Publications

A hold-and-feed mechanism drives directional DNA loop extrusion by condensin.

Shaltiel IA, Datta S, Lecomte L, Hassler M, Kschonsak M, Bravo S, Stober C, Ormanns J, Eustermann S, Haering CH

Science, 2022

doi:10.1126/science.abm4012.

Publisher correction: the condensin holocomplex cycles dynamically between open and collapsed states.

Ryu JK, Katan AJ, van der Sluis EO, Wisse T, de Groot R, Haering CH, Dekker C

Nature structural & molecular biology, 2020

doi:10.1038/s41594-020-00524-y.

The condensin holocomplex cycles dynamically between open and collapsed states.

Ryu JK, Katan AJ, van der Sluis EO, Wisse T, de Groot R, Haering CH, Dekker C

Nature structural & molecular biology, 2020

doi:10.1038/s41594-020-0508-3.

Structural insights into DNA loop extrusion by SMC protein complexes.

Datta S, Lecomte L, Haering CH

Current opinion in structural biology, 2020

doi:10.1016/j.sbi.2020.06.009.

DNA-loop extruding condensin complexes can traverse one another.

Kim E, Kerssemakers J, Shaltiel IA, Haering CH, Dekker C

Nature, 2020

doi:10.1038/s41586-020-2067-5.

Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism.

Lee B-G, Merkel F, Allegretti M, Hassler M, Cawood C, Lecomte L, O'Reilly FJ, Sinn LR, Gutierrez-Escribano P, Kschonsak M, Bravo S, Nakane T, Rappsilber J, Aragon L, Beck M, Löwe J, Haering CH

2020

doi:10.1038/s41594-020-0457-x.

Distinct roles for condensin's two ATPase sites in chromosome condensation.

Elbatsh AMO, Kim E, Eeftens JM, Raaijmakers JA, van der Weide RH, García-Nieto A, Bravo S, Ganji M, Uit de Bos J, Teunissen H, Medema RH, de Wit E, Haering CH, Dekker C, Rowland BD

Molecular cell, 2019

doi:10.1016/j.molcel.2019.09.020.

Solution structure and flexibility of the condensin HEAT-repeat subunit Ycg1.

Manalastas-Cantos K, M, Haering CH, Svergun DI

The Journal of biological chemistry, 2019

doi:10.1074/jbc.RA119.008661.

Structural basis of an asymmetric condensin ATPase cycle.

Hassler M, Shaltiel IA, Kschonsak M, Simon B, Merkel F, Thärichen L, Bailey HJ, Macošek J, Bravo S, Metz J, Hennig J, Haering CH

Molecular cell, 2019

doi:10.1016/j.molcel.2019.03.037.

Twist to disentangle.

Bisht S, Haering CH

Nature structural & molecular biology, 2019

doi:10.1038/s41594-019-0209-y.

Towards a unified model of SMC complex function.

Hassler M, Shaltiel IA, Haering CH

Current biology : CB, 2018

doi:10.1016/j.cub.2018.08.034.

Condensin controls cellular RNA levels through the accurate segregation of chromosomes instead of directly regulating transcription

Hocquet C, Robellet X, Modolo L, Sun X-M, Burny C, Cuylen-Haering S, Toselli E, Clauder-Munster S, Steinmetz L, Haering CH, Marguerat S, Bernard P

2018

doi:10.7554/eLife.38517.

Structural basis for Scc3-dependent cohesin recruitment to chromatin.

Li Y, Muir K, Bowler MW, Metz J, Haering CH, Panne D

eLife, 2018

doi:10.7554/eLife.38356.

Control of mitotic chromosome condensation by the fission yeast transcription factor Zas1

Schiklenk C, Petrova B, Kschonsak M, Hassler M, Klein C, Gibson TJ, Haering CH

2018

doi:10.1083/jcb.201711097.

Real-time imaging of DNA loop extrusion by condensin.

Ganji M, Shaltiel IA, Bisht S, Kim E, Kalichava A, Haering CH, Dekker C

Science (New York, N.Y.), 2018

doi:10.1126/science.aar7831.

Real-time detection of condensin-driven DNA compaction reveals a multistep binding mechanism.

