Publications – Hyman Group

Polo/PLK1 phosphorylation relieves Centrosomin/Cnn autoinhibition to promote centrosome scaffold assembly.

Mohamad N, Wong SS, Majumdar A, Wainman A, Holland-Kaye I, Hubatsch L, Novak Z, Pozniakovsky A, Ruer-Gruss M, Haensele AFM, Caballe A, Johnson S, Lea SM, Hyman AA, Raff JW

The EMBO journal, 2026

doi:10.1038/s44318-026-00878-x.

A conserved motif tunes Sidekick condensate dynamics to control tricellular junction recruitment during epithelial remodeling.

Uechi H, Sun D, Saeki Y, Hiraiwa T, Honigmann A, Hyman AA, Kuranaga E

Cell reports, 2026

doi:10.1016/j.celrep.2026.117336.

Biomolecular condensates mediate C-N bond formation.

Song X, Ma Y, Chen MW, Yu W, Yan X, Xu J, Lyu L, Hyman AA, Dai Y, Zare RN

Nature chemical biology, 2026

doi:10.1038/s41589-026-02169-2.

Origins of the Intrinsic Redox Activity of Biomolecular Condensates.

Yu W, Zhou Y, Yang L, Yan X, Smukowski SN, Ma Y, Fan J, Goo YA, Hyman AA, Dai Y

Journal of the American Chemical Society, 2026

doi:10.1021/jacs.6c01750.

Transport kinetics across interfaces between coexisting liquid phases.

Hubatsch L, Bo S, Harmon ST, Hyman AA, Weber AC, Jülicher F

eLife, 2026

doi:10.7554/eLife.106842.

Biomolecular condensates sustain pH gradients at equilibrium through charge neutralization.

Ausserwöger H, Scrutton R, Fischer CM, Sneideris T, Qian D, de Csilléry E, Baronaite I, Saar KL, Białek AZ, Oeller M, Krainer G, Franzmann TM, Wittmann S, Iglesias-Artola JM, Invernizzi G, Hyman AA, Alberti S, Lorenzen N, Knowles TPJ

Nature chemistry, 2026

doi:10.1038/s41557-025-02039-9.

CD-CODE 2.0: an enhanced condensate knowledgebase integrating pathobiology, condensate modulating drugs, and host-pathogen interactions.

Kuznetsova K, Scheremetjew M, Yin J, Moon H, Vargas DA, Hadarovich A, Lewis N, Hoege C, Chow CFW, Kuster D, Nijssen J, Hernandez-Armendariz A, Savage JC, Wei Y, Zedlitz S, Singh HR, Ghosh S, Kemraj AP, Hersemann L, Hyman AA, Mitrea DM, Toth-Petroczy A

Nucleic acids research, 2026

doi:10.1093/nar/gkaf1104.

Fast, Bright, and Reversible Fluorescent Labeling of Rhodamine-Binding Proteins.

Kompa J, Dornfeld LJ, Porzberg N, Jang S, Zedlitz S, Lilje SH, Catapano C, Jocher D, Merk L, Hoege C, Mao R, Wilhelm J, Dietz MS, Tarnawski M, Hiblot J, Hyman AA, Heilemann M, Johnsson K

Journal of the American Chemical Society, 2025

doi:10.1021/jacs.5c18083.

Computational design of metalloproteases.

Chen A, Wu K, Choi H, Venkatesh P, Pellock SJ, Hanikel N, shin H, Evans D, Didi K, Schaaf LL, Díaz-Perlas C, Coventry B, Kim D, Woodbury SM, Ji P, Honda S, Bera AK, Nguyen H, Kang A, Wang Y, Li X, Gerben S, Chang L, Yan X, Oller-Salvia B, Hyman AA, Hilvert D, Baker D

bioRxiv, 2025

doi:10.1101/2025.11.20.689622.

A label-free method for measuring the composition of multicomponent biomolecular condensates.

McCall PM, Kim K, Shevchenko A, Ruer-Gruß M, Peychl J, Guck J, Shevchenko A, Hyman AA, Brugués J

Nature chemistry, 2025

doi:10.1038/s41557-025-01928-3.

Quantifying collective interactions in biomolecular phase separation.

Ausserwöger H, de Csilléry E, Qian D, Krainer G, Welsh TJ, Sneideris T, Franzmann TM, Qamar S, Erkamp NA, Nixon-Abell J, Kar M, St George-Hyslop P, Hyman AA, Alberti S, Pappu RV, Knowles TPJ

Nature communications, 2025

doi:10.1038/s41467-025-62437-y.

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates.

Yan X, Kuster D, Mohanty P, Nijssen J, Pombo-García K, Garcia Morato J, Rizuan A, Franzmann TM, Sergeeva A, Ly AM, Liu F, Passos PM, George L, Wang SH, Shenoy J, Danielson HL, Ozguney B, Honigmann A, Ayala YM, Fawzi NL, Dickson DW, Rossoll W, Mittal J, Alberti S, Hyman AA

Cell, 2025

doi:10.1016/j.cell.2025.04.039.

Small-molecule dissolution of stress granules by redox modulation benefits ALS models.

Uechi H, Sridharan S, Nijssen J, Bilstein J, Iglesias-Artola JM, Kishigami S, Casablancas-Antras V, Poser I, Martinez EJ, Boczek E, Wagner M, Tomschke N, de Jesus Domingues AM, Pal A, Doeleman T, Kour S, Anderson EN, Stein F, Lee HO, Zhang X, Fritsch AW, Jahnel M, Fürsch J, Murthy AC, Alberti S, Bickle M, Fawzi NL, Nadler A, David DC, Pandey UB, Hermann A, Stengel F, Davis BG, Baldwin AJ, Savitski MM, Hyman AA, Wheeler RJ

Nature chemical biology, 2025

doi:10.1038/s41589-025-01893-5.

A mechanism for MEX-5-driven disassembly of PGL-3/RNA condensates in vitro.

Lewis NS, Zedlitz S, Ausserwöger H, McCall PM, Hubatsch L, Nousch M, Ruer-Gruß M, Hoege C, Jülicher F, Eckmann CR, Knowles TPJ, Hyman AA

Proceedings of the National Academy of Sciences of the United States of America, 2025

doi:10.1073/pnas.2412218122.

SUMO2/3 conjugation of TDP-43 protects against aggregation.

Verde EM, Antoniani F, Mediani L, Secco V, Crotti S, Ferrara MC, Vinet J, Sergeeva A, Yan X, Hoege C, Stuani C, Paron F, Kao TT, Shrivastava R, Polanowska J, Bailly A, Rosa A, Aronica E, Goswami A, Shneider N, Hyman AA, Buratti E, Xirodimas D, Franzmann TM, Alberti S, Carra S

Science advances, 2025

doi:10.1126/sciadv.adq2475.

Mesoscale properties of protein clusters determine the size and nature of liquid-liquid phase separation (LLPS).

Golani G, Seal M, Kar M, Hyman AA, Goldfarb D, Safran S

Communications physics, 2025

doi:10.1038/s42005-025-02134-w.

Stress Granule Sequestration of CCR4–NOT Promotes Poly(A) Lengthening of Stress-Survival Transcripts.

Tsai Y, Uechi H, Millar SR, Kadijk E, Minkovich A, Ouyang JPT, Schreiber KJ, Huang JQ, Lyons CA, Kasmaeifar V, Zhang Z, Barsacchi R, Möbius C, Janosch A, Savage JC, Rissland OS, Röst H, Hyman AA, Youn J

bioRxiv, 2025

doi:10.1101/2025.02.04.636058.

Mesoscale landscaping of the TRIM protein family reveals a novel human condensatopathy.

Singh HR, Sharma V, Nijssen J, Pozniakovski A, Rubin A, Liang L, Ball D, Hong S, Gauntner V, Yu G, Ranga A, Salant D, Hildebrandt F, Hyman AA, Majmundar AJ

bioRxiv, 2025

doi:10.1101/2025.01.02.630836.

SARS-CoV-2 nucleocapsid protein directly prevents cGAS–DNA recognition through competitive binding.

Gutmann T, Kuster D, Hyman AA

Proceedings of the National Academy of Sciences, 2025

doi:10.1073/pnas.2426204122.

Single-step discovery of high-affinity RNA ligands by UltraSelex.

Zhang Y, Jiang Y, Kuster D, Ye Q, Huang W, Fürbacher S, Zhang J, Doll P, Lin W, Dong S, Wang H, Tang Z, Ibberson D, Wild K, Sinning I, Hyman AA, Jäschke A

Nature Chemical Biology, 2025

doi:10.1038/s41589-025-01868-6.

Assembly of tight junction belts by ZO1 surface condensation and local actin polymerization.

Sun D, Zhao X, Wiegand T, Martin-Lemaitre C, Borianne T, Kleinschmidt L, Grill SW, Hyman AA, Weber C, Honigmann A

Developmental cell, 2024

doi:10.1016/j.devcel.2024.12.012.

PICNIC accurately predicts condensate-forming proteins regardless of their structural disorder across organisms.

Hadarovich A, Singh HR, Ghosh S, Scheremetjew M, Rostam N, Hyman AA, Toth-Petroczy A

Nature communications, 2024

doi:10.1038/s41467-024-55089-x.

Actin polymerization counteracts prewetting of N-WASP on supported lipid bilayers.

Wiegand T, Liu J, Vogeley L, LuValle-Burke I, Geisler J, Fritsch AW, Hyman AA, Grill SW

Proceedings of the National Academy of Sciences of the United States of America, 2024

doi:10.1073/pnas.2407497121.

Functional specificity in biomolecular condensates revealed by genetic complementation.

Sabari BR, Hyman AA, Hnisz D

Nature reviews. Genetics, 2024

doi:10.1038/s41576-024-00780-4.

Solutes unmask differences in clustering versus phase separation of FET proteins.

Kar M, Vogel LT, Chauhan G, Chauhan G, Felekyan S, Ausserwöger H, Welsh TJ, Dar F, Kamath AR, Knowles TPJ, Hyman AA, Seidel CAM, Pappu RV

Nature communications, 2024

doi:10.1038/s41467-024-48775-3.

Local and dynamic regulation of neuronal glycolysis in vivo.

Wolfe AD, Koberstein JN, Smith CB, Stewart ML, Gonzalez IJ, Hammarlund M, Hyman AA, Stork PJS, Goodman RH, Colón-Ramos DA

Proceedings of the National Academy of Sciences of the United States of America, 2024

doi:10.1073/pnas.2314699121.

Glutamate helps unmask the differences in driving forces for phase separation versus clustering of FET family proteins in sub-saturated solutions.

Kar M, Vogel LT, Chauhan G, Ausserwöger H, Welsh TJ, Kamath AR, Knowles TPJ, Hyman AA, Seidel CAM, Pappu RV

bioRxiv, 2023

doi:10.1101/2023.08.11.552963.

CD-CODE: crowdsourcing condensate database and encyclopedia.

Rostam N, Ghosh S, Chow CFW, Hadarovich A, Landerer C, Ghosh R, Moon H, Hersemann L, Mitrea DM, Klein IA, Hyman AA, Toth-Petroczy A

Nature methods, 2023

doi:10.1038/s41592-023-01831-0.

Molecular mechanisms of stress-induced reactivation in mumps virus condensates.

