Systems Genetics: From Genomes to Complex Traits

Overview

The programme, poster listing, bus schedule and onsite handout (with logistical information)  are now available for download. 

Symposium Overview

Next generation sequencing, genome editing, deep mutational scans and single cell biology are opening up unprecedented opportunities to understand how genetic variation alters molecular mechanisms to cause phenotypic variation amongst individuals, including quantitative traits and human disease. This first EMBO|EMBL Symposium on systems genetics will focus on the central questions of when and how changes in genotype result in changes in phenotype. This meeting will bring together groups using experimental, statistical and mechanistic modelling approaches to address these questions at different scales and in diverse model systems, including for human disease.

Session Topics

• Deep mutational scans
• Evolution
• Gene regulation
• Genetic interactions
• Genetic prediction 
• Genetics of human disease
• Genotype-phenotype landscapes
• Personal genomes
• Quantitative traits
• Reverse genetics and gene editing
• Single cell genetics
• Statistical methods
• Variability and noise

Speakers

Speakers and Trainers

Keynote Speakers

Brenda Andrews

University of Toronto

Canada

Michael Snyder

Stanford University

USA

Speakers

Bart Deplancke

École Polytechnique F édérale de Lausanne

Switzerland

Maitreya Dunham

University of Washington

USA

Tuuli Lappalainen

New York Genome Center and Columbia University

USA

Ben Lehner

Centre for Genomic Regulation

Spain

Marcelo Nobrega

The University of Chicago

USA

Leopold Parts

Wellcome Sanger Institute

UK

Marylyn Ritchie

University of Pennsylvania

USA

Rickard Sandberg

Karolinska Institutet

Sweden

Oliver Stegle

EMBL Heidelberg and German Cancer Research Center

Germany

Lars Steinmetz

EMBL Heidelberg

Germany

Jussi Taipale

University of Cambridge

UK

Patricia Wittkopp

University of Michigan

USA

Gaël Yvert

CNRS and École Normale Supérieure de Lyon

France

Judith Zaugg

EMBL Heidelberg

Germany

Eleftheria Zeggini

Helmholtz Zentrum München

Germany

Alexandra Zhernakova

University Medical Center Groningen

The Netherlands

Scientific Organisers

Tuuli Lappalainen

New York Genome Center and Columbia University

USA

Ben Lehner

Centre for Genomic Regulation

Spain

Thomas Lemberger

EMBO

Germany

Lars Steinmetz

EMBL Heidelberg

Germany

Conference Organisers

Lisa Trinh

EMBL Heidelberg

Germany

Programme