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EMBO Workshop

In situ structural biology: bridging molecular mechanisms with system-wide approaches

Overview

This conference will take place at EMBL Heidelberg, with the option to attend virtually.

Conference overview

In situ structural biology is a rapidly advancing field focused on understanding the structure and function of macromolecular complexes within intact cells and tissues. There is a growing recognition that a mechanistic understanding of complex cellular processes depends on structural insights into the macromolecules that drive them. Recent advances in cryo-electron microscopy and tomography, mass spectrometry–based proteomics, fluorescence and super-resolution microscopy, protein structure prediction, and multiscale computational modelling have expanded the ability to study molecular structures within intact cells. While these technologies have independently generated valuable insights, a comprehensive understanding of molecular interactions and functions in their native environments requires systematic integration of complementary methods and data types.

Started in 2020, and now in its fourth edition, this EMBO Workshop has established itself in a rapidly growing in situ structural biology community as the main platform to foster dialogue and collaboration amongst different communities (cryo‑EM/ET, MS‑based proteomics, fluorescence and super‑resolution imaging, protein structure prediction, multi‑scale computational modelling, as well as new, emerging methods and tools). With an additional focus on system-wide approaches for 2027, we aim to again bring together experts and early-career researchers from diverse disciplines across the life sciences to:

  • Showcase recent technological and methodological advances and promote their application as powerful tools for cell biology across multiple scales.
  • Provide a forum for discussing structural biology approaches in the context of intact cells and tissues.
  • Foster dialogue on effective strategies for integrating data from different experimental and computational methods.
  • Identify the biological questions that can currently be addressed through in situ structural biology and explore future opportunities and challenges for the field.

Topics

  • Molecular systems
  • Novel technologies 1
  • Subcellular organization
  • Beyond single cells
  • Whole-cell systems
  • Novel technologies 2

What past participants say about the conference

The conference was fantastic, with an amazing list of speakers. As an early career researcher, I found this event very inspirational and broadening for research opportunities later.” — Kamila Kamuda, University College London, UK

I immensely benefited from the workshop organised by EMBL through talks of so many brilliant scientists who had explained the fast-evolving technique to capture the whole cell structure at near-atomic resolution.” — Samar Ballabha Mohapatra, Indian Institute of Technology, India


This event has been granted the following EMBO sustainability badge:

Grade 2 of 3

Speakers

Keynote speakers

Edward Marcotte

The University of Texas at Austin

USA

Gaia Pigino

Human Technopole

Italy

Speakers

Max Bonomi

Institut Pasteur

France

Gautam Dey

EMBL Heidelberg

Germany

Svetlana Dodonova

EMBL Heidelberg

Germany

Stefan Hell

Max Planck Institute for Biophysical Chemistry

Germany

Jan Kosiński

EMBL Hamburg

Germany

Manuel Leonetti

Chan Zuckerberg Biohub

USA

Christophe Leterrier

INP, CNRS-Aix Marseille University

France

Bronwyn Lucas

University of California, Berkeley

USA

Francis O'Reilly

St. Jude Children's Research Hospital

USA

Paola Picotti

ETH Zürich

Switzerland

Anđela Šarić

Institute of Science and Technology Austria

Austria

Beata Turoňová

Max Planck Institute of Biophysics

Germany

Gregor Weiss

University of Zürich

Switzerland

Hui Ye

China Pharmaceutical University

China

Yongdeng Zhang

Westlake University

China

Scientific organisers

Fan Liu

Leibniz-Forschungsinstitut für Molekulare Pharmakologie

Germany

Julia Mahamid

EMBL Heidelberg

Germany

Jonas Ries

University of Vienna

Austria

Stefano Vanni

University of Fribourg

Switzerland

Conference organiser

Chris Stocks

Chris Stocks

Course and Conference Team Lead

EMBL Heidelberg

Germany

Programme

Are you on social media? Post using #EMBOinsitu and don’t forget to tag @EMBLEvents