Zhang X, Sridharan S, Zagoriy I, Eugster Oegema C, Ching C, Pflaesterer T, Fung HKH, Becher I, Poser I, Müller CW, Hyman AA, Savitski MM, Mahamid J

Cell, 2023

doi:10.1016/j.cell.2023.03.015.

Biomolecular condensate phase diagrams with a combinatorial microdroplet platform.

Arter EW, Qi R, Erkamp AN, Krainer G, Didi K, Welsh JT, Acker J, Nixon-Abell J, Qamar S, Guillén-Boixet J, Franzmann MT, Kuster D, Hyman AA, Borodavka A, George-Hyslop SP, Alberti S, Knowles PJT

Nature Communications, 2022

doi:10.1038/s41467-022-35265-7.

Characterization of RNA content in individual phase-separated coacervate microdroplets.

Wollny D, Vernot B, Wang J, Hondele M, Safrastyan A, Aron F, Micheel J, He Z, Hyman AA, Weis K, Camp JG, Tang TD, Treutlein B

Nature Communications, 2022

doi:10.1038/s41467-022-30158-1.

SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA.

Maharana S, Kretschmer S, Hunger S, Yan X, Kuster D, Traikov S, Zillinger T, Gentzel M, Elangovan S, Dasgupta P, Chappidi N, Lucas N, Maser KI, Maatz H, Rapp A, Marchand V, Chang YT, Motorin Y, Hubner N, Hartmann G, Hyman AA, Alberti S, Lee-Kirsch MA

Molecular cell, 2022

doi:10.1016/j.molcel.2022.08.031.

Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions.

Kar M, Dar F, Welsh TJ, Vogel LT, Kühnemuth R, Majumdar A, Krainer G, Franzmann TM, Alberti S, Seidel CAM, Knowles TPJ, Hyman AA, Pappu RV

Proceedings of the National Academy of Sciences of the United States of America, 2022

doi:10.1073/pnas.2202222119.

Adaptation to environmental temperature in divergent clades of the nematode Pristionchus pacificus.

Leaver M, Moreno E, Kayhan M, McGaughran A, Rödelsperger C, Sommer RJ, Hyman AA

Evolution; international journal of organic evolution, 2022

doi:10.1111/evo.14520.

Adaptation to environmental temperature in divergent clades of the nematode Pristionchus pacificus.

Leaver M, Moreno E, Kayhan M, McGaughran A, Rödelsperger C, Sommer RJ, Hyman AA

Evolution, 2022

doi:10.1111/evo.14520.

Glycine-Rich Peptides from FUS Have an Intrinsic Ability to Self-Assemble into Fibers and Networked Fibrils.

Kar M, Posey AE, Dar F, Hyman AA, Pappu RV

Biochemistry, 2021

doi:10.1021/acs.biochem.1c00501.

Quantitative theory for the diffusive dynamics of liquid condensates.

Hubatsch L, Jawerth LM, Love C, Bauermann J, Tang TD, Bo S, Hyman AA, Weber CA

eLife, 2021

doi:10.7554/elife.68620.

HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain.

Boczek EE, Fürsch J, Niedermeier ML, Jawerth L, Jahnel M, Ruer-Gruß M, Kammer KM, Heid P, Mediani L, Wang J, Yan X, Pozniakovski A, Poser I, Mateju D, Hubatsch L, Carra S, Alberti S, Hyman AA, Stengel F

eLife, 2021

doi:10.7554/elife.69377.

Local thermodynamics govern formation and dissolution of Caenorhabditis elegans P granule condensates.

Fritsch AW, Diaz-Delgadillo AF, Adame-Arana O, Hoege C, Mittasch M, Kreysing M, Leaver M, Hyman AA, Jülicher F, Weber CA

Proceedings of the National Academy of Sciences of the United States of America, 2021

doi:10.1073/pnas.2102772118.

Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions.

Krainer G, Welsh TJ, Joseph JA, Espinosa JR, Wittmann S, de Csilléry E, Sridhar A, Toprakcioglu Z, Gudiškytė G, Czekalska MA, Arter WE, Guillén-Boixet J, Franzmann TM, Qamar S, George-Hyslop PS, Hyman AA, Collepardo-Guevara R, Alberti S, Knowles TPJ

Nature communications, 2021

doi:10.1038/s41467-021-21181-9.

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing.

Alberti S, Hyman AA

Nature reviews. Molecular cell biology, 2021

doi:10.1038/s41580-020-00326-6.

Protein condensates as aging Maxwell fluids.

Jawerth L, Fischer-Friedrich E, Saha S, Wang J, Franzmann T, Zhang X, Sachweh J, Ruer M, Ijavi M, Saha S, Mahamid J, Hyman AA, Jülicher F

Science (New York, N.Y.), 2020

doi:10.1126/science.aaw4951.

ESI mutagenesis: a one-step method for introducing mutations into bacterial artificial chromosomes.

Rondelet A, Pozniakovsky A, Namboodiri D, Cardoso da Silva R, Singh D, Leuschner M, Poser I, Ssykor A, Berlitz J, Schmidt N, Röhder L, Vader G, Hyman AA, Bird AW

Life science alliance, 2020

doi:10.26508/lsa.202000836.

ASCB Keith Porter Lecture.

Hyman AA

Molecular biology of the cell, 2020

doi:10.1091/mbc.e20-08-0566.

Drops and fibers - how biomolecular condensates and cytoskeletal filaments influence each other.

Wiegand T, Hyman AA

Emerging topics in life sciences, 2020

doi:10.1042/etls20190174.

Erratum: Salt-Dependent Rheology and Surface Tension of Protein Condensates Using Optical Traps [Phys. Rev. Lett. 121, 258101 (2018)].

Jawerth LM, Ijavi M, Ruer M, Saha S, Jahnel M, Hyman AA, Jülicher F, Fischer-Friedrich E

Physical review letters, 2020

doi:10.1103/PhysRevLett.125.229901.

Generalized models for bond percolation transitions of associative polymers.

Choi JM, Hyman AA, Pappu RV

Physical review. E, 2020

doi:10.1103/physreve.102.042403.

Phosphofructokinase relocalizes into subcellular compartments with liquid-like properties in vivo.

Jang S, Xuan Z, Lagoy RC, Jawerth LM, Gonzalez IJ, Singh M, Prashad S, Kim HS, Patel A, Albrecht DR, Hyman AA, Colón-Ramos DA

Biophysical journal, 2020

doi:10.1016/j.bpj.2020.08.002.

Partitioning of cancer therapeutics in nuclear condensates.

Klein IA, Boija A, Afeyan LK, Hawken SW, Fan M, Dall'Agnese A, Oksuz O, Henninger JE, Shrinivas K, Sabari BR, Sagi I, Clark VE, Platt JM, Kar M, McCall PM, Zamudio AV, Manteiga JC, Coffey EL, Li CH, Hannett NM, Guo YE, Decker TM, Lee TI, Zhang T, Weng JK, Taatjes DJ, Chakraborty A, Sharp PA, Chang YT, Hyman AA, Gray NS, Young RA

Science (New York, N.Y.), 2020

doi:10.1126/science.aaz4427.

Condensation of Ded1p promotes a translational switch from housekeeping to stress protein production.

Iserman C, Desroches Altamirano C, Jegers C, Friedrich U, Zarin T, Fritsch AW, Mittasch M, Domingues A, Hersemann L, Jahnel M, Richter D, Guenther UP, Hentze MW, Moses AM, Hyman AA, Kreysing M, Kramer G, Alberti S, Franzmann TM

Cell, 2020

doi:10.1016/j.cell.2020.04.009.

RNA-induced conformational switching and clustering of G3BP drive stress granule assembly by condensation.

Guillén-Boixet J, Kopach A, Holehouse AS, Wittmann S, Jahnel M, Schlüßler R, Kim K, Trussina IREA, Wang J, Mateju D, Poser I, Maharana S, Ruer-Gruß M, Richter D, Zhang X, Guck J, Chang YT, Mahamid J, Honigmann A, Pappu RV, Hyman AA, Franzmann TM, Alberti S

Cell, 2020

doi:10.1016/j.cell.2020.03.049.

Phase separation provides a mechanism to reduce noise in cells.

Klosin A, Oltsch F, Harmon T, Honigmann A, Jülicher F, Hyman AA, Zechner C

Science (New York, N.Y.), 2020

doi:10.1126/science.aav6691.

Soluble tubulin is significantly enriched at mitotic centrosomes.

Baumgart J, Kirchner M, Redemann S, Bond A, Woodruff J, Verbavatz JM, Jülicher F, Müller-Reichert T, Hyman AA, Brugués J

The Journal of cell biology, 2019

doi:10.1083/jcb.201902069.

Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes.

Siahaan V, Krattenmacher J, Hyman AA, Diez S, Hernández-Vega A, Lansky Z, Braun M

Nature cell biology, 2019

doi:10.1038/s41556-019-0374-6.

Publisher Correction: Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding.

Stewart MP, Helenius J, Toyoda Y, Ramanathan SP, Muller DJ, Hyman AA

Nature, 2019

doi:10.1038/s41586-019-1327-8.

FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy.

Marrone L, Drexler HCA, Wang J, Tripathi P, Distler T, Heisterkamp P, Anderson EN, Kour S, Moraiti A, Maharana S, Bhatnagar R, Belgard TG, Tripathy V, Kalmbach N, Hosseinzadeh Z, Crippa V, Abo-Rady M, Wegner F, Poletti A, Troost D, Aronica E, Busskamp V, Weis J, Pandey UB, Hyman AA, Alberti S, Goswami A, Sterneckert J

Acta neuropathologica, 2019

doi:10.1007/s00401-019-01998-x.

Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells.

Mariappan A, Soni K, Schorpp K, Zhao F, Minakar A, Zheng X, Mandad S, Macheleidt I, Ramani A, Kubelka T, Dawidowski M, Golfmann K, Wason A, Yang C, Simons J, Schmalz HG, Hyman AA, Aneja R, Ullrich R, Urlaub H, Odenthal M, Büttner R, Li H, Sattler M, Hadian K, Gopalakrishnan J, Gopalakrishnan J

The EMBO journal, 2018

doi:10.15252/embj.201899876.

Salt-Dependent Rheology and Surface Tension of Protein Condensates Using Optical Traps.

Jawerth LM, Ijavi M, Ruer M, Saha S, Jahnel M, Hyman AA, Jülicher F, Fischer-Friedrich E

Physical review letters, 2018

doi:10.1103/physrevlett.121.258101.

Positioning of Particles in Active Droplets.

Zwicker D, Baumgart J, Redemann S, Müller-Reichert T, Hyman AA, Jülicher F

Physical review letters, 2018

doi:10.1103/physrevlett.121.158102.

Phase Transitions Drive the Formation of Vesicular Stomatitis Virus Replication Compartments.

Heinrich BS, Maliga Z, Stein DA, Hyman AA, Whelan SPJ

mBio, 2018

doi:10.1128/mbio.02290-17.

The replicative helicase MCM recruits cohesin acetyltransferase ESCO2 to mediate centromeric sister chromatid cohesion.

Ivanov MP, Ladurner R, Poser I, Beveridge R, Rampler E, Hudecz O, Novatchkova M, Hériché JK, Wutz G, van der Lelij P, Kreidl E, Hutchins JR, Axelsson-Ekker H, Ellenberg J, Hyman AA, Peters JM, Mechtler K

The EMBO journal, 2018

doi:10.15252/embj.201797150.

