Publications – Blanchet Team

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Buffer specificity of ionizable lipid nanoparticle transfection efficiency and bulk phase transition.

Carucci C, Philipp J, Müller JA, Sudarsan A, Kostyurina E, Blanchet CE, Schwierz N, Parsons DF, Salis A, Rädler JO

ACS nano, 2025

doi:10.1021/acsnano.4c14098.

Biodegradable ultrahigh-purity magnesium and its alloy ZX00 promote osteogenesis in the medullary cavity and glycogenolysis in the liver.

Okutan B, Schwarze UY, Habisch H, Iskhakova K, Ćwieka H, Ribeiro-Machado C, Moosmann JP, Blanchet C, Brcic I, Santos SG, Madl T, Zeller-Plumhoff B, Weinberg AM, Wieland DCF, Sommer NG

Acta biomaterialia, 2025

doi:10.1016/j.actbio.2025.02.007.

Polytrauma impairs fracture healing accompanied by increased persistence of innate inflammatory stimuli and reduced adaptive response.

Saiz AM, Rahmati M, Gresham RCH, Baldini TD, Burgan J, Lee MA, Osipov B, Christiansen BA, Khassawna TE, Wieland DCF, Marinho AL, Blanchet C, Czachor M, Working ZM, Bahney CS, Leach JK

Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2025

doi:10.1002/jor.26015.

Iron-carbohydrate complexes treating iron anaemia: Understanding the nano-structure and interactions with proteins through orthogonal characterisation.

Krupnik L, Avaro J, Liebi M, Anaraki NI, Kohlbrecher J, Sologubenko A, Handschin S, Rzepiela AJ, Appel C, Totu T, Blanchet CE, Barton Alston AE, Digigow R, Philipp E, Flühmann B, Silva BFB, Neels A, Wick P

Journal of controlled release : official journal of the Controlled Release Society, 2024

doi:10.1016/j.jconrel.2024.02.044.

pH-dependent structural transitions in cationic ionizable lipid mesophases are critical for lipid nanoparticle function.

Philipp J, Dabkowska A, Reiser A, Frank K, Krzysztoń R, Brummer C, Nickel B, Blanchet CE, Sudarsan A, Ibrahim M, Johansson S, Skantze P, Skantze U, Östman S, Johansson M, Henderson N, Elvevold K, Smedsrød B, Schwierz N, Lindfors L, Rädler JO

Proceedings of the National Academy of Sciences of the United States of America, 2023

doi:10.1073/pnas.2310491120.

Form factor determination of biological molecules with X-ray free electron laser small-angle scattering (XFEL-SAS).

Blanchet CE, Round A, Mertens HDT, Ayyer K, Graewert M, Awel S, Franke D, Dörner K, Bajt S, Bean R, Custódio TF, de Wijn R, Juncheng E, Henkel A, Gruzinov A, Jeffries CM, Kim Y, Kirkwood H, Kloos M, Knoška J, Koliyadu J, Letrun R, Löw C, Makroczyova J, Mall A, Meijers R, Pena Murillo GE, Oberthür D, Round E, Seuring C, Sikorski M, Vagovic P, Valerio J, Wollweber T, Zhuang Y, Schulz J, Haas H, Chapman HN, Mancuso AP, Svergun D

Communications biology, 2023

doi:10.1038/s42003-023-05416-7.

Quantitative size-resolved characterization of mRNA nanoparticles by in-line coupling of asymmetrical-flow field-flow fractionation with small angle X-ray scattering.

Graewert MA, Wilhelmy C, Bacic T, Schumacher J, Blanchet C, Meier F, Drexel R, Welz R, Kolb B, Bartels K, Nawroth T, Klein T, Svergun D, Langguth P, Haas H

Scientific reports, 2023

doi:10.1038/s41598-023-42274-z.

Controlled modulation of the dynamics of the Deinococcus grandis Dps N-terminal tails by divalent metals.

Guerra JPL, Blanchet CE, Vieira BJC, Waerenborgh JC, Jones NC, Hoffmann SV, Pereira AS, Tavares P

Protein science : a publication of the Protein Society, 2023

doi:10.1002/pro.4567.

Time-resolved study on self-assembling behavior of PEGylated gold nanoparticles in the presence of human serum albumin: a system for nanomedical applications.