  • Please note that the programme is subject to change. Some speakers may need to join virtually to give their talk.
  • For registered participants, recorded talks will be accessible on demand for 4 weeks after the end of the event, unless indicated otherwise.
Day 1 – Tuesday 9th February 2027
Time (Europe/Berlin)Speaker
12:00 – 13:30Registration and light refreshments
13:30 – 13:45Opening remarks
13:45 – 14:45Keynote lecture
Edward Marcotte – University of Texas, USA
14:45 – 17:45Session 1: Molecular systems
14:45 – 15:00Short talk speaker #1
15:00 – 15:30Invited speaker #1 –
Max Bonomi – Institut Pasteur, France
15:30 – 16:00Coffee Break and Meet the speakers
16:00 – 16:15Short talk speaker #2
16:15 – 16:45Invited speaker #2
Building a molecular map of an archaeal cell
Svetlana Dodonova – EMBL Heidelberg, Germany
16:45 – 17:00Short talk speaker #3
17:00 – 17:15Short talk speaker #4
17:15 – 17:45Invited speaker #3
Francis O’Reilly – St. Jude Childen’s Research Hospital, USA
17:45 – 18:30Poster sneak peek session with drinks
18:30 – 20:00Dinner in Canteen
20:00 – 22:00Pub quiz and after dinner drinks
Day 2 – Wednesday 10th February 2027
Time (Europe/Berlin)Speaker
09:00 – 12:00Session 2: Novel Technologies 1
09:00 – 09:30Invited speaker #4
Stephan Hell – Max Planck Institute for Medical Research, Germany
09:30 – 09:45Short talk speaker #5
09:45 – 10:00Short talk speaker #6
10:00 – 10:30Coffee Break and Meet the speakers
10:30 – 11:00Invited speaker #5
Beata Turonova – Max Planck Institue of Biophysics
11:00 – 11:15Short talk speaker #7
11:15 – 11:30Short talk speaker #8
11:30 – 12:00Invited speaker #6
Hui Ye – China Pharmaceutical University, China
12:00 – 13:30Lunch and Meet the Editors
13:30-16:00Session 3: Subcellular organization
13:30 – 14:00Invited speaker #7
Manuel Leonetti – CZ Biohub, USA
14:00 – 14:15Short talk speaker #9
14:15 – 14:30Short talk speaker #10
14:30 – 15:00Coffee Break and Meet the speakers
15:00 – 15:30Invited speaker #8
Andela Saric – ISTA, Austria
15:30 – 15:45Short talk speaker #11
15:45 – 16:00Short talk speaker #12
16:00 – 18:30Poster Session 1 (odd numbers)
Free evening
Day 3 – Thursday 11th February 2027
Time (Europe/Berlin)Speaker
09:00 – 11:30Session 4: Whole-cell systems
09:00 – 09:30Invited speaker #9
Paola Picotti – ETHZ, Switzerland
09:30 – 09:45Short talk speaker #13
09:45 – 10:00Short talk speaker #14
10:00 – 10:30Coffee Break and Meet the speakers
10:30 – 11:00Invited speaker #10
Single molecule structural cell biology
Brownwyn Lucas – LMB-MRC, UK
11:00 – 11:15Short talk speaker #15
11:15 – 11:30Short talk speaker #16
11:30 – 12:00Invited speaker #11
Christophe Letterier – CNRS, France
12:00 – 13:30Lunch (and optional: Career Session for 45 min or Job Fair)
13:30 – 16:00Session 5: Beyond single cells
13:30 – 14:00Invited speaker #12
Gregor Weiss – University of Zurich, Switzerland
14:00 – 14:15Short talk speaker #17
14:15 – 14:30Short talk speaker #18
14:30 – 15:00Coffee Break and Meet the speakers
15:00 – 15:15Short talk speaker #19
15:15 – 15:30Short talk speaker #20
15:30 – 16:00Invited speaker #13
Expansion microscopy as a gateway to environmental structural biology
Gautam Dey – EMBL Heidelberg, Germany
16:00 – 18:30Poster Session 2 (even numbers)
18:30 – 20:30Conference dinner in the canteen
20:30 – 23:45Party
Day 4 – Friday 12th February 2027
Time (Europe/Berlin)Speaker
09:00 – 12:30Session 6: Novel Technologies 2
09:00 – 09:30Invited speaker #14
Jan Kosinski – EMBL Heidelberg, Germany
09:30 – 09:45Short talk speaker #21
09:45 – 10:00Short talk speaker #22
10:00 – 10:15Short talk speaker #23
10:15 – 10:45Coffee Break and Meet the speakers
10:45 – 11:15Invited speaker #15
Elucidating Molecular Architecture and Dynamics with 4Pi Single-Molecule Localization Microscopy
Yongdeng Zhang – Westlake Unviersity, China
11:15 – 11:30Short talk speaker #24
11:15 – 12:15Keynote lecture
Gaia Pigino – Human Technopole, Italy
12:15 – 12:30Closing Remarks and Poster Prize Announcements
12:30Packed lunch and departure

