Publications – Watt Group

Avissar-Whiting M, Belliard F, Bertozzi SM, Brand A, Brown K, Clément-Stoneham G, Dawson S, Dey G, Ecer D, Edmunds SC, Farley A, Fischer TD, Franko M, Fraser JS, Funk K, Ganier C, Harrison M, Hatch A, Hazlett H, Hindle S, Hook DW, Hurst P, Kamoun S, Kiley R, Lacy MM, LaFlamme M, Lawrence R, Lemberger T, Leptin M, Lumb E, MacCallum CJ, Marcum CS, Marinello G, Mendonça A, Monaco S, Neves K, Pattinson D, Polka JK, Puebla I, Rittman M, Royle SJ, Saderi D, Sever R, Shearer K, Spiro JE, Stern B, Taraborelli D, Vale R, Vasquez CG, Waltman L, Watt FM, Weinberg ZY, Williams M

PLoS biology, 2024

doi:10.1371/journal.pbio.3002502.

Multiscale spatial mapping of cell populations across anatomical sites in healthy human skin and basal cell carcinoma.

Ganier C, Mazin P, Herrera-Oropeza G, Du-Harpur X, Blakeley M, Gabriel J, Predeus AV, Cakir B, Prete M, Harun N, Darrigrand JF, Haiser A, Wyles S, Shaw T, Teichmann SA, Haniffa M, Watt FM, Lynch MD

Proceedings of the National Academy of Sciences of the United States of America, 2024

doi:10.1073/pnas.2313326120.

Single-cell RNA sequencing of human epidermis identifies Lunatic fringe as a novel regulator of the stem cell compartment.

Negri VA, Louis B, Zijl S, Ganier C, Philippeos C, Ali S, Reynolds G, Haniffa M, Watt FM

Stem cell reports, 2023

doi:10.1016/j.stemcr.2023.09.007.

Myc-dependent dedifferentiation of Gata6+ epidermal cells resembles reversal of terminal differentiation.

Bernabé-Rubio M, Ali S, Bhosale PG, Goss G, Mobasseri SA, Tapia-Rojo R, Zhu T, Hiratsuka T, Battilocchi M, Tomás IM, Ganier C, Garcia-Manyes S, Watt FM

Nature cell biology, 2023

doi:10.1038/s41556-023-01234-5.

How to avoid mistakes in science publications.

Watt FM

EMBO reports, 2023

doi:10.15252/embr.202357887.

A Roadmap for a consensus human skin cell atlas and single-cell data standardization.

Almet AA, Yuan H, Annusver K, Ramos R, Liu Y, Wiedemann J, Sorkin DH, Landén NX, Sonkoly E, Haniffa M, Nie Q, Lichtenberger BM, Luecken MD, Andersen B, Tsoi LC, Watt FM, Gudjonsson JE, Plikus MV, Kasper M

The Journal of investigative dermatology, 2023

doi:10.1016/j.jid.2023.03.1679.

Caspase activation in tumour-infiltrating lymphocytes is associated with lymph node metastasis in oral squamous cell carcinoma.

Bhosale PG, Kennedy RA, Watt FM

The Journal of pathology, 2023

doi:10.1002/path.6145.

Hydrogen peroxide production by epidermal dual oxidase 1 regulates nociceptive sensory signals.

Pató A, Bölcskei K, Donkó Á, Kaszás D, Boros M, Bodrogi L, Várady G, Pape VFS, Roux BT, Enyedi B, Helyes Z, Watt FM, Sirokmány G, Geiszt M

Redox biology, 2023

doi:10.1016/j.redox.2023.102670.

Progress and challenges in stem cell biology.

Apostolou E, Blau H, Chien K, Lancaster MA, Tata PR, Trompouki E, Watt FM, Zeng YA, Zernicka-Goetz M

Nature Cell Biology, 2023

doi:10.1038/s41556-023-01087-y.

Embigin is a fibronectin receptor that affects sebaceous gland differentiation and metabolism.

Sipilä K, Rognoni E, Jokinen J, Tewary M, Vietri Rudan M, Talvi S, Jokinen V, Dahlström KM, Liakath-Ali K, Mobasseri A, Du-Harpur X, Käpylä J, Nutt SL, Salminen TA, Heino J, Watt FM

Developmental cell, 2022

doi:10.1016/j.devcel.2022.05.011.

Understanding human epidermal stem cells at single-cell resolution.

Negri VA, Watt FM

The Journal of investigative dermatology, 2022

doi:10.1016/j.jid.2022.04.003.

Dynamic regulation of human epidermal differentiation by adhesive and mechanical forces.

Zijl S, Salameti V, Louis B, Negri VA, Watt FM

Current topics in developmental biology, 2022

doi:10.1016/bs.ctdb.2022.03.004.

Functional genomics and the future of iPSCs in disease modeling.

Brooks IR, Garrone CM, Kerins C, Kiar CS, Syntaka S, Xu JZ, Spagnoli FM, Watt FM

Stem cell reports, 2022

doi:10.1016/j.stemcr.2022.03.019.

Translational control of stem cell function.

Saba JA, Liakath-Ali K, Green R, Watt FM

Nature Reviews Molecular Cell Biology, 2022

doi:10.1038/s41580-021-00386-2.

An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function.

Cujba AM, Alvarez-Fallas ME, Pedraza-Arevalo S, Laddach A, Shepherd MH, Hattersley AT, Watt FM, Sancho R

Cell reports, 2022

doi:10.1016/j.celrep.2022.110425.

Angiotensin-converting enzyme 2 expression is detectable in keratinocytes, cutaneous appendages, and blood vessels by multiplex RNA in situ hybridization.

Ganier C, Harun N, Peplow I, Du-Harpur X, Arthurs C, Watt FM, Lynch MD

Advances in skin & wound care, 2022

doi:10.1097/01.ASW.0000819776.56007.18.

Gradient boosting approaches can outperform logistic regression for risk prediction in cutaneous allergy.

Cunningham L, Ganier C, Ferguson F, White IR, Watt FM, McFadden J, Lynch MD

Contact dermatitis, 2022

doi:10.1111/cod.14011.

Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage.

Rognoni E, Goss G, Hiratsuka T, Sipilä KH, Kirk T, Kober KI, Lui PP, Tsang VS, Hawkshaw NJ, Pilkington SM, Cho I, Ali N, Rhodes LE, Watt FM

eLife, 2022

doi:10.7554/eLife.71052.

Pluripotent stem cell-derived hepatocytes inhibit T cell proliferation in vitro through tryptophan starvation.

Romano M, Elgueta R, McCluskey D, Ortega-Prieto AM, Stolarczyk E, Dazzi F, Lucendo-Villarin B, Meseguer-Ripolles J, Williams J, Fanelli G, Hay DC, Watt FM, Lombardi G

Cells, 2022

doi:10.3390/cells11010024.

Differential expression of insulin-like growth factor 1 and Wnt family member 4 correlates with functional heterogeneity of human dermal fibroblasts.

Culley OJ, Louis B, Philippeos C, Oulès B, Tihy M, Segal JM, Hyliands D, Jenkins G, Bhogal RK, Siow RC, Watt FM

Frontiers in cell and developmental biology, 2021

doi:10.3389/fcell.2021.628039.

