Publications – Lancrin Group

Identifying a novel role for the master regulator Tal1 in the Endothelial to Hematopoietic Transition.

Serina Secanechia YN, Bergiers I, Rogon M, Arnold C, Descostes N, Le S, López-Anguita N, Ganter K, Kapsali C, Bouilleau L, Gut A, Uzuotaite A, Aliyeva A, Zaugg JB, Lancrin C

Scientific reports, 2022

doi:10.1038/s41598-022-20906-0.

Operation of a TCA cycle subnetwork in the mammalian nucleus.

Kafkia E, Andres-Pons A, Ganter K, Seiler M, Smith TS, Andrejeva A, Jouhten P, Pereira F, Franco C, Kuroshchenkova A, Leone S, Sawarkar R, Boston R, Thaventhiran J, Zaugg JB, Lilley KS, Lancrin C, Beck M, Patil KR

Science advances, 2022

doi:10.1126/sciadv.abq5206.

Single-cell transcriptome analysis of embryonic and adult endothelial cells allows to rank the hemogenic potential of post-natal endothelium.

Adamov A, Serina Secanechia YN, Lancrin C

Scientific reports, 2022

doi:10.1038/s41598-022-16127-0.

MOF histone acetyltransferase in blood cell development.

Serina Secanechia Y, Lancrin C

Trends in genetics : TIG, 2020

doi:10.1016/j.tig.2020.06.010.

Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition.

Oatley M, Bölükbası ÖV, Svensson V, Shvartsman M, Ganter K, Zirngibl K, Pavlovich PV, Milchevskaya V, Foteva V, Natarajan KN, Baying B, Benes V, Patil KR, Teichmann SA, Lancrin C

2020

doi:10.1038/s41467-019-14171-5.

Single-cell atlas of major haematopoietic tissues sheds light on blood cell formation from embryonic endothelium.

Shvartsman M, Pavlovich PV, Oatley M, Ganter K, McKernan R, Prialgauskaite R, Adamov A, Chukreev K, Descostes N, Buness A, Cabezas-Wallscheid N, Lancrin C

2019

doi:10.1101/774547.

Iron deficiency disrupts embryonic haematopoiesis but not the endothelial to haematopoietic transition.

Shvartsman M, Bilican S, Lancrin C

Scientific reports, 2019

doi:10.1038/s41598-019-42765-y.

Quantification of mouse hematopoietic progenitors' formation using time-lapse microscopy and image analysis.

Bergiers I, Tischer C, Vargel Bölükbaşı Ö, Lancrin C

Bio-protocol, 2019

doi:10.21769/BioProtoc.3137.

Iron deficiency affects early stages of embryonic hematopoiesis but not the endothelial to hematopoietic transition.

Shvartsman M, Bilican S, Lancrin C

2018

doi:10.1101/462978.

Single-cell transcriptomics identifies CD44 as a new marker and regulator of haematopoietic stem cells development.

Oatley M, Vargel O, Svensson V, Shvartsman M, Ganter K, Zirngibl K, Pavlovich PV, Milchevskaya V, Foteva VV, Natarajan KN, Baying B, Benes V, Patil KR, Teichmann SA, Lancrin C

2018

doi:10.1101/338178.

Discovery of a new path for red blood cell generation in the mouse embryo.

Pinheiro I, Vargel O, Ganter K, Sabou LA, Tew VK, Bolasco G, Shvartsman M, Pavlovich PV, Buness A, Nikolakopoulou C, Bergiers I, Kouskoff V, Lacaud G, Lancrin C

2018

doi:10.1101/309054.

Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis.

Bergiers I, Andrews T, Vargel Bölükbaşı Ö, Buness A, Janosz E, Lopez-Anguita N, Ganter K, Kosim K, Celen C, Itır Perçin G, Collier P, Baying B, Benes V, Hemberg M, Lancrin C

eLife, 2018

doi:10.7554/eLife.29312.

Regulation of RUNX1 dosage is crucial for efficient blood formation from hemogenic endothelium.

Lie-A-Ling M, Marinopoulou E, Lilly AJ, Challinor M, Patel R, Lancrin C, Kouskoff V, Lacaud G

Development (Cambridge, England), 2018

doi:10.1242/dev.149419.

Activation of the TGFβ pathway impairs endothelial to haematopoietic transition.

Vargel O, Zhang Y, Kosim K, Ganter K, Foehr S, Mardenborough Y, Shvartsman M, Enright AJ, Krijgsveld J, Lancrin C

SCIENTIFIC REPORTS, 2016

doi:10.1038/srep21518.

GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1.

Thambyrajah R, Mazan M, Patel R, Moignard V, Stefanska M, Marinopoulou E, Li Y, Lancrin C, Clapes T, Möröy T, Robin C, Miller C, Cowley S, Göttgens B, Kouskoff V, Lacaud G

Nature cell biology, 2015

doi:10.1038/ncb3276.

TGFβ pathway activation blocks the endothelial to hematopoietic transition.

Vargel O, Zhang Y, Collier P, Baying B, Benes V, Lancrin C

EXPERIMENTAL HEMATOLOGY, 2014

doi:10.1016/j.exphem.2014.07.243.

GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment.

Lancrin C, Mazan M, Stefanska M, Patel R, Lichtinger M, Costa G, Vargel O, Wilson NK, Möröy T, Bonifer C, Göttgens B, Kouskoff V, Lacaud G

Blood, 2012

doi:10.1182/blood-2011-10-386094.

Identification and characterization of a novel transcriptional target of RUNX1/AML1 at the onset of hematopoietic development.

Ferreras C, Lancrin C, Lie-A-Ling M, Kouskoff V, Lacaud G

Blood, 2011

doi:10.1182/blood-2010-06-294124.

The sequential expression of CD40 and Icam2 defines progressive steps in the formation of blood precursors from the mesoderm germ layer

Pearson S, Lancrin C, Lacaud G, Kouskoff V

Stem cells (Dayton, Ohio), 2010

doi:10.1002/stem.434.

Blood cell generation from the hemangioblast

Lancrin C, Sroczynska P, Serrano AG, Gandillet A, Ferreras C, Kouskoff V, Lacaud G

Journal of molecular medicine (Berlin, Germany), 2010

doi:10.1007/s00109-009-0554-0.

The differential activities of Runx1 promoters define milestones during embryonic hematopoiesis

Sroczynska P, Lancrin C, Kouskoff V, Lacaud G

Blood, 2009

doi:10.1182/blood-2009-05-222307.

Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program

Hoogenkamp M, Lichtinger M, Krysinska H, Lancrin C, Clarke D, Williamson A, Mazzarella L, Ingram R, Jorgensen H, Fisher A, Tenen DG, Kouskoff V, Lacaud G, Bonifer C

Blood, 2009

doi:10.1182/blood-2008-11-191890.