Anaraki NI, Liebi M, Iranshahi K, Blanchet C, Wick P, Neels A

ACS Applied Nano Material, 2022

doi:10.1021/ACSANM.2C04628.

Expanding the Toolbox for Bicelle-Forming Surfactant–Lipid Mixtures.

Giudice RD, Paracini N, Laursen T, Blanchet C, Roosen-Runge F, Cárdenas M

Molecules (Basel, Switzerland), 2022

doi:10.3390/molecules27217628.

A round-robin approach provides a detailed assessment of biomolecular small-angle scattering data reproducibility and yields consensus curves for benchmarking.

Trewhella J, Vachette P, Bierma J, Blanchet C, Brookes E, Chakravarthy S, Chatzimagas L, Cleveland TE, Cowieson N, Crossett B, Duff AP, Franke D, Gabel F, Gillilan RE, Graewert M, Grishaev A, Guss JM, Hammel M, Hopkins J, Huang Q, Hub JS, Hura GL, Irving TC, Jeffries CM, Jeong C, Kirby N, Krueger S, Martel A, Matsui T, Li N, Pérez J, Porcar L, Prangé T, Rajkovic I, Rocco M, Rosenberg DJ, Ryan TM, Seifert S, Sekiguchi H, Svergun D, Teixeira S, Thureau A, Weiss TM, Whitten AE, Wood K, Zuo X

Acta crystallographica. Section D, Structural biology, 2022

doi:10.1107/s2059798322009184.

Smart video plug-in system for Beamline operation at EMBL Hamburg.

Galikeev E, Ristau U, Blanchet C, von Stetten D, Palnati V, Fiedler S

PCaPAC, 2022

doi:10.18429/JACoW-PCaPAC2022-THP09.

The conformation of the N-terminal tails of Deinococcus grandis Dps is modulated by the ionic strength.

Guerra JPL, Blanchet CE, Vieira BJC, Almeida AV, Waerenborgh JC, Jones NC, Hoffmann SV, Tavares P, Pereira AS

International journal of molecular sciences, 2022

doi:10.3390/ijms23094871.

In-situ investigations on gold nanoparticles stabilization mechanisms in biological environments containing HSA.

Anaraki NI, Liebi M, Ong Q, Blanchet C, Maurya AK, Stellacci F, Salentinig S, Wick P, Neels A

ADVANCED FUNCTIONAL MATERIALS, 2021

doi:10.1002/adfm.202110253.

Probing the existence of non-thermal Terahertz radiation induced changes of the protein solution structure.

Schroer MA, Schewa S, Gruzinov AY, Rönnau C, Lahey-Rudolph JM, Blanchet CE, Zickmantel T, Song YH, Svergun DI, Roessle M

Scientific reports, 2021

doi:10.1038/s41598-021-01774-6.

ASAXS measurements on ferritin and apoferritin at the bioSAXS beamline P12 (PETRA III, DESY).

Wieland DCF, Schroer MA, Gruzinov AY, Blanchet CE, Jeffries CM, Svergun DI

Journal of applied crystallography, 2021

doi:10.1107/S1600576721003034.

Anomalous SAXS at P12 beamline EMBL Hamburg: instrumentation and applications.

Gruzinov AY, Schroer MA, Manalastas-Cantos K, Kikhney AG, Hajizadeh NR, Schulz F, Franke D, Svergun DI, Blanchet CE

Journal of synchrotron radiation, 2021

doi:10.1107/S1600577521003404.

Hallmarks of Alpha- and Betacoronavirus non-structural protein 7+8 complexes.

Krichel B, Bylapudi G, Schmidt C, Blanchet C, Schubert R, Brings L, Koehler M, Zenobi R, Svergun D, Lorenzen K, Madhugiri R, Ziebuhr J, Uetrecht C

Science advances, 2021

doi:10.1126/sciadv.abf1004.

Adding size exclusion chromatography (SEC) and light scattering (LS) devices to obtain high-quality small angle X-ray scattering (SAXS) data.

Graewert MA, Da Vela S, Gräwert TW, Molodenskiy DS, Blanchet CE, Svergun DI, Jeffries CM

Crystals, 2020

doi:10.3390/cryst10110975.

Investigation of pH-responsiveness inside lipid nanoparticles for parenteral mRNA application using small-angle X-ray scattering.