Distinct fibroblast lineages give rise to NG2+ pericyte populations in mouse skin development and repair.

Goss G, Rognoni E, Salameti V, Watt FM

Frontiers in cell and developmental biology, 2021

doi:10.3389/fcell.2021.675080.

Plating human iPSC lines on micropatterned substrates reveals role for ITGB1 nsSNV in endoderm formation.

Vickers A, Tewary M, Laddach A, Poletti M, Salameti V, Fraternali F, Danovi D, Watt FM

Stem cell reports, 2021

doi:10.1016/j.stemcr.2021.09.017.

Fibrotic enzymes modulate wound-induced skin tumorigenesis.

Van Hove L, Lecomte K, Roels J, Vandamme N, Vikkula HK, Hoorens I, Ongenae K, Hochepied T, Donati G, Saeys Y, Quist SR, Watt FM, van Loo G, Hoste E

EMBO reports, 2021

doi:10.15252/embr.202051573.

Clinically relevant vulnerabilities of deep machine learning systems for skin cancer diagnosis.

Du-Harpur X, Arthurs C, Ganier C, Woolf R, Laftah Z, Lakhan M, Salam A, Wan B, Watt FM, Luscombe NM, Lynch MD

The Journal of investigative dermatology, 2021

doi:10.1016/j.jid.2020.07.034.

Developmental cell programs are co-opted in inflammatory skin disease.

Reynolds G, Vegh P, Fletcher J, Poyner EFM, Stephenson E, Goh I, Botting RA, Huang N, Olabi B, Dubois A, Dixon D, Green K, Maunder D, Engelbert J, Efremova M, Polański K, Jardine L, Jones C, Ness T, Horsfall D, McGrath J, Carey C, Popescu DM, Webb S, Wang XN, Sayer B, Park JE, Negri VA, Belokhvostova D, Lynch MD, McDonald D, Filby A, Hagai T, Meyer KB, Husain A, Coxhead J, Vento-Tormo R, Behjati S, Lisgo S, Villani AC, Bacardit J, Jones PH, O'Toole EA, Ogg GS, Rajan N, Reynolds NJ, Teichmann SA, Watt FM, Haniffa M

Science (New York, N.Y.), 2021

doi:10.1126/science.aba6500.

Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology.

Sequeira I, Rashid M, Tomás IM, Williams MJ, Graham TA, Adams DJ, Vigilante A, Watt FM

Nature communications, 2020

doi:10.1038/s41467-020-19401-9.

Contribution of GATA6 to homeostasis of the human upper pilosebaceous unit and acne pathogenesis.

Oulès B, Philippeos C, Segal J, Tihy M, Vietri Rudan M, Cujba AM, Grange PA, Quist S, Natsuga K, Deschamps L, Dupin N, Donati G, Watt FM

Nature communications, 2020

doi:10.1038/s41467-020-18784-z.

Regulation of ERK basal and pulsatile activity control proliferation and exit from the stem cell compartment in mammalian epidermis.

Hiratsuka T, Bordeu I, Pruessner G, Watt FM

Proceedings of the National Academy of Sciences of the United States of America, 2020

doi:10.1073/pnas.2006965117.

Human epidermal stem cell differentiation is modulated by specific lipid subspecies.

Vietri Rudan M, Mishra A, Klose C, Eggert US, Watt FM

Proceedings of the National Academy of Sciences of the United States of America, 2020

doi:10.1073/pnas.2011310117.

Population-scale proteome variation in human induced pluripotent stem cells.

Mirauta BA, Seaton DD, Bensaddek D, Brenes A, Bonder MJ, Kilpinen H, HipSci Consortium, Stegle O, Lamond AI

eLife, 2020

doi:10.7554/eLife.57390.

Functional comparison of adult and pluripotent stem cell-derived hepatocytes.

Mawer CM, Ene D, Watt FM

Matters, 2020

doi:.

Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression.

Cuomo ASE, Seaton DD, McCarthy DJ, Martinez I, Bonder MJ, Garcia-Bernardo J, Amatya S, Madrigal P, Isaacson A, Buettner F, Knights A, Natarajan KN, HipSci Consortium, Vallier L, Marioni JC, Stegle O, Chhatriwala M

Nature communications, 2020

doi:10.1038/s41467-020-14457-z.

Heterogeneity within stratified epithelial stem cell populations maintains the oral mucosa in response to physiological stress.

Byrd KM, Piehl NC, Patel JH, Huh WJ, Sequeira I, Lough KJ, Wagner BL, Marangoni P, Watt FM, Klein OD, Coffey RJ, Williams SE

Cell stem cell, 2020

doi:10.1016/j.stem.2019.11.005.

High-throughput micropatterning platform reveals Nodal-dependent bisection of peri-gastrulation-associated versus preneurulation-associated fate patterning.

Tewary M, Dziedzicka D, Ostblom J, Prochazka L, Shakiba N, Heydari T, Aguilar-Hidalgo D, Woodford C, Piccinini E, Becerra-Alonso D, Vickers A, Louis B, Rahman N, Danovi D, Geens M, Watt FM, Zandstra PW

PLoS biology, 2019

doi:10.1371/journal.pbio.3000081.

NOTCH1 signaling in oral squamous cell carcinoma via a TEL2/SERPINE1 axis.

Salameti V, Bhosale PG, Ames-Draycott A, Sipilä K, Watt FM

Oncotarget, 2019

doi:10.18632/oncotarget.27306.

Delta-like 1-mediated cis-inhibition of Jagged1/2 signalling inhibits differentiation of human epidermal cells in culture.

Negri VA, Logtenberg MEW, Renz LM, Oules B, Walko G, Watt FM

Scientific reports, 2019

doi:10.1038/s41598-019-47232-2.

Mutant Lef1 controls Gata6 in sebaceous gland development and cancer.

Oulès B, Rognoni E, Hoste E, Goss G, Fiehler R, Natsuga K, Quist S, Mentink R, Donati G, Watt FM

The EMBO journal, 2019

doi:10.15252/embj.2018100526.

Myosin 10 is involved in murine pigmentation.

Liakath-Ali K, Vancollie VE, Sequeira I, Lelliott CJ, Watt FM

Experimental dermatology, 2019

doi:10.1111/exd.13528.

Patterning of human epidermal stem cells on undulating elastomer substrates reflects differences in cell stiffness.

Mobasseri SA, Zijl S, Salameti V, Walko G, Stannard A, Garcia-Manyes S, Watt FM

Acta biomaterialia, 2019

doi:10.1016/j.actbio.2019.01.063.

Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02.

Tziotzios C, Petridis C, Dand N, Ainali C, Saklatvala JR, Pullabhatla V, Onoufriadis A, Pramanik R, Baudry D, Lee SH, Wood K, Liu L, Seegobin S, Michelotti GA, Lwin SM, Christou EAA, Curtis CJ, de Rinaldis E, Saxena A, Holmes S, Harries M, Palamaras I, Cunningham F, Parkins G, Kaur M, Farrant P, McDonagh A, Messenger A, Jones J, Jolliffe V, Ali I, Ardern-Jones M, Mitchell C, Burrows N, Atkar R, Banfield C, Alexandroff A, Champagne C, Cooper HL, Vañó-Galván S, Molina-Ruiz AM, Perez NO, Patel GK, Macbeth A, Page M, Bryden A, Mowbray M, Wahie S, Armstrong K, Cooke N, Goodfield M, Man I, de Berker D, Dunnill G, Takwale A, Rao A, Siah TW, Sinclair R, Wade MS, Dlova NC, Setterfield J, Lewis F, Bhargava K, Kirkpatrick N, Estivill X, Stefanato CM, Flohr C, Spector T, Watt FM, Smith CH, Barker JN, Fenton DA, Simpson MA, McGrath JA

Nature communications, 2019

doi:10.1038/s41467-019-09117-w.

