi	Bitte rufen Sie mir ein Taxi
How do I get to….?	Wie komme ich zum/zur…..?
A beer/two beers please	Ein Bier/zwei Bier bitte
A glass of red/white wine please	Ein Glas Rot/Weisswein bitte
The menu, please	Die Speisekarte, bitte
Is there a local speciality?	Gibt es eine Spezialität aus dieser Gegend?
I’m Vegetarian	Ich bin Vegetarier
It was delicious	Es war hervorragend
The bill, please	Die Rechnung, bitte
I have a headache	Ich habe Kopfschmerzen
I have a sore throat	Ich habe Halsschmerzen
My stomach hurts	Ich habe Magenschmerzen
I’m allergic to	Ich bin allergisch gegen
I need a doctor who speaks English	Gibt es einen Arzt, der Englisch spricht?

What’s included?

• Access to all the livestreamed talks
• Video library of the recorded talks during and after the event
• Facility to submit questions

Please note that only on-site participants are able to submit abstracts and participate in the poster sessions.

Event platform

We are using an event platform for this conference. More information about the platform will be shared ahead of the conference.

Guidelines

• Do not broadcast the conference to unregistered participants.
• You are encouraged to tweet and post about the event. Tweet unless the speaker specifically says otherwise, but be mindful of unpublished data. 
• Please do not capture, transmit or redistribute data presented at the meeting.

Additional information can be found in our Code of Conduct.

Health and well-being

It is important to stay healthy and move around, especially when you are attending an event virtually. We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event.

How to ask questions

Please use the Q&A function in the event platform.

If you have any other questions, you can go to the Help Desk in the event platform. Click on ‘more’ on the top menu and click Help Desk. 

Time zone

The programme is planned based on the Europe/Berlin time zone, unless otherwise stated. Please take your time zone into consideration when planning your attendance.

Please find additional information including FAQs, terms and conditions, COVID-19 safety policy and travelling to EMBL on our Information for Participants page.

COVID-19 information for on-site events at EMBL Heidelberg can be found in our COVID-19 FAQs.