Open access to cutting-edge electron and light microscopy
We provide researchers from Europe and beyond with a synergistic portfolio of imaging services including cryo-EM, super-resolution and intravital microscopy to enable new ground-breaking research that crosses the scales of biology.
STELLARIS 8 STED with TauSTED from Leica Microsystems allows the study of multiple dynamic events simultaneously and investigation of molecular relationships and mechanisms within the cellular context.
FALCON (FAst Lifetime CONtrast) includes phasors for quantitative FLIM analysis. It is a fully integrated solution for fluorescence lifetime imaging (FLIM) and enables video-rate image acquisition for rapid kinetic studies in live cells.
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THUNDER is an opto-digital technology from Leica Microsystems that uses the Computational Clearing method for haze removal to generate high-resolution and high-contrast images.
A THUNDER Imager Live Cell provides a complete microscopy imaging system for minimally invasive and precise live-cell imaging. High-speed and/or long term examination of specimens, e.g. cell cultures and organoids, can be performed at low phototoxicity and photobleaching.
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The MultiView-SPIM (Selective plane illumination microscope) is an advanced light sheet fluorescence microscope utilising multiple orthogonal optical paths for in vivo imaging of small embryos, organisms and cell cultures. The MultiView-SPIM available at the EMBL IC has originally been developed by the lab of Lars Hufnagel at EMBL and further developed by the lab of Robert Prevedel at EMBL. Owing to its plane wise illumination confinement and fast imaging on multiple cameras, the MultiView-SPIM is able to capture developmental dynamics with minimal photodamage to the living subjects.+
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STELLARIS 8 DIVE with the 4Tune detection system is a spectrally tunable multiphoton microscope from Leica Microsystems. Four non-descanned spectrally flexible channels provide multicolor multiphoton imaging at > 1 mm depth.
Lifetime-based information can be directly obtained in addition to distinguish spectrally similar fluorophores, separate second harmonic (SHG) signals from fluorescence or visualise the metabolic state of cells. Lifetime analysis and quantification can be done FALCON.
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DMi8 S from Leica Microsystems is a live cell imaging system to execute advanced experiments with imaging modalities like photomanipulation or TIRF, both simultaneously or sequential. For dynamic processes at the cell surface TIRF (Total Internal Reflection Fluorescence) microscopy is the method of choice to visualize single molecules with super-resolution by maximizing the fluorescent signal- to-noise-ratio. Furthermore, the system can be set-up for multispectral photomanipulation techniques like FRAP, acceptor bleaching, activation, optogenetics, DNA damage, or ablation within one single experiment. Imaging specialists are on site to support your particular application.
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