Practical information

Registration fees

On-site registration fees include:

  • Admission to the event
  • Possibility to submit an abstract
  • Meals and coffee breaks as indicated in the programme
  • Conference materials
  • Access to the online event platform
  • Access to all livestreamed talks
  • Video library of the recorded talks during the event and for four weeks afterwards. Please note: at the request of individual speakers, some talks are not recorded.
  • A letter to support your visa application (for more information, check the ‘Travel and accommodation’ tab)

Accommodation and travel are not included in the fees. Participants are expected to book and pay their own expenses.

On-site Academia€350
On-site PhD Student€450
On-site Industry€770
On-site Journal Editors*€300

* Editors from scientific journals are allowed to attend at a reduced rate, but asked to contribute to the conference in return by taking part in ‘meet the editors’ sessions or other planned activities within the programme. Please contact Chris Stocks to ask for the special registration link for editors.

Virtual registration fees include:

  • Access to the online event platform
  • Access to all the livestreamed talks
  • Opportunity to submit questions
  • Video library of the recorded talks during the event and for four weeks afterwards.
    Please note: at the request of individual speakers, some talks are not recorded.

Virtual Academia€150
Virtual PhD Student€200
Virtual Industry€275

Note: accredited journalists may be eligible to register for complimentary on-site or virtual press registration. Registrants may be required to provide accreditation or equivalent proof of press membership after registration. Please contact Chris Stocks for more information.

Confirmation and payment

Registration will be on a first come, first served basis. You can register and submit your abstract without paying the conference fee in advance but your place can only be confirmed after payment of the registration fee.

If you are added to our waiting list, please consider taking advantage of our offerings to participate virtually.

On-site participants: types of payments accepted are international bank transfers and credit card payments. 

Virtual participants: we are only able to accept card payments. In exceptional cases we can accept bank transfers. Please contact events@embl.de for details.

Cancellation policy

If you are no longer able to take part in the conference, please inform your conference contact responsible for this event. Your registration and the submitted abstract will be deleted.

Please also check our Terms and Conditions for the cancellation policy.

Abstract submission and selection

Abstract submission

Only participants registering to attend the on-site event are eligible to submit an abstract. Unfortunately, abstracts will not be accepted from virtual participants.

After registration you can submit your abstract via a separate link that will be provided in the email confirmation. Alternatively, you can access the link on the confirmation page directly after registering. The same login credentials are used for both processes.

Abstract selection

The selection process will take place with the results announced by email to all applicants/submitters. We aim to announce 3 weeks (21 days) after the abstract submission deadline but delays may occur.

Things to keep in mind when preparing the abstract:

Abstract body: The limit of 2,000 characters refers to manually typed text and excludes spaces. If an error occurs try using a different web browser (preferably Google Chrome or Mozilla Firefox).

If you copy-paste the text into the form, hidden formatting might still be included which may cause the text to exceed the 2,000 character limit resulting in an error message. We recommend you clear all formatting before pasting in the text.

If you have special symbols in your text, make sure you are using Unicode characters, otherwise these will not be recognised.