Dynamic culture substrates that mimic the topography of the epidermal-dermal junction.

Helling AL, Viswanathan P, Cheliotis KS, Mobasseri SA, Yang Y, El Haj AJ, Watt FM

Tissue engineering. Part A, 2019

doi:10.1089/ten.TEA.2018.0125.

Identifying extrinsic versus intrinsic drivers of variation in cell behavior in human iPSC lines from healthy donors.

Vigilante A, Laddach A, Moens N, Meleckyte R, Leha A, Ghahramani A, Culley OJ, Kathuria A, Hurling C, Vickers A, Wiseman E, Tewary M, Zandstra PW, HipSci Consortium, Durbin R, Fraternali F, Stegle O, Birney E, Luscombe NM, Danovi D, Watt FM

Cell reports, 2019

doi:10.1016/j.celrep.2019.01.094.

Micro-scaled topographies direct differentiation of human epidermal stem cells.

Zijl S, Vasilevich AS, Viswanathan P, Helling AL, Beijer NRM, Walko G, Chiappini C, de Boer J, Watt FM

Acta biomaterialia, 2019

doi:10.1016/j.actbio.2018.12.003.

Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation.

Kober KI, Cano A, Géraud C, Sipilä K, Mobasseri SA, Philippeos C, Pisco AO, Stannard A, Martin A, Salvador F, Santos V, Boutros M, Rognoni E, Watt FM

PloS one, 2018

doi:10.1371/journal.pone.0199679.

Hair follicle epidermal stem cells define a niche for tactile sensation.

Cheng CC, Tsutsui K, Taguchi T, Sanzen N, Nakagawa A, Kakiguchi K, Yonemura S, Tanegashima C, Keeley SD, Kiyonari H, Furuta Y, Tomono Y, Watt FM, Fujiwara H

eLife, 2018

doi:10.7554/eLife.38883.

Lrig1 marks a population of gastric epithelial cells capable of long-term tissue maintenance and growth in vitro.

Schweiger PJ, Clement DL, Page ME, Schepeler T, Zou X, Sirokmány G, Watt FM, Jensen KB

Scientific reports, 2018

doi:10.1038/s41598-018-33578-6.

Immunomodulatory role of Keratin 76 in oral and gastric cancer.

Sequeira I, Neves JF, Carrero D, Peng Q, Palasz N, Liakath-Ali K, Lord GM, Morgan PR, Lombardi G, Watt FM

Nature communications, 2018

doi:10.1038/s41467-018-05872-4.

Fibroblast state switching orchestrates dermal maturation and wound healing.

Rognoni E, Pisco AO, Hiratsuka T, Sipilä KH, Belmonte JM, Mobasseri SA, Philippeos C, Dilão R, Watt FM

Molecular systems biology, 2018

doi:10.15252/msb.20178174.

An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis.

Liakath-Ali K, Mills EW, Sequeira I, Lichtenberger BM, Pisco AO, Sipilä KH, Mishra A, Yoshikawa H, Wu CC, Ly T, Lamond AI, Adham IM, Green R, Watt FM

Nature, 2018

doi:10.1038/s41586-018-0032-3.

Spatial and single-cell transcriptional profiling identifies functionally distinct human dermal fibroblast subpopulations.

Philippeos C, Telerman SB, Oulès B, Pisco AO, Shaw TJ, Elgueta R, Lombardi G, Driskell RR, Soldin M, Lynch MD, Watt FM

The Journal of investigative dermatology, 2018

doi:10.1016/j.jid.2018.01.016.

Epidermal Wnt signalling regulates transcriptome heterogeneity and proliferative fate in neighbouring cells.

Ghahramani A, Donati G, Luscombe NM, Watt FM

Genome biology, 2018

doi:10.1186/s13059-017-1384-y.

Dermal Blimp1 acts downstream of epidermal TGFβ and Wnt/β-Catenin to regulate hair follicle formation and growth.

Telerman SB, Rognoni E, Sequeira I, Pisco AO, Lichtenberger BM, Culley OJ, Viswanathan P, Driskell RR, Watt FM

The Journal of investigative dermatology, 2017

doi:10.1016/j.jid.2017.06.015.

Spatial constraints govern competition of mutant clones in human epidermis.

Lynch MD, Lynch CNS, Craythorne E, Liakath-Ali K, Mallipeddi R, Barker JN, Watt FM

Nature communications, 2017

doi:10.1038/s41467-017-00993-8.

A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis.

Mishra A, Oulès B, Pisco AO, Ly T, Liakath-Ali K, Walko G, Viswanathan P, Tihy M, Nijjher J, Dunn SJ, Lamond AI, Watt FM

eLife, 2017

doi:10.7554/eLife.27356.

Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation.

Galleu A, Riffo-Vasquez Y, Trento C, Lomas C, Dolcetti L, Cheung TS, von Bonin M, Barbieri L, Halai K, Ward S, Weng L, Chakraverty R, Lombardi G, Watt FM, Orchard K, Marks DI, Apperley J, Bornhauser M, Walczak H, Bennett C, Dazzi F

Science translational medicine, 2017

doi:10.1126/scitranslmed.aam7828.

Type XVII collagen coordinates proliferation in the interfollicular epidermis.

Watanabe M, Natsuga K, Nishie W, Kobayashi Y, Donati G, Suzuki S, Fujimura Y, Tsukiyama T, Ujiie H, Shinkuma S, Nakamura H, Murakami M, Ozaki M, Nagayama M, Watt FM, Shimizu H

eLife, 2017

doi:10.7554/eLife.26635.

Common genetic variation drives molecular heterogeneity in human iPSCs.

Kilpinen H, Goncalves A, Leha A, Afzal V, Alasoo K, Ashford S, Bala S, Bensaddek D, Casale FP, Culley OJ, Danecek P, Faulconbridge A, Harrison PW, Kathuria A, McCarthy D, McCarthy SA, Meleckyte R, Memari Y, Moens N, Soares F, Mann A, Streeter I, Agu CA, Alderton A, Nelson R, Harper S, Patel M, White A, Patel SR, Clarke L, Halai R, Kirton CM, Kolb-Kokocinski A, Beales P, Birney E, Danovi D, Lamond AI, Ouwehand WH, Vallier L, Watt FM, Durbin R, Stegle O, Gaffney DJ

Nature, 2017

doi:10.1038/nature22403.

Wounding induces dedifferentiation of epidermal Gata6(+) cells and acquisition of stem cell properties.

Donati G, Rognoni E, Hiratsuka T, Liakath-Ali K, Hoste E, Kar G, Kayikci M, Russell R, Kretzschmar K, Mulder KW, Teichmann SA, Watt FM

Nature cell biology, 2017

doi:10.1038/ncb3532.

