Publications – Hackett Group

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Papillomavirus-like particles as vectors for ex vivo gene therapy of the skin.

Diversi F, Dabin J, Mazza E, Rinaldin M, de Castro Reis F, Hackett JA, Heppenstall PA

Molecular therapy. Nucleic acids, 2025

doi:10.1016/j.omtn.2025.102501.

Systematic epigenome editing captures the context-dependent instructive function of chromatin modifications.

Policarpi C, Munafò M, Tsagkris S, Carlini V, Hackett JA

Nature genetics, 2024

doi:10.1038/s41588-024-01706-w.

Paternal microbiome perturbations impact offspring fitness.

Argaw-Denboba A, Schmidt TSB, Di Giacomo M, Ranjan B, Devendran S, Mastrorilli E, Lloyd CT, Pugliese D, Paribeni V, Dabin J, Pisaniello A, Espinola S, Crevenna A, Ghosh S, Humphreys N, Boruc O, Sarkies P, Zimmermann M, Bork P, Hackett JA

Nature, 2024

doi:10.1038/s41586-024-07336-w.

Esrrb guides naive pluripotent cells through the formative transcriptional programme.

Carbognin E, Carlini V, Panariello F, Chieregato M, Guerzoni E, Benvegnù D, Perrera V, Malucelli C, Cesana M, Grimaldi A, Mutarelli M, Carissimo A, Tannenbaum E, Kugler H, Hackett JA, Cacchiarelli D, Martello G

Nature cell biology, 2023

doi:10.1038/s41556-023-01131-x.

Epigenetic inheritance is gated by naïve pluripotency and Dppa2.

Carlini V, Policarpi C, Hackett JA

The EMBO journal, 2022

doi:10.15252/embj.2021108677.

Genome-scale CRISPR screening for regulators of cell fate transitions.

Carlini V, Gretarsson KH, Hackett JA

Methods in molecular biology (Clifton, N.J.), 2021

doi:10.1007/978-1-0716-0958-3_7.

Epigenetic editing: dissecting chromatin function in context.

Policarpi C, Dabin J, Hackett JA

BioEssays : news and reviews in molecular, cellular and developmental biology, 2021

doi:10.1002/bies.202000316.

Cell surface mechanics gate embryonic stem cell differentiation.

Bergert M, Lembo S, Sharma S, Russo L, Milovanović D, Gretarsson KH, Börmel M, Neveu PA, Hackett JA, Petsalaki E, Diz-Muñoz A

Cell stem cell, 2020

doi:10.1016/j.stem.2020.10.017.

Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development.

Gretarsson KH, Hackett JA

Nature structural & molecular biology, 2020

doi:10.1038/s41594-020-0445-1.

A ligand-based system for receptor-specific delivery of proteins.

Maffei M, Morelli C, Graham E, Patriarca S, Donzelli L, Doleschall B, de Castro Reis F, Nocchi L, Chadick CH, Reymond L, Corrêa IR, Johnsson K, Hackett JA, Heppenstall PA

Scientific reports, 2019

doi:10.1038/s41598-019-55797-1.

Tracing the transitions from pluripotency to germ cell fate with CRISPR screening.

Hackett JA, Huang Y, Günesdogan U, Gretarsson KA, Kobayashi T, Surani MA

Nature communications, 2018

doi:10.1038/s41467-018-06230-0.

Activation of lineage regulators and transposable elements across a pluripotent Spectrum.

Hackett JA, Kobayashi T, Dietmann S, Surani MA

Stem cell reports, 2017

doi:10.1016/j.stemcr.2017.05.014.

STELLA modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition.

Huang Y, Kim JK, Do DV, Lee C, Penfold CA, Zylicz JJ, Marioni JC, Hackett JA, Surani MA

eLife, 2017

doi:10.7554/elife.22345.

Stella modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition.

Huang Y, Kim JK, Do DV, Lee C, Penfold CA, Zylicz JJ, Marioni JC, Hackett JA, Surani MA

ELIFE, 2017

doi:10.7554/eLife.22345.

Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development.

Zylicz JJ, Dietmann S, Gunesdogan U, Hackett JA, Cougot D, Lee C, Surani MA

ELIFE, 2015

doi:10.7554/eLife.09571.

A unique gene regulatory network resets the human germline epigenome for development.

Tang WWC, Dietmann S, Irie N, Leitch HG, Floros VI, Bradshaw CR, Hackett JA, Chinnery PF, Surani MA

Cell, 2015

doi:10.1016/j.cell.2015.04.053.

Regulatory principles of pluripotency: from the ground state up.

Hackett JA, Surani MA

Cell Stem Cell , 2014

doi:10.1016/j.stem.2014.09.015.

Dynamic heterogeneity and DNA methylation in embryonic stem cells.

Singer ZS, Yong J, Tischler J, Hackett JA, Altinok A, Surani MA, Cai L, Elowitz MB

Molecular cell, 2014

doi:10.1016/j.molcel.2014.06.029.

Synergistic mechanisms of DNA demethylation during transition to ground-state pluripotency.

Hackett JA, Dietmann S, Murakami K, Down TA, Leitch HG, Surani MA

Stem Cell Reports, 2013

doi:10.1016/j.stemcr.2013.11.010.

Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation.

Grabole N, Tischler J, Hackett JA, Kim S, Tang FC, Leitch HG, Magnusdottir E, Surani MA

EMBO Reports, 2013

doi:10.1038/embor.2013.67.

Beyond DNA: programming and inheritance of parental methylomes.

Hackett JA, Surani MA

Cell, 2013

doi:10.1016/j.cell.2013.04.044.

Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine.

Hackett JA, Sengupta R, Zylicz JJ, Murakami K, Lee C, Down TA, Surani MA

Science, 2013

doi:10.1126/science.1229277.

Promoter DNA methylation couples genome-defence mechanisms to epigenetic reprogramming in the mouse germline.

Hackett JA, Reddington JP, Nestor CE, Dunican DS, Branco MR, Reichmann J, Reik W, Surani MA, Adams IR, Meehan RR

Development (Cambridge, England), 2012

doi:10.1242/dev.081661.

Parallel mechanisms of epigenetic reprogramming in the germline.

Hackett JA, Zylicz JJ, Surani MA

Trends in Genetics, 2012

doi:10.1016/j.tig.2012.01.005.

Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome.

Thomson JP, Lempiainen H, Hackett JA, Nestor CE, Muller A, Bolognani F, Oakeley EJ, Schubeler D, Terranova R, Reinhardt D, Moggs JG, Meehan RR

Genome Biology, 2012

doi:10.1186/gb-2012-13-10-R93.