Eeftens JM, Bisht S, Kerssemakers J, Kschonsak M, Haering CH, Dekker C

The EMBO journal, 2017

doi:10.15252/embj.201797596.

The condensin complex is a mechanochemical motor that translocates along DNA

Terakawa T, Bisht S, Eeftens JM, Dekker C, Haering CH, Greene EC

2017

doi:10.1126/science.aan6516.

Two independent modes of chromatin organization revealed by cohesin removal

Schwarzer W, Abdennur N, Goloborodko A, Pekowska A, Fudenberg G, Loe-Mie Y, Fonseca NA, Huber W, Haering CH, Mirny L, Spitz F

2017

doi:10.1038/nature24281.

Structural Basis for a Safety-Belt Mechanism That Anchors Condensin to Chromosomes.

Kschonsak M, Merkel F, Bisht S, Metz J, Rybin V, Hassler M, Haering CH

Cell, 2017

doi:10.1016/j.cell.2017.09.008.

A Protocol for Measuring Mitotic Chromosome Condensation Quantitatively in Fission Yeast Cells.

Schiklenk C, Petrova B, Haering CH

Methods in molecular biology (Clifton, N.J.), 2016

doi:10.1007/978-1-4939-6545-8_15.

Nucleosome eviction in mitosis assists condensin loading and chromosome condensation

Toselli-Mollereau E, Robellet X, Fauque L, Lemaire S, Schiklenk C, Klein C, Hocquet C, Legros P, N'Guyen L, Mouillard L, Chautard E, Auboeuf D, Haering CH, Bernard P

2016

doi:10.15252/embj.201592849.

Structure of the Pds5-Scc1 Complex and Implications for Cohesin Function.

Muir KW, Kschonsak M, Li Y, Metz J, Haering CH, Panne D

Cell reports, 2016

doi:10.1016/j.celrep.2016.01.078.

Condensin Smc2-Smc4 Dimers Are Flexible and Dynamic.

Eeftens JM, Katan AJ, Kschonsak M, Hassler M, de Wilde L, Dief EM, Haering CH, Dekker C

Cell reports, 2016

doi:10.1016/j.celrep.2016.01.063.

SnapShot: SMC Protein Complexes Part II.

Haering CH, Gruber S

Cell, 2016

doi:10.1016/j.cell.2016.01.052.

SnapShot: SMC Protein Complexes Part I.

Haering CH, Gruber S

Cell, 2016

doi:10.1016/j.cell.2015.12.026.

Shaping mitotic chromosomes: From classical concepts to molecular mechanisms.

Kschonsak M, Haering CH

BioEssays : news and reviews in molecular, cellular and developmental biology, 2015

doi:10.1002/bies.201500020.

Control of chromosome interactions by condensin complexes.

Frosi Y, Haering CH

Current opinion in cell biology, 2015

doi:10.1016/j.ceb.2015.05.008.

Integration of biological data by kernels on graph nodes allows prediction of new genes involved in mitotic chromosome condensation

Hériché JK, Lees JG, Morilla I, Walter T, Petrova B, Roberti MJ, Hossain MJ, Adler P, Fernández JM, Krallinger M, Haering CH, Vilo J, Valencia A, Ranea JA, Orengo C, Ellenberg J

Molecular biology of the cell, 2014

doi:10.1091/mbc.e13-04-0221.

Association of condensin with chromosomes depends on DNA binding by its HEAT-repeat subunits

Piazza I, Rutkowska A, Ori A, Walczak M, Metz J, Pelechano V, Beck M, Haering CH

Nature structural & molecular biology, 2014

doi:10.1038/nsmb.2831.

Entrapment of chromosomes by condensin rings prevents their breakage during cytokinesis

Cuylen S, Metz J, Hruby A, Haering CH

Developmental cell, 2013

doi:10.1016/j.devcel.2013.10.018.

Condensin: crafting the chromosome landscape

Piazza I, Haering CH, Rutkowska A

Chromosoma, 2013

doi:10.1007/s00412-013-0405-1.

Quantitative analysis of chromosome condensation in fission yeast

Petrova B, Dehler S, Kruitwagen T, Hériché JK, Miura K, Haering CH

Molecular and cellular biology, 2013

doi:10.1128/mcb.01400-12.