Expression of a chimeric antigen receptor specific for donor HLA class I enhances the potency of human regulatory T cells in preventing human skin transplant rejection.

Boardman DA, Philippeos C, Fruhwirth GO, Ibrahim MA, Hannen RF, Cooper D, Marelli-Berg FM, Watt FM, Lechler RI, Maher J, Smyth LA, Lombardi G

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2017

doi:10.1111/ajt.14185.

A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells.

Walko G, Woodhouse S, Pisco AO, Rognoni E, Liakath-Ali K, Lichtenberger BM, Mishra A, Telerman SB, Viswanathan P, Logtenberg M, Renz LM, Donati G, Quist SR, Watt FM

Nature communications, 2017

doi:10.1038/ncomms14744.

Integrative genomic and functional analysis of human oral squamous cell carcinoma cell lines reveals synergistic effects of FAT1 and CASP8 inactivation.

Hayes TF, Benaich N, Goldie SJ, Sipilä K, Ames-Draycott A, Cai W, Yin G, Watt FM

Cancer letters, 2017

doi:10.1016/j.canlet.2016.09.014.

A novel automated high-content analysis workflow capturing cell population dynamics from induced pluripotent stem cell live imaging data.

Kerz M, Folarin A, Meleckyte R, Watt FM, Dobson RJ, Danovi D

Journal of biomolecular screening, 2016

doi:10.1177/1087057116652064.

Galectin-6 is a novel skin anti-microbial peptide that is modulated by the skin barrier and microbiome.

Natsuga K, Watt FM

Journal of dermatological science, 2016

doi:10.1016/j.jdermsci.2016.06.008.

Pelota regulates epidermal differentiation by modulating BMP and PI3K/AKT signaling pathways.

Elkenani M, Nyamsuren G, Raju P, Liakath-Ali K, Hamdaoui A, Kata A, Dressel R, Klonisch T, Watt FM, Engel W, Thliveris JA, Krishna Pantakani DV, Adham IM

The Journal of investigative dermatology, 2016

doi:10.1016/j.jid.2016.04.020.

Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure.

Liakath-Ali K, Vancollie VE, Lelliott CJ, Speak AO, Lafont D, Protheroe HJ, Ingvorsen C, Galli A, Green A, Gleeson D, Ryder E, Glover L, Vizcay-Barrena G, Karp NA, Arends MJ, Brenn T, Spiegel S, Adams DJ, Watt FM, van der Weyden L

The Journal of pathology, 2016

doi:10.1002/path.4737.

Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing.

Rognoni E, Gomez C, Pisco AO, Rawlins EL, Simons BD, Watt FM, Driskell RR

Development (Cambridge, England), 2016

doi:10.1242/dev.131797.

β-Catenin stabilization in skin fibroblasts causes fibrotic lesions by preventing adipocyte differentiation of the reticular dermis.

Mastrogiannaki M, Lichtenberger BM, Reimer A, Collins CA, Driskell RR, Watt FM

The Journal of investigative dermatology, 2016

doi:10.1016/j.jid.2016.01.036.

A high-content platform to characterise human induced pluripotent stem cell lines.

Leha A, Moens N, Meleckyte R, Culley OJ, Gervasio MK, Kerz M, Reimer A, Cain SA, Streeter I, Folarin A, Stegle O, Kielty CM, Kielty CM, Durbin R, Watt FM, Danovi D

Methods (San Diego, Calif.), 2016

doi:10.1016/j.ymeth.2015.11.012.

Macrophage infiltration and alternative activation during wound healing promote MEK1-induced skin carcinogenesis.

Weber C, Telerman SB, Reimer AS, Sequeira I, Liakath-Ali K, Arwert EN, Watt FM

Cancer research, 2016

doi:10.1158/0008-5472.CAN-14-3676.

Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages.

Lichtenberger BM, Mastrogiannaki M, Watt FM

Nature communications, 2016

doi:10.1038/ncomms10537.

Increased bacterial load and expression of antimicrobial peptides in skin of barrier-deficient mice with reduced cancer susceptibility.

Natsuga K, Cipolat S, Watt FM

The Journal of investigative dermatology, 2016

doi:10.1038/JID.2015.383.

Mimicking the topography of the epidermal-dermal interface with elastomer substrates.

Viswanathan P, Guvendiren M, Chua W, Telerman SB, Liakath-Ali K, Burdick JA, Watt FM

Integrative biology : quantitative biosciences from nano to macro, 2016

doi:10.1039/c5ib00238a.

Scalable topographies to support proliferation and Oct4 expression by human induced pluripotent stem cells.

Reimer A, Vasilevich A, Hulshof F, Viswanathan P, van Blitterswijk CA, de Boer J, Watt FM

Scientific reports, 2016

doi:10.1038/srep18948.

Compartmentalized epidermal activation of β-catenin differentially affects lineage reprogramming and underlies tumor heterogeneity.

Kretzschmar K, Weber C, Driskell RR, Calonje E, Watt FM

Cell reports, 2016

doi:10.1016/j.celrep.2015.12.041.

Fate of Prominin-1 expressing dermal papilla cells during homeostasis, wound healing and Wnt activation.

Kaushal GS, Rognoni E, Lichtenberger BM, Driskell RR, Kretzschmar K, Hoste E, Watt FM

The Journal of investigative dermatology, 2015

doi:10.1038/jid.2015.319.

The androgen receptor antagonizes Wnt/β-catenin signaling in epidermal stem cells.

Kretzschmar K, Cottle DL, Schweiger PJ, Watt FM

The Journal of investigative dermatology, 2015

doi:10.1038/jid.2015.242.

Innate sensing of microbial products promotes wound-induced skin cancer.

Hoste E, Arwert EN, Lal R, South AP, Salas-Alanis JC, Murrell DF, Donati G, Watt FM

Nature communications, 2015

doi:10.1038/ncomms6932.

Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.

DiTommaso T, Jones LK, Cottle DL, WTSI Mouse Genetics Program, Gerdin AK, Vancollie VE, Watt FM, Ramirez-Solis R, Bradley A, Steel KP, Sundberg JP, White JK, Smyth IM

PLoS genetics, 2014

doi:10.1371/journal.pgen.1004705.

BLIMP1 is required for postnatal epidermal homeostasis but does not define a sebaceous gland progenitor under steady-state conditions.

Kretzschmar K, Cottle DL, Donati G, Chiang MF, Quist SR, Gollnick HP, Natsuga K, Lin KI, Watt FM

Stem cell reports, 2014

doi:10.1016/j.stemcr.2014.08.007.

Rewiring of an epithelial differentiation factor, miR-203, to inhibit human squamous cell carcinoma metastasis.

Benaich N, Woodhouse S, Goldie SJ, Mishra A, Quist SR, Watt FM

Cell reports, 2014

doi:10.1016/j.celrep.2014.08.062.

Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility.

Cipolat S, Hoste E, Natsuga K, Quist SR, Watt FM

eLife, 2014

doi:10.7554/eLife.01888.

Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors.

Donati G, Proserpio V, Lichtenberger BM, Natsuga K, Sinclair R, Fujiwara H, Watt FM

Proceedings of the National Academy of Sciences of the United States of America, 2014

doi:10.1073/pnas.1312880111.

Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.

