Deciphering enzymes from human microbiota for drug discovery and development – a minireview.

Beliaeva MA, Wilmanns M, Zimmermann M

OSF Preprints, 2023

doi:10.31219/osf.io/243wj.

Structural basis of domain destabilization by dilated-cardiomyopathy-causing missense mutations in titin.

Martinez-Martin I, Crousilles A, Herrero-Galan E, Velazquez-Carreras D, Mortensen SA, Pablo Ochoa J, Garcia-Pavia P, de Sancho D, Wilmanns M, Alegre-Cebollada J

Biophysical journal, 2023

doi:10.1016/j.bpj.2022.11.1077.

Asymmetric horseshoe-like assembly of peroxisomal yeast oxalyl-CoA synthetase.

Bürgi J, Lill P, Giannopoulou EA, Jeffries CM, Chojnowski G, Raunser S, Gatsogiannis C, Wilmanns M

Biological chemistry, 2023

doi:10.1515/hsz-2022-0273.

Structure and dynamics of the von Willebrand Factor C6 domain.

Chen PC, Kutzki F, Mojzisch A, Simon B, Xu ER, Aponte-Santamaría C, Horny K, Jeffries C, Schneppenheim R, Wilmanns M, Brehm MA, Gräter F, Hennig J

Journal of structural biology, 2022

doi:10.1016/j.jsb.2022.107923.

C25-modified rifamycin derivatives with improved activity against Mycobacterium abscessus.

Paulowski L, Beckham KSH, Johansen MD, Berneking L, Van N, Degefu Y, Staack S, Sotomayor FV, Asar L, Rohde H, Aldridge BB, Aepfelbacher M, Parret A, Wilmanns M, Kremer L, Combrink K, Maurer FP

PNAS Nexus, 2022

doi:10.1093/pnasnexus/pgac130.

Phosphorylation of the receptor protein Pex5p modulates import of proteins into peroxisomes.

Fischer S, Bürgi J, Gabay-Maskit S, Maier R, Mastalski T, Yifrach E, Obarska-Kosinska A, Rudowitz M, Erdmann R, Platta HW, Wilmanns M, Schuldiner M, Zalckvar E, Oeljeklaus S, Drepper F, Warscheid B

Biological chemistry, 2022

doi:10.1515/hsz-2022-0168.

Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions.

Yifrach E, Holbrook-Smith D, Bürgi J, Othman A, Eisenstein M, van Roermund CW, Visser W, Tirosh A, Rudowitz M, Bibi C, Galor S, Weill U, Fadel A, Peleg Y, Erdmann R, Waterham HR, Wanders RJA, Wilmanns M, Zamboni N, Schuldiner M, Zalckvar E

Molecular systems biology, 2022

doi:10.15252/msb.202211186.

The ESX-4 substrates, EsxU and EsxT, modulate Mycobacterium abscessus fitness.

Lagune M, Le Moigne V, Johansen MD, Vásquez Sotomayor F, Daher W, Petit C, Cosentino G, Paulowski L, Gutsmann T, Wilmanns M, Maurer FP, Herrmann JL, Girard-Misguich F, Kremer L

PLoS pathogens, 2022

doi:10.1371/journal.ppat.1010771.

Synergy of protease binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation.

Nagy ZA, Héja D, Bencze D, Kiss B, Boros E, Szakács D, Fodor K, Wilmanns M, Kocsis A, Dobó J, Gál P, Harmat V, Pál G

The Journal of biological chemistry, 2022

doi:10.1016/j.jbc.2022.101985.

TBX2 controls a proproliferative gene expression program in melanoma.

Lu S, Louphrasitthiphol P, Goradia N, Lambert JP, Schmidt J, Chauhan J, Rughani MG, Larue L, Wilmanns M, Goding CR

Genes & development, 2021

doi:10.1101/gad.348746.121.

Conserved and specialized functions of Type VII secretion systems in non-tuberculous mycobacteria.

Lagune M, Petit C, Sotomayor FV, Johansen MD, Beckham KSH, Ritter C, Girard-Misguich F, Wilmanns M, Kremer L, Maurer FP, Herrmann JL

Microbiology (Reading, England), 2021

doi:10.1099/mic.0.001054.

Structure of the mycobacterial ESX-5 type VII secretion system pore complex.

Beckham KSH, Ritter C, Chojnowski G, Ziemianowicz DS, Mullapudi E, Rettel M, Savitski MM, Mortensen SA, Kosinski J, Wilmanns M

Science advances, 2021

doi:10.1126/sciadv.abg9923.

Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex.

Wurm JP, Sung S, Kneuttinger AC, Hupfeld E, Sterner R, Wilmanns M, Sprangers R

Nature communications, 2021

doi:10.1038/s41467-021-22968-6.

FoldAffinity: binding affinities from nDSF experiments.

Niebling S, Burastero O, Bürgi J, Günther C, Defelipe LA, Sander S, Gattkowski E, Anjanappa R, Wilmanns M, Springer S, Tidow H, García-Alai M

Scientific reports, 2021

doi:10.1038/s41598-021-88985-z.

Across scales: novel insights into kidney health and disease by structural biology.

Tomas NM, Mortensen SA, Wilmanns M, Huber TB

Kidney international, 2021

doi:10.1016/j.kint.2021.03.042.

Versatile allosteric properties in Pex5-like tetratricopeptide repeat proteins to induce diverse downstream function.

Bürgi J, Ekal L, Wilmanns M

Traffic (Copenhagen, Denmark), 2021

doi:10.1111/tra.12785.

The XBI BioLab for life science experiments at the European XFEL.

Han H, Round E, E, Schubert R, Gül Y, Makroczyová J, Meza D, Heuser P, Aepfelbacher M, Barák I, Betzel C, Fromme P, Kursula I, Nissen P, Tereschenko E, Schulz J, Uetrecht C, Ulicný J, Wilmanns M, Hajdu J, Lamzin VS, Lorenzen K

Journal of applied crystallography, 2021

doi:10.1107/S1600576720013989.

Gain-of-function variant p.Pro2555Arg of von Willebrand factor increases aggregate size through altering stem dynamics.

Huck V, Chen PC, Xu ER, Tischer A, Klemm U, Aponte-Santamaría C, Mess C, Obser T, Kutzki F, König G, Denis C, Gräter F, Wilmanns M, Auton M, Schneider SW, Schneppenheim R, Hennig J, Brehm MA

Thrombosis and haemostasis, 2020

doi:10.1055/a-1344-4405.

The crystal structure of mycobacterial epoxide hydrolase A.

Schulz EC, Henderson SR, Illarionov B, Crosskey T, Southall SM, Krichel B, Uetrecht C, Fischer M, Wilmanns M

Scientific reports, 2020

doi:10.1038/s41598-020-73452-y.

The pMy vector series: a versatile cloning platform for the recombinant production of mycobacterial proteins in Mycobacterium smegmatis.

Beckham KSH, Staack S, Wilmanns M, Parret AHA

Protein science : a publication of the Protein Society, 2020

doi:10.1002/pro.3962.

Multiscale computation delivers organophosphorus reactivity and stereoselectivity to immunoglobulin scavengers.

Mokrushina YA, Golovin AV, Smirnov IV, Chatziefthimiou SD, Stepanova AV, Bobik TV, Zalevsky AO, Zlobin AS, Konovalov KA, Terekhov SS, Stepanov AV, Pipiya SO, Shamborant OG, Round E, Belogurov AA, Makarov AA, Bourenkov G, Xie J, Wilmanns M, Gabibov AG, Blackburn GM, Lerner RA

Proceedings of the National Academy of Sciences of the United States of America, 2020

doi:10.1073/pnas.2010317117.

Uncovering targeting priority to yeast peroxisomes using an in-cell competition assay.

Rosenthal M, Metzl-Raz E, Bürgi J, Yifrach E, Drwesh L, Fadel A, Peleg Y, Rapaport D, Wilmanns M, Barkai N, Schuldiner M, Zalckvar E

Proceedings of the National Academy of Sciences of the United States of America, 2020

doi:10.1073/pnas.1920078117.

