Marie Sorin and Bina Kumari Singh of the Carlson Lab at University of Umeå in Sweden, spent one week at the EMBL IC performing cryo-electron tomography (cryo-ET) to study the replication process of enteroviruses, a group of viruses that includes poliovirus, coxsackievirus, and rhinovirus. This imaging technique allows scientists to visualise the structure and dynamics of these viruses at a molecular level, providing valuable insights into their replication mechanism and potential vulnerabilities for targeted therapies.

Our Application Specialist, Zhengyi Yang, provided support to the users during their visit, assisting in the preparation of cryo-lamellae using FIB-milling and the acquisition of data through transmission electron microscopy (TEM) conducted under strict BioSafety Level 2 conditions.

This visit was made possible thanks to the Euro-Bioimaging infrastructure and funding from ISIDORe. For more information, you can access the full article here.