Publications – Bhogaraju Group

Ub-POD: A Ubiquitin-Specific Proximity-Dependent Labeling Technique to Identify E3 Ubiquitin Ligase Substrates in Human Cells.

Mukhopadhyay U, Levantovsky S, Behrends C, Bhogaraju S

Bio-protocol, 2025

doi:10.21769/bioprotoc.5351.

Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling.

Zacharia NK, Kuhns S, Boegholm N, Christensen A, Wang J, Petriman NA, Lorentzen A, Fialova JL, Menguy L, Saunier S, Christensen ST, Andersen JS, Bhogaraju S, Lorentzen E

eLife, 2024

doi:10.7554/eLife.104906.1.

A ubiquitin-specific, proximity-based labeling approach for the identification of ubiquitin ligase substrates.

Mukhopadhyay U, Levantovsky S, Carusone TM, Gharbi S, Stein F, Behrends C, Bhogaraju S

Science advances, 2024

doi:10.1126/sciadv.adp3000.

Response to Forker et al.

Griffith-Jones S, Álvarez L, Mukhopadhyay U, Gharbi S, Rettel M, Adams M, Hennig J, Bhogaraju S

The EMBO journal, 2024

doi:10.1038/s44318-024-00141-1.

Structural basis for RAD18 regulation by MAGEA4 and its implications for RING ubiquitin ligase binding by MAGE family proteins.

Griffith-Jones S, Álvarez L, Mukhopadhyay U, Gharbi S, Rettel M, Adams M, Hennig J, Bhogaraju S

The EMBO journal, 2024

doi:10.1038/s44318-024-00058-9.

USP7/Maged1-mediated H2A monoubiquitination in the paraventricular thalamus: an epigenetic mechanism involved in cocaine use disorder.

Cheron J, Beccari L, Hagué P, Icick R, Despontin C, Carusone T, Defrance M, Bhogaraju S, Martin-Garcia E, Capellan R, Maldonado R, Vorspan F, Bonnefont J, de Kerchove d'Exaerde A

Nature communications, 2023

doi:10.1038/s41467-023-44120-2.

Structural basis for the toxicity of Legionella pneumophila effector SidH.

Sharma R, Adams M, Griffith-Jones S, Sahr T, Gomez-Valero L, Weis F, Hons M, Gharbi S, Berkane R, Stolz A, Buchrieser C, Bhogaraju S

Nature communications, 2023

doi:10.1038/s41467-023-42683-8.

Structural basis for protein glutamylation by the Legionella pseudokinase SidJ.

Adams M, Sharma R, Colby T, Weis F, Matic I, Bhogaraju S

Nature communications, 2021

doi:10.1038/s41467-021-26429-y.

Purification and crystal structure of human ODA16: implications for ciliary import of outer dynein arms by the intraflagellar transport machinery.

Wang JL, Taschner M, Petriman NA, Andersen MB, Basquin J, Bhogaraju S, Vetter M, Wachter S, Lorentzen A, Lorentzen E

Protein Science, 2020

doi:10.1002/pro.3864.

Regulation of phosphoribosyl-linked serine ubiquitination by deubiquitinases DupA and DupB.

Shin D, Mukherjee R, Liu Y, Gonzalez A, Bonn F, Liu Y, Rogov VV, Heinz M, Stolz A, Hummer G, Dötsch V, Luo ZQ, Bhogaraju S, Dikic I

Molecular cell, 2020

doi:10.1016/j.molcel.2019.10.019.

Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin-catalysed glutamylation.

Bhogaraju S, Bonn F, Mukherjee R, Adams M, Pfleiderer MM, Galej WP, Matkovic V, Lopez-Mosqueda J, Kalayil S, Shin D, Dikic I

Nature, 2019

doi:10.1038/s41586-019-1440-8.

Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination.

Kalayil S, Bhogaraju S, Bonn F, Shin D, Liu Y, Gan N, Basquin J, Grumati P, Luo ZQ, Dikic I

Nature, 2018

doi:10.1038/s41586-018-0145-8.

Crystal structure of tetrameric human Rabin8 GEF domain.

Vetter M, Boegholm N, Christensen A, Bhogaraju S, Andersen MB, Lorentzen A, Lorentzen E

Proteins, 2018

doi:10.1002/prot.25455.

A General Approach Towards Triazole-Linked Adenosine Diphosphate Ribosylated Peptides and Proteins.

Liu Q, Kistemaker HAV, Bhogaraju S, Dikic I, Overkleeft HS, van der Marel GA, Ovaa H, van der Heden van Noort GJ, Filippov DV

Angewandte Chemie (International ed. in English), 2018

doi:10.1002/anie.201710527.

Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA.

Fiskin E, Bhogaraju S, Herhaus L, Kalayil S, Hahn M, Dikic I

Nature communications, 2017

doi:10.1038/ncomms14004.

Phosphoribosylation of ubiquitin promotes serine ubiquitination and impairs conventional ubiquitination.

Bhogaraju S, Kalayil S, Liu Y, Bonn F, Colby T, Matic I, Dikic I

Cell, 2016

doi:10.1016/j.cell.2016.11.019.

Cell biology: Ubiquitination without E1 and E2 enzymes.

Bhogaraju S, Dikic I

Nature, 2016

doi:10.1038/nature17888.

Bacteria-host relationship: ubiquitin ligases as weapons of invasion.

Maculins T, Fiskin E, Bhogaraju S, Dikic I

Cell research, 2016

doi:10.1038/cr.2016.30.

Intraflagellar transport proteins 172, 80, 57, 54, 38, and 20 form a stable tubulin-binding IFT-B2 complex.

Taschner M, Weber K, Mourão A, Vetter M, Awasthi M, Stiegler M, Bhogaraju S, Lorentzen E

The EMBO journal, 2016

doi:10.15252/embj.201593164.

PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins.

McEwan DG, Popovic D, Gubas A, Terawaki S, Suzuki H, Stadel D, Coxon FP, Miranda de Stegmann D, Bhogaraju S, Maddi K, Kirchof A, Gatti E, Helfrich MH, Wakatsuki S, Behrends C, Pierre P, Dikic I

Molecular cell, 2015

doi:10.1016/j.molcel.2014.11.006.