A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding.

Terekhov SS, Mokrushina YA, Nazarov AS, Zlobin A, Zalevsky A, Bourenkov G, Golovin A, Belogurov A, Osterman IA, Kulikova AA, Mitkevich VA, Lou HJ, Turk BE, Wilmanns M, Smirnov IV, Altman S, Gabibov AG

Science advances, 2020

doi:10.1126/sciadv.aaz9861.

Structure-based identification and functional characterization of a lipocalin in the malaria parasite Plasmodium falciparum.

Burda PC, Crosskey T, Lauk K, Zurborg A, Söhnchen C, Liffner B, Wilcke L, Pietsch E, Strauss J, Jeffries CM, Svergun DI, Wilson DW, Wilmanns M, Gilberger TW

Cell reports, 2020

doi:10.1016/j.celrep.2020.107817.

1 H, 13 C, and 15 N backbone assignments of the C-terminal region of the human retinoic acid-induced protein 2.

Lang A, Goradia N, Wikman H, Werner S, Wilmanns M, Ohlenschläger O

Biomolecular NMR assignments, 2020

doi:10.1007/s12104-020-09960-9.

Tuning transcription factor availability through acetylation-mediated genomic redistribution.

Louphrasitthiphol P, Siddaway R, Loffreda A, Pogenberg V, Friedrichsen H, Schepsky A, Zeng Z, Lu M, Strub T, Freter R, Lisle R, Suer E, Thomas B, Schuster-Böckler B, Filippakopoulos P, Middleton M, Lu X, Patton EE, Davidson I, Lambert JP, Wilmanns M, Steingrímsson E, Mazza D, Goding CR

Molecular cell, 2020

doi:10.1016/j.molcel.2020.05.025.

Mechanism of conditional partner selectivity in MITF/TFE family transcription factors with a conserved coiled coil stammer motif.

Pogenberg V, Ballesteros-Álvarez J, Schober R, Sigvaldadóttir I, Obarska-Kosinska A, Milewski M, Schindl R, Ögmundsdóttir MH, Steingrímsson E, Wilmanns M

Nucleic acids research, 2019

doi:10.1093/nar/gkz1104.

Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake.

Jakobi AJ, Huber ST, Mortensen SA, Schultz SW, Palara A, Kuhm T, Shrestha BK, Lamark T, Hagen WJH, Wilmanns M, Johansen T, Brech A, Sachse C

Nature communications, 2020

doi:10.1038/s41467-020-14343-8.

Structural diversity in the atomic resolution 3D fingerprint of the titin M-band segment.

Chatziefthimiou SD, Hornburg P, Sauer F, Mueller S, Ugurlar D, Xu ER, Wilmanns M

PloS one, 2019

doi:10.1371/journal.pone.0226693.

The ATPases of the mycobacterial type VII secretion system: structural and mechanistic insights into secretion.

Crosskey TD, Beckham KSH, Wilmanns M

Progress in biophysics and molecular biology, 2019

doi:10.1016/j.pbiomolbio.2019.11.008.

An NAD+ phosphorylase toxin triggers Mycobacterium tuberculosis cell death.

Freire DM, Gutierrez C, Garza-Garcia A, Grabowska AD, Sala AJ, Ariyachaokun K, Panikova T, Beckham KSH, Colom A, Pogenberg V, Cianci M, Tuukkanen A, Boudehen YM, Peixoto A, Botella L, Schnappinger D, Svergun DI, Schneider TR, Genevaux P, de Carvalho LPS, Wilmanns M, Parret AHA, Neyrolles O

Molecular cell, 2019

doi:10.1016/j.molcel.2019.01.028.

Subcellular localization and stability of MITF are modulated by the bHLH-Zip domain.

Fock V, Gudmundsson SR, Gunnlaugsson HO, Stefansson JA, Ionasz V, Schepsky A, Viarigi J, Reynisson IE, Pogenberg V, Wilmanns M, Ogmundsdottir MH, Steingrimsson E

Pigment cell & melanoma research, 2018

doi:10.1111/pcmr.12721.

MITF has a central role in regulating starvation-induced autophagy in melanoma

Moller K, Sigurbjornsdottir S, Arnthorsson AO, Pogenberg V, Dilshat R, Fock V, Brynjolfsdottir SH, Bindesboll C, Bessadottir M, Ogmundsdottir HM, Simonsen A, Larue L, Wilmanns M, Thorsson V, Steingrimsson E, Ogmundsdottir MH

SCIENTIFIC REPORTS, 2019

doi:10.1038/s41598-018-37522-6.

The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction.

Schneppenheim R, Hellermann N, Brehm MA, Klemm U, Obser T, Huck V, Schneider SW, Denis CV, Tischer A, Auton M, März W, Xu ER, Wilmanns M, Zotz RB

Blood, 2018

doi:10.1182/blood-2018-04-843425.

Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor.

Xu ER, von Bülow S, Chen PC, Lenting PJ, Kolšek K, Aponte-Santamaría C, Simon B, Foot J, Obser T, Schneppenheim R, Gräter F, Denis CV, Wilmanns M, Hennig J

Blood, 2018

doi:10.1182/blood-2018-04-843615.

Structural variability of EspG chaperones from mycobacterial ESX-1, ESX-3 and ESX-5 type VII secretion systems.

Tuukkanen AT, Freire D, Chan S, Arbing MA, Reed RW, Evans TJ, Zenkeviciutė G, Kim J, Kahng S, Sawaya MR, Chaton CT, Wilmanns M, Eisenberg D, Parret AHA, Korotkov KV

Journal of molecular biology, 2018

doi:10.1016/j.jmb.2018.11.003.

Publisher Correction: A short isoform of ATG7 fails to lipidate LC3/GABARAP.

Ogmundsdottir MH, Fock V, Sooman L, Pogenberg V, Dilshat R, Bindesbøll C, Ogmundsdottir HM, Simonsen A, Wilmanns M, Steingrimsson E

Scientific reports, 2018

doi:10.1038/s41598-018-35540-y.

A short isoform of ATG7 fails to lipidate LC3/GABARAP.

Ogmundsdottir MH, Fock V, Sooman L, Pogenberg V, Dilshat R, Bindesbøll C, Ogmundsdottir HM, Simonsen A, Wilmanns M, Steingrimsson E

Scientific reports, 2018

doi:10.1038/s41598-018-32694-7.

Crystallographic insights into a cobalt (III) sepulchrate based alternative cofactor system of P450 BM3 monooxygenase.

Panneerselvam S, Shehzad A, Mueller-Dieckmann J, Wilmanns M, Bocola M, Davari MD, Schwaneberg U

Biochimica et biophysica acta, 2017

doi:10.1016/j.bbapap.2017.07.010.

Model-based local density sharpening of cryo-EM maps.

Jakobi AJ, Wilmanns M, Sachse C

eLife, 2017

doi:10.7554/eLife.27131.

Intermolecular base stacking mediates RNA-RNA interaction in a crystal structure of the RNA chaperone Hfq

Schulz EC, Seiler M, Zuliani C, Voigt F, Rybin V, Pogenberg V, Mücke N, Wilmanns M, Gibson TJ, Barabas O.

2017

doi:10.1038/s41598-017-10085-8.

Evolution of catalytic centers of antibodies by virtual screening of broad repertoire of mutants using supercomputer

Golovin AV, Smirnov IV, Stepanova AV, Zalevskiy AO, Zlobin AS, Ponomarenko NA, Belogurov AA, Knorre VD, Hurs EN, Chatziefthimiou SD, Wilmanns M, Blackburn GM, Khomutov RM, Gabibov AG

DOKLADY BIOCHEMISTRY AND BIOPHYSICS, 2017

doi:10.1134/S1607672917040019.

Predicting the targeting of tail-anchored proteins to subcellular compartments in mammalian cells.

