Chromatin and Epigenetics – Course and Conference Office

EMBL Conference

Chromatin and Epigenetics


EMBL is committed to sharing research advances and sustaining scientific interaction throughout the coronavirus pandemic. We are delighted to announce that the conference is going virtual and invite you to join us online. The virtual conference includes live talks from invited speakers, short talk presenters, digital poster sessions and networking opportunities.

Conference Overview

Epigenetics refers to heritable changes in gene expression that do not involve changes to the underlying DNA sequence. At least three systems including DNA methylation, histone modifications and non-coding RNAs (ncRNA) are considered to play fundamental roles in epigenetic regulation. Research over the last two decades has uncovered the role of epigenetics in a variety of human disorders and fatal diseases. Moreover influence of age, environment, lifestyle, and disease state on epigenetic states is being increasingly appreciated and actively studied. This conference provides an international forum for cutting edge research in chromatin and epigenetics. It provides the “focal hub” for people to present their research and exchange ideas in a virtual format. Renowned speakers will cover the latest advances in the field.

Session Topics

  • Heterochromatin and HP1
  • Developmental epigenetics
  • Chromatin regulation
  • Nucleosomes structure and function
  • Transcription and chromatin defects and diseases
  • Nuclear architecture
  • Chromatin and RNA modifications


Keynote speaker


Asifa Akhtar

Max Planck Institute of

Immunobiology and



Nicola Iovino

Max Planck Institute of

Immunobiology and



Cigall Kadoch

Dana-Farber Cancer

Institute and Harvard

Medical School


Scientific Organisers

Asifa Akhtar

Max Planck Institute of

Immunobiology and



Nicola Iovino

Max Planck Institute of

Immunobiology and



Cigall Kadoch

Dana-Farber Cancer

Institute and Harvard

Medical School


Conference Organiser

Maryann Heck

EMBL Heidelberg


Tim Nürnberger

EMBL Heidelberg



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  • The virtual conference includes live-streamed invited speaker talks and live-streamed selected short talks with live Q&A sessions after each talk
    as well as meet the speaker sessions.
  • All digital poster presenters are encouraged to upload a recorded flash talk or narration with their digital poster and to schedule video calls during poster session times.
  • Information on the live stream and access to the discussion platform and digital posters will be provided 1 week before the start of the event.

The following times are used in the programme below:

  • Central European Summer Time (CEST): eg. Berlin, Amsterdam, Paris
  • Eastern Daylight Time (EDT): eg. New York, Quebec

To find out the equivalent time zone in your location, enter Berlin, the CEST programme time and your city into the Time Zone Converter.

Day 1 – Monday 17 May 2021
14:00 – 14:10 (CEST)
08:00 – 08:10 (EDT)
Opening remarks by scientific organisers
14:10 – 16:10 
08:10 – 10:10 (EDT)
Session 1: Developmental epigenetics
Chairs: Asifa Akhtar and Nicola Iovino
14:10 – 14:40 (CEST)
08:10 – 08:40 (EDT)
Amanda G. Fisher – MRC London Institute of Medical Sciences, UK
14:40 – 15:10 (CEST)
08:40 – 09:10 (EDT)
Cold-induced epigenetic switching
Caroline Dean – John Innes Centre, UK
15:10 – 15:40 (CEST)
09:10 – 09:40 (EDT)
Histone H3 variants in the nucleus, make your choice
Geneviève Almouzni – Institut Curie, France
15:40 – 15:55 (CEST)
09:40 – 09:55 (EDT)
The chromatin remodeler DDM1 prevents transposon
mobility through deposition of histone variant H2A.W