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins.

Wang J, Choi JM, Holehouse AS, Lee HO, Zhang X, Jahnel M, Maharana S, Lemaitre R, Pozniakovsky A, Drechsel D, Poser I, Pappu RV, Alberti S, Hyman AA

Cell, 2018

doi:10.1016/j.cell.2018.06.006.

A User's Guide for Phase Separation Assays with Purified Proteins.

Alberti S, Saha S, Woodruff JB, Franzmann TM, Wang J, Hyman AA

Journal of molecular biology, 2018

doi:10.1016/j.jmb.2018.06.038.

Different Material States of Pub1 Condensates Define Distinct Modes of Stress Adaptation and Recovery.

Kroschwald S, Munder MC, Maharana S, Franzmann TM, Richter D, Ruer M, Hyman AA, Alberti S

Cell reports, 2018

doi:10.1016/j.celrep.2018.05.041.

Controlling compartmentalization by non-membrane-bound organelles.

Wheeler RJ, Hyman AA

Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2018

doi:10.1098/rstb.2017.0193.

RNA buffers the phase separation behavior of prion-like RNA binding proteins.

Maharana S, Wang J, Papadopoulos DK, Richter D, Pozniakovsky A, Poser I, Bickle M, Rizk S, Guillén-Boixet J, Franzmann TM, Jahnel M, Marrone L, Chang YT, Sterneckert J, Tomancak P, Hyman AA, Alberti S

Science (New York, N.Y.), 2018

doi:10.1126/science.aar7366.

Protein Dynamics in Complex DNA Lesions.

Aleksandrov R, Dotchev A, Poser I, Krastev D, Georgiev G, Panova G, Babukov Y, Danovski G, Dyankova T, Hubatsch L, Ivanova A, Atemin A, Nedelcheva-Veleva MN, Hasse S, Sarov M, Buchholz F, Hyman AA, Grill SW, Stoynov SS

Molecular cell, 2018

doi:10.1016/j.molcel.2018.02.016.

Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria.

Hsu F, Spannl S, Ferguson C, Hyman AA, Parton RG, Zerial M

eLife, 2018

doi:10.7554/elife.32282.

Tau protein liquid-liquid phase separation can initiate tau aggregation.

Wegmann S, Eftekharzadeh B, Tepper K, Zoltowska KM, Bennett RE, Dujardin S, Laskowski PR, MacKenzie D, Kamath T, Commins C, Vanderburg C, Roe AD, Fan Z, Molliex AM, Hernandez-Vega A, Muller D, Hyman AA, Mandelkow E, Taylor JP, Hyman BT

The EMBO journal, 2018

doi:10.15252/embj.201798049.

Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation.

Naumann M, Pal A, Goswami A, Lojewski X, Japtok J, Vehlow A, Naujock M, Günther R, Jin M, Stanslowsky N, Reinhardt P, Sterneckert J, Frickenhaus M, Pan-Montojo F, Storkebaum E, Poser I, Freischmidt A, Weishaupt JH, Holzmann K, Troost D, Ludolph AC, Boeckers TM, Liebau S, Petri S, Cordes N, Hyman AA, Wegner F, Grill SW, Weis J, Storch A, Hermann A

Nature communications, 2018

doi:10.1038/s41467-017-02299-1.

Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy.

Marrone L, Poser I, Casci I, Japtok J, Reinhardt P, Janosch A, Andree C, Lee HO, Moebius C, Koerner E, Reinhardt L, Cicardi ME, Hackmann K, Klink B, Poletti A, Alberti S, Bickle M, Hermann A, Pandey UB, Hyman AA, Sterneckert JL

Stem cell reports, 2018

doi:10.1016/j.stemcr.2017.12.018.

Phosphatase PP2A and microtubule-mediated pulling forces disassemble centrosomes during mitotic exit.

Enos SJ, Dressler M, Gomes BF, Hyman AA, Woodruff JB

Biology open, 2018

doi:10.1242/bio.029777.

Phase separation of a yeast prion protein promotes cellular fitness

Franzmann T, Jahnel M, Pozniakovsky A, Mahamid J, Holehouse AS, Nüske E, Richter D, Baumeister W, Grill SW, Pappu RV, Hyman AA, Alberti S

2018

doi:10.1126/science.aao5654.

Phase separation of a yeast prion protein promotes cellular fitness.

Franzmann T, Jahnel M, Pozniakovsky A, Mahamid J, Holehouse AS, Nüske E, Richter D, Baumeister W, Grill SW, Pappu RV, Hyman AA, Alberti S

Science, 2018

doi:10.1126/science.aao5654.

Organization and Function of Non-dynamic Biomolecular Condensates.

Woodruff JB, Hyman AA, Boke E

Trends in biochemical sciences, 2017

doi:10.1016/j.tibs.2017.11.005.

Molecular biology: A liquid reservoir for silent chromatin.

Klosin A, Hyman AA

Nature, 2017

doi:10.1038/nature23089.

An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function.

Mateju D, Franzmann TM, Patel A, Kopach A, Boczek EE, Maharana S, Lee HO, Carra S, Hyman AA, Alberti S

The EMBO journal, 2017

doi:10.15252/embj.201695957.

The centrosome is a selective phase that nucleates microtubules by concentrating tubulin

Woodruff JB, Ferreira Gomes B, Widlund PO, Mahamid J, Honigmann A and Hyman AA.

2017

doi:10.1016/j.cell.2017.05.028.

Stem cells: the new "model organism".

Drubin DG, Hyman AA

Molecular biology of the cell, 2017

doi:10.1091/mbc.e17-03-0183.

The centrosome is a selective phase that nucleates microtubules by concentrating tubulin.

Woodruff JB, Ferreira Gomes B, Widlund PO, Mahamid J, Honigmann A and Hyman AA.

Cell, 2017

doi:10.1016/j.cell.2017.05.028.

Biomolecular condensates: organizers of cellular biochemistry.

Banani SF, Lee HO, Hyman AA, Rosen MK

Nature reviews. Molecular cell biology, 2017

doi:10.1038/nrm.2017.7.

ATP as a biological hydrotrope.

Patel A, Malinovska L, Saha S, Wang J, Alberti S, Krishnan Y, Hyman AA

Science (New York, N.Y.), 2017

doi:10.1126/science.aaf6846.

In vitro Reconstitution of a Membrane Switch Mechanism for the Polarity Protein LGL.

Visco I, Hoege C, Hyman AA, Schwille P

Journal of molecular biology, 2016

doi:10.1016/j.jmb.2016.10.003.

Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation.

Wueseke O, Zwicker D, Schwager A, Wong YL, Oegema K, Jülicher F, Hyman AA, Woodruff JB

Biology open, 2016

doi:10.1242/bio.020990.

The Mitotic Spindle in the One-Cell C. elegans Embryo Is Positioned with High Precision and Stability.

Pécréaux J, Redemann S, Alayan Z, Mercat B, Pastezeur S, Garzon-Coral C, Hyman AA, Howard J

Biophysical journal, 2016

doi:10.1016/j.bpj.2016.09.007.

Are aberrant phase transitions a driver of cellular aging?

Alberti S, Hyman AA

BioEssays, 2016

doi:10.1002/bies.201600042.

A locus in Pristionchus pacificus that is responsible for the ability to give rise to fertile offspring at higher temperatures.

Leaver M, Kienle S, Begasse ML, Sommer RJ, Hyman AA

Biology open, 2016

doi:10.1242/bio.018127.

Rheology of the Active Cell Cortex in Mitosis.

Fischer-Friedrich E, Toyoda Y, Cattin CJ, Müller DJ, Hyman AA, Jülicher F

Biophysical journal, 2016

doi:10.1016/j.bpj.2016.06.008.

Amyloid-like Self-Assembly of a Cellular Compartment.

Boke E, Ruer M, Wühr M, Coughlin M, Lemaitre R, Gygi SP, Alberti S, Drechsel D, Hyman AA, Mitchison TJ

Cell, 2016

doi:10.1016/j.cell.2016.06.051.

Ki-67 acts as a biological surfactant to disperse mitotic chromosomes.

Cuylen S, Blaukopf C, Politi AZ, Müller-Reichert T, Neumann B, Poser I, Ellenberg J, Hyman AA, Gerlich DW

Nature, 2016

doi:10.1038/nature18610.

Priority of discovery in the life sciences.

Vale RD, Hyman AA

eLife, 2016

doi:10.7554/elife.16931.

Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length.

Zheng X, Ramani A, Soni K, Gottardo M, Zheng S, Ming Gooi L, Li W, Feng S, Mariappan A, Wason A, Widlund P, Pozniakovsky A, Poser I, Deng H, Ou G, Riparbelli M, Giuliano C, Hyman AA, Sattler M, Gopalakrishnan J, Li H

Nature communications, 2016

doi:10.1038/ncomms11874.

PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins.

Guerrera D, Shah J, Vasileva E, Sluysmans S, Méan I, Jond L, Poser I, Mann M, Hyman AA, Citi S

The Journal of biological chemistry, 2016

doi:10.1074/jbc.M115.712935.

CPAP promotes timely cilium disassembly to maintain neural progenitor pool.

Gabriel E, Wason A, Ramani A, Gooi LM, Keller P, Pozniakovsky A, Poser I, Noack F, Telugu NS, Calegari F, Šarić T, Hescheler J, Hyman AA, Gottardo M, Callaini G, Alkuraya FS, Gopalakrishnan J

The EMBO journal, 2016

doi:10.15252/embj.201593679.

Visualizing the molecular sociology at the HeLa cell nuclear periphery

Mahamid J, Pfeffer S, Schaffer M, Villa E, Danev R, Cuellar LK, Förster F, Hyman AA, Plitzko JM, Baumeister W

Science (New York, N.Y.), 2016

doi:10.1126/science.aad8857.

Visualizing the molecular sociology at the HeLa cell nuclear periphery.

Mahamid J, Pfeffer S, Schaffer M, Villa E, Danev R, Cuellar LK, Förster F, Hyman AA, Plitzko JM, Baumeister W

Science (New York, N.Y.), 2016

doi:10.1126/science.aad8857.

Site-Specific Cryo-focused Ion Beam Sample Preparation Guided by 3D Correlative Microscopy

Arnold J, Mahamid J, Lucic V, de Marco A, Fernandez JJ, Laugks T, Mayer T, Hyman AA, Baumeister W, Plitzko JM

Biophysical journal, 2016

doi:10.1016/j.bpj.2015.10.053.

Site-Specific Cryo-focused Ion Beam Sample Preparation Guided by 3D Correlative Microscopy.

Arnold J, Mahamid J, Lucic V, de Marco A, Fernandez JJ, Laugks T, Mayer T, Hyman AA, Baumeister W, Plitzko JM

Biophysical journal, 2016

doi:10.1016/j.bpj.2015.10.053.

Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement.

Sorce B, Escobedo C, Toyoda Y, Stewart MP, Cattin CJ, Newton R, Banerjee I, Stettler A, Roska B, Eaton S, Hyman AA, Hierlemann A, Müller DJ

Nature communications, 2015

doi:10.1038/ncomms9872.

