Publications

The absence of the caffeine synthase gene is involved in the naturally decaffeinated status of Coffea humblotiana, a wild species from Comoro archipelago.

Raharimalala N, Rombauts S, McCarthy A, Garavito A, Orozco-Arias S, Bellanger L, Morales-Correa AY, Froger S, Michaux S, Berry V, Metairon S, Fournier C, Lepelley M, Mueller L, Couturon E, Hamon P, Rakotomalala JJ, Descombes P, Guyot R, Crouzillat D

Scientific reports 2021

33854089. doi:10.1038/s41598-021-87419-0.

Statistically correcting dynamical electron scattering improves the refinement of protein nanocrystals, including charge refinement of coordinated metals.

Blum TB, Housset D, Clabbers MTB, van Genderen E, Bacia-Verloop M, Zander U, McCarthy AA, Schoehn G, Ling WL, Abrahams JP

Acta crystallographica. Section D, Structural biology 2021

33404527. doi:10.1107/S2059798320014540.

Attaining atomic resolution from in situ data collection at room temperature using counter-diffusion-based low-cost microchips.

Gavira JA, Rodriguez-Ruiz I, Martinez-Rodriguez S, Basu S, Teychené S, McCarthy AA, Mueller-Dieckman C

Acta crystallographica. Section D, Structural biology 2020

32744257. doi:10.1107/S2059798320008475.

X-ray structure of the human karyopherin RanBP5, an essential factor for influenza polymerase nuclear trafficking.

Swale C, Da Costa B, Sedano L, Garzoni F, McCarthy AA, Berger I, Bieniossek C, Ruigrok RWH, Delmas B, Crépin T

Journal of molecular biology 2020

32222384. doi:10.1016/j.jmb.2020.03.021.

Structure and function of roundabout receptors.

Bisiak F, McCarthy AA

Sub-cellular biochemistry 2019

31939155. doi:10.1007/978-3-030-28151-9_9.

Decapping enzyme NUDT12 partners with BLMH for cytoplasmic surveillance of NAD-capped RNAs.

Wu H, Li L, Chen KM, Homolka D, Gos P, Fleury-Olela F, McCarthy AA, Pillai RS

Cell reports 2019

31875550. doi:10.1016/j.celrep.2019.11.108.

Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy.

Ashraf U, Tengo L, Le Corre L, Fournier G, Busca P, McCarthy AA, Rameix-Welti MA, Gravier-Pelletier C, Ruigrok RWH, Jacob Y, Vidalain PO, Pietrancosta N, Crépin T, Naffakh N

Proceedings of the National Academy of Sciences of the United States of America 2019

31076555. doi:10.1073/pnas.1901214116.

Structural principles in Robo activation and auto-inhibition.

Barak R, Yom-Tov G, Guez-Haddad J, Gasri-Plotnitsky L, Maimon R, Cohen-Berkman M, McCarthy AA, Perlson E, Henis-Korenblit S, Isupov MN, Opatowsky Y

Cell 2019

30853216. doi:10.1016/j.cell.2019.02.004.

MXCuBE2: the dawn of MXCuBE Collaboration.

Oscarsson M, Beteva A, Flot D, Gordon E, Guijarro M, Leonard G, McSweeney S, Monaco S, Mueller-Dieckmann C, Nanao M, Nurizzo D, Popov AN, von Stetten D, Svensson O, Rey-Bakaikoa V, Chavas LMG, Chado I, Gourhant P, Gadea L, Legrand P, Isabet T, Sirigu S, Savko M, Thompson A, Shepard W, Nan J, Mueller U, Bolmsten F, Eguiraun M, Milàn-Otero A, Nardella A, Kastner A, Schmuckermaier L, Thunnissen M, Hellmig M, Weiss MS, Gerlach M, Feiler C, Bowler MW, Gobbo A, Papp G, Sinoir J, McCarthy AA, Karpics I, Nikolova M, Bourenkov G, Schneider T, Boer R, Juanhuix J, Cuní G, Andreu J, Paciorek W, Flensburg C, Keller P, Fogh R, de Sanctis D, Bricogne G, Vonrhein C

Journal of synchrotron radiation 2019

30855248. doi:10.1107/S1600577519001267.