Frederic Berger – GMI, Austria
15:55 – 16:10 (CEST)
09:55 – 10:10 (EDT)
Distal and proximal cis-regulatory elements sense
X-chromosomal dosage and developmental state
at the Xist locus
Edda Schulz – Max Planck Institute for Molecular Genetics, Germany
16:10 – 16:20 
10:10 – 10:20 (EDT)
16:20 – 16:50 
10:20 – 10:50 (EDT)
Meet all the speakers from Session 1
in individual Zoom rooms
16:50 – 17:50 
10:50 – 11:50 (EDT)
Poster Session 1 (A-F)
(live chats and video calls with poster presenters)
17:50 – 18:00 
11:50 – 12:00 (EDT)
18:00 – 20:30
12:00 – 14:30 (EDT)
Session 2: Heterochromatin and HP1
Chairs: Cigall Kadoch and Giacomo Cavalli
18:00 – 18:30 (CEST)
12:00 – 12:30 (EDT)
Heterochromatin-associated RNA degradation and epigenetic inheritance
Danesh Moazed – Harvard Medical School, USA
18:30 – 19:00 (CEST)
12:30 – 13:00 (EDT)
HP1 drives de novo 3D genome reorganization in early Drosophila embryos
Nicola Iovino – Max Planck Institute of Immunobiology
and Epigenetics, Germany
19:00 – 19:30 (CEST)
13:00 – 13:30 (EDT)
Can phase-separation explain heterochromatin properties?
Geeta J. Narlikar – University of California, San Francisco, USA
19:30 – 19:40 (CEST)
13:30 – 13:40 (EDT)
19:40 – 19:55 (CEST)
13:40 – 13:55 (EDT)
Heterochromatin condensate formation and function
Gary Karpen – University of California, Berkeley, USA
19:55 – 20:10 (CEST)
13:55 – 14:10 (EDT)
Heterochromatin dynamics across scales
Serena Sanulli – Stanford University, USA
20:10 – 20:25 
14:10 – 14:25 (EDT)
Genome organization in and around the nucleolus
Raffaella Santoro – University of Zurich, Switzerland
20:25 – 20:30 
14:25 – 14:30 (EDT)
Transition (switch to individual Zoom rooms)
20:30 – 21:00 
14:30 – 15:00 (EDT)
Meet all the speakers from Session 2
in individual Zoom rooms
21:00 – 21:30 
15:00 – 15:30 (EDT)
Virtual speed networking – optional
(Rotating through 5-min meet ups
in random groups of 2-3 people in a breakout room)

Digital posters, recordings and discussion channels will be available for registered participants throughout the whole virtual conference (as well as 1 week before and 2 weeks after)

Day 2 – Tuesday 18 May 2021
13:00 – 13:45 
07:00 – 07:45 (EDT)
Career fire-side chat on academic careers – optional
hosted by Rachel Coulthard-Graf, EMBL Heidelberg

Magda Bienko, Karolinska Institutet
Alan Cheung , University of Bristol
13:45 – 14:00 
07:45 – 08:00 (EDT)
14:00 – 16:40 
08:00 – 10:40 (EDT)
Session 3: 
Transcription and chromatin defects and diseases
Chairs: Asifa Akhtar and Wolf Reik
14:00 – 14:30 (CEST)
08:00 – 08:30 (EDT)
Controlling transcription at coding and non-coding RNA loci
Karen Adelman – Harvard Medical School, USA
14:30 – 15:00 (CEST)
08:30 – 09:00 (EDT)
The distinct role of Polycomb and MLL proteins
in stem cell biology and cancer
Luciano Di Croce – Centre for Genomic Regulation, Spain
15:00 – 15:30 (CEST)
09:00 – 09:30 (EDT)
Epigenetic pathways involving p53 as a tumor suppressor and oncogene
Shelley L. Berger – University of Pennsylvania, USA
15:30 – 15:40 (CEST)
09:30 – 09:40 (EDT)
15:40 – 16:10 (CEST)
09:40 – 10:10 (EDT)
Principles of epigenetics and chromatin
in development and human disease
Ali Shilatifard – Northwestern University, USA
16:10- 16:25 (CEST)
10:10- 10:25 (EDT)
The impact of cancer associated CTCF mutations
on chromatin structure and gene regulation
Jane Skok – NYU School of Medicine, USA
16:25 – 16:40 (CEST)
10:25 – 10:40 (EDT)
Chromatin regulation through intrinsic disorder:
What does it take to be a boundary/insulator?
Philipp Korber – Biomedical Center, LMU Munich, Germany
16:40 – 16:50 
10:40 – 10:50 (EDT)
16:50 – 17:20 
10:40 – 11:20 (EDT)
Meet all the speakers from Session 3 
in individual Zoom rooms
17:20 – 18:20 
11:20 – 12:20 (EDT)
Poster Session 2 (G-M)
(live chats and video calls with poster presenters)
12:20 – 12:30 (EDT)
18:30 – 21:00 
12:15 – 14:05 (EDT)
Session 4: Chromatin regulation
Chairs: Anja Groth and Peter Becker
18:30 – 19:00 (CEST)
12:30 – 13:00 (EDT)
Epigenetic regulation by histone acetylation
Asifa Akhtar – Max Planck Institute of Immunobiology
and Epigenetics, Germany
19:00 – 19:30 (CEST)
13:00 – 13:30 (EDT)
Nucleosome compaction, phase separation,
and Polycomb-Group maintenance of repression
Robert E. Kingston – Harvard Medical School, USA
19:30 – 20:00 (CEST)
13:30 – 14:00 (EDT)
Polycomb, inheritance and disease
Danny Reinberg – New York University School of Medicine, USA
20:00 – 20:10 (CEST)
14:00 – 14:10 (EDT)
20:10 – 20:25 (CEST)
14:10 – 14:25 (EDT)
Role of chromatin condensates in establishing
nuclear architecture