A focused ion beam milling and lift-out approach for site-specific preparation of frozen-hydrated lamellas from multicellular organisms

Mahamid J, Schampers R, Persoon H, Hyman AA, Baumeister W, Plitzko JM

Journal of structural biology, 2015

doi:10.1016/j.jsb.2015.07.012.

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.

Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M

Cell, 2015

doi:10.1016/j.cell.2015.09.053.

TransgeneOmics--A transgenic platform for protein localization based function exploration.

Hasse S, Hyman AA, Sarov M

Methods (San Diego, Calif.), 2015

doi:10.1016/j.ymeth.2015.10.005.

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

Patel A, Lee HO, Jawerth L, Maharana S, Jahnel M, Hein MY, Stoynov S, Mahamid J, Saha S, Franzmann TM, Pozniakovski A, Poser I, Maghelli N, Royer LA, Weigert M, Myers EW, Grill S, Drechsel D, Hyman AA, Alberti S

Cell, 2015

doi:10.1016/j.cell.2015.07.047.

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.

Patel A, Lee HO, Jawerth L, Maharana S, Jahnel M, Hein MY, Stoynov S, Mahamid J, Saha S, Franzmann TM, Pozniakovski A, Poser I, Maghelli N, Royer LA, Weigert M, Myers EW, Grill S, Drechsel D, Hyman AA, Alberti S

Cell, 2015

doi:10.1016/j.cell.2015.07.047.

Suppression of Ostwald ripening in active emulsions.

Zwicker D, Hyman AA, Jülicher F

Physical review. E, Statistical, nonlinear, and soft matter physics, 2015

doi:10.1103/physreve.92.012317.

Emergent Properties of the Metaphase Spindle.

Reber S, Hyman AA

Cold Spring Harbor perspectives in biology, 2015

doi:10.1101/cshperspect.a015784.

Method: In vitro analysis of pericentriolar material assembly.

Woodruff JB, Hyman AA

Methods in cell biology, 2015

doi:10.1016/bs.mcb.2015.04.006.

Centrosomes. Regulated assembly of a supramolecular centrosome scaffold in vitro.

Woodruff JB, Wueseke O, Viscardi V, Mahamid J, Ochoa SD, Bunkenborg J, Widlund PO, Pozniakovsky A, Zanin E, Bahmanyar S, Zinke A, Hong SH, Decker M, Baumeister W, Andersen JS, Oegema K, Hyman AA

Science (New York, N.Y.), 2015

doi:10.1126/science.aaa3923.

Temperature Dependence of Cell Division Timing Accounts for a Shift in the Thermal Limits of C. elegans and C. briggsae.

Begasse ML, Leaver M, Vazquez F, Grill SW, Hyman AA

Cell reports, 2015

doi:10.1016/j.celrep.2015.01.006.

Cdk1-dependent mitotic enrichment of cortical myosin II promotes cell rounding against confinement.

Ramanathan SP, Helenius J, Stewart MP, Cattin CJ, Hyman AA, Muller DJ

Nature cell biology, 2015

doi:10.1038/ncb3098.

Quantitative comparison of a human cancer cell surface proteome between interphase and mitosis.

Özlü N, Qureshi MH, Toyoda Y, Renard BY, Mollaoglu G, Özkan NE, Bulbul S, Poser I, Timm W, Hyman AA, Mitchison TJ, Steen JA

The EMBO journal, 2015

doi:10.15252/embj.201385162.

Liquid-liquid phase separation in biology.

Hyman AA, Weber CA, Jülicher F

Annual review of cell and developmental biology, 2014

doi:10.1146/annurev-cellbio-100913-013325.

Pericentriolar material structure and dynamics.

Woodruff JB, Wueseke O, Hyman AA

Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2014

doi:10.1098/rstb.2013.0459.

Quantification of surface tension and internal pressure generated by single mitotic cells.

Fischer-Friedrich E, Hyman AA, Jülicher F, Müller DJ, Helenius J

Scientific reports, 2014

doi:10.1038/srep06213.

The Caenorhabditis elegans pericentriolar material components SPD-2 and SPD-5 are monomeric in the cytoplasm before incorporation into the PCM matrix.

Wueseke O, Bunkenborg J, Hein MY, Zinke A, Viscardi V, Woodruff JB, Oegema K, Mann M, Andersen JS, Hyman AA

Molecular biology of the cell, 2014

doi:10.1091/mbc.e13-09-0514.

Coiled-coil proteins facilitated the functional expansion of the centrosome.

Kuhn M, Hyman AA, Beyer A

PLoS computational biology, 2014

doi:10.1371/journal.pcbi.1003657.

Timing and mechanism of the initial cue establishing handed left–right asymmetry in Caenorhabditis elegans embryos.

Schonegg S, Hyman AA, Wood WB

Genesis (New York, N.Y. : 2000), 2014

doi:10.1002/dvg.22749.

Centrosomes are autocatalytic droplets of pericentriolar material organized by centrioles.

Zwicker D, Decker M, Jaensch S, Hyman AA, Jülicher F

Proceedings of the National Academy of Sciences of the United States of America, 2014

doi:10.1073/pnas.1404855111.

Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival.

Toyoda Y, Erkut C, Pan-Montojo F, Boland S, Stewart MP, Müller DJ, Wurst W, Hyman AA, Kurzchalia TV

Biology open, 2014

doi:10.1242/bio.20149399.

Encouraging innovation.

Hyman AA

Molecular biology of the cell, 2014

doi:10.1091/mbc.e13-10-0596.

Conserved TCP domain of Sas-4/CPAP is essential for pericentriolar material tethering during centrosome biogenesis.

Zheng X, Gooi LM, Wason A, Gabriel E, Mehrjardi NZ, Yang Q, Zhang X, Debec A, Basiri ML, Avidor-Reiss T, Pozniakovsky A, Poser I, Saric T, Hyman AA, Li H, Gopalakrishnan J

Proceedings of the National Academy of Sciences of the United States of America, 2014

doi:10.1073/pnas.1317535111.

The segmentation of microtubules in electron tomograms using Amira.

Redemann S, Weber B, Möller M, Verbavatz JM, Hyman AA, Baum D, Prohaska S, Müller-Reichert T

Methods in molecular biology (Clifton, N.J.), 2014

doi:10.1007/978-1-4939-0329-0_12.

C11ORF24 is a novel type I membrane protein that cycles between the Golgi apparatus and the plasma membrane in Rab6-positive vesicles.

Fraisier V, Kasri A, Miserey-Lenkei S, Sibarita JB, Nair D, Mayeux A, Bardin S, Toyoda Y, Poser I, Poznyakovskiy A, Goud B, Hyman AA, Dimitrov A

PloS one, 2013

doi:10.1371/journal.pone.0082223.

XMAP215 activity sets spindle length by controlling the total mass of spindle microtubules.

Reber SB, Baumgart J, Widlund PO, Pozniakovsky A, Howard J, Hyman AA, Jülicher F

Nature cell biology, 2013

doi:10.1038/ncb2834.

Spatial organization of the cell cytoplasm by position-dependent phase separation.

Lee CF, Brangwynne CP, Gharakhani J, Hyman AA, Jülicher F

Physical review letters, 2013

doi:10.1103/physrevlett.111.088101.

Synergy between XMAP215 and EB1 increases microtubule growth rates to physiological levels.

Zanic M, Widlund PO, Hyman AA, Howard J

Nature cell biology, 2013

doi:10.1038/ncb2744.

Principles of PAR polarity in Caenorhabditis elegans embryos.

Hoege C, Hyman AA

Nature reviews. Molecular cell biology, 2013

doi:10.1038/nrm3558.

A genomic toolkit to investigate kinesin and myosin motor function in cells.

Maliga Z, Junqueira M, Toyoda Y, Ettinger A, Mora-Bermúdez F, Klemm RW, Vasilj A, Guhr E, Ibarlucea-Benitez I, Poser I, Bonifacio E, Huttner WB, Shevchenko A, Hyman AA

Nature cell biology, 2013

doi:10.1038/ncb2689.

A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility.

Bassik MC, Kampmann M, Lebbink RJ, Wang S, Hein MY, Poser I, Weibezahn J, Horlbeck MA, Chen S, Mann M, Hyman AA, Leproust EM, McManus MT, Weissman JS

Cell, 2013

doi:10.1016/j.cell.2013.01.030.

Funding innovative science.

Hyman AA

Science (New York, N.Y.), 2013

doi:10.1126/science.1234741.

Stoichiometry of chromatin-associated protein complexes revealed by label-free quantitative mass spectrometry-based proteomics.

Smits AH, Jansen PW, Poser I, Hyman AA, Vermeulen M

Nucleic acids research, 2013

doi:10.1093/nar/gks941.

APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.

Uzunova K, Dye BT, Schutz H, Ladurner R, Petzold G, Toyoda Y, Jarvis MA, Brown NG, Poser I, Novatchkova M, Mechtler K, Hyman AA, Stark H, Schulman BA, Peters JM

Nature structural & molecular biology, 2012

doi:10.1038/nsmb.2412.

One-step purification of assembly-competent tubulin from diverse eukaryotic sources.

Widlund PO, Podolski M, Reber S, Alper J, Storch M, Hyman AA, Howard J, Drechsel DN

Molecular biology of the cell, 2012

doi:10.1091/mbc.e12-06-0444.

BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures.

Splinter D, Razafsky DS, Schlager MA, Serra-Marques A, Grigoriev I, Demmers J, Keijzer N, Jiang K, Poser I, Hyman AA, Hoogenraad CC, King SJ, Akhmanova A

Molecular biology of the cell, 2012

doi:10.1091/mbc.e12-03-0210.

A genome-scale resource for in vivo tag-based protein function exploration in C. elegans.

Sarov M, Murray JI, Schanze K, Pozniakovski A, Niu W, Angermann K, Hasse S, Rupprecht M, Vinis E, Tinney M, Preston E, Zinke A, Enst S, Teichgraber T, Janette J, Reis K, Janosch S, Schloissnig S, Ejsmont RK, Slightam C, Xu X, Kim SK, Reinke V, Stewart AF, Snyder M, Waterston RH, Hyman AA

Cell, 2012

doi:10.1016/j.cell.2012.08.001.

Cell biology. Beyond oil and water--phase transitions in cells.

Hyman AA, Simons K

Science (New York, N.Y.), 2012

doi:10.1126/science.1223728.

Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores.

Wurzenberger C, Held M, Lampson MA, Poser I, Hyman AA, Gerlich DW

The Journal of cell biology, 2012

doi:10.1083/jcb.201112112.

Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions.

Frost A, Elgort MG, Brandman O, Ives C, Collins SR, Miller-Vedam L, Weibezahn J, Hein MY, Poser I, Mann M, Hyman AA, Weissman JS

Cell, 2012

doi:10.1016/j.cell.2012.04.028.

Organelle growth control through limiting pools of cytoplasmic components.

Goehring NW, Hyman AA

Current biology : CB, 2012

doi:10.1016/j.cub.2012.03.046.

Tracking mechanics and volume of globular cells with atomic force microscopy using a constant-height clamp.

Stewart MP, Toyoda Y, Hyman AA, Müller DJ

Nature protocols, 2012

doi:10.1038/nprot.2011.434.

GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration

Scolz M, Widlund PO, Piazza S, Bublik DR, Reber S, Peche LY, Ciani Y, Hubner N, Isokane M, Monte M, Ellenberg J, Hyman AA, Schneider C, Bird AW

PloS one, 2012

doi:10.1371/journal.pone.0051259.

High-efficiency counterselection recombineering for site-directed mutagenesis in bacterial artificial chromosomes.

Bird AW, Erler A, Fu J, Hériché JK, Maresca M, Zhang Y, Hyman AA, Stewart AF

Nature methods, 2012

doi:10.1038/nmeth.1803.

High-efficiency counterselection recombineering for site-directed mutagenesis in bacterial artificial chromosomes

Bird AW, Erler A, Fu J, Hériché JK, Maresca M, Zhang Y, Hyman AA, Stewart AF

Nature methods, 2012

doi:10.1038/nmeth.1803.

GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration.

Scolz M, Widlund PO, Piazza S, Bublik DR, Reber S, Peche LY, Ciani Y, Hubner N, Isokane M, Monte M, Ellenberg J, Hyman AA, Schneider C, Bird AW

PloS one, 2012

doi:10.1371/journal.pone.0051259.

Purification of tubulin from porcine brain.

Gell C, Friel CT, Borgonovo B, Drechsel DN, Hyman AA, Howard J

Methods in molecular biology (Clifton, N.J.), 2011

doi:10.1007/978-1-61779-252-6_2.

Whither systems biology.

Hyman AA

Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2011

doi:10.1098/rstb.2011.0074.

Automated tracing of microtubules in electron tomograms of plastic embedded samples of Caenorhabditis elegans embryos.

Weber B, Greenan G, Prohaska S, Baum D, Hege HC, Müller-Reichert T, Hyman AA, Verbavatz JM

Journal of structural biology, 2011

doi:10.1016/j.jsb.2011.12.004.

Samurai sword sets spindle size.

Reber S, Hyman AA

Cell, 2011

doi:10.1016/j.cell.2011.11.039.

Polarization of PAR proteins by advective triggering of a pattern-forming system.

Goehring NW, Trong PK, Bois JS, Chowdhury D, Nicola EM, Hyman AA, Grill SW

Science (New York, N.Y.), 2011

doi:10.1126/science.1208619.

Proliferating versus differentiating stem and cancer cells exhibit distinct midbody-release behaviour.

Ettinger AW, Wilsch-Bräuninger M, Marzesco AM, Bickle M, Lohmann A, Maliga Z, Karbanová J, Corbeil D, Hyman AA, Huttner WB

Nature communications, 2011

doi:10.1038/ncomms1511.

Limiting amounts of centrosome material set centrosome size in C. elegans embryos.

Decker M, Jaensch S, Pozniakovsky A, Zinke A, O'Connell KF, Zachariae W, Myers E, Hyman AA

Current biology : CB, 2011

doi:10.1016/j.cub.2011.06.002.

Beyond stereospecificity: liquids and mesoscale organization of cytoplasm.

Hyman AA, Brangwynne CP

Developmental cell, 2011

doi:10.1016/j.devcel.2011.06.013.

Force probing cell shape changes to molecular resolution.

Stewart MP, Toyoda Y, Hyman AA, Muller DJ

Trends in biochemical sciences, 2011

doi:10.1016/j.tibs.2011.05.001.

A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue.

Green RA, Kao HL, Audhya A, Arur S, Mayers JR, Fridolfsson HN, Schulman M, Schloissnig S, Niessen S, Laband K, Wang S, Starr DA, Hyman AA, Schedl T, Desai A, Piano F, Gunsalus KC, Oegema K

Cell, 2011

doi:10.1016/j.cell.2011.03.037.

PAR proteins diffuse freely across the anterior-posterior boundary in polarized C. elegans embryos.

Goehring NW, Hoege C, Grill SW, Hyman AA

The Journal of cell biology, 2011

doi:10.1083/jcb.201011094.

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.

Jakobsen L, Vanselow K, Skogs M, Toyoda Y, Lundberg E, Poser I, Falkenby LG, Bennetzen M, Westendorf J, Nigg EA, Uhlen M, Hyman AA, Andersen JS

The EMBO journal, 2011

doi:10.1038/emboj.2011.63.

Codon adaptation-based control of protein expression in C. elegans.

Redemann S, Schloissnig S, Ernst S, Pozniakowsky A, Ayloo S, Hyman AA, Bringmann H

Nature methods, 2011

doi:10.1038/nmeth.1565.

Codon adaptation-based control of protein expression in C. elegans

Redemann S, Schloissnig S, Ernst S, Pozniakowsky A, Ayloo S, Hyman AA, Bringmann H

Nature methods, 2011

doi:10.1038/nmeth.1565.

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes.

Brangwynne CP, Mitchison TJ, Hyman AA

Proceedings of the National Academy of Sciences of the United States of America, 2011

doi:10.1073/pnas.1017150108.

XMAP215 polymerase activity is built by combining multiple tubulin-binding TOG domains and a basic lattice-binding region.

Widlund PO, Stear JH, Pozniakovsky A, Zanic M, Reber S, Brouhard GJ, Hyman AA, Howard J

Proceedings of the National Academy of Sciences of the United States of America, 2011

doi:10.1073/pnas.1016498108.

Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding.

Stewart MP, Helenius J, Toyoda Y, Ramanathan SP, Muller DJ, Hyman AA

Nature, 2011

doi:10.1038/nature09642.

Systematic phosphorylation analysis of human mitotic protein complexes

Hegemann B, Hutchins JR, Hudecz O, Novatchkova M, Rameseder J, Sykora MM, Liu S, Mazanek M, Lénárt P, Hériché JK, Poser I, Kraut N, Hyman AA, Yaffe MB, Mechtler K, Peters JM

Science signaling, 2011

doi:10.1126/scisignal.2001993.

Systematic phosphorylation analysis of human mitotic protein complexes.

Hegemann B, Hutchins JR, Hudecz O, Novatchkova M, Rameseder J, Sykora MM, Liu S, Mazanek M, Lénárt P, Hériché JK, Poser I, Kraut N, Hyman AA, Yaffe MB, Mechtler K, Peters JM

Science signaling, 2011

doi:10.1126/scisignal.2001993.

The first cell cycle of the Caenorhabditis elegans embryo: spatial and temporal control of an asymmetric cell division.

Begasse ML, Hyman AA

Results and problems in cell differentiation, 2011

doi:10.1007/978-3-642-19065-0_6.

Diverse transcription factor binding features revealed by genome-wide ChIP-seq in C. elegans.

Niu W, Lu ZJ, Zhong M, Sarov M, Murray JI, Brdlik CM, Janette J, Chen C, Alves P, Preston E, Slightham C, Jiang L, Hyman AA, Kim SK, Waterston RH, Gerstein M, Snyder M, Reinke V

Genome research, 2010

doi:10.1101/gr.114587.110.

Sororin mediates sister chromatid cohesion by antagonizing Wapl.

Nishiyama T, Ladurner R, Schmitz J, Kreidl E, Schleiffer A, Bhaskara V, Bando M, Shirahige K, Hyman AA, Mechtler K, Peters JM

Cell, 2010

doi:10.1016/j.cell.2010.10.031.

FRAP analysis of membrane-associated proteins: lateral diffusion and membrane-cytoplasmic exchange.

Goehring NW, Chowdhury D, Hyman AA, Grill SW

Biophysical journal, 2010

doi:10.1016/j.bpj.2010.08.033.

Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.

Vermeulen M, Eberl HC, Matarese F, Marks H, Denissov S, Butter F, Lee KK, Olsen JV, Hyman AA, Stunnenberg HG, Mann M

Cell, 2010

doi:10.1016/j.cell.2010.08.020.

Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells.

Schmitz MH, Held M, Janssens V, Hutchins JR, Hudecz O, Ivanova E, Goris J, Trinkle-Mulcahy L, Lamond AI, Poser I, Hyman AA, Mechtler K, Peters JM, Gerlich DW

Nature cell biology, 2010

doi:10.1038/ncb2092.

LGL can partition the cortex of one-cell Caenorhabditis elegans embryos into two domains.

Hoege C, Constantinescu AT, Schwager A, Goehring NW, Kumar P, Hyman AA

Current biology : CB, 2010

doi:10.1016/j.cub.2010.05.061.

Automated tracking and analysis of centrosomes in early Caenorhabditis elegans embryos.

Jaensch S, Decker M, Hyman AA, Myers EW

Bioinformatics (Oxford, England), 2010

doi:10.1093/bioinformatics/btq190.

Cortical domain correction repositions the polarity boundary to match the cytokinesis furrow in C. elegans embryos.

Schenk C, Bringmann H, Hyman AA, Cowan CR

Development (Cambridge, England), 2010

doi:10.1242/dev.040436.

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes.

Neumann B, Walter T, Hériché JK, Bulkescher J, Erfle H, Conrad C, Rogers P, Poser I, Held M, Liebel U, Cetin C, Sieckmann F, Pau G, Kabbe R, Wünsche A, Satagopam V, Schmitz MH, Chapuis C, Gerlich DW, Schneider R, Eils R, Huber W, Peters JM, Hyman AA, Durbin R, Pepperkok R, Ellenberg J

Nature, 2010

doi:10.1038/nature08869.

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM

Science (New York, N.Y.), 2010

doi:10.1126/science.1181348.

Systematic analysis of human protein complexes identifies chromosome segregation proteins

Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM

Science (New York, N.Y.), 2010

doi:10.1126/science.1181348.

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes

Neumann B, Walter T, Hériché JK, Bulkescher J, Erfle H, Conrad C, Rogers P, Poser I, Held M, Liebel U, Cetin C, Sieckmann F, Pau G, Kabbe R, Wünsche A, Satagopam V, Schmitz MH, Chapuis C, Gerlich DW, Schneider R, Eils R, Huber W, Peters JM, Hyman AA, Durbin R, Pepperkok R, Ellenberg J

Nature, 2010

doi:10.1038/nature08869.

Centrosome size sets mitotic spindle length in Caenorhabditis elegans embryos.

Greenan G, Brangwynne CP, Jaensch S, Gharakhani J, Jülicher F, Hyman AA

Current biology : CB, 2010

doi:10.1016/j.cub.2009.12.050.

Genome-wide identification of binding sites defines distinct functions for Caenorhabditis elegans PHA-4/FOXA in development and environmental response.

Zhong M, Niu W, Lu ZJ, Sarov M, Murray JI, Janette J, Raha D, Sheaffer KL, Lam HY, Preston E, Slightham C, Hillier LW, Brock T, Agarwal A, Auerbach R, Hyman AA, Gerstein M, Mango SE, Kim SK, Waterston RH, Reinke V, Snyder M

PLoS genetics, 2010

doi:10.1371/journal.pgen.1000848.

Membrane invaginations reveal cortical sites that pull on mitotic spindles in one-cell C. elegans embryos.

Redemann S, Pecreaux J, Goehring NW, Khairy K, Stelzer EH, Hyman AA, Howard J

PloS one, 2010

doi:10.1371/journal.pone.0012301.

Membrane invaginations reveal cortical sites that pull on mitotic spindles in one-cell C. elegans embryos

Redemann S, Pecreaux J, Goehring NW, Khairy K, Stelzer EH, Hyman AA, Howard J

PloS one, 2010

doi:10.1371/journal.pone.0012301.

