Publications

Genome-scale CRISPR screening for regulators of cell fate transitions.

Carlini V, Gretarsson KH, Hackett JA

Methods in molecular biology (Clifton, N.J.) 2021

32944905. doi:10.1007/978-1-0716-0958-3_7.

Epigenetic editing: dissecting chromatin function in context.

Policarpi C, Dabin J, Hackett JA

BioEssays : news and reviews in molecular, cellular and developmental biology 2021

33724509. doi:10.1002/bies.202000316.

Cell surface mechanics gate embryonic stem cell differentiation.

Bergert M, Lembo S, Sharma S, Russo L, Milovanović D, Gretarsson KH, Börmel M, Neveu PA, Hackett JA, Petsalaki E, Diz-Muñoz A

Cell stem cell 2020

33207217. doi:10.1016/j.stem.2020.10.017.

Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development.

Gretarsson KH, Hackett JA

Nature structural & molecular biology 2020

32572256. doi:10.1038/s41594-020-0445-1.

A ligand-based system for receptor-specific delivery of proteins.

Maffei M, Morelli C, Graham E, Patriarca S, Donzelli L, Doleschall B, de Castro Reis F, Nocchi L, Chadick CH, Reymond L, Corrêa IR, Johnsson K, Hackett JA, Heppenstall PA

Scientific reports 2019

31844114. doi:10.1038/s41598-019-55797-1.

Publisher Correction: Tracing the transitions from pluripotency to germ cell fate with CRISPR screening.

Hackett JA, Huang Y, Günesdogan U, Gretarsson KA, Kobayashi T, Surani MA

Nature communications 2018

30538240. doi:10.1038/s41467-018-07765-y.

Tracing the transitions from pluripotency to germ cell fate with CRISPR screening.

Hackett JA, Huang Y, Günesdogan U, Gretarsson KA, Kobayashi T, Surani MA

Nature communications 2018

30327475. doi:10.1038/s41467-018-06230-0.

Activation of Lineage Regulators and Transposable Elements across a Pluripotent Spectrum.

Hackett JA, Kobayashi T, Dietmann S, Surani MA

Stem cell reports 2017

28591649. doi:10.1016/j.stemcr.2017.05.014.

STELLA modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition.

Huang Y, Kim JK, Do DV, Lee C, Penfold CA, Zylicz JJ, Marioni JC, Hackett JA, Surani MA

eLife 2017

28323615. doi:10.7554/elife.22345.

Stella modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition.

Huang Y, Kim JK, Do DV, Lee C, Penfold CA, Zylicz JJ, Marioni JC, Hackett JA, Surani MA

ELIFE 2017

28323615. doi:10.7554/eLife.22345.

A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development.

Tang WW, Dietmann S, Irie N, Leitch HG, Floros VI, Bradshaw CR, Hackett JA, Chinnery PF, Surani MA

Cell 2015

26046444. doi:10.1016/j.cell.2015.04.053.

Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development.

Zylicz JJ, Dietmann S, Günesdogan U, Hackett JA, Cougot D, Lee C, Surani MA

eLife 2015

26551560. doi:10.7554/elife.09571.

PRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos.

Kim S, Günesdogan U, Zylicz JJ, Hackett JA, Cougot D, Bao S, Lee C, Dietmann S, Allen GE, Sengupta R, Surani MA

Molecular cell 2014

25457166. doi:10.1016/j.molcel.2014.10.003.

Regulatory principles of pluripotency: from the ground state up.

Hackett JA, Surani MA

Cell stem cell 2014

25280218. doi:10.1016/j.stem.2014.09.015.

Dynamic heterogeneity and DNA methylation in embryonic stem cells.

Singer ZS, Yong J, Tischler J, Hackett JA, Altinok A, Surani MA, Cai L, Elowitz MB

Molecular cell 2014

25038413. doi:10.1016/j.molcel.2014.06.029.

Synergistic mechanisms of DNA demethylation during transition to ground-state pluripotency.

Hackett JA, Dietmann S, Murakami K, Down TA, Leitch HG, Surani MA

Stem cell reports 2013

24371807. doi:10.1016/j.stemcr.2013.11.010.

Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation.

Grabole N, Tischler J, Hackett JA, Kim S, Tang F, Leitch HG, Magnúsdóttir E, Surani MA

EMBO reports 2013

23670199. doi:10.1038/embor.2013.67.

Beyond DNA: programming and inheritance of parental methylomes.

Hackett JA, Surani MA

Cell 2013

23663772. doi:10.1016/j.cell.2013.04.044.

Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine.

Hackett JA, Sengupta R, Zylicz JJ, Murakami K, Lee C, Down TA, Surani MA

Science (New York, N.Y.) 2013

23223451. doi:10.1126/science.1229277.

DNA methylation dynamics during the mammalian life cycle.

Hackett JA, Surani MA

Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2013

23166392. doi:10.1098/rstb.2011.0328.

Promoter DNA methylation couples genome-defence mechanisms to epigenetic reprogramming in the mouse germline.

Hackett JA, Reddington JP, Nestor CE, Dunican DS, Branco MR, Reichmann J, Reik W, Surani MA, Adams IR, Meehan RR

Development (Cambridge, England) 2012

22949617. doi:10.1242/dev.081661.

Parallel mechanisms of epigenetic reprogramming in the germline.

Hackett JA, Zylicz JJ, Surani MA

Trends in genetics : TIG 2012

22386917. doi:10.1016/j.tig.2012.01.005.

Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome.

Thomson JP, Lempiäinen H, Hackett JA, Nestor CE, Müller A, Bolognani F, Oakeley EJ, Schübeler D, Terranova R, Reinhardt D, Moggs JG, Meehan RR

Genome biology 2012

23034186. doi:.

Apoptosis and DNA methylation.

Meng HX, Hackett JA, Nestor C, Dunican DS, Madej M, Reddington JP, Pennings S, Harrison DJ, Meehan RR

Cancers 2011

24212783. doi:10.3390/cancers3021798.

The interaction of xKaiso with xTcf3: a revised model for integration of epigenetic and Wnt signalling pathways.

Ruzov A, Hackett JA, Prokhortchouk A, Reddington JP, Madej MJ, Dunican DS, Prokhortchouk E, Pennings S, Meehan RR

Development (Cambridge, England) 2009

19158184. doi:10.1242/dev.025577.

The non-methylated DNA-binding function of Kaiso is not required in early Xenopus laevis development.

Ruzov A, Savitskaya E, Hackett JA, Reddington JP, Prokhortchouk A, Madej MJ, Chekanov N, Li M, Dunican DS, Prokhortchouk E, Pennings S, Meehan RR

Development (Cambridge, England) 2009

19158185. doi:10.1242/dev.025569.

Identification of nuclear and cytoplasmic mRNA targets for the shuttling protein SF2/ASF.

Sanford JR, Coutinho P, Hackett JA, Wang X, Ranahan W, Caceres JF

PloS one 2008

18841201. doi:10.1371/journal.pone.0003369.

xDnmt1 regulates transcriptional silencing in pre-MBT Xenopus embryos independently of its catalytic function.

Dunican DS, Ruzov A, Hackett JA, Meehan RR

Development (Cambridge, England) 2008

18305009. doi:10.1242/dev.016402.