Liakath-Ali K, Vancollie VE, Heath E, Smedley DP, Estabel J, Sunter D, Ditommaso T, White JK, Ramirez-Solis R, Smyth I, Steel KP, Watt FM

Nature communications, 2014

doi:10.1038/ncomms4540.

Downregulation of keratin 76 expression during oral carcinogenesis of human, hamster and mouse.

Ambatipudi S, Bhosale PG, Heath E, Pandey M, Kumar G, Kane S, Patil A, Maru GB, Desai RS, Watt FM, Mahimkar MB

PloS one, 2013

doi:10.1371/journal.pone.0070688.

The interfollicular epidermis of adult mouse tail comprises two distinct cell lineages that are differentially regulated by Wnt, Edaradd, and Lrig1.

Gomez C, Chua W, Miremadi A, Quist S, Headon DJ, Watt FM

Stem cell reports, 2013

doi:10.1016/j.stemcr.2013.04.001.

Distinct fibroblast lineages determine dermal architecture in skin development and repair.

Driskell RR, Lichtenberger BM, Hoste E, Kretzschmar K, Simons BD, Charalambous M, Ferron SR, Herault Y, Pavlovic G, Ferguson-Smith AC, Watt FM

Nature, 2013

doi:10.1038/nature12783.

Sox2 modulates the function of two distinct cell lineages in mouse skin.

Lesko MH, Driskell RR, Kretzschmar K, Goldie SJ, Watt FM

Developmental biology, 2013

doi:10.1016/j.ydbio.2013.08.004.

Decoupling geometrical and chemical cues directing epidermal stem cell fate on polymer brush-based cell micro-patterns.

Tan KY, Lin H, Ramstedt M, Watt FM, Huck WT, Gautrot JE

Integrative biology : quantitative biosciences from nano to macro, 2013

doi:10.1039/c3ib40026c.

Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes

White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP

Cell, 2013

doi:10.1016/j.cell.2013.06.022.

Single-cell gene expression profiling reveals functional heterogeneity of undifferentiated human epidermal cells.

Tan DW, Jensen KB, Trotter MW, Connelly JT, Broad S, Watt FM

Development (Cambridge, England), 2013

doi:10.1242/dev.087551.

LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and pre-invasive squamous cell carcinoma development.

Lu L, Teixeira VH, Yuan Z, Graham TA, Endesfelder D, Kolluri K, Al-Juffali N, Hamilton N, Nicholson AG, Falzon M, Kschischo M, Swanton C, Wright NA, Carroll B, Watt FM, George JP, Jensen KB, Giangreco A, Janes SM

The Journal of pathology, 2013

doi:10.1002/path.4148.

c-MYC-induced sebaceous gland differentiation is controlled by an androgen receptor/p53 axis.

Cottle DL, Kretzschmar K, Schweiger PJ, Quist SR, Gollnick HP, Natsuga K, Aoyagi S, Watt FM

Cell reports, 2013

doi:10.1016/j.celrep.2013.01.013.

Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells.

Foijer F, DiTommaso T, Donati G, Hautaviita K, Xie SZ, Heath E, Smyth I, Watt FM, Sorger PK, Bradley A

Proceedings of the National Academy of Sciences of the United States of America, 2013

doi:10.1073/pnas.1217388110.

Efficient differentiation of embryonic stem cells into mesodermal precursors by BMP, retinoic acid and Notch signalling.

Torres J, Prieto J, Durupt FC, Broad S, Watt FM

PloS one, 2012

doi:10.1371/journal.pone.0036405.

Exons 5-15 of kazrin are dispensable for murine epidermal morphogenesis and homeostasis.

Chhatriwala MK, Cipolat S, Sevilla LM, Nachat R, Watt FM

The Journal of investigative dermatology, 2012

doi:10.1038/jid.2012.110.

Mimicking normal tissue architecture and perturbation in cancer with engineered micro-epidermis.

Gautrot JE, Wang C, Liu X, Goldie SJ, Trappmann B, Huck WT, Watt FM

Biomaterials, 2012

doi:10.1016/j.biomaterials.2012.04.009.

FRMD4A upregulation in human squamous cell carcinoma promotes tumor growth and metastasis and is associated with poor prognosis.

Goldie SJ, Mulder KW, Tan DW, Lyons SK, Sims AH, Watt FM

Cancer research, 2012

doi:10.1158/0008-5472.CAN-12-0423.

Diverse epigenetic strategies interact to control epidermal differentiation.

Mulder KW, Wang X, Escriu C, Ito Y, Schwarz RF, Gillis J, Sirokmány G, Donati G, Uribe-Lewis S, Pavlidis P, Murrell A, Markowetz F, Watt FM

Nature cell biology, 2012

doi:10.1038/ncb2520.

Polyclonal origin and hair induction ability of dermal papillae in neonatal and adult mouse back skin.

Collins CA, Jensen KB, MacRae EJ, Mansfield W, Watt FM

Developmental biology, 2012

doi:10.1016/j.ydbio.2012.03.016.

Extracellular-matrix tethering regulates stem-cell fate.

Trappmann B, Gautrot JE, Connelly JT, Strange DG, Li Y, Oyen ML, Cohen Stuart MA, Boehm H, Li B, Vogel V, Spatz JP, Watt FM, Huck WT

Nature materials, 2012

doi:10.1038/nmat3339.

Clonal growth of dermal papilla cells in hydrogels reveals intrinsic differences between Sox2-positive and -negative cells in vitro and in vivo.

Driskell RR, Juneja VR, Connelly JT, Kretzschmar K, Tan DW, Watt FM

The Journal of investigative dermatology, 2012

doi:10.1038/jid.2011.428.

β-Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial-mesenchymal transition.

Giangreco A, Lu L, Vickers C, Teixeira VH, Groot KR, Butler CR, Ilieva EV, George PJ, Nicholson AG, Sage EK, Watt FM, Janes SM

The Journal of pathology, 2012

doi:10.1002/path.3962.

Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling.

Wong VW, Stange DE, Page ME, Buczacki S, Wabik A, Itami S, van de Wetering M, Poulsom R, Wright NA, Trotter MW, Watt FM, Winton DJ, Clevers H, Jensen KB

Nature cell biology, 2012

doi:10.1038/ncb2464.

Sin3a is essential for the genome integrity and viability of pluripotent cells.

McDonel P, Demmers J, Tan DW, Watt F, Hendrich BD

Developmental biology, 2012

doi:10.1016/j.ydbio.2011.12.019.

Upregulation of CD26 expression in epithelial cells and stromal cells during wound-induced skin tumour formation.

Arwert EN, Mentink RA, Driskell RR, Hoste E, Goldie SJ, Quist S, Watt FM

Oncogene, 2012

doi:10.1038/onc.2011.298.

Epidermal Cadm1 expression promotes autoimmune alopecia via enhanced T cell adhesion and cytotoxicity.

Giangreco A, Hoste E, Takai Y, Rosewell I, Watt FM

Journal of immunology (Baltimore, Md. : 1950), 2012

doi:10.4049/jimmunol.1003342.

The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate.

Blanco S, Kurowski A, Nichols J, Watt FM, Benitah SA, Frye M

PLoS genetics, 2011

doi:10.1371/journal.pgen.1002403.

Reprogramming adult dermis to a neonatal state through epidermal activation of β-catenin.

