Edit

EMBL Taxonomy:

Epigenetics and neurobiology

Showing results out of

Year
10 January 2025 Colourful image of mouse cells

Sweet gene regulation in the mammalian embryo

Researchers in the Boulard group at EMBL Rome demonstrated that the catalytic activity of the OGT enzyme is essential for embryonic development, and that when it’s reduced, embryo development is delayed – especially in males.

SCIENCE & TECHNOLOGY

2025

science-technology

22 November 2024

Celebrating 25 years of EMBL Rome

EMBL Rome celebrates its 25th anniversary this year – some impressions of the symposium and party organised for staff and alumni to mark this special occasion.

LAB MATTERS

2024

lab-matters

1 May 2024 Alt Text: An artistic representation of gut microbes and sperm cells

Father’s gut microbes affect the next generation

Scientists from EMBL Rome and EMBL Heidelberg found that disrupting the gut microbiome of male mice increases the risk of disease in their offspring. Their findings suggest that a father’s pre-conception environment can have lifelong effects on offspring.

SCIENCE & TECHNOLOGY

2024

science-technology

16 November 2023

New evidence on retinal function

A new study from the Asari group at EMBL Rome shows a different retinal function in awake mice compared to isolated retinal samples. These new insights could help to develop prosthetic devices that can act as a retina in the future.

SCIENCE & TECHNOLOGY

2023

sciencescience-technology

8 April 2022 a metaphor for the process of epigenetic inheritance

A metaphor for epigenetic inheritance

Recent studies from the Hackett group at EMBL Rome have revealed new insights on the mechanism regulating transmission of non-genetic information during embryonic development, and inspired a scientific illustration

SCIENCE & TECHNOLOGY

2022

sciencescience-technology

19 January 2012 Artist's impression of a chromosome exploding

Rigged to explode?

An inherited mutation in a gene known as the guardian of the genome is likely the link between exploding chromosomes and some particularly aggressive types of cancer, scientists at the European Molecular Biology Laboratory (EMBL), the German Cancer Research Centre (DKFZ) and the University…

SCIENCE & TECHNOLOGY

2012

sciencescience-technology

10 December 2009 These microscopy images demonstrate the effects of Notch signalling on the hearts of newborn mice (top) and of adult mice after a heart attack (bottom). In a normal neonatal heart (top left), the two major heart chambers (ventricles) are clearly separated by tissue (septum). But when Notch signalling was inactivated in an embryo’s heart muscle cells, the septum between the ventricles of the newborn mouse’s heart was incomplete (asterisk). The same defect commonly occurs in humans with congenital heart disease, often leading to circulatory distress. In the images of adult hearts (bottom), healthy tissue is shown in red and damaged tissue in blue. Normally (bottom left), a heart attack causes extensive tissue damage to the left ventricle (right-hand cavity), but mice in which Notch was re-activated after the heart attack had reduced tissue damage (bottom right) and improved cardiac function. Image credit: EMBL

From fruit fly wings to heart failure. Why Not(ch)?

Almost a century after it was discovered in fruit flies with notches in their wings, the Notch signalling pathway may come to play an important role in the recovery from heart attacks. In a study published today in Circulation Research, scientists at the European Molecular Biology Laboratory (EMBL)…

SCIENCE & TECHNOLOGY

2009

sciencescience-technology

21 September 2009 This microscopy image, taken ten days after injury, shows that the muscle fibres of normal mice (left) had re-grown, while in mice which couldn’t boost C/EBPβ production (right) there were still many fibres that had not regenerated (arrowheads), and the tissue had a number of scars (arrows).

To regenerate muscle, cellular garbage men must become builders

For scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, what seemed like a disappointing result turned out to be an important discovery. Their findings, published online this week in the journal Proceedings of the National Academy of Sciences (PNAS), provide…

SCIENCE & TECHNOLOGY

2009

sciencescience-technology

13 September 2009 In normal skin (left), the stem cells at the base, shown in green, differentiate into skin cells, shown in red. In mice whose skin has neither C/EBPα nor C/EBPβ (middle), this differentiation is blocked: green-labeled stem cells appear in upper layers of skin, and there are no differentiated skin cells (no red staining). This also happens at the initial stages of basal cell carcinomas. In skin where C/EBPα is present but has lost its capacity to interact with E2F, a molecule that regulates the cell cycle (right), skin cells start differentiating abnormally, before they have properly exited the stem cell ‘program’ (yellow/orange). This is similar to what is observed in the initial stages of squamous cell carcinomas, a more aggressive and invasive skin tumour.

How stem cells make skin

Stem cells have a unique ability: when they divide, they can either give rise to more stem cells, or to a variety of specialised cell types. In both mice and humans, a layer of cells at the base of the skin contains stem cells that can develop into the specialised cells in the layers above.…

SCIENCE & TECHNOLOGY

2009

sciencescience-technology

No results found

News archive

E-newsletter archive

EMBLetc archive

News archive

For press

Contact the Press Office
Edit