CrystalDirect-To-Beam: Opening the shortest path from crystal to data.

Felisaz F, Sinoir J, Papp G, Pica A, Bowler MW, Murphy P, Hoffmann G, Zander U, Lopez-Marrero M, Janocha R, Giraud T, Svensson O, Popov S, Leonard G, Mueller-Dieckmann C, Márquez JA, McCarthy A, Cipriani F

2019

doi:10.1063/1.5084627.

Structural basis for the activation of the deubiquitinase Calypso by the Polycomb protein ASX.

De I, Chittock EC, Grötsch H, Miller TCR, McCarthy AA, Müller CW

Structure (London, England : 1993) 2019

30639226. doi:10.1016/j.str.2018.11.013.

Methylation of Structured RNA by the m6A Writer METTL16 Is Essential for Mouse Embryonic Development.

Mendel M, Chen KM, Homolka D, Gos P, Pandey RR, McCarthy AA, Pillai RS

Molecular cell 2018

30197299. doi:10.1016/j.molcel.2018.08.004.

Calibration of rotation axes for multi-axis goniometers in macromolecular crystallography.

White KI, Bugris V, McCarthy AA, Ravelli RBG, Csankó K, Cassetta A, Brockhauser S

Journal of applied crystallography 2018

30279641. doi:10.1107/S1600576718010956.

ID30B - a versatile beamline for macromolecular crystallography experiments at the ESRF.

McCarthy AA, Barrett R, Beteva A, Caserotto H, Dobias F, Felisaz F, Giraud T, Guijarro M, Janocha R, Khadrouche A, Lentini M, Leonard GA, Lopez Marrero M, Malbet-Monaco S, McSweeney S, Papp G, Nurizzo D, Sinoir J, Rossi C, Surr J, Sorez C, Zander U, Svensson O, Theveneau P, Cipriani F, Mueller-Dieckmann C

Journal of synchrotron radiation 2018

29979188. doi:10.1107/S1600577518007166.

Robo1 Forms a Compact Dimer-of-Dimers Assembly.

Aleksandrova N, Gutsche I, Kandiah E, Avilov SV, Petoukhov MV, Seiradake E, McCarthy AA

Structure (London, England : 1993) 2018

29307485. doi:10.1016/j.str.2017.12.003.

A new MR-SAD algorithm for the automatic building of protein models from low-resolution X-ray data and a poor starting model

Skubak P, Arac D, Bowler MW, Correia A, Hoelz A, Larsen S, Leonard G, McCarthy A, McSweeney S, Mueller-Dieckmann C, Otten H, Salzman G, Pannu N

IUCrJ 2018

29765606. doi:10.1107/S2052252517017961.

Towards a compact and precise sample holder for macromolecular crystallography.

Papp G, Rossi C, Janocha R, Sorez C, Lopez-Marrero M, Astruc A, McCarthy A, Belrhali H, Bowler MW, Cipriani F

Acta crystallographica. Section D, Structural biology 2017

28994412. doi:10.1107/S2059798317013742.

Death-Associated Protein Kinase Activity Is Regulated by Coupled Calcium/Calmodulin Binding to Two Distinct Sites

Simon B, Huart A, Temmerman K, Vahokoski J, Mertens H, Komadina D, Hoffmann J, Yumerefendi H, Svergun D, Kursula P, Schultz C, McCarthy A, Hart D, Wilmanns M

Structure 2016

27133022. doi:10.1016/j.str.2016.03.020.

PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway.

Yang Z, Chen KM, Pandey RR, Homolka D, Reuter M, Janeiro BK, Sachidanandam R, Fauvarque MO, McCarthy AA, Pillai RS

Molecular cell 2015

26669262. doi:10.1016/j.molcel.2015.11.009.

Asymmetric ring structure of Vps4 required for ESCRT-III disassembly.

Caillat C, Macheboeuf P, Wu Y, McCarthy AA, Boeri-Erba E, Effantin G, Göttlinger HG, Weissenhorn W, Renesto P

Nature communications 2015

26632262. doi:10.1038/ncomms9781.

