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Genome biology

An illustration of single-cell RNA sequencing (scRNA-seq)

Enabling functional genomics studies in individual cells

Scientists at EMBL Heidelberg have developed a new method, called Targeted Perturb-seq (TAP-seq), which increases the scale and precision of functional genomics CRISPR–Cas9 screens by orders of magnitude. Their method overcomes limitations in previous applications of single-cell RNA sequencing,…

By Marius Bruer

Science

Key visual for the EMBO | EMBL symposium ‘The Four-Dimensional Genome’

EMBL hosts its first virtual conference

The virtual EMBO | EMBL symposium ‘The Four-Dimensional Genome’ brought together 470 participants. Here, Jürgen Deka, Head of External Scientific Training, discusses how he and his team overcame the organisational challenges.…

By Marius Bruer

Events

New insights into gene regulation

EMBL researchers investigate the role of a histone protein in regulating gene expression…

By Chloe Cross

Science

A visualisation of a membraneless organelle in the green-yellow style of the data presented in the Nature Communications paper

ATP affects proteome-wide solubility

Scientists develop technology to measure how ATP concentration affects protein solubility in cells…

By Josh Tapley

Science

As a cell prepares to divide, the chromosomes (shown here in pink) condense, becoming more tightly coiled and easier to observe under the microscope. The faint structure in the centre is a cell nucleus in which the chromosomes are in their usual decondensed state.

Exploring genetic variation

EMBL group leader Jan Korbel reflects on his scientific origins and current research…

By Edward Dadswell

Science

How drugs affect the life and death of proteins. IMAGE: Cell

How drugs affect the life and death of proteins

Scientists at EMBL and Cellzome develop technology to monitor the effects of drug treatments on protein degradation and synthesis…

By Iris Kruijen

Science

Architecture dependent turnover of the nuclear pore subunits. Top row shows the nuclear pore subunits seen from top, bottom row shows subunits of the nuclear pore cut in half.

Life and death of proteins

EMBL scientists create a turnover catalogue of almost 10.000 proteins from primary cells…

By Berta Carreño

Science

Arnaud Krebs, EMBL’s new group leader studies how gene expression is controlled

Welcome: Arnaud Krebs

EMBL’s new group leader studies how gene expression is controlled…

By Berta Carreño

Science

Enhancer activity (green) and promoter activity (purple) in the same regulatory element. IMAGE: EMBL / Eileen Furlong

Multipurpose enhancers and promoters in embryonic development

EMBL scientists show that some promoters can act as enhancers and vice versa…

By Iris Kruijen

Science

The most curious genomes in Ensebl. Credit: Spencer Phillips/EMBL-EBI

Curious genomes

What are the strangest genomes in EMBL-EBI's Ensembl?…

By Mary Todd Bergman

Science

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