Investigating pulmonary neuroendocrine cells in human respiratory diseases with airway models.

Candeli N, Dayton T

Disease models & mechanisms, 2024

doi:10.1242/dmm.050620.

Druggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine neoplasms from multiple body sites.

Dayton TL, Alcala N, Moonen L, den Hartigh L, Geurts V, Mangiante L, Lap L, Dost AFM, Beumer J, Levy S, van Leeuwaarde RS, Hackeng WM, Samsom K, Voegele C, Sexton-Oates A, Begthel H, Korving J, Hillen L, Brosens LAA, Lantuejoul S, Jaksani S, Kok NFM, Hartemink KJ, Klomp HM, Borel Rinkes IHM, Dingemans AM, Valk GD, Vriens MR, Buikhuisen W, van den Berg J, Tesselaar M, Derks J, Speel EJ, Foll M, Fernández-Cuesta L, Clevers H

Cancer cell, 2023

doi:10.1016/j.ccell.2023.11.007.

The 2022 generation.

Barry-Hundeyin M, Carrot-Zhang J, Dayton T, Ghazanfar S, Guenther LM, Nguyen DTT, Pitarresi JR, Rajput S, Santana-Codina N, Shree T, Zeng Z, Zhang Y

Nature cancer, 2022

doi:10.1038/s43018-022-00481-z.

Diffuse hormonal systems.

Andersson-Rolf A, Clevers H, Dayton TL

2021

doi:.

Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma.

Davidson SM, Heyman JE, O’Brien JP, Liu AC, Schmidt DR, Israelsen WJ, Dayton TL, Sehgal R, Bronson RT, Freinkman E, Mak H, Malstrom S, Bellinger G, Carracedo A, Pandolfi PP, Courtney KD, Jha A, DePinho RA, Horner JW, Thomas CJ, Cantley LC, Loda M, Heiden MV

bioRxiv, 2021

doi:10.1101/2021.05.09.443334.

Intestinal organoids as tools for enriching and studying specific and rare cell types: advances and future directions.

Boonekamp KE, Dayton TL, Clevers H

Journal of molecular cell biology, 2020

doi:10.1093/jmcb/mjaa034.

Probing the tumor suppressor function of BAP1 in CRISPR-engineered human liver organoids.

Artegiani B, van Voorthuijsen L, Lindeboom RGH, Seinstra D, Heo I, Tapia P, López-Iglesias C, Postrach D, Dayton T, Oka R, Hu H, van Boxtel R, van Es JH, Offerhaus J, Peters PJ, van Rheenen J, Vermeulen M, Clevers H

Cell stem cell, 2019

doi:10.1016/j.stem.2019.04.017.

Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma.

Dayton TL, Gocheva V, Miller KM, Bhutkar A, Lewis CA, Bronson RT, Vander Heiden MG, Jacks T

Cancer & metabolism, 2018

doi:10.1186/s40170-018-0179-2.

PKM2 is not required for pancreatic ductal adenocarcinoma.

Hillis AL, Lau AN, Devoe CX, Dayton TL, Danai LV, Di Vizio D, Vander Heiden MG

Cancer & metabolism, 2018

doi:10.1186/s40170-018-0188-1.

PKM2 is not required for colon cancer initiated by APC loss.

Lau AN, Israelsen WJ, Roper J, Sinnamon MJ, Georgeon L, Dayton TL, Hillis AL, Yilmaz OH, Di Vizio D, Hung KE, Vander Heiden MG

Cancer & metabolism, 2017

doi:10.1186/s40170-017-0172-1.

Beyond growth signaling: Paneth cells metabolically support ISCs.

Dayton TL, Clevers H

Cell research, 2017

doi:10.1038/cr.2017.59.

Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival.

Gocheva V, Naba A, Bhutkar A, Guardia T, Miller KM, Li CM, Dayton TL, Sanchez-Rivera FJ, Kim-Kiselak C, Jailkhani N, Winslow MM, Del Rosario A, Hynes RO, Jacks T

Proceedings of the National Academy of Sciences of the United States of America, 2017

doi:10.1073/pnas.1707054114.

PKM2, cancer metabolism, and the road ahead.

Dayton TL, Jacks T, Vander Heiden MG

EMBO reports, 2016

doi:10.15252/embr.201643300.

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.

