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crispr

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21 January 2022 The cross-section of a cell expressing a green fluorescently tagged protein and illuminated by a blue laser is visible in the foreground, surrounded by a vortex of cells

Cell sorting enters a new dimension

Science EMBL researchers, in collaboration with BD Biosciences, have demonstrated a new technology that allows rapid image-based sorting of cells. The new technology represents a major upgrade to flow cytometry and has applications in diverse life science fields.

2022

science

3 July 2020 stem cells neurons differentiation

From stem cells to neurons

Science Scientists at EMBL Heidelberg have investigated stem cells and how they differentiate to become neurons. Their approach included an assessment of the complex interplay of molecules during the differentiation process and generated fundamental new insights into the role of a protein called Sox2 in…

2020

science

2 July 2020 epigenetic reprogramming, epigenetic memory, Hackett group

Unravelling epigenetic reprogramming

Science A study conducted by the Hackett group at EMBL Rome has identified key factors controlling the complex system of gene regulation during early embryo development, shedding new light on the mechanisms behind these events and on their evolutionary implications. Their findings are published in Nature…

2020

science

25 June 2020 Scientists in the Hackett group at EMBL Rome doing lab work

Silencing the SARS-CoV-2 receptor with epigenetic modifications

Science EMBL scientists develop a new molecular tool to prevent SARS-CoV-2 infection in mice. This tool is able to cause targeted epigenetic modifications of specific genes in specific cell populations. They will use it in mice to target airway cells that express the ACE2 protein – the receptor that…

2020

science

1 June 2020 An illustration of single-cell RNA sequencing (scRNA-seq)

Enabling functional genomics studies in individual cells

Science Scientists at EMBL Heidelberg have developed a new method, called Targeted Perturb-seq (TAP-seq), which increases the scale and precision of functional genomics CRISPR–Cas9 screens by orders of magnitude. Their method overcomes limitations in previous applications of single-cell RNA sequencing,…

2020

science

15 May 2020 Cell division

Tracing the origins of cells

Science Researchers from the Sharpe group at EMBL Barcelona have published a method to track the developmental history of a cell using the gene editing tool CRISPR–Cas9, but without the need to create transgenic organisms.

2020

science

29 November 2019 Choanocyte chamber of sponge, with neuroid cell

Neural pathways

Science Exploring the diverse routes by which EMBL scientists are driving forward neurobiology

2019

science

21 September 2017

Fish on fire

Science New study by Paola Kuri and Maria Leptin shows how inflammation happens in zebrafish in real time

2017

science

30 August 2016

Gene editing 3.0

Science Emmanuelle Charpentier sheds light on how CRISPR–Cas9 went from side project to global revolution

2016

science

26 January 2015

Awards & Honours

Lab Matters EMBL scientists regularly receive prestigious awards – meet the latest honourees.

2015

lab-matters

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