EB1 recognizes the nucleotide state of tubulin in the microtubule lattice.

Zanic M, Stear JH, Hyman AA, Howard J

PloS one, 2009

doi:10.1371/journal.pone.0007585.

Growth, fluctuation and switching at microtubule plus ends.

Howard J, Hyman AA

Nature reviews. Molecular cell biology, 2009

doi:10.1038/nrm2713.

Germline P granules are liquid droplets that localize by controlled dissolution/condensation.

Brangwynne CP, Eckmann CR, Courson DS, Rybarska A, Hoege C, Gharakhani J, Jülicher F, Hyman AA

Science (New York, N.Y.), 2009

doi:10.1126/science.1172046.

Comparative profiling identifies C13orf3 as a component of the Ska complex required for mammalian cell division.

Theis M, Slabicki M, Junqueira M, Paszkowski-Rogacz M, Sontheimer J, Kittler R, Heninger AK, Glatter T, Kruusmaa K, Poser I, Hyman AA, Pisabarro MT, Gstaiger M, Aebersold R, Shevchenko A, Buchholz F

The EMBO journal, 2009

doi:10.1038/emboj.2009.114.

HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity.

Lawo S, Bashkurov M, Mullin M, Ferreria MG, Kittler R, Habermann B, Tagliaferro A, Poser I, Hutchins JR, Hegemann B, Pinchev D, Buchholz F, Peters JM, Hyman AA, Gingras AC, Pelletier L

Current biology : CB, 2009

doi:10.1016/j.cub.2009.04.033.

Characterization of protein dynamics in asymmetric cell division by scanning fluorescence correlation spectroscopy.

Petrásek Z, Hoege C, Mashaghi A, Ohrt T, Hyman AA, Schwille P

Biophysical journal, 2008

doi:10.1529/biophysj.108.135152.

Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication.

Mouysset J, Deichsel A, Moser S, Hoege C, Hyman AA, Gartner A, Hoppe T

Proceedings of the National Academy of Sciences of the United States of America, 2008

doi:10.1073/pnas.0805944105.

A protein domain-based interactome network for C. elegans early embryogenesis.

Boxem M, Maliga Z, Klitgord N, Li N, Lemmens I, Mana M, de Lichtervelde L, Mul JD, van de Peut D, Devos M, Simonis N, Yildirim MA, Cokol M, Kao HL, de Smet AS, Wang H, Schlaitz AL, Hao T, Milstein S, Fan C, Tipsword M, Drew K, Galli M, Rhrissorrakrai K, Drechsel D, Koller D, Roth FP, Iakoucheva LM, Dunker AK, Bonneau R, Gunsalus KC, Hill DE, Piano F, Tavernier J, van den Heuvel S, Hyman AA, Vidal M

Cell, 2008

doi:10.1016/j.cell.2008.07.009.

Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A.

Bird AW, Hyman AA

The Journal of cell biology, 2008

doi:10.1083/jcb.200802005.

BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals.

Poser I, Sarov M, Hutchins JR, Hériché JK, Toyoda Y, Pozniakovsky A, Weigl D, Nitzsche A, Hegemann B, Bird AW, Pelletier L, Kittler R, Hua S, Naumann R, Augsburg M, Sykora MM, Hofemeister H, Zhang Y, Nasmyth K, White KP, Dietzel S, Mechtler K, Durbin R, Stewart AF, Peters JM, Buchholz F, Hyman AA

Nature methods, 2008

doi:10.1038/nmeth.1199.

The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis.

Zhu F, Lawo S, Bird A, Pinchev D, Ralph A, Richter C, Müller-Reichert T, Kittler R, Hyman AA, Pelletier L

Current biology : CB, 2008

doi:10.1016/j.cub.2007.12.055.

XMAP215 is a processive microtubule polymerase.

Brouhard GJ, Stear JH, Noetzel TL, Al-Bassam J, Kinoshita K, Harrison SC, Howard J, Hyman AA

Cell, 2008

doi:10.1016/j.cell.2007.11.043.

Genome-scale RNAi profiling of cell division in human tissue culture cells.

Kittler R, Pelletier L, Heninger AK, Slabicki M, Theis M, Miroslaw L, Poser I, Lawo S, Grabner H, Kozak K, Wagner J, Surendranath V, Richter C, Bowen W, Jackson AL, Habermann B, Hyman AA, Buchholz F

Nature cell biology, 2007

doi:10.1038/ncb1659.

Efficient chaperone-mediated tubulin biogenesis is essential for cell division and cell migration in C. elegans.

Lundin VF, Srayko M, Hyman AA, Leroux MR

Developmental biology, 2007

doi:10.1016/j.ydbio.2007.10.022.

Straight GDP-tubulin protofilaments form in the presence of taxol.

Elie-Caille C, Severin F, Helenius J, Howard J, Muller DJ, Hyman AA

Current biology : CB, 2007

doi:10.1016/j.cub.2007.08.063.

The Rho GTPase-activating proteins RGA-3 and RGA-4 are required to set the initial size of PAR domains in Caenorhabditis elegans one-cell embryos.

Schonegg S, Constantinescu AT, Hoege C, Hyman AA

Proceedings of the National Academy of Sciences of the United States of America, 2007

doi:10.1073/pnas.0706941104.

Stress generation and filament turnover during actin ring constriction.

Zumdieck A, Kruse K, Bringmann H, Hyman AA, Jülicher F

PloS one, 2007

doi:10.1371/journal.pone.0000696.

Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression.

Stirling PC, Srayko M, Takhar KS, Pozniakovsky A, Hyman AA, Leroux MR

Molecular biology of the cell, 2007

doi:10.1091/mbc.e07-01-0069.

Crystal structure of a TOG domain: conserved features of XMAP215/Dis1-family TOG domains and implications for tubulin binding.

Al-Bassam J, Larsen NA, Hyman AA, Harrison SC

Structure (London, England : 1993), 2007

doi:10.1016/j.str.2007.01.012.

Acto-myosin reorganization and PAR polarity in C. elegans.

Cowan CR, Hyman AA

Development (Cambridge, England), 2007

doi:10.1242/dev.000513.

LET-99, GOA-1/GPA-16, and GPR-1/2 are required for aster-positioned cytokinesis.

Bringmann H, Cowan CR, Kong J, Hyman AA

Current biology : CB, 2007

doi:10.1016/j.cub.2006.11.070.

The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly.

Schlaitz AL, Srayko M, Dammermann A, Quintin S, Wielsch N, MacLeod I, de Robillard Q, Zinke A, Yates JR, Müller-Reichert T, Shevchenko A, Oegema K, Hyman AA

Cell, 2007

doi:10.1016/j.cell.2006.10.050.

Microtubule polymerases and depolymerases.

Howard J, Hyman AA

Current opinion in cell biology, 2006

doi:10.1016/j.ceb.2006.12.009.

Cyclin E-Cdk2 temporally regulates centrosome assembly and establishment of polarity in Caenorhabditis elegans embryos.

Cowan CR, Hyman AA

Nature cell biology, 2006

doi:10.1038/ncb1511.

Centriole assembly in Caenorhabditis elegans.

Pelletier L, O'Toole E, Schwager A, Hyman AA, Müller-Reichert T

Nature, 2006

doi:10.1038/nature05318.

Spindle oscillations during asymmetric cell division require a threshold number of active cortical force generators.

Pecreaux J, Röper JC, Kruse K, Jülicher F, Hyman AA, Grill SW, Howard J

Current biology : CB, 2006

doi:10.1016/j.cub.2006.09.030.

Katanin disrupts the microtubule lattice and increases polymer number in C. elegans meiosis.

Srayko M, O'toole ET, Hyman AA, Müller-Reichert T

Current biology : CB, 2006

doi:10.1016/j.cub.2006.08.029.

A recombineering pipeline for functional genomics applied to Caenorhabditis elegans.

Sarov M, Schneider S, Pozniakovski A, Roguev A, Ernst S, Zhang Y, Hyman AA, Stewart AF

Nature methods, 2006

doi:10.1038/nmeth933.

Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner.

Varga V, Helenius J, Tanaka K, Hyman AA, Tanaka TU, Howard J

Nature cell biology, 2006

doi:10.1038/ncb1462.

CDC-42 and RHO-1 coordinate acto-myosin contractility and PAR protein localization during polarity establishment in C. elegans embryos.

Schonegg S, Hyman AA

Development (Cambridge, England), 2006

doi:10.1242/dev.02527.

Global and local control of microtubule destabilization promoted by a catastrophe kinesin MCAK/XKCM1.

Kinoshita K, Noetzel TL, Arnal I, Drechsel DN, Hyman AA

Journal of muscle research and cell motility, 2006

doi:10.1007/s10974-005-9045-2.

Cell division.

Oegema K, Hyman AA

WormBook : the online review of C. elegans biology, 2006

doi:10.1895/wormbook.1.72.1.

Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis.

Kinoshita K, Noetzel TL, Pelletier L, Mechtler K, Drechsel DN, Schwager A, Lee M, Raff JW, Hyman AA

The Journal of cell biology, 2005

doi:10.1083/jcb.200503023.

Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules.

Barros TP, Kinoshita K, Hyman AA, Raff JW

The Journal of cell biology, 2005

doi:10.1083/jcb.200504097.

Identification and characterization of factors required for microtubule growth and nucleation in the early C. elegans embryo.

Srayko M, Kaya A, Stamford J, Hyman AA

Developmental cell, 2005

doi:10.1016/j.devcel.2005.07.003.

An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles.

Ozlü N, Srayko M, Kinoshita K, Habermann B, O'toole ET, Müller-Reichert T, Schmalz N, Desai A, Hyman AA

Developmental cell, 2005

doi:10.1016/j.devcel.2005.07.002.

A cytokinesis furrow is positioned by two consecutive signals.

Bringmann H, Hyman AA

Nature, 2005

doi:10.1038/nature03823.

Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis.

Gunsalus KC, Ge H, Schetter AJ, Goldberg DS, Han JD, Hao T, Berriz GF, Bertin N, Huang J, Chuang LS, Li N, Mani R, Hyman AA, Sönnichsen B, Echeverri CJ, Roth FP, Vidal M, Piano F

Nature, 2005

doi:10.1038/nature03876.

The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae.

Kurz T, Ozlü N, Rudolf F, O'Rourke SM, Luke B, Hofmann K, Hyman AA, Bowerman B, Peter M

Nature, 2005

doi:10.1038/nature03662.

Spindle positioning by cortical pulling forces.

Grill SW, Hyman AA

Developmental cell, 2005

doi:10.1016/j.devcel.2005.03.014.

Boveri revisited.

Hyman AA

The EMBO journal, 2005

doi:10.1038/sj.emboj.7600583.

Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans.

Sönnichsen B, Koski LB, Walsh A, Marschall P, Neumann B, Brehm M, Alleaume AM, Artelt J, Bettencourt P, Cassin E, Hewitson M, Holz C, Khan M, Lazik S, Martin C, Nitzsche B, Ruer M, Stamford J, Winzi M, Heinkel R, Röder M, Finell J, Häntsch H, Jones SJ, Jones M, Piano F, Gunsalus KC, Oegema K, Gönczy P, Coulson A, Hyman AA, Echeverri CJ

Nature, 2005

doi:10.1038/nature03353.