Costello JL, Castro IG, Camões F, Schrader TA, McNeall D, Yang J, Giannopoulou EA, Gomes S, Pogenberg V, Bonekamp NA, Ribeiro D, Wilmanns M, Jedd G, Islinger M, Schrader M

Journal of cell science, 2017

doi:10.1242/jcs.200204.

Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis.

Beckham KS, Ciccarelli L, Bunduc CM, Mertens HD, Ummels R, Lugmayr W, Mayr J, Rettel M, Savitski MM, Svergun DI, Bitter W, Wilmanns M, Marlovits TC, Parret AH, Houben EN

Nature microbiology, 2017

doi:10.1038/nmicrobiol.2017.47.

Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19.

Emmanouilidis L, Schütz U, Tripsianes K, Madl T, Radke J, Rucktäschel R, Wilmanns M, Schliebs W, Erdmann R, Sattler M

Nature communications, 2017

doi:10.1038/ncomms14635.

Robotic QM/MM-driven maturation of antibody combining sites.

Smirnov IV, Golovin AV, Chatziefthimiou SD, Stepanova AV, Peng Y, Zolotareva OI, Belogurov AA, Kurkova IN, Ponomarenko NA, Wilmanns M, Blackburn GM, Gabibov AG, Lerner RA

Science advances, 2016

doi:10.1126/sciadv.1501695.

A standardized production pipeline for high profile targets from Mycobacterium tuberculosis.

Milewski MC, Broger T, Kirkpatrick J, Filomena A, Komadina D, Schneiderhan-Marra N, Wilmanns M, Parret AH

Proteomics. Clinical applications, 2016

doi:10.1002/prca.201600033.

Combination of Whole Genome Sequencing, Linkage and Functional Studies Implicates a Missense Mutation in Titin as a Cause of Autosomal Dominant Cardiomyopathy with Features of Left Ventricular Non-Compaction.

Hastings R, de Villiers C, Hooper C, Ormondroyd L, Pagnamenta A, Lise S, Salatino S, Knight SJ, Taylor JC, Thomson KL, Arnold L, Chatziefthimiou SD, Konarev PV, Wilmanns M, Ehler E, Ghisleni A, Gautel M, Blair E, Watkins H, Gehmlich K

Circulation. Cardiovascular genetics, 2016

doi:10.1161/CIRCGENETICS.116.001431.

Using the fluorescent properties of STO-609 as a tool to assist structure-function analyses of recombinant CaMKK2

Gerner L, Munack S, Temmerman K, Lawrence-Dærner A, Besir H, Wilmanns M, Jensen JK, Thiede B, Mills IG, Morth JP

2016

doi:10.1016/j.bbrc.2016.05.045.

Higher-order assemblies of oligomeric cargo receptor complexes form the membrane scaffold of the Cvt vesicle.

Bertipaglia C, Schneider S, Jakobi AJ, Tarafder AK, Bykov YS, Picco A, Kukulski W, Kosinski J, Hagen WJ, Ravichandran AC, Wilmanns M, Kaksonen M, Briggs JA, Sachse C

EMBO reports, 2016

doi:10.15252/embr.201541960.

Data for the co-expression and purification of human recombinant CaMKK2 in complex with calmodulin in Escherichia coli.

Gerner L, Munack S, Temmerman K, Lawrence-Dörner AM, Besir H, Wilmanns M, Jensen JK, Thiede B, Mills IG, Morth JP

Data in brief, 2016

doi:10.1016/j.dib.2016.06.033.

Death-Associated Protein Kinase Activity Is Regulated by Coupled Calcium/Calmodulin Binding to Two Distinct Sites

Simon B, Huart A, Temmerman K, Vahokoski J, Mertens H, Komadina D, Hoffmann J, Yumerefendi H, Svergun D, Kursula P, Schultz C, McCarthy A, Hart D, Wilmanns M

Structure, 2016

doi:10.1016/j.str.2016.03.020.

Structural biology of the import pathways of peroxisomal matrix proteins.

Emmanouilidis L, Gopalswamy M, Passon DM, Wilmanns M, Sattler M

Biochimica et biophysica acta, 2015

doi:10.1016/j.bbamcr.2015.09.034.

Towards the molecular mechanism of the integration of peroxisomal membrane proteins.

Giannopoulou EA, Emmanouilidis L, Sattler M, Dodt G, Wilmanns M

Biochimica et biophysica acta, 2015

doi:10.1016/j.bbamcr.2015.09.031.

In cellulo serial crystallography of alcohol oxidase crystals inside yeast cells.

Jakobi AJ, Passon DM, Knoops K, Stellato F, Liang M, White TA, Seine T, Messerschmidt M, Chapman HN, Wilmanns M

IUCrJ, 2016

doi:10.1107/s2052252515022927.

Structural Insights into Cargo Recognition by the Yeast PTS1 Receptor.

Hagen S, Drepper F, Fischer S, Fodor K, Passon D, Platta HW, Zenn M, Schliebs W, Girzalsky W, Wilmanns M, Warscheid B, Erdmann R

The Journal of biological chemistry, 2015

doi:10.1074/jbc.m115.657973.

Molecular mechanisms of protein kinase regulation by calcium/calmodulin.

Simon B, Huart AS, Wilmanns M

Bioorganic & medicinal chemistry, 2015

doi:10.1016/j.bmc.2015.04.051.

Refined Requirements for Protein Regions Important for Activity of the TALE AvrBs3.

Schreiber T, Sorgatz A, List F, Blüher D, Thieme S, Wilmanns M, Bonas U

PloS one, 2015

doi:10.1371/journal.pone.0120214.

Characterization of the Mycobacterial Acyl-CoA Carboxylase Holo Complexes Reveals Their Functional Expansion into Amino Acid Catabolism.

Ehebauer MT, Zimmermann M, Jakobi AJ, Noens EE, Laubitz D, Cichocki B, Marrakchi H, Lanéelle MA, Daffé M, Sachse C, Dziembowski A, Sauer U, Wilmanns M

PLoS pathogens, 2015

doi:10.1371/journal.ppat.1004623.

Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic acid induced 2.

Werner S, Brors B, Eick J, Marques E, Pogenberg V, Parret A, Kemming D, Wood AW, Edgren H, Neubauer H, Streichert T, Riethdorf S, Bedi U, Baccelli I, Jucker M, Eils R, Fehm T, Trumpp A, Johnsen SA, Klefstrom J, Wilmanns M, Muller V, Pantel K, Wikman H

Cancer discovery, 2015

doi:10.1158/2159-8290.CD-14-1042.

Induction of insulin-like growth factor 1 splice forms by subfragments of myofibrillar proteins

Kravchenko IV, Furalyov VA, Chatziefthimiou S, Wilmanns M, Popov VO

Molecular and cellular endocrinology, 2014

doi:10.1016/j.mce.2014.08.010.

Ligand-induced compaction of the PEX5 receptor-binding cavity impacts protein import efficiency into peroxisomes.

Fodor K, Wolf J, Reglinski K, Passon DM, Lou Y, Schliebs W, Erdmann R, Wilmanns M

Traffic (Copenhagen, Denmark), 2014

doi:10.1111/tra.12238.

Crystal structure of the VapBC-15 complex from Mycobacterium tuberculosis reveals a two-metal ion dependent PIN-domain ribonuclease and a variable mode of toxin-antitoxin assembly.

Das U, Pogenberg V, Subhramanyam UK, Wilmanns M, Gourinath S, Srinivasan A

Journal of structural biology, 2014

doi:10.1016/j.jsb.2014.10.002.

Structure of the Mycobacterium tuberculosis type VII secretion system chaperone EspG5 in complex with PE25-PPE41 dimer.

Korotkova N, Freire D, Phan TH, Ummels R, Creekmore CC, Evans TJ, Wilmanns M, Bitter W, Parret AH, Houben EN, Korotkov KV

Molecular microbiology, 2014

doi:10.1111/mmi.12770.

