Seeing antibiotics in action inside a pathogenic bacterium
Science New research by EMBL scientists shows at atomic detail how antibiotics affect the process of protein production inside bacteria.
2022
science
Puzzling out the structure of a molecular giant
Science Scientists have solved several mysteries around the structure and function of a true molecular giant: the human nuclear pore complex. They created the most complete model of the complex thanks to combining the program AlphaFold2 with cryo-electron tomography, integrative modelling, molecular…
2022
science
Observing the secret life of molecules inside the cell
Science EMBL Hamburg’s Kosinski Group, the Beck Laboratory at the Max Planck Institute of Biophysics, and colleagues at EMBL Heidelberg recorded the nuclear pore complex contracting in living cells. They visualised the movement with an unprecedented level of detail with help of new software called…
2021
science
Seeing deeper inside cells
Science While cryo-electron tomography (cryo-ET) was first envisioned in 1968, the advances the Mahamid group are bringing to this 3D method for studying molecules directly inside cells are new, and are likely to greatly expand its use.
2020
science
Nuclear pores in their natural context
Science Scientists from the Beck group have studied the 3D structure of nuclear pores in budding yeast. They show how the architecture of the nuclear pore complex differs inside cells compared to its form observed in vitro studies.
2020
science
Visualising the cell’s molecular machinery in action
Science A new approach that allows researchers to see molecular machinery at work inside cells has offered a deeper understanding of how bacteria produce proteins and a unique glimpse into how they respond to antibiotics.
2020
science
Solving the structure of retromer
Science Retromer’s 3D structure improves understanding of cellular sorting and packaging
2018
science
The closest look ever at native human tissue
Science Seeing proteins in their natural environment and interactions inside cells has been a longstanding goal. Using an advanced microscopy technique called cryo-electron tomography, researchers from the European Molecular Biology Laboratory (EMBL) have visualised proteins responsible for cell-cell…
2007
science
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