Gene regulation: one molecule at a time

Overview

This conference will take place at EMBL Heidelberg, with the option to attend virtually.

Registration is not yet open for this event. If you are interested in receiving more information please register your interest.

Conference overview

Gene expression is controlled by the dynamic action of dozens of macromolecular complexes that assemble on DNA to transcribe genes and translate mRNAs to proteins. Understanding of these mechanisms has historically been driven by biochemical and structural characterisation of the players, as well as probing their function through genetic deletions. The genomics revolution has provided us with a near- comprehensive picture of where these factors bind to regulate the genome and which transcripts are processed in various biological contexts.

A key limitation of the resulting models is that they are derived using data that are static by nature, unfaithfully representing the dynamics of these regulatory processes in vivo. The last few years has seen the independent emergence of microscopy and genomics technologies to monitor gene regulation processes with single molecule resolution. Recording the dynamic function of regulatory proteins on DNA and RNA now opens opportunities to understand key parameters of the process such as its kinetics, or how various activities are combined in vivo.

This meeting will bring together pioneers of the single molecule microscopy and single molecule genomics field, as well as theoretical biologists to catalyse the emergence of a new generation of mechanistic models of the regulation of genes across each steps of the central dogma.

Topics

• RNA processing
• Translation
• Transcription and chromatin regulation
• Method development
• Theory

What past participants say about the conference

“It was an excellent conference. The first conference on single-molecule genomics, the complementary microscopy and theory gave excellent perspectives on the same phenomena. It is important that this conference happens again in future years.” – Nick Owens, University of Exeter, UK

““Gene regulation: one molecule at a time” was all about discussing and sharing exciting new ideas and technologies to get at the nitty gritty details of gene expression with an enthusiastic crowd of like-minded fellow scientists. A scientifically inspiring conference!” – Franziska Lorbeer, Research Institute of Molecular Pathology (IMP), Austria

“The organizers have brought together a very original and timely blend of fields that I am sure will foster the creation of a vibrant new community in quantitative biology, focused on one molecule at a time.” – Nacho Molina, IGBMC – CNRS, France

Speakers

Karine Choquet

Université de Sherbrooke

Canada

Antoine Coulon

Institut Curie

France

Xavier Darzacq

University of California, Berkeley

USA

Hernan Garcia

University of California, Berkeley

USA

Luca Giorgetti

Friedrich Miescher Institute for Biomedical Research (FMI)

Switzerland

Hiroshi Kimura

Institute of Science Tokyo

Japan

Tineke Lenstra

Netherlands Cancer Institute (NKI)

The Netherlands

Michael Levine

Princeton University

USA

Francesca Mattiroli

Hubrecht Institute

The Netherlands

Kate Miroshnikova

Max Planck Institute for Molecular Biomedicine

Germany

Dirk Schübeler

Friedrich Miescher Institute for Biomedical Research (FMI)

Switzerland

Winston Timp

Johns Hopkins University

USA

Alexander van Oudenaarden

Hubrecht Institute

The Netherlands

Nadine Vastenhouw

University of Lausanne (UNIL)

Switzerland

Franka Voigt

University of Zurich

Switzerland

Jie Xiao

Johns Hopkins University

USA

Jian Zhou

Emory University School of Medicine

USA

Scientific organisers

Stirling Churchman

Harvard Medical School

USA

Arnaud Krebs

EMBL Heidelberg

Germany

Mounia Lagha

Institute of Molecular Genetics of Montpellier (IGMM)

France

Daniel Larson

National Cancer Institute Center for Cancer Research

USA

Sponsors

We offer a variety of event sponsoring possibilities, with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget. Discounts are available for companies sponsoring multiple events at EMBL Heidelberg. View other conferences, or contact sponsorship@embl.org for further information on sponsoring possibilities.

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