Active site conformational changes upon reaction intermediate biotinyl-5'-AMP binding in biotin protein ligase from Mycobacterium tuberculosis

Ma Q, Akhter Y, Wilmanns M, Ehebauer MT

Protein science : a publication of the Protein Society, 2014

doi:10.1002/pro.2475.

Group III alcohol dehydrogenase from Pectobacterium atrosepticum: insights into enzymatic activity and organization of the metal ion-containing region.

Elleuche S, Fodor K, von der Heyde A, Klippel B, Wilmanns M, Antranikian G

Applied microbiology and biotechnology, 2014

doi:10.1007/s00253-013-5374-z.

Development of accessible peptidic tool compounds to study the phosphatase PTP1B in intact cells

Meyer C, Hoeger B, Temmerman K, Tatarek-Nossol M, Pogenberg V, Bernhagen J, Wilmanns M, Kapurniotu A, Köhn M

ACS chemical biology, 2014

doi:10.1021/cb400903u.

Design of a bZip transcription factor with homo/heterodimer-induced DNA-binding preference

Pogenberg V, Consani TL, Vanhille L, Holton SJ, Sieweke MH, Wilmanns M

Structure (London, England : 1993), 2014

doi:10.1016/j.str.2013.12.017.

Role of κ→λ light-chain constant-domain switch in the structure and functionality of A17 reactibody

Ponomarenko N, Chatziefthimiou SD, Kurkova I, Mokrushina Y, Mokrushina Y, Stepanova A, Smirnov I, Avakyan M, Bobik T, Mamedov A, Mitkevich V, Belogurov A Jr, Fedorova OS, Dubina M, Golovin A, Lamzin V, Friboulet A, Makarov AA, Wilmanns M, Gabibov A

Acta crystallographica. Section D, Biological crystallography, 2014

doi:10.1107/s1399004713032446.

WXG100 protein superfamily consists of three subfamilies and exhibits an α-helical C-terminal conserved residue pattern

Poulsen C, Panjikar S, Holton SJ, Wilmanns M, Song YH

PloS one, 2014

doi:10.1371/journal.pone.0089313.

A PEF/Y substrate recognition and signature motif plays a critical role in DAPK-related kinase activity

Temmerman K, de Diego I, Pogenberg V, Simon B, Jonko W, Li X, Wilmanns M

Chemistry & biology, 2014

doi:10.1016/j.chembiol.2013.12.008.

Crystal structure of the S187F variant of human liver alanine: Aminotransferase associated with primary hyperoxaluria type I and its functional implications (vol 81, pg 1457, 2013)

Oppici E, Fodor K, Paiardini A, Williams C, Voltattorni CB, Wilmanns M, Cellini B

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2014

doi:10.1002/prot.24447.

The 11th International Conference on Biology and Synchrotron Radiation

Wilmanns M, Svergun DI

Journal of synchrotron radiation, 2014

doi:10.1107/s1600577513030609.

Catalytic mechanism of α-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, 31P-NMR spectroscopy and reaction path modelling

Barabás O, Németh V, Bodor A, Perczel A, Rosta E, Kele Z, Zagyva I, Szabadka Z, Grolmusz VI, Wilmanns M, Vértessy BG

Nucleic acids research, 2013

doi:10.1093/nar/gkt756.

MITF mutations associated with pigment deficiency syndromes and melanoma have different effects on protein function

Grill C, Bergsteinsdóttir K, Ogmundsdóttir MH, Pogenberg V, Schepsky A, Wilmanns M, Pingault V, Steingrímsson E

Human molecular genetics, 2013

doi:10.1093/hmg/ddt285.

Structural and functional diversity in the activity and regulation of DAPK-related protein kinases

Temmerman K, Simon B, Wilmanns M

The FEBS journal, 2013

doi:10.1111/febs.12384.

Structural and biochemical characterisation of a NAD⁺-dependent alcohol dehydrogenase from Oenococcus oeni as a new model molecule for industrial biotechnology applications

Elleuche S, Fodor K, Klippel B, von der Heyde A, Wilmanns M, Antranikian G

Applied microbiology and biotechnology, 2013

doi:10.1007/s00253-013-4725-0.

Identification of Xin-repeat proteins as novel ligands of the SH3 domains of nebulin and nebulette and analysis of their interaction during myofibril formation and remodeling

Eulitz S, Sauer F, Pelissier MC, Boisguerin P, Molt S, Schuld J, Orfanos Z, Kley RA, Volkmer R, Wilmanns M, Kirfel G, van der Ven PF, Fürst DO

Molecular biology of the cell, 2013

doi:10.1091/mbc.e13-04-0202.

Structural and biochemical characterization of Rv2140c, a phosphatidylethanolamine-binding protein from Mycobacterium tuberculosis

Eulenburg G, Higman VA, Diehl A, Wilmanns M, Holton SJ

FEBS letters, 2013

doi:10.1016/j.febslet.2013.07.038.

Crystal structure of the S187F variant of human liver alanine: glyoxylate [corrected] aminotransferase associated with primary hyperoxaluria type I and its functional implications

Oppici E, Fodor K, Paiardini A, Williams C, Voltattorni CB, Wilmanns M, Cellini B

Proteins, 2013

doi:10.1002/prot.24300.

Elucidating human phosphatase-substrate networks

Li X, Wilmanns M, Thornton J, Köhn M

Science signaling, 2013

doi:10.1126/scisignal.2003203.

P450 BM3 crystal structures reveal the role of the charged surface residue Lys/Arg184 in inversion of enantioselective styrene epoxidation

Shehzad A, Panneerselvam S, Linow M, Bocola M, Roccatano D, Mueller-Dieckmann J, Wilmanns M, Schwaneberg U

Chemical communications (Cambridge, England), 2013

doi:10.1039/c3cc39076d.

A unique Oct4 interface is crucial for reprogramming to pluripotency

Esch D, Vahokoski J, Groves MR, Pogenberg V, Cojocaru V, Vom Bruch H, Han D, Drexler HC, Araúzo-Bravo MJ, Ng CK, Jauch R, Wilmanns M, Schöler HR

Nature cell biology, 2013

doi:10.1038/ncb2680.

Structural characterization of a D-isomer specific 2-hydroxyacid dehydrogenase from Lactobacillus delbrueckii ssp. bulgaricus

Holton SJ, Anandhakrishnan M, Geerlof A, Wilmanns M

Journal of structural biology, 2013

doi:10.1016/j.jsb.2012.10.009.

A disulphide bond in the E2 enzyme Pex4p modulates ubiquitin-conjugating activity

Williams C, van den Berg M, Stanley WA, Wilmanns M, Distel B

Scientific reports, 2013

doi:10.1038/srep02212.

Catalysis uncoupling in a glutamine amidotransferase bienzyme by unblocking the glutaminase active site

List F, Vega MC, Razeto A, Häger MC, Sterner R, Wilmanns M

Chemistry & biology, 2012

doi:10.1016/j.chembiol.2012.10.012.

Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF

Pogenberg V, Ogmundsdóttir MH, Bergsteinsdóttir K, Schepsky A, Phung B, Deineko V, Milewski M, Steingrímsson E, Wilmanns M

Genes & development, 2012

doi:10.1101/gad.198192.112.

Mycobacterium tuberculosis prokaryotic ubiquitin-like protein-deconjugating enzyme is an unusual aspartate amidase

Burns KE, McAllister FE, Schwerdtfeger C, Mintseris J, Cerda-Maira F, Noens EE, Wilmanns M, Hubbard SR, Melandri F, Ovaa H, Gygi SP, Darwin KH

The Journal of biological chemistry, 2012

doi:10.1074/jbc.m112.384784.

The role of active-site Phe87 in modulating the organic co-solvent tolerance of cytochrome P450 BM3 monooxygenase

Kuper J, Tee KL, Wilmanns M, Roccatano D, Schwaneberg U, Wong TS

Acta crystallographica. Section F, Structural biology and crystallization communications, 2012

doi:10.1107/s1744309112031570.

Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 Are essential for lectin pathway activation and reveal structural plasticity of MASP-2

Héja D, Harmat V, Fodor K, Wilmanns M, Dobó J, Kékesi KA, Závodszky P, Gál P, Pál G

The Journal of biological chemistry, 2012

doi:10.1074/jbc.m112.354332.

Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties

Pinotsis N, Chatziefthimiou SD, Berkemeier F, Beuron F, Mavridis IM, Konarev PV, Svergun DI, Morris E, Rief M, Wilmanns M

PLoS biology, 2012

doi:10.1371/journal.pbio.1001261.

Two immunoglobulin tandem proteins with a linking β-strand reveal unexpected differences in cooperativity and folding pathways

Steward A, Chen Q, Chapman RI, Borgia MB, Rogers JM, Wojtala A, Wilmanns M, Clarke J

Journal of molecular biology, 2012

doi:10.1016/j.jmb.2011.12.012.

Molecular requirements for peroxisomal targeting of alanine-glyoxylate aminotransferase as an essential determinant in primary hyperoxaluria type 1

Fodor K, Wolf J, Erdmann R, Schliebs W, Wilmanns M

PLoS biology, 2012

doi:10.1371/journal.pbio.1001309.

Insights into ubiquitin-conjugating enzyme/ co-activator interactions from the structure of the Pex4p:Pex22p complex

Williams C, van den Berg M, Panjikar S, Stanley WA, Distel B, Wilmanns M

The EMBO journal, 2012

doi:10.1038/emboj.2011.411.

Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart

Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didié M, Quentin T, Maier LS, Teucher N, Unsöld B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien KR

Circulation research, 2011

doi:10.1161/circresaha.111.245787.

Structural insights into transcription complexes

Berger I, Blanco AG, Boelens R, Cavarelli J, Coll M, Folkers GE, Nie Y, Pogenberg V, Schultz P, Wilmanns M, Moras D, Poterszman A

Journal of structural biology, 2011

doi:10.1016/j.jsb.2011.04.015.

Fast-folding alpha-helices as reversible strain absorbers in the muscle protein myomesin

Berkemeier F, Bertz M, Xiao S, Pinotsis N, Wilmanns M, Gräter F, Rief M

Proceedings of the National Academy of Sciences of the United States of America, 2011

doi:10.1073/pnas.1105734108.

Expression of protein complexes using multiple Escherichia coli protein co-expression systems: a benchmarking study

Busso D, Peleg Y, Heidebrecht T, Romier C, Jacobovitch Y, Dantes A, Salim L, Troesch E, Schuetz A, Heinemann U, Folkers GE, Geerlof A, Wilmanns M, Polewacz A, Quedenau C, Büssow K, Adamson R, Blagova E, Walton J, Cartwright JL, Bird LE, Owens RJ, Berrow NS, Wilson KS, Sussman JL, Perrakis A, Celie PH

Journal of structural biology, 2011

doi:10.1016/j.jsb.2011.03.004.

The progress made in determining the Mycobacterium tuberculosis structural proteome

Ehebauer MT, Wilmanns M

Proteomics, 2011

doi:10.1002/pmic.201000787.

Structural features of peroxisomal catalase from the yeast Hansenula polymorpha

Peña-Soler E, Vega MC, Wilmanns M, Williams C

Acta crystallographica. Section D, Biological crystallography, 2011

doi:10.1107/s0907444911022463.

Related (βα)8-barrel proteins in histidine and tryptophan biosynthesis: a paradigm to study enzyme evolution

List F, Sterner R, Wilmanns M

Chembiochem : a European journal of chemical biology, 2011

doi:10.1002/cbic.201100082.

Rapid development of genetically encoded FRET reporters

Piljić A, de Diego I, Wilmanns M, Schultz C

ACS chemical biology, 2011

doi:10.1021/cb100402n.

Bisubstrate specificity in histidine/tryptophan biosynthesis isomerase from Mycobacterium tuberculosis by active site metamorphosis

Due AV, Kuper J, Geerlof A, von Kries JP, Wilmanns M

Proceedings of the National Academy of Sciences of the United States of America, 2011

doi:10.1073/pnas.1015996108.

Improved mycobacterial protein production using a Mycobacterium smegmatis groEL1ΔC expression strain

Noens EE, Williams C, Anandhakrishnan M, Poulsen C, Ehebauer MT, Wilmanns M

BMC biotechnology, 2011

doi:10.1186/1472-6750-11-27.

The Peroxisomal Targeting Signal 1 in sterol carrier protein 2 is autonomous and essential for receptor recognition

Williams CP, Schueller N, Thompson CA, van den Berg M, Van Haren SD, Erdmann R, Bond CS, Distel B, Schliebs W, Wilmanns M, Stanley WA

BMC biochemistry, 2011

doi:10.1186/1471-2091-12-12.

Structural synthetic biotechnology: from molecular structure to predictable design for industrial strain development

Chen Z, Wilmanns M, Zeng AP

Trends in biotechnology, 2010

doi:10.1016/j.tibtech.2010.07.004.

The peroxisomal receptor Pex19p forms a helical mPTS recognition domain

Schueller N, Holton SJ, Fodor K, Milewski M, Konarev P, Stanley WA, Wolf J, Erdmann R, Schliebs W, Song YH, Wilmanns M

The EMBO journal, 2010

doi:10.1038/emboj.2010.115.

Highlight: of systems and structures

Heinz DW, Betzel C, Wilmanns M

Biological chemistry, 2010

doi:10.1515/bc.2010.095.

Proteome-wide identification of mycobacterial pupylation targets

Poulsen C, Akhter Y, Jeon AH, Schmitt-Ulms G, Meyer HE, Stefanski A, Stühler K, Wilmanns M, Song YH

Molecular systems biology, 2010

doi:10.1038/msb.2010.39.

Molecular basis of the head-to-tail assembly of giant muscle proteins obscurin-like 1 and titin

Sauer F, Vahokoski J, Song YH, Wilmanns M

EMBO reports, 2010

doi:10.1038/embor.2010.65.

Stoichiometric protein complex formation and over-expression using the prokaryotic native operon structure

Poulsen C, Holton S, Geerlof A, Wilmanns M, Song YH

FEBS letters, 2010

doi:10.1016/j.febslet.2009.12.057.

Molecular basis of the death-associated protein kinase-calcium/calmodulin regulator complex

de Diego I, Kuper J, Bakalova N, Kursula P, Wilmanns M

Science signaling, 2010

doi:10.1126/scisignal.2000552.

Solution structure of human Pex5.Pex14.PTS1 protein complexes obtained by small angle X-ray scattering

Shiozawa K, Konarev PV, Neufeld C, Wilmanns M, Svergun DI

The Journal of biological chemistry, 2009

doi:10.1074/jbc.m109.002311.

The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk

Bertz M, Wilmanns M, Rief M

Proceedings of the National Academy of Sciences of the United States of America, 2009

doi:10.1073/pnas.0902312106.

Structure-based prediction of the Saccharomyces cerevisiae SH3-ligand interactions

Fernandez-Ballester G, Beltrao P, Gonzalez JM, Song YH, Wilmanns M, Valencia A, Serrano L

Journal of molecular biology, 2009

doi:10.1016/j.jmb.2009.03.038.

Accurate solution structures of proteins from X-ray data and a minimal set of NMR data: calmodulin-peptide complexes as examples

Bertini I, Kursula P, Luchinat C, Parigi G, Vahokoski J, Wilmanns M, Yuan J

Journal of the American Chemical Society, 2009

doi:10.1021/ja8080764.

Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19

Neufeld C, Filipp FV, Simon B, Neuhaus A, Schüller N, David C, Kooshapur H, Madl T, Erdmann R, Schliebs W, Wilmanns M, Sattler M

The EMBO journal, 2009

doi:10.1038/emboj.2009.7.