Crystallization and X-ray diffraction studies of a complete bacterial fatty-acid synthase type I.

Enderle M, McCarthy A, Paithankar KS, Grininger M

Acta crystallographica. Section F, Structural biology communications 2015

26527268. doi:10.1107/s2053230x15018336.

MeshAndCollect: an automated multi-crystal data-collection workflow for synchrotron macromolecular crystallography beamlines.

Zander U, Bourenkov G, Popov AN, de Sanctis D, Svensson O, McCarthy AA, Round E, Gordeliy V, Mueller-Dieckmann C, Leonard GA

Acta crystallographica. Section D, Biological crystallography 2015

26527148. doi:10.1107/s1399004715017927.

Metazoan Maelstrom is an RNA-binding protein that has evolved from an ancient nuclease active in protists.

Chen KM, Campbell E, Pandey RR, Yang Z, McCarthy AA, Pillai RS

2015

25778731. doi:10.1261/rna.049437.114.

The status of the macromolecular crystallography beamlines at the European Synchrotron Radiation Facility

Mueller-Dieckmann C, Bowler MW, Carpentier P, Flot D, McCarthy AA, Nanao MH, Nurizzo D, Pernot P, Popov A, Round A, Royant A, de Sanctis D, von Stetten D, Leonard GA

EUROPEAN PHYSICAL JOURNAL PLUS 2015

doi:10.1140/epjp/i2015-15070-0.

Mammalian translation elongation factor eEF1A2: X-ray structure and new features of GDP/GTP exchange mechanism in higher eukaryotes.

Crepin T, Shalak VF, Yaremchuk AD, Vlasenko DO, McCarthy A, Negrutskii BS, Tukalo MA, El'skaya AV

Nucleic acids research 2014

25326326. doi:10.1093/nar/gku974.

Protein assembly mediated by sulfonatocalix[4]arene.

McGovern RE, McCarthy AA, Crowley PB

Chemical communications (Cambridge, England) 2014

25068633. doi:10.1039/c4cc04897k.

The MID-PIWI module of Piwi proteins specifies nucleotide- and strand-biases of piRNAs

Cora E, Pandey RR, Xiol J, Taylor J, Sachidanandam R, McCarthy AA, Pillai RS

RNA (New York, N.Y.) 2014

24757166. doi:10.1261/rna.044701.114.

The use of a mini-κ goniometer head in macromolecular crystallography diffraction experiments

Brockhauser S, Ravelli RB, McCarthy AA

Acta crystallographica. Section D, Biological crystallography 2013

23793150. doi:10.1107/s0907444913003880.

Automatic processing of macromolecular crystallography X-ray diffraction data at the ESRF

Monaco S, Gordon E, Bowler MW, Delagenière S, Guijarro M, Spruce D, Svensson O, McSweeney SM, McCarthy AA, Leonard G, Nanao MH

Journal of applied crystallography 2013

23682196. doi:10.1107/s0021889813006195.

A structural basis for the biosynthesis of the major chlorogenic acids found in coffee

Lallemand LA, Zubieta C, Lee SG, Wang Y, Acajjaoui S, Timmins J, McSweeney S, Jez JM, McCarthy JG, McCarthy AA

Plant physiology 2012

22822210. doi:10.1104/pp.112.202051.

The use of workflows in the design and implementation of complex experiments in macromolecular crystallography

Brockhauser S, Svensson O, Bowler MW, Nanao M, Gordon E, Leal RM, Popov A, Gerring M, McCarthy AA, Gotz A

Acta crystallographica. Section D, Biological crystallography 2012

22868763. doi:10.1107/s090744491201863x.

Purification, crystallization and preliminary X-ray diffraction analysis of a hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyltransferase (HCT) from Coffea canephora involved in chlorogenic acid biosynthesis

Lallemand LA, McCarthy JG, McSweeney S, McCarthy AA

Acta crystallographica. Section F, Structural biology and crystallization communications 2012

22750875. doi:10.1107/s1744309112019082.

Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA

Kowalinski E, Lunardi T, McCarthy AA, Louber J, Brunel J, Grigorov B, Gerlier D, Cusack S

Cell 2011

22000019. doi:10.1016/j.cell.2011.09.039.

Translation calibration of inverse-kappa goniometers in macromolecular crystallography

Brockhauser S, White KI, McCarthy AA, Ravelli RB

Acta crystallographica. Section A, Foundations of crystallography 2011

21487180. doi:10.1107/s0108767311004831.

Inducing phase transitions in protein crystals by controlled crystal dehydration.

Silvia R, Babu M, McCarthy A, Cipriani F, Hassan B

2011

doi:10.1107/S010876731107944X.

Visualizing the metal-binding versatility of copper trafficking sites

Badarau A, Firbank SJ, McCarthy AA, Banfield MJ, Dennison C

Biochemistry 2010

20726513. doi:10.1021/bi101064w.

MxCuBE: a synchrotron beamline control environment customized for macromolecular crystallography experiments

Gabadinho J, Beteva A, Guijarro M, Rey-Bakaikoa V, Spruce D, Bowler MW, Brockhauser S, Flot D, Gordon EJ, Hall DR, Lavault B, McCarthy AA, McCarthy J, Mitchell E, Monaco S, Mueller-Dieckmann C, Nurizzo D, Ravelli RB, Thibault X, Walsh MA, Leonard GA, McSweeney SM

Journal of synchrotron radiation 2010

20724792. doi:10.1107/s0909049510020005.

Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain

Hinz A, Miguet N, Natrajan G, Usami Y, Yamanaka H, Renesto P, Hartlieb B, McCarthy AA, Simorre JP, Göttlinger H, Weissenhorn W

Cell host & microbe 2010

20399176. doi:10.1016/j.chom.2010.03.005.

A decade of user operation on the macromolecular crystallography MAD beamline ID14-4 at the ESRF

McCarthy AA, Brockhauser S, Nurizzo D, Theveneau P, Mairs T, Spruce D, Guijarro M, Lesourd M, Ravelli RB, McSweeney S

Journal of synchrotron radiation 2009

19844017. doi:10.1107/s0909049509035377.

Structure and functional relevance of the Slit2 homodimerization domain

Seiradake E, von Philipsborn AC, Henry M, Fritz M, Lortat-Jacob H, Jamin M, Hemrika W, Bastmeyer M, Cusack S, McCarthy AA

EMBO reports 2009

19498462. doi:10.1038/embor.2009.95.

Structure of SRP14 from the Schizosaccharomyces pombe signal recognition particle

Brooks MA, Ravelli RB, McCarthy AA, Strub K, Cusack S

Acta crystallographica. Section D, Biological crystallography 2009

19390147. doi:10.1107/s0907444909005484.

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

Dias A, Bouvier D, Crépin T, McCarthy AA, Hart DJ, Baudin F, Cusack S, Ruigrok RW

Nature 2009

19194459. doi:10.1038/nature07745.

X-ray tomographic reconstruction of macromolecular samples

Brockhauser S, Di Michiel M, McGeehan JE, McCarthy AA, Ravelli RBG

Journal of applied crystallography 2008

doi:10.1107/S002188980802935X.

Capturing the Shape of Macromolecular Crystals in 3D

Leal RMF, Teixeira SCM, Rey V, Forsyth VT, Mitchel EP, Brockhauser S, Di Michiel M, McGeehan JE, McCarthy A, Ravelli RBG

2008

doi:.

Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3

Morlot C, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA

Acta crystallographica. Section D, Biological crystallography 2007

17704564. doi:10.1107/s0907444907035470.

Structural insights into the Slit-Robo complex

Morlot C, Thielens NM, Ravelli RB, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA

Proceedings of the National Academy of Sciences of the United States of America 2007

17848514. doi:10.1073/pnas.0705310104.

Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase

Martinez Molina D, Wetterholm A, Kohl A, McCarthy AA, Niegowski D, Ohlson E, Hammarberg T, Eshaghi S, Haeggström JZ, Nordlund P

Nature 2007

17632546. doi:10.1038/nature06009.