Alessio Zippo – University of Trento, Italy
20:25 – 20:40 (CEST)
14:25 – 14:40 (EDT)
Structural basis of cGAS inhibition by the nucleosome
Robert McGinty – University of North Carolina at Chapel Hill, USA
20:40 – 20:55 (CEST)
14:40 – 14:55 (EDT)
Distinct PRC2 subunits regulate maintenance and
establishment of Polycomb repression during differentiation

Ana Petracovici – University of Pennsylvania, USA
20:55 – 21:00 
14:55 – 15:00 (EDT)
Transition (switch to individual Zoom rooms)
21:00 – 21:30 
15:00 – 15:30 (EDT)
Meet all the speakers from Session 4 
in individual Zoom rooms
21:30 – 22:30 
15:30 – 16:30 (EDT)
Live Jazz and Virtual Bar Mixer – optional
(Rotating through 10-min meet ups in random groups
of 5-6 people in a breakout room plus live music)

Digital posters, recordings and discussion channels will be available for registered participants throughout the whole virtual conference (as well as 1 week before and 2 weeks after)

Day 3 – Wednesday 19 May 2021
07:15-07:45 (EDT)
Meet the editors in individual Zoom rooms – optional
Poonam Bheda, Nature Communications
Krista Bledsoe, Molecular Cell, Cell Press
Stefanie Boehm, The EMBO Journal
Dorothy Clyde, Nature Reviews Genetics
Alex Eccleston, Nature
Di Jiang, Science
Sara Monaco, Review Commons
Esther Schnapp, EMBO reports
Anke Sparmann, Nature Structural & Molecular Biology
07:45- 08:00 (EDT)
08:00-10:40 (EDT)
Session 5: Nucleosomes structure and function
Chairs: Geneviève Almouzni and Nicola Iovino
14:00- 14:30 (CEST)
08:00- 08:30 (EDT)
Chromatin replication and epigenome maintenance
Anja Groth – University of Copenhagen, Denmark
14:30- 15:00 (CEST)
08:30- 09:00 (EDT)
Cooperation, competition and combination: Principles of targeting the X for chromosome-wide regulation
Peter Becker – Ludwig-Maximilians-Universität München, Germany
15:00- 15:30 (CEST)
09:00- 09:30 (EDT)
Structure and function of mammalian SWI/SNF chromatin remodeling complexes in human cancer
Cigall Kadoch – Dana-Farber Cancer Institute and Harvard Medical School, USA
15:30- 15:40 (CEST)
09:30- 09:40 (EDT)
15:40- 16:10 (CEST)
09:40- 10:10 (EDT)
Some assembly required: Structure and function of chromatin assembly factors and remodelers
Karolin Luger – University of Colorado Boulder, USA
16:10- 16:25 (CEST)
10:10- 10:25 (EDT)
The non-canonical SMC protein SMCHD1 has separable roles in long range chromatin interactions
and gene silencing
Marnie Blewitt – Walter and Eliza Hall Institute of Medical Research, Australia
16:25-16:40 (CEST)
10:25- 10:40 (EDT)
Genetic and epigenetic regulation
of imprinting control regions
Tuncay Baubec – University of Zurich, Switzerland
10:40- 10:50 (EDT)
10:40- 11:20 (EDT)
Meet all the speakers from Session 5 
in individual Zoom rooms
11:20- 12:20 (EDT)
Poster Session 3 (N-Z)
(live chats and video calls with poster presenters)
12:20- 12:30 (EDT)
12:30- 15:00 (EDT)
Session 6: Nuclear architecture
Chairs: Karolin Luger and Luciano Di Croce
18:30- 19:00 (CEST)
12:30- 13:00 (EDT)
Enhancer promoter communication during embryonic development
Eileen Furlong – EMBL Heidelberg, Germany
19:00-19:30 (CEST)
13:00-13:30 (EDT)
Principles and functional role of 3D genome folding
Giacomo Cavalli – Institute of Human Genetics – CNRS, France
19:30-20:00 (CEST)
13:30-14:00 (EDT)
Visualizing variable chromatin structures and robust transcriptional control
Alistair Boettiger – Stanford University, USA
20:00-20:10 (CEST)
14:00-14:10 (EDT)
20:10-20:25 (CEST)
14:10-14:25 (EDT)
Nonlinear control of transcription levels through
enhancer-promoter interactions