Collins CA, Kretzschmar K, Watt FM

Development (Cambridge, England), 2011

doi:10.1242/dev.064592.

Shape-induced terminal differentiation of human epidermal stem cells requires p38 and is regulated by histone acetylation.

Connelly JT, Mishra A, Gautrot JE, Watt FM

PloS one, 2011

doi:10.1371/journal.pone.0027259.

Rac1 deletion causes thymic atrophy.

Hunziker L, Benitah SA, Aznar Benitah S, Braun KM, Jensen K, McNulty K, Butler C, Potton E, Nye E, Boyd R, Laurent G, Glogauer M, Wright NA, Watt FM, Janes SM

PloS one, 2011

doi:10.1371/journal.pone.0019292.

The basement membrane of hair follicle stem cells is a muscle cell niche.

Fujiwara H, Ferreira M, Donati G, Marciano DK, Linton JM, Sato Y, Hartner A, Sekiguchi K, Reichardt LF, Watt FM

Cell, 2011

doi:10.1016/j.cell.2011.01.014.

Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1.

Ambler CA, Watt FM

Development (Cambridge, England), 2010

doi:10.1242/dev.050310.

Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity.

Cho K, Vaught TG, Ji H, Gu D, Papasakelariou-Yared C, Horstmann N, Jennings JM, Lee M, Sevilla LM, Kloc M, Reynolds AB, Watt FM, Brennan RG, Kowalczyk AP, McCrea PD

Journal of cell science, 2010

doi:10.1242/jcs.072041.

Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate.

Arwert EN, Lal R, Quist S, Rosewell I, van Rooijen N, Watt FM

Proceedings of the National Academy of Sciences of the United States of America, 2010

doi:10.1073/pnas.1007404107.

Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions.

Connelly JT, Gautrot JE, Trappmann B, Tan DW, Donati G, Huck WT, Watt FM

Nature cell biology, 2010

doi:10.1038/ncb2074.

Differential sensitivity of epidermal cell subpopulations to beta-catenin-induced ectopic hair follicle formation.

Baker CM, Verstuyf A, Jensen KB, Watt FM

Developmental biology, 2010

doi:10.1016/j.ydbio.2010.04.005.

Exploiting the superior protein resistance of polymer brushes to control single cell adhesion and polarisation at the micron scale.

Gautrot JE, Trappmann B, Oceguera-Yanez F, Connelly J, He X, Watt FM, Huck WT

Biomaterials, 2010

doi:10.1016/j.biomaterials.2010.02.066.

Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis.

Jensen KB, Driskell RR, Watt FM

Nature protocols, 2010

doi:10.1038/nprot.2010.39.

Human skin aging is associated with reduced expression of the stem cell markers beta1 integrin and MCSP.

Giangreco A, Goldie SJ, Failla V, Saintigny G, Watt FM

The Journal of investigative dermatology, 2010

doi:10.1038/jid.2009.297.

Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer.

Frye M, Dragoni I, Chin SF, Spiteri I, Kurowski A, Provenzano E, Green A, Ellis IO, Grimmer D, Teschendorff A, Zouboulis CC, Caldas C, Watt FM

Cancer letters, 2010

doi:10.1016/j.canlet.2009.08.004.

Dose and context dependent effects of Myc on epidermal stem cell proliferation and differentiation.

Berta MA, Baker CM, Cottle DL, Watt FM

EMBO molecular medicine, 2010

doi:10.1002/emmm.200900047.

KazrinE is a desmosome-associated liprin that colocalises with acetylated microtubules.

Nachat R, Cipolat S, Sevilla LM, Chhatriwala M, Groot KR, Watt FM

Journal of cell science, 2009

doi:10.1242/jcs.047266.

Necl2 regulates epidermal adhesion and wound repair.

Giangreco A, Jensen KB, Takai Y, Miyoshi J, Watt FM

Development (Cambridge, England), 2009

doi:10.1242/dev.038232.

Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis.

Driskell RR, Giangreco A, Jensen KB, Mulder KW, Watt FM

Development (Cambridge, England), 2009

doi:10.1242/dev.038620.

Stem cells are dispensable for lung homeostasis but restore airways after injury.

Giangreco A, Arwert EN, Rosewell IR, Snyder J, Watt FM, Stripp BR

Proceedings of the National Academy of Sciences of the United States of America, 2009

doi:10.1073/pnas.0900668106.

Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis.

Jensen KB, Collins CA, Nascimento E, Tan DW, Frye M, Itami S, Watt FM

Cell stem cell, 2009

doi:10.1016/j.stem.2009.04.014.

Autophagy mediates the mitotic senescence transition.

Young AR, Narita M, Ferreira M, Kirschner K, Sadaie M, Darot JF, Tavaré S, Arakawa S, Shimizu S, Watt FM, Narita M

Genes & development, 2009

doi:10.1101/gad.519709.

PI3-kinase-dependent activation of apoptotic machinery occurs on commitment of epidermal keratinocytes to terminal differentiation.

Janes SM, Ofstad TA, Campbell DH, Eddaoudi A, Warnes G, Davies D, Watt FM

Cell research, 2009

doi:10.1038/cr.2008.281.

An activating beta1 integrin mutation increases the conversion of benign to malignant skin tumors.

Ferreira M, Fujiwara H, Morita K, Watt FM

Cancer research, 2009

doi:10.1158/0008-5472.CAN-08-3051.

A stem cell gene expression profile of human squamous cell carcinomas.

Jensen KB, Jones J, Watt FM

Cancer letters, 2008

doi:10.1016/j.canlet.2008.06.014.

Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for beta-catenin and Notch signalling.

Collins CA, Watt FM

Developmental biology, 2008

doi:10.1016/j.ydbio.2008.08.034.

Kazrin regulates keratinocyte cytoskeletal networks, intercellular junctions and differentiation.

Sevilla LM, Nachat R, Groot KR, Watt FM

Journal of cell science, 2008

doi:10.1242/jcs.029538.

The vitamin D receptor is required for mouse hair cycle progression but not for maintenance of the epidermal stem cell compartment.

Pálmer HG, Martinez D, Carmeliet G, Watt FM

The Journal of investigative dermatology, 2008

doi:10.1038/jid.2008.43.

KazrinA is required for axial elongation and epidermal integrity in Xenopus tropicalis.

Sevilla LM, Rana AA, Watt FM, Smith JC

Developmental dynamics : an official publication of the American Association of Anatomists, 2008

doi:10.1002/dvdy.21557.

Characterization of bipotential epidermal progenitors derived from human sebaceous gland: contrasting roles of c-Myc and beta-catenin.

Lo Celso C, Berta MA, Braun KM, Frye M, Lyle S, Zouboulis CC, Watt FM

Stem cells (Dayton, Ohio), 2008

doi:10.1634/stemcells.2007-0651.

Role of the Notch ligand Delta1 in embryonic and adult mouse epidermis.

Estrach S, Cordes R, Hozumi K, Gossler A, Watt FM

The Journal of investigative dermatology, 2008

doi:10.1038/sj.jid.5701113.

Epidermal stem cells are retained in vivo throughout skin aging.

Giangreco A, Qin M, Pintar JE, Watt FM

Aging cell, 2008

doi:10.1111/j.1474-9726.2008.00372.x.

Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkappaB and cooperating with Stat3.

