Engineering structural variation to understand human genome function
The lab will open in November 2026, and we are recruiting our first PhD students and postdoctoral researchers. If you are interested in genome engineering, noncoding genome function, and building new tools to study genome architecture, I would love to hear from you.
This is an especially exciting moment for genome biology. New genome engineering technologies are making it possible to manipulate mammalian genomes at a scale that was previously out of reach, opening the door to entirely new ways of studying genome function. The lab will build a broad experimental and conceptual toolkit for structural variant engineering, and postdoctoral researchers will be encouraged to develop their own ideas and pursue the genome biology questions they find most compelling. Please feel free to contact Jonas by email.
PhD students in the lab will have the opportunity to work with and help develop the next generation of genome engineering technologies, including bridge recombinases, prime editing, CRISPR-Cas3, and future emerging tools. They will also gain experience in genome sequencing, single-cell methods, and computational analysis, with opportunities to develop predictive models that deepen our understanding of genome function. Students should apply through the EMBL International PhD Programme and are very welcome to get in touch to discuss potential projects and the EMBL environment.