Luca Giorgetti – Friedrich Miescher Institute for Biomedical Research, Switzerland
20:25-20:40 (CEST)
14:25-14:40 (EDT)
Rapid reorganization of the 3D genome reveals principal features of chromosome architecture
Elzo de Wit – Oncode Institute & Netherlands Cancer Institute, The Netherlands
20:40- 20:55 (CEST)
14:40- 14:55 (EDT)
Chromosomal coordination and differential structure
of asynchronous replicating regions

Yehudit Bergman – The Hebrew University Medical School, Israel
14:55- 15:00 (EDT)
Transition (switch to individual Zoom rooms)
21:00-21:30 (CEST)
15:00-15:30 (EDT)
Meet all the speakers from Session 6 
in individual Zoom rooms

Digital posters, recordings and discussion channels will be available for registered participants throughout the whole virtual conference (as well as 1 week before and 2 weeks after)

Day 4 – Thursday 20 May 2021
14:00- 15:45 
08:00 – 09:45 (EDT)
Session 7: Chromatin and RNA modifications
Chairs: Caroline Dean and Cigall Kadoch
14:00 – 14:30 (CEST)
08:00 – 08:30 (EDT)
Nuclear condensates in gene regulation and disease
Richard A. Young – Whitehead Institute for Biomedical Research, USA
14:30 – 15:00 (CEST)
08:30 – 09:00 (EDT)
Chemical approaches to studying chromatin
Tom Muir – Princeton University, USA
15:00 – 15:05 (CEST)
09:00 – 09:05 (EDT)
15:05 – 15:20 (CEST)
09:05 – 09:20 (EDT)
Inducible condensation of chromatin regulators drives
rapid transcriptional changes

Ritwick Sawarkar – University of Cambridge, UK
15:20 – 15:35 (CEST)
09:20 – 09:35 (EDT)
Single-molecule systems for cancer research
and diagnostics: Decoding the epigenome
of pediatric gliomas
Efrat Shema – Weizmann Institute of Science, Israel
15:35 – 15:50 (CEST)
09:35 – 09:50 (EDT)
Control of enhancer activity by DNA methylation
Arnaud Krebs – EMBL Heidelberg, Germany
15:50 – 16:00 (CEST)
09:50 – 10:00 (EDT)
16:00- 16:45 
10:00 – 10:45 (EDT)
Keynote: Single cell multi-omics landscape of development and ageing 
Wolf Reik – Babraham Institute, UK
16:45- 16:55 
10:45 – 10:55 (EDT)
Poster prize talk 1
16:55- 17:05 
10:55 – 11:05 (EDT)
Poster prize talk 2
17:05- 17:15 
11:05 – 11:15 (EDT)
Poster prize talk 3
17:15- 17:25 
11:15 – 11:25 (EDT)
Closing remarks
17:25- 17:55 
11:25 – 11:55 (EDT)
Meet all the speakers from Session 7 
in individual Zoom rooms

Digital posters, recordings and discussion channels will be available for registered participants throughout the whole virtual conference (as well as 1 week before and 2 weeks after)

Practical information

Registration Fees and Abstract Submission

Registration Fees (include access to all of the talks, digital poster sessions and online group discussions, and help us cover our costs to run the event.) 
For further information please refer to the FAQ page):

Academia190 Euro
PhD Student140 Euro
Industry240 Euro
EMBL StaffIntranet access

Accredited journalists may be eligible to register for a reduced press rate or in some cases for complimentary registration. Registrants may be required to provide accreditation or equivalent proof of press membership after registration. Please contact Tim Nürnberger for more information.