Title: The title should not exceed 20 words. Only the first word of the title should start with a capital letter and the rest should be lowercase.

Authors and affiliations: Please fill in the author’s details as requested in the online form. The compulsory fields are: First Name, Last Name, Organisation Name (Affiliation or Company), Country and Email.

Kindly mark only one author in the role of First Author and please don’t forget to indicate who will be the Presenter.

Please enter your co-authors correctly via the system by adding accounts together with their organisation/institute. Do not copy-paste them into the body of the abstract text, as they will not be indexed in the abstract book.

Presentation types: When submitting your abstract, you can apply for an oral or poster presentation. A selection process will take place with the results announced 3 weeks after the abstract submission deadline (delays may occur).

For detailed instructions on how to submit a conference abstract, follow the instructions provided in this video.

Please check our FAQs pages for further information on how to submit an abstract.

Financial assistance

Financial assistance

Limited financial assistance is provided by EMBO in the form of travel grants, childcare grants, and accessibility grants.

Your place in the meeting is only confirmed by paying the registration fee, which is mandatory even when receiving a travel grant/fee waiver.

Travel grant

The travel grant will cover the cost of travel to an on-site event (airfare, train, bus, taxi, accommodation, visa) and/or registration fees and is provided up to specified caps which are normally as follows:

  • up to €500 for any participant travelling to an EMBO Workshop.
  • up to €1000 for any participant working in Chile, India, Singapore, or Taiwan travelling to an EMBO Workshop.

The organisers may reduce the grant cap to accommodate more participants. Recipients will be notified of their travel cap amount when they are informed of the outcome of their application. Receipts (and boarding passes for air travel) must be provided via email with your signature for all costs incurred within two months of completion of travel.

Childcare grant

There is the possibility to apply for a childcare grant to offset child care costs incurred by participants, speakers, and organisers when attending a conference.

Eligible costs include (but are not limited to) fees for a baby-sitter or child-care facility, and travel costs for a caregiver. Please note that priority will be given to early stage researchers. You may apply for a childcare grant at the same time when submitting your abstract. There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants.

EMBO accessibility grant

For EMBO Workshop participants with accessibility needs, there is the possibility to apply for an accessibility grant to offset costs incurred by participants or speakers when participating at a conference. Eligible costs include costs incurred for equipment or adaptations to the conference environment, or travel costs for an event companion to assist the participant or speaker during the conference where necessary. While we do our best to accommodate needs, please note that extensive changes to the conference environment might not be possible. Priority will be given to early-stage researchers. A maximum amount of €500 can be awarded per participant applying for an EMBO accessibility grant. In order to apply for this grant for EMBO Workshops, you must be registered by the abstract submission deadline. 

Application

On-site participants

You may apply for financial assistance when submitting your abstract. After finishing the registration you will receive an email with a link to apply for financial assistance.

In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career. Application for financial support will not influence the outcome of the abstract selection.

Virtual participants

If you are attending virtually, you can apply for financial assistance in the submission portal by the abstract deadline. Read the instructions on how to apply for financial assistance as a virtual participant.

In your application you will be asked to summarise your current work,  answer questions regarding why your lab cannot fund your attendance, and how your attendance will make a difference to your career.

Results

The scientific organisers will select the recipients of grant allocations during the abstract selection process. They will be announced after the abstract selection.

Grant allocation results do not influence your admission to the meeting. The selection is based on scientific merit, your current work or study location, the reasons for needing financial support, and the impact this event will have on your career.

Please note that for childcare grants, priority will be given to early-stage researchers.

Reimbursement

Costs will be reimbursed after the meeting only once a reimbursement form and original receipts (from travel costs) have been received.

Further details

View our list of external funding opportunities or refer to the FAQ page.

Become an event reporter

At our conferences we also offer the option to become an event reporter. By attending the meeting, sharing your insights on social media, and writing a detailed report, you can offset the conference fees. Please read the instructions on how to apply.