Uebbing L, Ziller A, Siewert C, Schroer MA, Blanchet CE, Svergun DI, Ramishetti S, Peer D, Sahin U, Haas H, Langguth P

Langmuir : the ACS journal of surfaces and colloids, 2020

doi:10.1021/acs.langmuir.0c02446.

Hybrid biopolymer and lipid nanoparticles with improved transfection efficacy for mRNA.

Siewert CD, Haas H, Cornet V, Nogueira SS, Nawroth T, Uebbing L, Ziller A, Al-Gousous J, Radulescu A, Schroer MA, Blanchet CE, Svergun DI, Radsak MP, Sahin U, Langguth P

Cells, 2020

doi:10.3390/cells9092034.

Rapid screening of in cellulo grown protein crystals via a small-angle X-ray scattering/X-ray powder diffraction synergistic approach.

Lahey-Rudolph JM, Schönherr R, Jeffries CM, Blanchet CE, Boger J, Ferreira Ramos AS, Riekehr WM, Triandafillidis DP, Valmas A, Margiolaki I, Svergun D, Redecke L

Journal of applied crystallography, 2020

doi:10.1107/S1600576720010687.

Polysarcosine-functionalized lipid nanoparticles for therapeutic mRNA delivery.

Nogueira SS, Schlegel A, Maxeiner K, Weber B, Barz M, Schroer MA, Blanchet CE, Svergun DI, Ramishetti S, Peer D, Langguth P, Sahin U, Haas H

{ACS} Applied Nano Materials, 2020

doi:10.1021/acsanm.0c01834.

A THz transparent 3D printed microfluidic cell for small angle x-ray scattering.

Schewa S, Schroer MA, Zickmantel T, Song YH, Blanchet CE, Gruzinov AY, Katona G, Svergun DI, Roessle M

REVIEW OF SCIENTIFIC INSTRUMENTS, 2020

doi:10.1063/5.0004706.

Structural kinetics of MsbA investigated by stopped-flow time-resolved small-angle X-ray scattering.

Josts I, Gao Y, Monteiro DCF, Niebling S, Nitsche J, Veith K, Gräwert TW, Blanchet CE, Schroer MA, Huse N, Pearson AR, Svergun DI, Tidow H

Structure (London, England : 1993), 2020

doi:10.1016/j.str.2019.12.001.

Molecular mechanisms of the interactions of N-(2-hydroxypropyl)methacrylamide copolymers designed for cancer therapy with blood plasma proteins.

Janisova L, Gruzinov A, Zaborova OV, Velychkivska N, Vaněk O, Chytil P, Etrych T, Janoušková O, Zhang X, Blanchet C, Papadakis CM, Svergun DI, Filippov SK

Pharmaceutics, 2020

doi:10.3390/pharmaceutics12020106.

On the origins of fracture toughness in advanced teleosts: how the swordfish sword's bone structure and composition allow for slashing under water to kill or stun prey.

Schmidt FN, Zimmermann EA, Walsh F, Plumeyer C, Schaible E, Fiedler IAK, Milovanovic P, Rößle M, Amling M, Blanchet C, Gludovatz B, Ritchie RO, Busse B

Advanced Science, 2019

doi:10.1002/advs.201900287.

Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.

Verschueren KHG, Blanchet C, Felix J, Dansercoer A, De Vos D, Bloch Y, Van Beeumen J, Svergun D, Gutsche I, Savvides SN, Verstraete K

Nature, 2019

doi:10.1038/s41586-019-1095-5.

Investigation of charge ratio variation in mRNA - DEAE-dextran polyplex delivery systems.

Siewert C, Haas H, Nawroth T, Ziller A, Nogueira SS, Schroer MA, Blanchet CE, Svergun DI, Radulescu A, Bates F, Huesemann Y, Radsak MP, Sahin U, Langguth P

Biomaterials, 2019

doi:10.1016/j.biomaterials.2018.10.020.

Smaller capillaries improve the small-angle X-ray scattering signal and sample consumption for biomacromolecular solutions.

Schroer MA, Blanchet CE, Gruzinov AY, Gräwert MA, Brennich ME, Hajizadeh NR, Jeffries CM, Svergun DI

Journal of Synchrotron Radiation, 2018

doi:10.1107/S1600577518007907.

Multi-channel in situ dynamic light scattering instrumentation enhancing biological small-angle X-ray scattering experiments at the PETRA III beamline P12.

