Karine Choquet
Université de Sherbrooke
Canada
Overview
This conference will take place at EMBL Heidelberg, with the option to attend virtually.
Registration is not yet open for this event. If you are interested in receiving more information please register your interest.
Conference overview
Gene expression is controlled by the dynamic action of dozens of macromolecular complexes that assemble on DNA to transcribe genes and translate mRNAs to proteins. Understanding of these mechanisms has historically been driven by biochemical and structural characterisation of the players, as well as probing their function through genetic deletions. The genomics revolution has provided us with a near- comprehensive picture of where these factors bind to regulate the genome and which transcripts are processed in various biological contexts.
A key limitation of the resulting models is that they are derived using data that are static by nature, unfaithfully representing the dynamics of these regulatory processes in vivo. The last few years has seen the independent emergence of microscopy and genomics technologies to monitor gene regulation processes with single molecule resolution. Recording the dynamic function of regulatory proteins on DNA and RNA now opens opportunities to understand key parameters of the process such as its kinetics, or how various activities are combined in vivo.
This meeting will bring together pioneers of the single molecule microscopy and single molecule genomics field, as well as theoretical biologists to catalyse the emergence of a new generation of mechanistic models of the regulation of genes across each steps of the central dogma.
Topics
- RNA processing
- Translation
- Transcription and chromatin regulation
- Method development
- Theory
What past participants say about the conference
“It was an excellent conference. The first conference on single-molecule genomics, the complementary microscopy and theory gave excellent perspectives on the same phenomena. It is important that this conference happens again in future years.” – Nick Owens, University of Exeter, UK
““Gene regulation: one molecule at a time” was all about discussing and sharing exciting new ideas and technologies to get at the nitty gritty details of gene expression with an enthusiastic crowd of like-minded fellow scientists. A scientifically inspiring conference!” – Franziska Lorbeer, Research Institute of Molecular Pathology (IMP), Austria
“The organizers have brought together a very original and timely blend of fields that I am sure will foster the creation of a vibrant new community in quantitative biology, focused on one molecule at a time.” – Nacho Molina, IGBMC – CNRS, France
Speakers
Antoine Coulon
Institut Curie
France
Xavier Darzacq
University of California, Berkeley
USA
Hernan Garcia
University of California, Berkeley
USA
Luca Giorgetti
Friedrich Miescher Institute for Biomedical Research (FMI)
Switzerland
Hiroshi Kimura
Institute of Science Tokyo
Japan
Tineke Lenstra
Netherlands Cancer Institute (NKI)
The Netherlands
Michael Levine
Princeton University
USA
Francesca Mattiroli
Hubrecht Institute
The Netherlands
Kate Miroshnikova
Max Planck Institute for Molecular Biomedicine
Germany
Dirk Schübeler
Friedrich Miescher Institute for Biomedical Research (FMI)
Switzerland
Winston Timp
Johns Hopkins University
USA
Alexander van Oudenaarden
Hubrecht Institute
The Netherlands
Nadine Vastenhouw
University of Lausanne (UNIL)
Switzerland
Franka Voigt
University of Zurich
Switzerland
Jie Xiao
Johns Hopkins University
USA
Jian Zhou
Emory University School of Medicine
USA
Scientific organisers
Stirling Churchman
Harvard Medical School
USA
Arnaud Krebs
EMBL Heidelberg
Germany
Mounia Lagha
Institute of Molecular Genetics of Montpellier (IGMM)
France
Daniel Larson
National Cancer Institute Center for Cancer Research
USA
Event Organiser
Julia Patricia Nohle
Course and Conference Officer
EMBL Heidelberg
Germany
Sponsors
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Date: 13 - 16 Jul 2027
Location: EMBL Heidelberg and Virtual
Venue: EMBL Advanced Training Centre
Organisers:
-
Stirling Churchman
Harvard Medical School, USA -
Arnaud Krebs
EMBL Heidelberg, Germany -
Mounia Lagha
Institute of Molecular Genetics of Montpellier (IGMM), France -
Daniel Larson
National Cancer Institute Center for Cancer Research, USA
Contact: Jules Nohle