Travel and accommodation

Visa

We can send you a registration confirmation to support your visa procedure (not an official invitation letter) after you have paid the registration fee. Please contact the conference officer responsible for your event. Read our FAQ for more information.

Travel

If you are travelling to Heidelberg via aeroplane, train, car or long-distance bus, you can find useful information on our travel information page.

Accommodation

Accommodation is not included in the conference registration fee.

Invited speakers please be wary of fraudulent ‘hotel services’ contacting you to ask for payments, see our Accommodation Scam Alert for more information.

Hotels for this conference will appear here soon.

Please note that as of 1 October 2025, Heidelberg City Council is introducing an overnight stay tax for tourists visiting Heidelberg (including work related trips). The cost will be 3.50 EUR per night for the first five nights of a consecutive stay and will be added to the hotel’s nightly rate. Please contact the individual hotel directly if you have any questions.

Local transportation

Conference shuttle buses

Conference shuttle buses are free of charge for participants, and depart from designated bus stops near the hotels to EMBL and back, mornings and evenings.

The bus stops for this conference are:

  • Staycity Aparthotel (Speyerer Str. 7)
  • Kurfürsten-Anlage (Opposite Main Train Station)
  • Premier Inn City Zentrum (Kurfürsten-Anlage 23)
  • Leonardo Hotel Heidelberg City Center (Bergheimer Str. 63)
  • Neckarmünzplatz (Heidelberg Tourist Information)
  • Peterskirche (Bus stop)
  • Hans-Böckler-Straße (Bus stop)
  • ISG Hotel (Im Eichwald 19)

View Conference shuttle bus stops and hotels in a larger map. Please note that not every bus stop will be used for every event.

Other local transportation

In addition to the shuttle busses, there is also the public bus 28 that serves the EMBL campus and taxis can be easily booked at any time. For more information, please refer to the local transportation (RNV) website.

Further details

Address: EMBL, Meyerhofstraße 1, 69117 Heidelberg, Germany.

For more information about accommodation and travel, please refer to the FAQ page.

On-site information

Here you will find useful information for when you are onsite at the event.

Catering

All meals and coffee breaks as indicated in the programme are included in the registration fee. Our catering staff will prepare a variety of vegetarian meals, meat and fish dishes, soups, pasta, fresh fruit and vegetables, as well as a variety of desserts.

Please wear your badge at all times when serving yourself.

No food or drinks are allowed in the auditorium.

Internet

Wi-Fi is available on campus using the EMBL-Events network and the event specific password, which will be provided on site. The eduroam network (secure, worldwide roaming access service developed for the international research and education community) is also available.

Photography

During the conference, an EMBL Photographer may be taking photos. If you would not like to appear in these, please inform the photographer or a member of the Course and Conference Office.

Charging stations

There are lockers available next to the stairs leading down into the Auditorium. You will find some of those equipped with sockets to charge your smartphone/tablet etc.

In most places the electricity is 220 volts AC (50 cycles). An adaptor and a plug that fits the German socket may be needed for your appliances/laptop (i.e. American, Japanese, etc.). A USB charging station for electronic devices is available at the registration desk.

Printing

We can help to print your boarding pass/train ticket. Please send it to events@embl.de and collect your print-outs at the registration desk.

Luggage

There are lockers available on-site to store your luggage, which require a 2 EURO coin to operate. There is another luggage room on level E0, which is free to use but remains unlocked during the conference.

Lost and found

‘’Lost and Found’’ items are kept at the registration desk until the end of the conference.

Nursing room

There is a nursing room available in the ATC Rooftop Lounge on level A29.

Room for prayers, meditation, and yoga

There is a room for prayer, yoga, and meditation, located on level E0 behind the Auditorium. Please be respectful of others using the room.

EMBL campus map

Health and safety notes

Please take a moment to read our health and safety policy.

  • Do not smoke in any EMBL building.
  • Eating and drinking is prohibited in the Auditorium and all laboratories.
  • Do not enter any restricted areas or the laboratories unless instructed to do so.