A comparison of the ability of XMAP215 and tau to inhibit the microtubule destabilizing activity of XKCM1.

Noetzel TL, Drechsel DN, Hyman AA, Kinoshita K

Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2005

doi:10.1098/rstb.2004.1613.

RNA interference rescue by bacterial artificial chromosome transgenesis in mammalian tissue culture cells.

Kittler R, Pelletier L, Ma C, Poser I, Fischer S, Hyman AA, Buchholz F

Proceedings of the National Academy of Sciences of the United States of America, 2005

doi:10.1073/pnas.0409861102.

Role of mitochondria in the pheromone- and amiodarone-induced programmed death of yeast.

Pozniakovsky AI, Knorre DA, Markova OV, Hyman AA, Skulachev VP, Severin FF

The Journal of cell biology, 2005

doi:10.1083/jcb.200408145.

Centrosomes direct cell polarity independently of microtubule assembly in C. elegans embryos.

Cowan CR, Hyman AA

Nature, 2004

doi:10.1038/nature02825.

The Caenorhabditis elegans centrosomal protein SPD-2 is required for both pericentriolar material recruitment and centriole duplication.

Pelletier L, Ozlü N, Hannak E, Cowan C, Habermann B, Ruer M, Müller-Reichert T, Hyman AA

Current biology : CB, 2004

doi:10.1016/j.cub.2004.04.012.

Asymmetric cell division in C. elegans: cortical polarity and spindle positioning.

Cowan CR, Hyman AA

Annual review of cell and developmental biology, 2004

doi:10.1146/annurev.cellbio.19.111301.113823.

The mbk-2 kinase is required for inactivation of MEI-1/katanin in the one-cell Caenorhabditis elegans embryo.

Quintin S, Mains PE, Zinke A, Hyman AA

EMBO reports, 2003

doi:10.1038/sj.embor.7400029.

Morphologically distinct microtubule ends in the mitotic centrosome of Caenorhabditis elegans.

O'Toole ET, McDonald KL, Mäntler J, McIntosh JR, Hyman AA, Müller-Reichert T

The Journal of cell biology, 2003

doi:10.1083/jcb.200304035.

The distribution of active force generators controls mitotic spindle position.

Grill SW, Howard J, Schäffer E, Stelzer EH, Hyman AA

Science (New York, N.Y.), 2003

doi:10.1126/science.1086560.

The distribution of active force generators controls mitotic spindle position

Grill SW, Howard J, Schäffer E, Stelzer EH, Hyman AA

Science (New York, N.Y.), 2003

doi:10.1126/science.1086560.

Dynamics and mechanics of the microtubule plus end.

Howard J, Hyman AA

Nature, 2003

doi:10.1038/nature01600.

Analysis of the distribution of the kinetochore protein Ndc10p in Saccharomyces cerevisiae using 3-D modeling of mitotic spindles

Müller-Reichert T, Sassoon I, O'Toole E, Romao M, Ashford AJ, Hyman AA, Antony C

Chromosoma, 2003

doi:10.1007/s00412-002-0220-6.

Analysis of the distribution of the kinetochore protein Ndc10p in Saccharomyces cerevisiae using 3-D modeling of mitotic spindles.

Müller-Reichert T, Sassoon I, O'Toole E, Romao M, Ashford AJ, Hyman AA, Antony C

Chromosoma, 2003

doi:10.1007/s00412-002-0220-6.

Caenorhabditis elegans TAC-1 and ZYG-9 Form a Complex that Is Essential for Long Astral and Spindle Microtubules.

Srayko M, Quintin S, Schwager A, Hyman AA

Current Biology, 2003

doi:10.1016/s0960-9822(03)00597-9.

SAS-4 Is a C. elegans Centriolar Protein that Controls Centrosome Size.

Kirkham M, Müller-Reichert T, Oegema K, Grill S, Hyman AA

Cell, 2003

doi:10.1016/s0092-8674(03)00117-x.

A ubiquitin C-terminal hydrolase is required to maintain osmotic balance and execute actin-dependent processes in the early C. elegans embryo.

Kaitna S, Schnabel H, Schnabel R, Hyman AA, Glotzer M

Journal of cell science, 2002

doi:10.1242/jcs.115.11.2293.

The kinetically dominant assembly pathway for centrosomal asters in Caenorhabditis elegans is gamma-tubulin dependent.

Hannak E, Oegema K, Kirkham M, Gönczy P, Habermann B, Hyman AA

The Journal of Cell Biology, 2002

doi:10.1083/jcb.200202047.

GTP Binding Induces Filament Assembly of a Recombinant Septin.

Mendoza M, Hyman AA., Glotzer M

Current Biology, 2002

doi:10.1016/s0960-9822(02)01258-7.

XMAP215: a key component of the dynamic microtubule cytoskeleton.

Kinoshita K, Habermann B, Hyman AA

Trends in Cell Biology, 2002

doi:10.1016/s0962-8924(02)02295-x.

Pheromone Induces Programmed Cell Death in S. cerevisiae.

Severin FF, Hyman AA

Current Biology, 2002

doi:10.1016/s0960-9822(02)00776-5.

In vitro reconstitution of endosome motility along microtubules.

Nielsen E, Severin F, Hyman AA, Zerial M

Methods in molecular biology (Clifton, N.J.), 2001

doi:10.1385/1-59259-069-1:133.

Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans

Hannak E, Kirkham M, Hyman AA, Oegema K

The Journal of cell biology, 2001

doi:10.1083/jcb.200108051.

Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans.

Hannak E, Kirkham M, Hyman AA, Oegema K

The Journal of cell biology, 2001

doi:10.1083/jcb.200108051.

Correct spindle elongation at the metaphase/anaphase transition is an APC-dependent event in budding yeast.

Severin F, Hyman AA, Piatti S

The Journal of cell biology, 2001

doi:10.1083/jcb.200104096.

Reconstitution of physiological microtubule dynamics using purified components.

Kinoshita K, Arnal I, Desai A, Drechsel DN, Hyman AA

Science (New York, N.Y.), 2001

doi:10.1126/science.1064629.

Reconstitution of physiological microtubule dynamics using purified components

Kinoshita K, Arnal I, Desai A, Drechsel DN, Hyman AA

Science (New York, N.Y.), 2001

doi:10.1126/science.1064629.

Functional analysis of kinetochore assembly in Caenorhabditis elegans.

Oegema K, Desai A, Rybina S, Kirkham M, Hyman AA

The Journal of cell biology, 2001

doi:10.1083/jcb.153.6.1209.

Functional analysis of kinetochore assembly in Caenorhabditis elegans

Oegema K, Desai A, Rybina S, Kirkham M, Hyman AA

The Journal of cell biology, 2001

doi:10.1083/jcb.153.6.1209.

XMAP215 regulates microtubule dynamics through two distinct domains.

Popov AV, Pozniakovsky A, Arnal I, Antony C, Ashford AJ, Kinoshita K, Tournebize R, Hyman AA, Karsenti E

The EMBO journal, 2001

doi:10.1093/emboj/20.3.397.

XMAP215 regulates microtubule dynamics through two distinct domains

Popov AV, Pozniakovsky A, Arnal I, Antony C, Ashford AJ, Kinoshita K, Tournebize R, Hyman AA, Karsenti E

The EMBO journal, 2001

doi:10.1093/emboj/20.3.397.

Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo

Grill SW, Gönczy P, Stelzer EH, Hyman AA

Nature, 2001

doi:10.1038/35054572.

Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo.

Grill SW, Gönczy P, Stelzer EH, Hyman AA

Nature, 2001

doi:10.1038/35054572.

Spindle positioning during the asymmetric first cell division of Caenorhabditis elegans embryos.

Gönczy P, Grill S, Stelzer EH, Kirkham M, Hyman AA

Novartis Foundation symposium, 2001

doi:10.1002/0470846666.ch13.

zyg-8, a Gene Required for Spindle Positioning in C. elegans, Encodes a Doublecortin-Related Kinase that Promotes Microtubule Assembly.

Gönczy P, Bellanger JM, Kirkham M, Pozniakowski A, Baumer K, Phillips JB, Hyman AA

Developmental Cell, 2001

doi:10.1016/s1534-5807(01)00046-6.

Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3β phosphorylation.

Zumbrunn J, Kinoshita K, Hyman AA, Näthke IS

Current Biology, 2001

doi:10.1016/s0960-9822(01)00002-1.

Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III

Gönczy P, Echeverri C, Oegema K, Coulson A, Jones SJ, Copley RR, Duperon J, Oegema J, Brehm M, Cassin E, Hannak E, Kirkham M, Pichler S, Flohrs K, Goessen A, Leidel S, Alleaume AM, Martin C, Ozlü N, Bork P, Hyman AA

Nature, 2000

doi:10.1038/35042526.

Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III.

Gönczy P, Echeverri C, Oegema K, Coulson A, Jones SJ, Copley RR, Duperon J, Oegema J, Brehm M, Cassin E, Hannak E, Kirkham M, Pichler S, Flohrs K, Goessen A, Leidel S, Alleaume AM, Martin C, Ozlü N, Bork P, Hyman AA

Nature, 2000

doi:10.1038/35042526.

CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis.

Jantsch-Plunger V, Gönczy P, Romano A, Schnabel H, Hamill D, Schnabel R, Hyman AA, Glotzer M

The Journal of cell biology, 2000

doi:10.1083/jcb.149.7.1391.

CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis

Jantsch-Plunger V, Gönczy P, Romano A, Schnabel H, Hamill D, Schnabel R, Hyman AA, Glotzer M

The Journal of cell biology, 2000

doi:10.1083/jcb.149.7.1391.

Structural transitions at microtubule ends correlate with their dynamic properties in Xenopus egg extracts

Arnal I, Karsenti E, Hyman AA

The Journal of cell biology, 2000

doi:10.1083/jcb.149.4.767.

Structural transitions at microtubule ends correlate with their dynamic properties in Xenopus egg extracts.

Arnal I, Karsenti E, Hyman AA

The Journal of cell biology, 2000

doi:10.1083/jcb.149.4.767.

OOC-3, a novel putative transmembrane protein required for establishment of cortical domains and spindle orientation in the P(1) blastomere of C. elegans embryos.

Pichler S, Gönczy P, Schnabel H, Pozniakowski A, Ashford A, Schnabel R, Hyman AA

Development (Cambridge, England), 2000

doi:10.1242/dev.127.10.2063.

Centrosomes: Sic transit gloria centri.

Hyman AA

Current biology : CB, 2000

doi:10.1016/s0960-9822(00)00406-1.

Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts.

Tournebize R, Popov A, Kinoshita K, Ashford AJ, Rybina S, Pozniakovsky A, Mayer TU, Walczak CE, Karsenti E, Hyman AA

Nature cell biology, 2000

doi:10.1038/71330.

Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts

Tournebize R, Popov A, Kinoshita K, Ashford AJ, Rybina S, Pozniakovsky A, Mayer TU, Walczak CE, Karsenti E, Hyman AA

Nature cell biology, 2000

doi:10.1038/71330.

Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryo.

Gönczy P, Pichler S, Kirkham M, Hyman AA

The Journal of cell biology, 1999

doi:10.1083/jcb.147.1.135.

Rab5 regulates motility of early endosomes on microtubules

Nielsen E, Severin F, Backer JM, Hyman AA, Zerial M

Nature cell biology, 1999

doi:10.1038/14075.

Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryo

Gönczy P, Pichler S, Kirkham M, Hyman AA

The Journal of cell biology, 1999

doi:10.1083/jcb.147.1.135.

Rab5 regulates motility of early endosomes on microtubules.

Nielsen E, Severin F, Backer JM, Hyman AA, Zerial M

Nature cell biology, 1999

doi:10.1038/14075.

The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast.

Biggins S, Severin FF, Bhalla N, Sassoon I, Hyman AA, Murray AW

Genes & development, 1999

doi:10.1101/gad.13.5.532.

Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p

Sassoon I, Severin FF, Andrews PD, Taba MR, Kaplan KB, Ashford AJ, Stark MJ, Sorger PK, Hyman AA

Genes & development, 1999

doi:10.1101/gad.13.5.545.

The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast

Biggins S, Severin FF, Bhalla N, Sassoon I, Hyman AA, Murray AW

Genes & development, 1999

doi:10.1101/gad.13.5.532.

Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p.

Sassoon I, Severin FF, Andrews PD, Taba MR, Kaplan KB, Ashford AJ, Stark MJ, Sorger PK, Hyman AA

Genes & development, 1999

doi:10.1101/gad.13.5.545.

Structural changes at microtubule ends accompanying GTP hydrolysis: information from a slowly hydrolyzable analogue of GTP, guanylyl (alpha,beta)methylenediphosphonate.

Müller-Reichert T, Chrétien D, Severin F, Hyman AA

Proceedings of the National Academy of Sciences of the United States of America, 1998

doi:10.1073/pnas.95.7.3661.

Structural changes at microtubule ends accompanying GTP hydrolysis: information from a slowly hydrolyzable analogue of GTP, guanylyl (alpha,beta)methylenediphosphonate

Müller-Reichert T, Chrétien D, Severin F, Hyman AA

Proceedings of the National Academy of Sciences of the United States of America, 1998

doi:10.1073/pnas.95.7.3661.

A role for microtubule dynamics in phagosome movement.

Blocker A, Griffiths G, Olivo JC, Hyman AA, Severin FF

Journal of cell science, 1998

doi:10.1242/jcs.111.3.303.

Motor proteins of the eukaryotic cytoskeleton.

Hoyt MA, Hyman AA, Bähler M

Proceedings of the National Academy of Sciences of the United States of America, 1997

doi:10.1073/pnas.94.24.12747.

Motor proteins of the eukaryotic cytoskeleton

Hoyt MA, Hyman AA, Bähler M

Proceedings of the National Academy of Sciences of the United States of America, 1997

doi:10.1073/pnas.94.24.12747.

Mitotic chromatin regulates phosphorylation of Stathmin/Op18.

Andersen SS, Ashford AJ, Tournebize R, Gavet O, Sobel A, Hyman AA, Karsenti E

Nature, 1997

doi:10.1038/39382.

Mitotic chromatin regulates phosphorylation of Stathmin/Op18

Andersen SS, Ashford AJ, Tournebize R, Gavet O, Sobel A, Hyman AA, Karsenti E

Nature, 1997

doi:10.1038/39382.

Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosis.

Tournebize R, Andersen SS, Verde F, Dorée M, Karsenti E, Hyman AA

The EMBO journal, 1997

doi:10.1093/emboj/16.18.5537.

Kinetochores distinguish GTP from GDP forms of the microtubule lattice.

Severin FF, Sorger PK, Hyman AA

Nature, 1997

doi:10.1038/42270.

CDK1 inactivation regulates anaphase spindle dynamics and cytokinesis in vivo

Wheatley SP, Hinchcliffe EH, Glotzer M, Hyman AA, Sluder G, Wang Yl

The Journal of cell biology, 1997

doi:10.1083/jcb.138.2.385.

CDK1 inactivation regulates anaphase spindle dynamics and cytokinesis in vivo.

Wheatley SP, Hinchcliffe EH, Glotzer M, Hyman AA, Sluder G, Wang Yl

The Journal of cell biology, 1997

doi:10.1083/jcb.138.2.385.

Molecular requirements for bi-directional movement of phagosomes along microtubules.

Blocker A, Severin FF, Burkhardt JK, Bingham JB, Yu H, Olivo JC, Schroer TA, Hyman AA, Griffiths G

The Journal of cell biology, 1997

doi:10.1083/jcb.137.1.113.

Molecular requirements for bi-directional movement of phagosomes along microtubules

Blocker A, Severin FF, Burkhardt JK, Bingham JB, Yu H, Olivo JC, Schroer TA, Hyman AA, Griffiths G

The Journal of cell biology, 1997

doi:10.1083/jcb.137.1.113.

Microtubule structure and dynamics.

Wade RH, Hyman AA

Current Opinion in Cell Biology, 1997

doi:10.1016/s0955-0674(97)80146-9.

Coupling cell division and cell death to microtubule dynamics.

Sorger PK, Dobles M, Tournebize R, Hyman AA

Current Opinion in Cell Biology, 1997

doi:10.1016/s0955-0674(97)80081-6.

Regulating the Yeast Kinetochore by Ubiquitin-Dependent Degradation and Skp1p-Mediated Phosphorylation.

Kaplan KB, Hyman AA, Sorger PK

Cell, 1997

doi:10.1016/s0092-8674(00)80435-3.

A requirement for Rho and Cdc42 during cytokinesis in Xenopus embryos.

Drechsel DN, Hyman AA, Hall A, Glotzer M

Current Biology, 1997

doi:10.1016/s0960-9822(06)00023-6.

Morphogenetic properties of microtubules and mitotic spindle assembly

Hyman AA, Karsenti E

Cell, 1996

doi:10.1016/s0092-8674(00)81285-4.

Microtubule-associated protein-dependent binding of phagosomes to microtubules

Blocker A, Severin FF, Habermann A, Hyman AA, Griffiths G, Burkhardt JK

The Journal of biological chemistry, 1996

doi:10.1074/jbc.271.7.3803.

Morphogenetic properties of microtubules and mitotic spindle assembly.

Hyman AA, Karsenti E

Cell, 1996

doi:10.1016/s0092-8674(00)81285-4.

Cortical domains and the mechanisms of asymmetric cell division.

Gönczy P, Hyman AA

Trends in Cell Biology, 1996

doi:10.1016/0962-8924(96)10035-0.

Two genes required for the binding of an essential Saccharomyces cerevisiae kinetochore complex to DNA

Sorger PK, Doheny KF, Hieter P, Kopski KM, Huffaker TC, Hyman AA

Proceedings of the National Academy of Sciences of the United States of America, 1995

doi:10.1073/pnas.92.26.12026.

Two genes required for the binding of an essential Saccharomyces cerevisiae kinetochore complex to DNA.

Sorger PK, Doheny KF, Hieter P, Kopski KM, Huffaker TC, Hyman AA

Proceedings of the National Academy of Sciences of the United States of America, 1995

doi:10.1073/pnas.92.26.12026.

Structural changes accompanying GTP hydrolysis in microtubules: information from a slowly hydrolyzable analogue guanylyl-(alpha,beta)-methylene-diphosphonate.

Hyman AA, Chrétien D, Arnal I, Wade RH

The Journal of cell biology, 1995

doi:10.1083/jcb.128.1.117.

Cell Polarity: The importance of being polar.

Glotzer M, Hyman AA

Current Biology, 1995

doi:10.1016/s0960-9822(95)00221-1.

Structure and function of kinetochores in budding yeast

Hyman AA, Sorger PK

Annual review of cell and developmental biology, 1995

doi:10.1146/annurev.cb.11.110195.002351.

Structure and function of kinetochores in budding yeast.

Hyman AA, Sorger PK

Annual review of cell and developmental biology, 1995

doi:10.1146/annurev.cb.11.110195.002351.

Microtubule Dynamics: Kinetochores get a grip.

Hyman AA

Current Biology, 1995

doi:10.1016/s0960-9822(95)00097-2.

Factors required for the binding of reassembled yeast kinetochores to microtubules in vitro

Sorger PK, Severin FF, Hyman AA

The Journal of cell biology, 1994

doi:10.1083/jcb.127.4.995.

Factors required for the binding of reassembled yeast kinetochores to microtubules in vitro.

Sorger PK, Severin FF, Hyman AA

The Journal of cell biology, 1994

doi:10.1083/jcb.127.4.995.

Cell Fate Determination: When is a determinant a determinant?

Cohen S, Hyman AA

Current Biology, 1994

doi:10.1016/s0960-9822(00)00091-9.

An assay for the activity of microtubule-based motors on the kinetochores of isolated Chinese hamster ovary chromosomes.

Hyman AA, Mitchison TJ

Methods in Cell Biology, 1993

doi:10.1016/s0091-679x(08)60176-4.

Identification of essential components of the S. cerevisiae kinetochore.

Doheny KF, Sorger PK, Hyman AA, Tugendreich S, Spencer F, Hieter P

Cell, 1993

doi:10.1016/0092-8674(93)90255-o.

Preparation of marked microtubules for the assay of the polarity of microtubule-based motors by fluorescence microscopy.

Howard J, Hyman AA

Methods in Cell Biology, 1993

doi:10.1016/s0091-679x(08)60164-8.

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.

Drechsel DN, Hyman AA, Cobb MH, Kirschner MW

Molecular biology of the cell, 1992

doi:10.1091/mbc.3.10.1141.

Role of GTP hydrolysis in microtubule dynamics: information from a slowly hydrolyzable analogue, GMPCPP.

Hyman AA, Salser S, Drechsel DN, Unwin N, Mitchison TJ

Molecular biology of the cell, 1992

doi:10.1091/mbc.3.10.1155.

Microtubule-motor activity of a yeast centromere-binding protein complex.

Hyman AA, Middleton K, Centola M, Mitchison TJ, Carbon J

Nature, 1992

doi:10.1038/359533a0.

Spindle positioning and cell polarity.

Hyman AA, Stearns T

Current Biology, 1992

doi:10.1016/0960-9822(92)90660-3.

Two different microtubule-based motor activities with opposite polarities in kinetochores.

Hyman AA, Mitchison TJ

Nature, 1991

doi:10.1038/351206a0.

Regulation of the direction of chromosome movement.

Hyman AA, Mitchison TJ

Cold Spring Harbor symposia on quantitative biology, 1991

doi:10.1101/sqb.1991.056.01.083.

Preparation of marked microtubules for the assay of the polarity of microtubule-based motors by fluorescence.

Hyman AA

Journal of cell science. Supplement, 1991

doi:10.1242/jcs.1991.supplement_14.25.

Modulation of microtubule stability by kinetochores in vitro.

Hyman AA, Mitchison TJ

The Journal of cell biology, 1990

doi:10.1083/jcb.110.5.1607.

Real-time visualization of cell cycle-dependent changes in microtubule dynamics in cytoplasmic extracts.

Belmont LD, Hyman AA, Sawin KE, Mitchison TJ

Cell, 1990

doi:10.1016/0092-8674(90)90022-7.

Centrosome movement in the early divisions of Caenorhabditis elegans: a cortical site determining centrosome position.

Hyman AA

The Journal of cell biology, 1989

doi:10.1083/jcb.109.3.1185.

Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans.

Hyman AA, White JG

The Journal of cell biology, 1987

doi:10.1083/jcb.105.5.2123.