Torres J, Watt FM

Nature cell biology, 2008

doi:10.1038/ncb1680.

The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis.

Pálmer HG, Anjos-Afonso F, Carmeliet G, Takeda H, Watt FM

PloS one, 2008

doi:10.1371/journal.pone.0001483.

Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier.

Sevilla LM, Nachat R, Groot KR, Klement JF, Uitto J, Djian P, Määttä A, Watt FM

The Journal of cell biology, 2007

doi:10.1083/jcb.200706187.

Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation.

Frye M, Fisher AG, Watt FM

PloS one, 2007

doi:10.1371/journal.pone.0000763.

Syntenin mediates Delta1-induced cohesiveness of epidermal stem cells in culture.

Estrach S, Legg J, Watt FM

Journal of cell science, 2007

doi:10.1242/jcs.016253.

Expression of Notch pathway genes in mammalian epidermis and modulation by beta-catenin.

Ambler CA, Watt FM

Developmental dynamics : an official publication of the American Association of Anatomists, 2007

doi:10.1002/dvdy.21151.

Epidermal deletion of Rac1 causes stem cell depletion, irrespective of whether deletion occurs during embryogenesis or adulthood.

Benitah SA, Watt FM

The Journal of investigative dermatology, 2007

doi:10.1038/sj.jid.5700738.

Dual role of inactivating Lef1 mutations in epidermis: tumor promotion and specification of tumor type.

Niemann C, Owens DM, Schettina P, Watt FM

Cancer research, 2007

doi:10.1158/0008-5472.CAN-06-3427.

Identification of novel keratinocyte differentiation modulating compounds by high-throughput screening.

Honma M, Stubbs M, Collins I, Workman P, Aherne W, Watt FM

Journal of biomolecular screening, 2006

doi:10.1177/1087057106292556.

Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis.

Estrach S, Ambler CA, Lo Celso C, Hozumi K, Watt FM

Development (Cambridge, England), 2006

doi:10.1242/dev.02644.

HAN11 binds mDia1 and controls GLI1 transcriptional activity.

Morita K, Lo Celso C, Spencer-Dene B, Zouboulis CC, Watt FM

Journal of dermatological science, 2006

doi:10.1016/j.jdermsci.2006.06.001.

The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells.

Nijhof JG, Braun KM, Giangreco A, van Pelt C, Kawamoto H, Boyd RL, Willemze R, Mullenders LH, Watt FM, de Gruijl FR, van Ewijk W

Development (Cambridge, England), 2006

doi:10.1242/dev.02443.

Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence.

Jensen KB, Watt FM

Proceedings of the National Academy of Sciences of the United States of America, 2006

doi:10.1073/pnas.0601886103.

The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors.

Frye M, Watt FM

Current biology : CB, 2006

doi:10.1016/j.cub.2006.04.027.

Human sebaceous tumors harbor inactivating mutations in LEF1.

Takeda H, Lyle S, Lazar AJ, Zouboulis CC, Smyth I, Watt FM

Nature medicine, 2006

doi:10.1038/nm1386.

Role of LIM kinases in normal and psoriatic human epidermis.

Honma M, Benitah SA, Watt FM

Molecular biology of the cell, 2006

doi:10.1091/mbc.e05-12-1173.

Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1.

Gebhardt A, Frye M, Herold S, Benitah SA, Braun K, Samans B, Watt FM, Elsässer HP, Eilers M

The Journal of cell biology, 2006

doi:10.1083/jcb.200506057.

Different consequences of beta1 integrin deletion in neonatal and adult mouse epidermis reveal a context-dependent role of integrins in regulating proliferation, differentiation, and intercellular communication.

López-Rovira T, Silva-Vargas V, Watt FM

The Journal of investigative dermatology, 2005

doi:10.1111/j.0022-202X.2005.23956.x.

Topo II alpha reporter mice reveal proliferative regions in the epidermis and small intestine.

Li ER, Watt FM

FEBS letters, 2005

doi:10.1016/j.febslet.2005.10.022.

Suprabasal alpha 5 beta1 integrin expression stimulates formation of epidermal squamous cell carcinomas without disrupting TGFbeta signaling or inducing spindle cell tumors.

Owens DM, Broad S, Yan X, Benitah SA, Watt FM

Molecular carcinogenesis, 2005

doi:10.1002/mc.20118.

Stem cell depletion through epidermal deletion of Rac1.

Benitah SA, Frye M, Glogauer M, Watt FM

Science (New York, N.Y.), 2005

doi:10.1126/science.1113579.

Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells.

Silva-Vargas V, Lo Celso C, Giangreco A, Ofstad T, Prowse DM, Braun KM, Watt FM

Developmental cell, 2005

doi:10.1016/j.devcel.2005.04.013.

Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs.

Jadeja S, Smyth I, Pitera JE, Taylor MS, van Haelst M, Bentley E, McGregor L, Hopkins J, Chalepakis G, Philip N, Perez Aytes A, Watt FM, Darling SM, Jackson I, Woolf AS, Scambler PJ

Nature genetics, 2005

doi:10.1038/ng1549.

Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions.

Hobbs RM, Silva-Vargas V, Groves R, Watt FM

The Journal of investigative dermatology, 2004

doi:10.1111/j.0022-202X.2004.23225.x.

Sequence variation in the I-like domain of the beta1 integrin subunit in human oral squamous cell carcinomas.

Evans RD, Jones J, Taylor C, Watt FM

Cancer letters, 2004

doi:10.1016/j.canlet.2004.05.013.

Kazrin, a novel periplakin-interacting protein associated with desmosomes and the keratinocyte plasma membrane.

Groot KR, Sevilla LM, Nishi K, DiColandrea T, Watt FM

The Journal of cell biology, 2004

doi:10.1083/jcb.200312123.

Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt.

Janes SM, Ofstad TA, Campbell DH, Watt FM, Prowse DM

Journal of cell science, 2004

doi:10.1242/jcs.01302.

Switch from alphavbeta5 to alphavbeta6 integrin expression protects squamous cell carcinomas from anoikis.

Janes SM, Watt FM

The Journal of cell biology, 2004

doi:10.1083/jcb.200312074.

Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours.

Lo Celso C, Prowse DM, Watt FM

Development (Cambridge, England), 2004

doi:10.1242/dev.01052.

Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis.

Legg J, Jensen UB, Broad S, Leigh I, Watt FM

Development (Cambridge, England), 2003

doi:10.1242/dev.00837.

Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway.

McMullan R, Lax S, Robertson VH, Radford DJ, Broad S, Watt FM, Rowles A, Croft DR, Olson MF, Hotchin NA

Current biology : CB, 2003

doi:10.1016/j.cub.2003.11.050.

Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis.

Braun KM, Niemann C, Jensen UB, Sundberg JP, Silva-Vargas V, Watt FM

Development (Cambridge, England), 2003

doi:10.1242/dev.00703.

Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis.

Niemann C, Unden AB, Lyle S, Zouboulis ChC, Toftgård R, Watt FM

Proceedings of the National Academy of Sciences of the United States of America, 2003

doi:10.1073/pnas.1834202100.

Suprabasal alpha6beta4 integrin expression in epidermis results in enhanced tumourigenesis and disruption of TGFbeta signalling.