If first aid is required

  • The first aid room is located next to the ATC Registration Desk (room 10- 205).
  • Dial the Emergency number 222 from any EMBL internal phone only.
  • Be prepared to answer the following questions: Where is the accident? What happened? How many injured?
  • Emergency number 06221-387 7821 from mobile phones.
  • Please report all accidents to the conference officer at the registration desk.

In case of fire

  • Press the nearest fire alarm button or the Emergency number 222 from any internal phone.
  • A loud fire alarm will go off if an evacuation is required. On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points
  • Do not use the lifts.

Beyond first aid

The Heidelberg University Hospital or ‘Universitätsklinikum‘ has a 24 hour accident and emergency facility and is at ‘Im Neuenheimer Feld 672’. It is a 8km or a 20 minute taxi ride away from EMBL. In a medical emergency, the ambulance service generally transports patients to this hospital.

Please remember to bring your own medication, if needed, to the conference. Note that the next pharmacy is a 4-minute drive from the EMBL, but for many medications you will be required to see a doctor to get a prescription.

Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg.

The EMBL course and conference office team are able to advise you on where to turn for emergency or non-emergency medical treatment in Heidelberg and can assist you in making appointments and / or arranging transport to get to the pharmacy or a doctor of your choice if necessary. Please note, we are not however permitted to personally accompany you off-campus.

Sightseeing

A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing.

Event platform

Access

Access to the event platform is given to all on-site and virtual participants.

You can use the event platform to:

  • Access to all the livestreamed talks
  • Opportunity to submit questions (for virtual participants)
  • Video library of the recorded talks during the event and for four weeks afterwards. Please note: at the request of individual speakers, some talks are not recorded
  • Access to the abstract book
  • Opportunity to engage with speakers and other participants via the discussion area and chat functionality
  • Other useful information (How to give a good scientific talk, or to make a good scientific poster, and more)

More information about the platform will be shared ahead of the conference.

Guidelines

  • Please do not share the link to the course or conference platform with anyone else
  • Do not broadcast the conference to unregistered participants.
  • You are encouraged to post about the event. Post unless the speaker specifically says otherwise, but be mindful of unpublished data. 
  • Please do not capture, transmit or redistribute data presented at the meeting.

Additional information can be found in our Code of Conduct.

Time zone

The programme is planned based on the Europe/Berlin time zone, unless otherwise stated. Please take your time zone into consideration when planning your attendance.

Additional information

Please find additional information including FAQs, terms and conditions, and travelling to EMBL on our Information for participants page.

Sponsors

Sponsorship opportunities

We offer a variety of event sponsoring possibilities, with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget. Discounts are available for companies sponsoring multiple events at EMBL Heidelberg. View other conferences, or contact sponsorship@embl.org for further information on sponsoring possibilities.

If you are interested in becoming a media partner of this event, please visit our media partnerships webpage.

Warning

EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials. One current scam campaign of which we are aware is conducted using the name ‘Judy Eastman’ (judy@gopcontact.a2hosted.com) and entails approaches to sponsors offering sponsorship opportunities on EMBL’s behalf. Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences, symposia and courses is handled by EMBL directly and is sent from an official EMBL account. EMBL does not work with any external providers on sponsorship acquisition.

Please also note that:

  • EMBL never provides attendee lists for purchase. Any offers of such are fraudulent.
  • EMBL will never call or email you to ask for your credit card details or to request a payment.
  • All payments are on invoice.

Suspicious communications purportedly from, for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship@embl.de.

Media kit

Want to let others know you’re attending this event? Take a look at our shareable media and feel free to use them in your social media channels or presentations.

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Date: 9 - 12 Feb 2027

Location: EMBL Heidelberg and Virtual

Venue: EMBL Advanced Training Centre


Deadline(s):

Abstract submission: 3 Nov 2026

Registration (On-site): 5 Jan 2027

Registration (Virtual): 2 Feb 2027


Organisers:

  • Fan Liu
    Leibniz-Forschungsinstitut für Molekulare Pharmakologie Germany

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