Postdoctoral Fellow - Somatic Mosaicism in Human Tissues
EMBL is seeking an experimental postdoc in single cell genomics to join Dr. Jan Korbel's group in the Genome Biology Unit to investigate patterns of human genetic and epigenetic mosaicism at cellular... EMBL is seeking an experimental postdoc in single cell genomics to join Dr. Jan Korbel's group in the Genome Biology Unit to investigate patterns of human genetic and epigenetic mosaicism at cellular resolution. Genomic structural variants (SVs, e.g. deletions and inversions) account for most varying bases in human genomes. Intriguingly, recent studies have demonstrated that somatic SVs occur post-zygotically throughout the human lifespan, and can have profound effects on aging and diseases. Funded by the ERC grant MOSAIC, the post holder will lead exciting studies in single cell multi-omics, and use the novel scTRIP single cell methodology developed in the Korbel group, to uncover the biological underpinnings, extent and functional impact of genetic and epigenetic mosaicism in different human tissues. Integration of data from high throughput single cell sequencing platforms, and state-of-the-art multiplexed bioimaging platforms will allow to elucidate these as yet largely unexplored layers of human cell-to-cell variation – and will serve as foundation for elucidating roles of somatic mosaicism in age-related phenotypes and diseases. This postdoctoral project will be highly inter-disciplinary, and can be – depending on the qualification and the interests of the candidate – more geared towards an entirely experimental, or a “hybrid” experimental/computational study.
POS Learn moreCloses 13 September 2020