Dayton TL, Gocheva V, Miller KM, Israelsen WJ, Bhutkar A, Clish CB, Davidson SM, Luengo A, Bronson RT, Jacks T, Vander Heiden MG

Genes & development, 2016

doi:10.1101/gad.278549.116.

Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation.

Lunt SY, Muralidhar V, Hosios AM, Israelsen WJ, Gui DY, Newhouse L, Ogrodzinski M, Hecht V, Xu K, Acevedo PN, Hollern DP, Bellinger G, Dayton TL, Christen S, Elia I, Dinh AT, Stephanopoulos G, Manalis SR, Yaffe MB, Andrechek ER, Fendt SM, Vander Heiden MG

Molecular cell, 2015

doi:10.1016/j.molcel.2014.10.027.

Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development.

Mayers JR, Wu C, Clish CB, Kraft P, Torrence ME, Fiske BP, Yuan C, Bao Y, Townsend MK, Tworoger SS, Davidson SM, Papagiannakopoulos T, Yang A, Dayton TL, Ogino S, Stampfer MJ, Giovannucci EL, Qian ZR, Rubinson DA, Ma J, Sesso HD, Gaziano JM, Cochrane BB, Liu S, Wactawski-Wende J, Manson JE, Pollak MN, Kimmelman AC, Souza A, Pierce K, Wang TJ, Gerszten RE, Fuchs CS, Vander Heiden MG, Wolpin BM

Nature medicine, 2014

doi:10.1038/nm.3686.

Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing.

McFadden DG, Papagiannakopoulos T, Taylor-Weiner A, Stewart C, Carter SL, Cibulskis K, Bhutkar A, McKenna A, Dooley A, Vernon A, Sougnez C, Malstrom S, Heimann M, Park J, Chen F, Farago AF, Dayton T, Shefler E, Gabriel S, Getz G, Jacks T

Cell, 2014

doi:10.1016/j.cell.2014.02.031.

PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW, Burga LN, Xie J, Jurczak MJ, DePinho RA, Clish CB, Jacks T, Kibbey RG, Wulf GM, Di Vizio D, Mills GB, Cantley LC, Vander Heiden MG

Cell, 2013

doi:10.1016/j.cell.2013.09.025.

Differential Tks5 isoform expression contributes to metastatic invasion of lung adenocarcinoma.

Li CM, Chen G, Dayton TL, Kim-Kiselak C, Hoersch S, Whittaker CA, Bronson RT, Beer DG, Winslow MM, Jacks T

Genes & development, 2013

doi:10.1101/gad.222745.113.

Nuclear factor I/B is an oncogene in small cell lung cancer.

Dooley AL, Winslow MM, Chiang DY, Banerji S, Stransky N, Dayton TL, Snyder EL, Senna S, Whittaker CA, Bronson RT, Crowley D, Barretina J, Garraway L, Meyerson M, Jacks T

Genes & development, 2011

doi:10.1101/gad.2046711.

Suppression of lung adenocarcinoma progression by Nkx2-1.

Winslow MM, Dayton TL, Verhaak RG, Kim-Kiselak C, Snyder EL, Feldser DM, Hubbard DD, DuPage MJ, Whittaker CA, Hoersch S, Yoon S, Crowley D, Bronson RT, Chiang DY, Meyerson M, Jacks T

Nature, 2011

doi:10.1038/nature09881.

p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis.

Kirsch DG, Santiago PM, di Tomaso E, Sullivan JM, Hou WS, Dayton T, Jeffords LB, Sodha P, Mercer KL, Cohen R, Takeuchi O, Korsmeyer SJ, Bronson RT, Kim CF, Haigis KM, Jain RK, Jacks T

Science (New York, N.Y.), 2010

doi:10.1126/science.1166202.

Chemical composition and antimicrobial activity of some oleogum resin essential oils from Boswellia spp. (Burseraceae).

Camarda L, Dayton T, Di Stefano V, Pitonzo R, Schillaci D

Annali di chimica, 2007

doi:10.1002/adic.200790068.

A QCM study of the immobilization of beta-galactosidase on polyelectrolyte surfaces: effect of the terminal polyion on enzymatic surface activity.

Hamlin RE, Dayton TL, Johnson LE, Johal MS

Langmuir : the ACS journal of surfaces and colloids, 2007

doi:10.1021/la063339t.