Falke S, Dierks K, Blanchet C, Graewert M, Cipriani F, Meijers R, Svergun D, Betzel C

Journal of synchrotron radiation, 2018

doi:10.1107/S1600577517017568.

Preparing monodisperse macromolecular samples for successful biological small-angle X-ray and neutron-scattering experiments.

Jeffries CM, Graewert MA, Blanchet CE, Langley DB, Whitten AE, Svergun DI

Nature protocols, 2016

doi:10.1038/nprot.2016.113.

Anisotropic lanthanide-based nano-clusters for imaging applications.

Yang X, Wang S, King TL, Kerr CJ, Blanchet C, Svergun D, Pal R, Beeby A, Vadivelu J, Brown KA, Jones RA, Zhang L, Huang S

Faraday discussions, 2016

doi:10.1039/c6fd00018e.

LabDisk for SAXS: a centrifugal microfluidic sample preparation platform for small-angle X-ray scattering.

Schwemmer F, Blanchet CE, Spilotros A, Kosse D, Zehnle S, Mertens HD, Graewert MA, Rössle M, Paust N, Svergun DI, von Stetten F, Zengerle R, Mark D

Lab on a chip, 2016

doi:10.1039/c5lc01580d.

Automated pipeline for purification, biophysical and x-ray analysis of biomacromolecular solutions.

Graewert MA, Franke D, Jeffries CM, Blanchet CE, Ruskule D, Kuhle K, Flieger A, Schäfer B, Tartsch B, Meijers R, Svergun DI

Scientific reports, 2015

doi:10.1038/srep10734.

Versatile sample environments and automation for biological solution X-ray scattering experiments at the P12 beamline (PETRA III, DESY).

Blanchet CE, Spilotros A, Schwemmer F, Graewert MA, Kikhney A, Jeffries CM, Franke D, Mark D, Zengerle R, Cipriani F, Fiedler S, Roessle M, Svergun DI

Journal of applied crystallography, 2015

doi:10.1107/s160057671500254x.

A small and robust active beamstop for scattering experiments on high-brilliance undulator beamlines.

Blanchet CE, Hermes C, Svergun DI, Fiedler S

Journal of synchrotron radiation, 2015

doi:10.1107/s160057751402829x.

Limiting radiation damage for high-brilliance biological solution scattering: practical experience at the EMBL P12 beamline PETRAIII

Jeffries CM, Graewert MA, Svergun DI, Blanchet CE

Journal of Synchrotron Radiation, 2015

doi:10.1107/S1600577515000375.

BioSAXS Sample Changer: a robotic sample changer for rapid and reliable high-throughput X-ray solution scattering experiments.

Round A, Felisaz F, Fodinger L, Gobbo A, Huet J, Villard C, Blanchet CE, Pernot P, McSweeney S, Roessle M, Svergun DI, Cipriani F

2015

doi:10.1107/S1399004714026959.

Linear assembly and 3D networks of peptide modified gold nanoparticles

Kalay S, Blanchet C, Culha M

TURKISH JOURNAL OF CHEMISTRY, 2014

doi:10.3906/kim-1311-6.

Structural determinants and mechanism of mammalian CRM1 allostery

Dölker N, Blanchet CE, Voß B, Haselbach D, Kappel C, Monecke T, Svergun DI, Stark H, Ficner R, Zachariae U, Grubmüller H, Dickmanns A

Structure (London, England : 1993), 2013

doi:10.1016/j.str.2013.05.015.

Quaternary structure of human, Drosophila melanogaster and Caenorhabditis elegans MFE-2 in solution from synchrotron small-angle X-ray scattering

Mehtälä ML, Haataja TJ, Blanchet CE, Hiltunen JK, Svergun DI, Glumoff T

FEBS letters, 2013

doi:10.1016/j.febslet.2012.12.014.

Small-angle X-ray scattering on biological macromolecules and nanocomposites in solution

Blanchet CE, Svergun DI

Annual review of physical chemistry, 2013

doi:10.1146/annurev-physchem-040412-110132.

Instrumental setup for high-throughput small- and wide-angle solution scattering at the X33 beamline of EMBL Hamburg

Blanchet CE, Zozulya AV, Kikhney AG, Franke D, Konarev PV, Shang WF, Klaering R, Robrahn B, Hermes C, Cipriani F, Svergun DI, Roessle M

Journal of applied crystallography, 2012

doi:10.1107/S0021889812013490.