Mechanical network in titin immunoglobulin from force distribution analysis

Stacklies W, Vega MC, Wilmanns M, Gräter F

PLoS computational biology, 2009

doi:10.1371/journal.pcbi.1000306.

Terminal assembly of sarcomeric filaments by intermolecular beta-sheet formation.

Pinotsis N, Abrusci P, Djinović-Carugo K, Wilmanns M

Trends in biochemical sciences, 2009

doi:10.1016/j.tibs.2008.09.009.

Crystal structure of the resuscitation-promoting factor (DeltaDUF)RpfB from M. tuberculosis

Ruggiero A, Tizzano B, Pedone E, Pedone C, Wilmanns M, Berisio R

Journal of molecular biology, 2009

doi:10.1016/j.jmb.2008.10.042.

Protein assemblies with palindromic structure motifs

Pinotsis N, Wilmanns M

Cellular and molecular life sciences : CMLS, 2008

doi:10.1007/s00018-008-8265-1.

Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization

Lamber EP, Vanhille L, Textor LC, Kachalova GS, Sieweke MH, Wilmanns M

The EMBO journal, 2008

doi:10.1038/emboj.2008.117.

Bimolecular fluorescence complementation in structural biology

Song YH, Wilmanns M

Methods (San Diego, Calif.), 2008

doi:10.1016/j.ymeth.2008.06.015.

Probing lipid- and drug-binding domains with fluorescent dyes

Black SL, Stanley WA, Filipp FV, Bhairo M, Verma A, Wichmann O, Sattler M, Wilmanns M, Schultz C

Bioorganic & medicinal chemistry, 2008

doi:10.1016/j.bmc.2007.10.080.

High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: the formin homology 1 domain of mDia1 and the proline-rich domain of VASP

Kursula P, Kursula I, Massimi M, Song YH, Downer J, Stanley WA, Witke W, Wilmanns M

Journal of molecular biology, 2008

doi:10.1016/j.jmb.2007.10.050.

Low resolution structural models of the basic helix-loop-helix leucine zipper domain of upstream stimulatory factor 1 and its complexes with DNA from small angle X-ray scattering data

Lamber EP, Wilmanns M, Svergun DI

Biophysical journal, 2008

doi:10.1529/biophysj.107.112243.

Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin

Pinotsis N, Lange S, Perriard JC, Svergun DI, Wilmanns M

The EMBO journal, 2008

doi:10.1038/sj.emboj.7601944.

Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor from Mycobacterium tuberculosis

Ruggiero A, Tizzano B, Geerlof A, Pedone E, Pedone C, Wilmanns M, Berisio R

Acta crystallographica. Section F, Structural biology and crystallization communications, 2007

doi:10.1107/s1744309107043217.

Protein translocation into peroxisomes by ring-shaped import receptors

Stanley WA, Fodor K, Marti-Renom MA, Schliebs W, Wilmanns M

FEBS letters, 2007

doi:10.1016/j.febslet.2007.09.001.

Second SH3 domain of ponsin solved from powder diffraction

Margiolaki I, Wright JP, Wilmanns M, Fitch AN, Pinotsis N

Journal of the American Chemical Society, 2007

doi:10.1021/ja073846c.

Structure-based approaches to drug discovery against tuberculosis

Holton SJ, Weiss MS, Tucker PA, Wilmanns M

Current protein & peptide science, 2007

doi:10.2174/138920307781369445.

Rigid conformation of an immunoglobulin domain tandem repeat in the A-band of the elastic muscle protein titin

Müller S, Lange S, Gautel M, Wilmanns M

Journal of molecular biology, 2007

doi:10.1016/j.jmb.2007.05.055.

Expression, purification, crystallization and preliminary crystallographic analysis of the mouse transcription factor MafB in complex with its DNA-recognition motif Cmare

Textor LC, Wilmanns M, Holton SJ

Acta crystallographica. Section F, Structural biology and crystallization communications, 2007

doi:10.1107/s1744309107031260.

Paxillin and ponsin interact in nascent costameres of muscle cells

Gehmlich K, Pinotsis N, Hayess K, van der Ven PF, Milting H, El Banayosy A, Körfer R, Wilmanns M, Ehler E, Fürst DO

Journal of molecular biology, 2007

doi:10.1016/j.jmb.2007.03.050.

Understanding a mechanism of organic cosolvent inactivation in heme monooxygenase P450 BM-3

Kuper J, Wong TS, Roccatano D, Wilmanns M, Schwaneberg U

Journal of the American Chemical Society, 2007

doi:10.1021/ja067036x.

Investigation of the ligand spectrum of human sterol carrier protein 2 using a direct mass spectrometry assay

Stanley WA, Versluis K, Schultz C, Heck AJ, Wilmanns M

Archives of biochemistry and biophysics, 2007

doi:10.1016/j.abb.2007.02.026.

On the routine use of soft X-rays in macromolecular crystallography. Part IV. Efficient determination of anomalous substructures in biomacromolecules using longer X-ray wavelengths

Mueller-Dieckmann C, Panjikar S, Schmidt A, Mueller S, Kuper J, Geerlof A, Wilmanns M, Singh RK, Tucker PA, Weiss MS

Acta crystallographica. Section D, Biological crystallography, 2007

doi:10.1107/s0907444906055624.

Octameric alcohol oxidase dissociates into stable, soluble monomers upon incubation with dimethylsulfoxide

Visser NV, Wang D, Stanley WA, Groves MR, Wilmanns M, Veenhuis M, van der Klei IJ

Archives of biochemistry and biophysics, 2007

doi:10.1016/j.abb.2007.01.005.

A previously unobserved conformation for the human Pex5p receptor suggests roles for intrinsic flexibility and rigid domain motions in ligand binding

Stanley WA, Pursiainen NV, Garman EF, Juffer AH, Wilmanns M, Kursula P

BMC structural biology, 2007

doi:10.1186/1472-6807-7-24.

Structural diversity in the six-fold redundant set of acyl-CoA carboxyltransferases in Mycobacterium tuberculosis

Holton SJ, King-Scott S, Nasser Eddine A, Kaufmann SH, Wilmanns M

FEBS letters, 2006

doi:10.1016/j.febslet.2006.11.054.

Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p

Stanley WA, Filipp FV, Kursula P, Schüller N, Erdmann R, Schliebs W, Sattler M, Wilmanns M

Molecular cell, 2006

doi:10.1016/j.molcel.2006.10.024.

Dynamic architecture of the peroxisomal import receptor Pex5p

Stanley WA, Wilmanns M

Biochimica et biophysica acta, 2006

doi:10.1016/j.bbamcr.2006.10.015.

Implementation of semi-automated cloning and prokaryotic expression screening: the impact of SPINE

Alzari PM, Berglund H, Berrow NS, Blagova E, Busso D, Cambillau C, Campanacci V, Christodoulou E, Eiler S, Fogg MJ, Folkers G, Geerlof A, Hart D, Haouz A, Herman MD, Macieira S, Nordlund P, Perrakis A, Quevillon-Cheruel S, Tarandeau F, van Tilbeurgh H, Unger T, Luna-Vargas MP, Velarde M, Willmanns M, Owens RJ

Acta crystallographica. Section D, Biological crystallography, 2006

doi:10.1107/s0907444906029775.

Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens

Fogg MJ, Alzari P, Bahar M, Bertini I, Betton JM, Burmeister WP, Cambillau C, Canard B, Corrondo MA, Coll M, Daenke S, Dym O, Egloff MP, Enguita FJ, Geerlof A, Haouz A, Jones TA, Ma Q, Manicka SN, Migliardi M, Nordlund P, Owens RJ, Peleg Y, Schneider G, Schnell R, Stuart DI, Tarbouriech N, Unge T, Wilkinson AJ, Wilmanns M, Wilson KS, Zimhony O, Grimes JM

Acta crystallographica. Section D, Biological crystallography, 2006

doi:10.1107/s0907444906030915.