Cloning, expression, crystallization and preliminary X-ray analysis of the first two Ig domains from human roundabout 1 (Robo1)

Morlot C, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA

Acta crystallographica. Section F, Structural biology and crystallization communications 2007

17671369. doi:10.1107/S1744309107033027.

The structure of two N-methyltransferases from the caffeine biosynthetic pathway

McCarthy AA, McCarthy JG

Plant physiology 2007

17434991. doi:10.1104/pp.106.094854.

Cloning, expression, crystallization and preliminary X-ray analysis of the XMT and DXMT N-methyltransferases from Coffea canephora (robusta)

McCarthy AA, Biget L, Lin C, Petiard V, Tanksley SD, McCarthy JG

Acta crystallographica. Section F, Structural biology and crystallization communications 2007

17401201. doi:10.1107/S1744309107009268.

Structure of dimeric SecA, the Escherichia coli preprotein translocase motor

Papanikolau Y, Papadovasilaki M, Ravelli RB, McCarthy AA, Cusack S, Economou A, Petratos K

Journal of molecular biology 2007

17229438. doi:10.1016/j.jmb.2006.12.049.

Plastic-embedded protein crystals

Ravelli RB, Haselmann-Weiss U, McGeehan JE, McCarthy AA, Marquez JA, Antony C, Frangakis AS, Stranzl G

Journal of synchrotron radiation 2007

17211079. doi:10.1107/s0909049506043111.

Structure of C3b reveals conformational changes that underlie complement activity

Janssen BJ, Christodoulidou A, McCarthy A, Lambris JD, Gros P

Nature 2006

17051160. doi:10.1038/nature05172.

High-throughput sample handling and data collection at synchrotrons: embedding the ESRF into the high-throughput gene-to-structure pipeline

Beteva A, Cipriani F, Cusack S, Delageniere S, Gabadinho J, Gordon EJ, Guijarro M, Hall DR, Larsen S, Launer L, Lavault CB, Leonard GA, Mairs T, McCarthy A, McCarthy J, Meyer J, Mitchell E, Monaco S, Nurizzo D, Pernot P, Pieritz R, Ravelli RG, Rey V, Shepard W, Spruce D, Stuart DI, Svensson O, Theveneau P, Thibault X, Turkenburg J, Walsh M, McSweeney SM

Acta crystallographica. Section D, Biological crystallography 2006

17001093. doi:10.1107/s0907444906032859.

The care and nurture of undulator data sets

Flot D, Gordon EJ, Hall DR, Leonard GA, McCarthy A, McCarthy J, McSweeney S, Mitchell E, Nurizzo D, Ravelli RG, Shepard W

Acta crystallographica. Section D, Biological crystallography 2006

16369095. doi:10.1107/s0907444905032646.

Automation of macromolecular crystallography beamlines

Arzt S, Beteva A, Cipriani F, Delageniere S, Felisaz F, Förstner G, Gordon E, Launer L, Lavault B, Leonard G, Mairs T, McCarthy A, McCarthy J, McSweeney S, Meyer J, Mitchell E, Monaco S, Nurizzo D, Ravelli R, Rey V, Shepard W, Spruce D, Svensson O, Theveneau P

Progress in biophysics and molecular biology 2005

15910915. doi:10.1016/j.pbiomolbio.2004.09.003.

Structure and function of the C-terminal domain of the polymerase cofactor of rabies virus

Mavrakis M, McCarthy AA, Roche S, Blondel D, Ruigrok RW

Journal of molecular biology 2004

15476803. doi:10.1016/j.jmb.2004.08.071.

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes

Harel M, Aharoni A, Gaidukov L, Brumshtein B, Khersonsky O, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, Sussman JL, Tawfik DS

Nature structural & molecular biology 2004

15098021. doi:10.1038/nsmb767.

Crystal structure of MshB from Mycobacterium tuberculosis, a deacetylase involved in mycothiol biosynthesis

McCarthy AA, Peterson NA, Knijff R, Baker EN

Journal of molecular biology 2004

14698305. doi:10.1016/j.jmb.2003.11.034.