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sybody

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6 April 2021 A model of Glycine Transporter 1, which is located in the cell membrane. In its lower-middle part, it is bound by its inhibitor, which is a much smaller molecule. At its top, Glycine Transporter 1 is bound by a synthetic mini-antibody, called a sybody.

New perspectives for treating psychiatric disorders

Science & Technology Scientists have determined the structure of Glycine Transporter 1. The finding could open new avenues for developing therapeutics for psychiatric disorders

2021

sciencescience-technology

4 November 2020 SARS-CoV-2 is represented as a sphere with spike proteins poking out of its surface, which give it a corona-like appearance. The spike proteins resemble triangular ‘bushes’ with three tips at the top. In the background, a cell surface is visible with ACE2 proteins poking out of it in many places. The virus is about to attach to the cell surface. The sybodies, represented as tiny V-shaped structures, bind to the viral spike proteins at their tips.

Scientists identify synthetic mini-antibody to combat COVID-19

Science & Technology By screening hundreds of sybodies (synthetic mini-antibodies), scientists have identified one that might stop SARS-CoV-2 from infecting human cells. This work, which holds promise for treating COVID-19, was conducted by EMBL Hamburg and collaborators from the Centre for Structural Systems Biology…

2020

sciencescience-technology

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