The impact of protein characterization in structural proteomics

Geerlof A, Brown J, Coutard B, Egloff MP, Enguita FJ, Fogg MJ, Gilbert RJ, Groves MR, Haouz A, Nettleship JE, Nordlund P, Owens RJ, Ruff M, Sainsbury S, Svergun DI, Wilmanns M

Acta crystallographica. Section D, Biological crystallography, 2006

doi:10.1107/s0907444906030307.

Cellular target genes of Epstein-Barr virus nuclear antigen 2

Maier S, Staffler G, Hartmann A, Höck J, Henning K, Grabusic K, Mailhammer R, Hoffmann R, Wilmanns M, Lang R, Mages J, Kempkes B

Journal of virology, 2006

doi:10.1128/jvi.00665-06.

The Ig doublet Z1Z2: a model system for the hybrid analysis of conformational dynamics in Ig tandems from titin

Marino M, Zou P, Svergun D, Garcia P, Edlich C, Simon B, Wilmanns M, Muhle-Goll C, Mayans O

Structure (London, England : 1993), 2006

doi:10.1016/j.str.2006.07.009.

Evidence for a dimeric assembly of two titin/telethonin complexes induced by the telethonin C-terminus

Pinotsis N, Petoukhov M, Lange S, Svergun D, Zou P, Gautel M, Wilmanns M

Journal of structural biology, 2006

doi:10.1016/j.jsb.2006.03.028.

The structure of the 2[4Fe-4S] ferredoxin from Pseudomonas aeruginosa at 1.32-A resolution: comparison with other high-resolution structures of ferredoxins and contributing structural features to reduction potential values

Giastas P, Pinotsis N, Efthymiou G, Wilmanns M, Kyritsis P, Moulis JM, Mavridis IM

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2006

doi:10.1007/s00775-006-0094-9.

The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase

Ma Q, Zhao X, Nasser Eddine A, Geerlof A, Li X, Cronan JE, Kaufmann SH, Wilmanns M

Proceedings of the National Academy of Sciences of the United States of America, 2006

doi:10.1073/pnas.0510436103.

Protein crystallization for X-ray

Mueller-Dieckmann H-J, Weiss MS, Wilmanns M

2006

doi:10.1007/3-540-29623-9_5060.

Mechanical strength of the titin Z1Z2-telethonin complex

Lee EH, Gao M, Pinotsis N, Wilmanns M, Schulten K

Structure (London, England : 1993), 2006

doi:10.1016/j.str.2005.12.005.

Crystal structure of the PB1 domain of NBR1

Müller S, Kursula I, Zou P, Wilmanns M

FEBS letters, 2006

doi:10.1016/j.febslet.2005.12.021.

Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk

Zou P, Pinotsis N, Lange S, Song YH, Popov A, Mavridis I, Mayans OM, Gautel M, Wilmanns M

Nature, 2006

doi:10.1038/nature04343.

Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences

Kim C, Gajendran N, Mittrücker HW, Weiwad M, Song YH, Hurwitz R, Wilmanns M, Fischer G, Kaufmann SH

Proceedings of the National Academy of Sciences of the United States of America, 2005

doi:10.1073/pnas.0500508102.

Two-fold repeated (betaalpha)4 half-barrels may provide a molecular tool for dual substrate specificity

Kuper J, Doenges C, Wilmanns M

EMBO reports, 2005

doi:10.1038/sj.embor.7400330.

Regulation of the hetero-octameric ATP phosphoribosyl transferase complex from Thermotoga maritima by a tRNA synthetase-like subunit

Vega MC, Zou P, Fernandez FJ, Murphy GE, Sterner R, Popov A, Wilmanns M

Molecular microbiology, 2005

doi:10.1111/j.1365-2958.2004.04422.x.

Molecular crystallography

Wilmanns M, Weiss MS

2005

doi:10.1016/b0-12-369401-9/00424-1.

Synergistic use of synchrotron radiation techniques for biological samples in solution: a case study on protein-ligand recognition by the peroxisomal import receptor Pex5p

Stanley WA, Sokolova A, Brown A, Clarke DT, Wilmanns M, Svergun DI

Journal of synchrotron radiation, 2004

doi:10.1107/s090904950402504x.

Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase

Barabás O, Pongrácz V, Kovári J, Wilmanns M, Vértessy BG

The Journal of biological chemistry, 2004

doi:10.1074/jbc.m406135200.

Combinatorial control of gene expression

Reményi A, Schöler HR, Wilmanns M

Nature structural & molecular biology, 2004

doi:10.1038/nsmb820.

Structural studies of the catalytic reaction pathway of a hyperthermophilic histidinol-phosphate aminotransferase

Fernandez FJ, Vega MC, Lehmann F, Sandmeier E, Gehring H, Christen P, Wilmanns M

The Journal of biological chemistry, 2004

doi:10.1074/jbc.m400291200.

Solvation in protein folding analysis: combination of theoretical and experimental approaches

Fernández-Escamilla AM, Cheung MS, Vega MC, Wilmanns M, Onuchic JN, Serrano L

Proceedings of the National Academy of Sciences of the United States of America, 2004

doi:10.1073/pnas.0304180101.

Adaptation of class-13 alpha-amylases to diverse living conditions

Linden A, Wilmanns M

Chembiochem : a European journal of chemical biology, 2004

doi:10.1002/cbic.200300734.

Evolutionary markers in the (beta/alpha)8-barrel fold

Vega MC, Lorentzen E, Linden A, Wilmanns M

Current opinion in chemical biology, 2003

doi:10.1016/j.cbpa.2003.10.004.

Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers

Reményi A, Lins K, Nissen LJ, Reinbold R, Schöler HR, Wilmanns M

Genes & development, 2003

doi:10.1101/gad.269303.

OBF1 enhances transcriptional potential of Oct1

Lins K, Reményi A, Tomilin A, Massa S, Wilmanns M, Matthias P, Schöler HR

The EMBO journal, 2003

doi:10.1093/emboj/cdg199.

Differential regulation of a hyperthermophilic alpha-amylase with a novel (Ca,Zn) two-metal center by zinc

Linden A, Mayans O, Meyer-Klaucke W, Antranikian G, Wilmanns M

The Journal of biological chemistry, 2003

doi:10.1074/jbc.m211339200.

The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology

Terwilliger TC, Park MS, Waldo GS, Berendzen J, Hung LW, Kim CY, Smith CV, Sacchettini JC, Bellinzoni M, Bossi R, De Rossi E, Mattevi A, Milano A, Riccardi G, Rizzi M, Roberts MM, Coker AR, Fossati G, Mascagni P, Coates AR, Wood SP, Goulding CW, Apostol MI, Anderson DH, Gill HS, Eisenberg DS, Taneja B, Mande S, Pohl E, Lamzin V, Tucker P, Wilmanns M, Colovos C, Meyer-Klaucke W, Munro AW, McLean KJ, Marshall KR, Leys D, Yang JK, Yoon HJ, Lee BI, Lee MG, Kwak JE, Han BW, Lee JY, Baek SH, Suh SW, Komen MM, Arcus VL, Baker EN, Lott JS, Jacobs W Jr, Alber T, Rupp B

Tuberculosis (Edinburgh, Scotland), 2003

doi:10.1016/s1472-9792(03)00051-9.

Solution scattering suggests cross-linking function of telethonin in the complex with titin

Zou P, Gautel M, Geerlof A, Wilmanns M, Koch MH, Svergun DI

The Journal of biological chemistry, 2003

doi:10.1074/jbc.m210217200.

Steered molecular dynamics studies of titin I1 domain unfolding

Gao M, Wilmanns M, Schulten K

Biophysical journal, 2002

doi:10.1016/s0006-3495(02)75343-5.

Topography for independent binding of alpha-helical and PPII-helical ligands to a peroxisomal SH3 domain

Douangamath A, Filipp FV, Klein AT, Barnett P, Zou P, Voorn-Brouwer T, Vega MC, Mayans OM, Sattler M, Distel B, Wilmanns M

Molecular cell, 2002

doi:10.1016/s1097-2765(02)00749-9.

