Would you like to create your own three-dimensional model of a protein using an A4 paper template?
You can do this by following the instructions to fold a triosephosphate isomerase (TIM) barrel. TIM barrels are some of the most common structural motifs found in proteins. In a TIM barrel eight α-helices and eight parallel β-strands form a solenoid that curves around to close on itself in a doughnut shape. Triosephosphate isomerase is a conserved metabolic enzyme that is involved in the production of chemical energy from sugar, a process called glycolysis.
Download the TIM barrel folding template here.
Some explanatory pictures accompanying the folding tutorial can be found on the TIM barrel folding template.
Topic area: Structural & Computational biology
Age group: 12-14, 14-16, 10-12, < 10
Author: Alex Bateman, Gary Battle