Directors’ Research

The Hyman group investigates how biomolecular condensates organise the cell’s biology by combining approaches across scales from single molecules to organisms. The group deciphers the principles underlying the formation and dissolution of biomolecular condensates and their functional roles in physiology and disease. Major research areas include the role of biomolecular condensates the context of the cellular stress response, cell division, transcription, metabolism, and immunity. The group also investigates how aberrant phase separation and protein aggregation contribute to neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS).

The Hentze group combines biochemical and systems-level approaches to investigate the connections between gene expression, cell metabolism, and their role in human disease. Key goals of the group include collaborative efforts to: uncover the biological roles of unexpected RNA-binding proteins (‘enigmRBPs’) in cell metabolism, differentiation, and development; explore, define, and understand REM networks; help elucidate the role of RNA metabolism in disease, and to develop novel diagnostic and therapeutic strategies based on this knowledge; and to understand the molecular mechanisms and regulatory circuits underlying physiological iron homeostasis.

The Watt group is investigating how adult stem cell renewal and lineage selection are controlled by reciprocal interactions with the cellular microenvironment, or niche. The focus of our research is mammalian skin, which we study using human cells in culture and genetically modified mice. We have previously found markers to isolate epidermal stem cells and elucidated several of the signalling pathways that regulate stem cell behaviour, two of which – integrin and Notch signalling – are a focus of our current research. We are also exploring the remarkable plasticity of epidermal stem and differentiated cells and ways in which epidermal-dermal communication controls skin homeostasis. We make extensive use of single-cell analysis and are defining how biophysical cues elicit transcriptional responses in epidermal stem cells. Having demonstrated the existence of different skin fibroblast lineages in mice, we are analysing different subpopulations of human skin fibroblasts, with the goal of developing new strategies to treat skin scarring.