Understanding chromatin and chromosomes: from static views to dynamic thinking

Haering CH, Losada A

EMBO reports, 2013

doi:10.1038/embor.2012.221.

Cohesin in determining chromosome architecture

Haering CH, Jessberger R

Experimental cell research, 2012

doi:10.1016/j.yexcr.2012.03.016.

A FlAsH-based cross-linker to study protein interactions in living cells

Rutkowska A, Haering CH, Schultz C

Angewandte Chemie (International ed. in English), 2011

doi:10.1002/anie.201106404.

Condensin engages chromatin

Petrova B, Haering CH

Chembiochem : a European journal of chemical biology, 2011

doi:10.1002/cbic.201100531.

Deciphering condensin action during chromosome segregation

Cuylen S, Haering CH

Trends in cell biology, 2011

doi:10.1016/j.tcb.2011.06.003.

Condensin structures chromosomal DNA through topological links

Cuylen S, Metz J, Haering CH

Nature structural & molecular biology, 2011

doi:10.1038/nsmb.2087.

A positively charged channel within the Smc1/Smc3 hinge required for sister chromatid cohesion

Kurze A, Michie KA, Dixon SE, Mishra A, Itoh T, Khalid S, Strmecki L, Shirahige K, Haering CH, Löwe J, Nasmyth K

The EMBO journal, 2011

doi:10.1038/emboj.2010.315.

A new cohesive team to mediate DNA looping

Cuylen S, Haering CH

Cell stem cell, 2010

doi:10.1016/j.stem.2010.09.006.

Keeping replicated chromatids together until mitosis

2009

doi:978-0-85404-164-0.

Foreword: the many fascinating functions of SMC protein complexes

Haering CH

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2009

doi:10.1007/s10577-008-9008-8.

Cohesin: its roles and mechanisms

Nasmyth K, Haering CH

Annual review of genetics, 2009

doi:10.1146/annurev-genet-102108-134233.

The cohesin ring concatenates sister DNA molecules

Haering CH, Farcas AM, Arumugam P, Metson J, Nasmyth K

Nature, 2008

doi:10.1038/nature07098.

Cohesin's ATPase activity is stimulated by the C-terminal Winged-Helix domain of its kleisin subunit

Arumugam P, Nishino T, Haering CH, Gruber S, Nasmyth K

Current biology : CB, 2006

doi:10.1016/j.cub.2006.09.002.

The structure and function of SMC and kleisin complexes

Nasmyth K, Haering CH

Annual review of biochemistry, 2005

doi:10.1146/annurev.biochem.74.082803.133219.

Structure and stability of cohesin's Smc1-kleisin interaction

Haering CH, Schoffnegger D, Nishino T, Helmhart W, Nasmyth K, Löwe J

Molecular cell, 2004

doi:10.1016/j.molcel.2004.08.030.

Building and breaking bridges between sister chromatids

Haering CH, Nasmyth K

BioEssays : news and reviews in molecular, cellular and developmental biology, 2003

doi:10.1002/bies.10361.

ATP hydrolysis is required for cohesin's association with chromosomes

Arumugam P, Gruber S, Tanaka K, Haering CH, Mechtler K, Nasmyth K

Current biology : CB, 2003

doi:10.1016/j.cub.2003.10.036.

Chromosomal cohesin forms a ring

Gruber S, Haering CH, Nasmyth K

Cell, 2003

doi:10.1016/s0092-8674(03)00162-4.

Molecular architecture of SMC proteins and the yeast cohesin complex

Haering CH, Löwe J, Hochwagen A, Nasmyth K

Molecular cell, 2002

doi:10.1016/s1097-2765(02)00515-4.

Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion

Ivanov D, Schleiffer A, Eisenhaber F, Mechtler K, Haering CH, Nasmyth K

Current biology : CB, 2002

doi:10.1016/s0960-9822(02)00681-4.

Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomycespombe

Haering CH, Nakamura TM, Baumann P, Cech TR

Proceedings of the National Academy of Sciences of the United States of America, 2000

doi:10.1073/pnas.130187397.