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EMBL-EBI_Structures_of_Christmas_2016_BETALACTAMASE

Structure of Christmas: no need to crystallise!

Beta-galactosidase: a fairly run-of-the-mill protein that cleaves sugars. What makes this molecule so special is that is was determined at very high resolution (~2.2 Ångströms) using cryo-Elecrton Microscopy – a fairly new technique. Cryo-EM gives us a highly detailed view of molecules that do not stand up to crystallography, and so opens up a new world of molecules to explore. Beta-galactosidase is one of the biggest occupants of EMPIAR: EMBL-EBI’s resource for raw, 2D structural data.

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