Owens DM, Romero MR, Gardner C, Watt FM

Journal of cell science, 2003

doi:10.1242/jcs.00725.

Regulation of keratinocyte shape, migration and wound epithelialization by IGF-1- and EGF-dependent signalling pathways.

Haase I, Evans R, Pofahl R, Watt FM

Journal of cell science, 2003

doi:10.1242/jcs.00610.

Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment.

Frye M, Gardner C, Li ER, Arnold I, Watt FM

Development (Cambridge, England), 2003

doi:10.1242/dev.00462.

Regulation of interleukin-1alpha expression by integrins and epidermal growth factor receptor in keratinocytes from a mouse model of inflammatory skin disease.

Hobbs RM, Watt FM

The Journal of biological chemistry, 2003

doi:10.1074/jbc.M300513200.

A tumor-associated beta 1 integrin mutation that abrogates epithelial differentiation control.

Evans RD, Perkins VC, Henry A, Stephens PE, Robinson MK, Watt FM

The Journal of cell biology, 2003

doi:10.1083/jcb.200209016.

Interaction of periplakin and envoplakin with intermediate filaments.

Karashima T, Watt FM

Journal of cell science, 2002

doi:10.1242/jcs.00191.

A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair.

Grose R, Hutter C, Bloch W, Thorey I, Watt FM, Fässler R, Brakebusch C, Werner S

Development (Cambridge, England), 2002

doi:10.1242/dev.129.9.2303.

Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours.

Niemann C, Owens DM, Hülsken J, Birchmeier W, Watt FM

Development (Cambridge, England), 2002

doi:10.1242/dev.129.1.95.

Gene targeting of envoplakin, a cytoskeletal linker protein and precursor of the epidermal cornified envelope.

Määttä A, DiColandrea T, Groot K, Watt FM

Molecular and cellular biology, 2001

doi:10.1128/MCB.21.20.7047-7053.2001.

Delta regulates keratinocyte spreading and motility independently of differentiation.

Lowell S, Watt FM

Mechanisms of development, 2001

doi:10.1016/s0925-4773(01)00459-2.

Cutting edge: amelioration of kidney disease in a transgenic mouse model of lupus nephritis by administration of the caspase inhibitor carbobenzoxy-valyl-alanyl-aspartyl-(beta-o-methyl)-fluoromethylketone.

Seery JP, Cattell V, Watt FM

Journal of immunology (Baltimore, Md. : 1950), 2001

doi:10.4049/jimmunol.167.5.2452.

A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis.

Haase I, Hobbs RM, Romero MR, Broad S, Watt FM

The Journal of clinical investigation, 2001

doi:10.1172/JCI12153.

Influence of beta1 integrins on epidermal squamous cell carcinoma formation in a transgenic mouse model: alpha3beta1, but not alpha2beta1, suppresses malignant conversion.

Owens DM, Watt FM

Cancer research, 2001

doi:.

Paraneoplastic pemphigus sera react strongly with multiple epitopes on the various regions of envoplakin and periplakin, except for the c-terminal homologous domain of periplakin.

Nagata Y, Karashima T, Watt FM, Salmhofer W, Kanzaki T, Hashimoto T

The Journal of investigative dermatology, 2001

doi:10.1046/j.1523-1747.2001.01263.x.

c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny.

Arnold I, Watt FM

Current biology : CB, 2001

doi:10.1016/s0960-9822(01)00154-3.

Dermal fibroblast-derived growth factors restore the ability of beta(1) integrin-deficient embryonal stem cells to differentiate into keratinocytes.

Bagutti C, Hutter C, Chiquet-Ehrismann R, Fässler R, Watt FM

Developmental biology, 2001

doi:10.1006/dbio.2000.0149.

Epithelial cell differentiation pathways in the human prostate: identification of intermediate phenotypes by keratin expression.

Hudson DL, Guy AT, Fry P, O'Hare MJ, Watt FM, Masters JR

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2001

doi:10.1177/002215540104900214.

p19ARF-independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes.

Roper E, Weinberg W, Watt FM, Land H

EMBO reports, 2001

doi:10.1093/embo-reports/kve020.

Expression of involucrin in normal, hyperproliferative and neoplastic mouse keratinocytes.

Li ER, Owens DM, Djian P, Watt FM

Experimental dermatology, 2000

doi:10.1034/j.1600-0625.2000.009006431.x.

PA-FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation.

O'Shaughnessy RF, Seery JP, Celis JE, Frischauf A, Watt FM

FEBS letters, 2000

doi:10.1016/s0014-5793(00)02252-3.

Asymmetric stem-cell divisions define the architecture of human oesophageal epithelium.

Seery JP, Watt FM

Current biology : CB, 2000

doi:10.1016/s0960-9822(00)00803-4.

Subcellular distribution of envoplakin and periplakin: insights into their role as precursors of the epidermal cornified envelope.

DiColandrea T, Karashima T, Määttä A, Watt FM

The Journal of cell biology, 2000

doi:10.1083/jcb.151.3.573.

Proliferative heterogeneity in the human prostate: evidence for epithelial stem cells.

Hudson DL, O'Hare M, Watt FM, Masters JR

Laboratory investigation; a journal of technical methods and pathology, 2000

doi:10.1038/labinvest.3780132.

The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development.

Sibilia M, Fleischmann A, Behrens A, Stingl L, Carroll J, Watt FM, Schlessinger J, Wagner EF

Cell, 2000

doi:10.1016/s0092-8674(00)00026-x.

Structure and regulation of the envoplakin gene.

Määttä A, Ruhrberg C, Watt FM

The Journal of biological chemistry, 2000

doi:10.1074/jbc.M001028200.

The alpha2 and alpha5 integrin genes: identification of transcription factors that regulate promoter activity in epidermal keratinocytes.

Corbi AL, Jensen UB, Watt FM

FEBS letters, 2000

doi:10.1016/s0014-5793(00)01591-x.

Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters.

Lowell S, Jones P, Le Roux I, Dunne J, Watt FM

Current biology : CB, 2000

doi:10.1016/s0960-9822(00)00451-6.

beta1B integrin subunit contains a double lysine motif that can cause accumulation within the endoplasmic reticulum.

Kee WJ, Li ER, Watt FM

Journal of cellular biochemistry, 2000

doi:10.1002/(sici)1097-4644(20000701)78:1<97::aid-jcb9>3.0.co;2-5.

beta1 integrins regulate keratinocyte adhesion and differentiation by distinct mechanisms.

Levy L, Broad S, Diekmann D, Evans RD, Watt FM

Molecular biology of the cell, 2000

doi:10.1091/mbc.11.2.453.

Envoplakin, a possible candidate gene for focal NEPPK/esophageal cancer (TOC): the integration of genetic and physical maps of the TOC region on 17q25.

Risk JM, Ruhrberg C, Hennies H, Mills HS, Di Colandrea T, Evans KE, Ellis A, Watt FM, Bishop DT, Spurr NK, Stevens HP, Leigh IM, Reis A, Kelsell DP, Field JK

Genomics, 1999

doi:10.1006/geno.1999.5857.

The distribution of actin cables and microtubules in hybrids between malignant and non-malignant cells, and in tumours derived from them.

Watt FM, Harris H, Weber K, Osborn M

Journal of cell science, 1978

doi:10.1242/jcs.32.1.419.