Structural conservation between the actin monomer-binding sites of twinfilin and actin-depolymerizing factor (ADF)/cofilin

Paavilainen VO, Merckel MC, Falck S, Ojala PJ, Pohl E, Wilmanns M, Lappalainen P

The Journal of biological chemistry, 2002

doi:10.1074/jbc.m208225200.

Differential activity by DNA-induced quarternary structures of POU transcription factors

Reményi A, Tomilin A, Schöler HR, Wilmanns M

Biochemical pharmacology, 2002

doi:10.1016/s0006-2952(02)01164-4.

Structural analysis of two enzymes catalysing reverse metabolic reactions implies common ancestry

Mayans O, Ivens A, Nissen LJ, Kirschner K, Wilmanns M

The EMBO journal, 2002

doi:10.1093/emboj/cdf298.

The crystal structure of the allosteric non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeum Thermoproteus tenax

Pohl E, Brunner N, Wilmanns M, Hensel R

The Journal of biological chemistry, 2002

doi:10.1074/jbc.m112244200.

Unusual binding properties of the SH3 domain of the yeast actin-binding protein Abp1: structural and functional analysis

Fazi B, Cope MJ, Douangamath A, Ferracuti S, Schirwitz K, Zucconi A, Drubin DG, Wilmanns M, Cesareni G, Castagnoli L

The Journal of biological chemistry, 2002

doi:10.1074/jbc.m109848200.

Stabilization of a (betaalpha)8-barrel protein by an engineered disulfide bridge

Ivens A, Mayans O, Szadkowski H, Jürgens C, Wilmanns M, Kirschner K

European journal of biochemistry / FEBS, 2002

doi:10.1046/j.1432-1033.2002.02745.x.

Integrated structural genomics in Europe

Wilmanns M

Gene function & disease, 2002

doi:.

Structural genomics in Europe and beyond - Shifting scientific directions at EMBL Hamburg

Wilmanns M

Acta Physica Polonica A, 2002

doi:.

Crystallization of redox-insensitive Oct1 POU domain with different DNA-response elements

Reményi A, Pohl E, Schöler HR, Wilmanns M

Acta crystallographica. Section D, Biological crystallography, 2001

doi:10.1107/s090744490101099x.

Divergent evolution of (betaalpha)8-barrel enzymes

Henn-Sax M, Höcker B, Wilmanns M, Sterner R

Biological chemistry, 2001

doi:10.1515/bc.2001.163.

Differential dimer activities of the transcription factor Oct-1 by DNA-induced interface swapping

Reményi A, Tomilin A, Pohl E, Lins K, Philippsen A, Reinbold R, Schöler HR, Wilmanns M

Molecular cell, 2001

doi:10.1016/s1097-2765(01)00336-7.

Matti Saraste (1949-2001)

Wilmanns M

Structure (London, England : 1993), 2001

doi:10.1016/s0969-2126(01)00650-5.

Stability, catalytic versatility and evolution of the (beta alpha)(8)-barrel fold

Höcker B, Jürgens C, Wilmanns M, Sterner R

Current opinion in biotechnology, 2001

doi:10.1016/s0958-1669(00)00230-5.

Purification, characterization and crystallization of thermostable anthranilate phosphoribosyltransferase from Sulfolobus solfataricus

Ivens A, Mayans O, Szadkowski H, Wilmanns M, Kirschner K

European journal of biochemistry / FEBS, 2001

doi:10.1046/j.1432-1327.2001.02102.x.

Structural evidence for a possible role of reversible disulphide bridge formation in the elasticity of the muscle protein titin

Mayans O, Wuerges J, Canela S, Gautel M, Wilmanns M

Structure (London, England : 1993), 2001

doi:10.1016/s0969-2126(01)00591-3.

Atomic resolution structure of a mutant of the spectrin SH3 domain

Berisio R, Viguera A, Serrano L, Wilmanns M

Acta crystallographica. Section D, Biological crystallography, 2001

doi:10.1107/s090744490001581x.

Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration

Tomilin A, Reményi A, Lins K, Bak H, Leidel S, Vriend G, Wilmanns M, Schöler HR

Cell, 2000

doi:10.1016/s0092-8674(00)00189-6.

Structural evidence for evolution of the beta/alpha barrel scaffold by gene duplication and fusion

Lang D, Thoma R, Henn-Sax M, Sterner R, Wilmanns M

Science (New York, N.Y.), 2000

doi:10.1126/science.289.5484.1546.

Directed evolution of a (beta alpha)8-barrel enzyme to catalyze related reactions in two different metabolic pathways

Jürgens C, Strom A, Wegener D, Hettwer S, Wilmanns M, Sterner R

Proceedings of the National Academy of Sciences of the United States of America, 2000

doi:10.1073/pnas.160255397.

Activation of calcium/calmodulin regulated kinases

Wilmann M, Gautel M, Mayans O

Cellular and molecular biology (Noisy-le-Grand, France), 2000

doi:.

Regulation von Proteinkinasen der MLCK-Familie

Wilmanns M, Gautel M

1999

doi:.

Crystallization and preliminary X-ray diffraction analysis of the NAD-dependent non--phosphorylating GAPDH of the hyperthermophilic archaeon Thermoproteus tenax

Brunner NA, Lang DA, Wilmanns M, Hensel R

Acta crystallographica. Section D, Biological crystallography, 2000

doi:10.1107/s0907444999014134.

Future structural biology applications with a free-electron laser - more than wild dreams?

Wilmanns M

Journal of synchrotron radiation, 2000

doi:.

The crystal structure of anthranilate synthase from Sulfolobus solfataricus: functional implications

Knöchel T, Ivens A, Hester G, Gonzalez A, Bauerle R, Wilmanns M, Kirschner K, Jansonius JN

Proceedings of the National Academy of Sciences of the United States of America, 1999

doi:10.1073/pnas.96.17.9479.

Efficient expression, purification and crystallisation of two hyperthermostable enzymes of histidine biosynthesis

Thoma R, Obmolova G, Lang DA, Schwander M, Jenö P, Sterner R, Wilmanns M

FEBS letters, 1999

doi:10.1016/s0014-5793(99)00757-7.

Thermodynamic analysis of alpha-spectrin SH3 and two of its circular permutants with different loop lengths: discerning the reasons for rapid folding in proteins

Martínez JC, Viguera AR, Berisio R, Wilmanns M, Mateo PL, Filimonov VV, Serrano L

Biochemistry, 1999

doi:10.1021/bi981515u.

X-ray analysis of protein crystals with thin-plate morphology

Mayans O, Wilmanns M

Journal of synchrotron radiation, 1999

doi:10.1107/s0909049599004616.

Structural basis for activation of the titin kinase domain during myofibrillogenesis

Mayans O, van der Ven PF, Wilm M, Mues A, Young P, Fürst DO, Wilmanns M, Gautel M

Nature, 1998

doi:10.1038/27603.

Crystal structure of the abl-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions

Pisabarro MT, Serrano L, Wilmanns M

Journal of molecular biology, 1998

doi:10.1006/jmbi.1998.1932.

Different folding transition states may result in the same native structure

Viguera AR, Serrano L, Wilmanns M

Nature structural biology, 1996

doi:10.1038/nsb1096-874.

Structure of the binding site for inositol phosphates in a PH domain

Hyvönen M, Macias MJ, Nilges M, Oschkinat H, Saraste M, Wilmanns M

The EMBO journal, 1995

doi:10.1002/j.1460-2075.1995.tb00149.x.

Inverse protein folding by the residue pair preference profile method: estimating the correctness of alignments of structurally compatible sequences

Wilmanns M, Eisenberg D

Protein engineering, 1995

doi:10.1093/protein/8.7.627.

High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides

Musacchio A, Saraste M, Wilmanns M

Nature structural biology, 1994

doi:10.1038/nsb0894-546.