Confirmation and Payment

Registration will be on a first-come first-served basis. Your place can only be confirmed after payment of the registration fee.
Types of payments accepted are international bank transfers (only up to 8 weeks before event) and credit card payments.

Abstract submission

Only registered participants are eligible to submit an abstract. We only accept online abstract submissions. 

After registration you can submit your abstract via a separate link that will be provided in the email confirmation. Alternatively, you can access the link on the confirmation page directly after registering. The same login credentials are used for both processes.

Please note:

Title: The title should not exceed 20 words. Only the first word of the title should start with a capital letter and the rest of the title should be in lowercase.

Authors and Affiliations: Please fill in the author’s details as requested in the online form. The compulsory details are: First Name, Last Name, Organisation Name (Affiliation or Company), Country and Email. Mark only one author as the role of First author and please don’t forget to indicate who will be presenting. The order of the authors will be listed as follows: First Author, Co-First Author (alphabetically if multiple), co-author(s) (in the order added by the submitter).

Presentation Types: When submitting your abstract, you can apply for an oral or digital poster presentation. A selection process will take place with the results announced 2-3 weeks after the abstract submission deadline.

Please check our FAQs pages for further information on how to submit an abstract.

Financial Assistance

Financial Assistance

Registration Fee Waivers

All academic and student registrants are invited to apply for a registration fee waiver, provided by the EMBL Advanced Training Centre Corporate Partnership Programme. The registration fee waiver covers the registration sum that you have paid to attend the meeting. Conference participants are not required to pre-pay the registration fee to be selected for a fee waiver for a virtual meeting. If you have already paid the registration fee and are awarded a fee waiver, it will be reimbursed after the meeting. Course participants are required to pay the course fee in advance, which will then be reimbursed after the course to the fee waiver recipients.

Childcare Grants

For participants with children, there is the possibility to apply for a childcare grant provided by the EMBL Advanced Training Centre Corporate Partnership Programme, to offset childcare costs incurred by participants or speakers when participating at a virtual event. Eligible costs include fees for a babysitter or childcare facility or travel costs for a care giver. Please note that priority will be given to early stage researchers. A maximum amount of 500 EUR can be awarded per participant selected for the virtual childcare grant. Costs will be reimbursed after the meeting only once a reimbursement form and original receipts have been received. In order to apply for this grant, you must be registered by the abstract submission deadline.


Applications for financial assistance can be submitted via the submission portal* (for the submission of abstracts for conferences or the submission of motivation letters for courses) by completing the Financial Assistance Application Section (underneath the section for entering abstract/motivation letter information). The link to the portal can be found in the registration confirmation email that you will receive after registering for the conference or course.

For conferences, if you are not submitting an abstract, you can still apply for financial assistance in the submission portal by following the instructions here. Note that priority will be given to those submitting an abstract to present at the conference. In your application you will be asked to answer questions regarding your motivation for applying, and, for registration fee waivers, the reasons why your lab cannot fund your attendance and how your attendance will make a difference to your career. Application for financial support will not affect the outcome of your registration application.

*For some events, applications for Childcare Grants will still be done by email. Information about the grant will be sent out shortly after the abstract/motivation letter deadline. Please contact the event Conference Officer if you have any questions.


The scientific organisers will select the recipients of registration fee waivers during the abstract selection process for conferences and the participant selection process for courses. Results will be announced approximately 3 – 4 weeks before the event start date. Selection results do not impact your admission to the meeting. Registration fee waiver selection is based on your current work or study location, your motivation for applying, the reasons for needing financial support and the impact this event will have on your career. Childcare grants are allocated based on career stage, with priority given to early stage researchers.

Further details

A list of external funding opportunities can be found here, and information on attending a conference as an event reporter here.

For further information about financial assistance please refer to the FAQ page.

Virtual Participation Guidelines


Please do:

  • Use the event-specific hashtag as communicated during the event for any related tweets
  • Tweet unless the speaker specifically says otherwise
  • Be mindful of unpublished data
  • Be respectful in tone and content

Please don’t:

  • Share Slack, live stream or poster session links with others
  • Broadcast the conference to unregistered participants
  • Capture, transmit or redistribute data presented at the meeting unless presenter gives explicit consent
  • Use offensive language in your posts
  • Engage in rudeness or personal attacks

Additional information can be found in our Code of Conduct.

Health and well-being

It is important to stay healthy and move around, especially when you are attending an event virtually. We have put together a few coffee break stretches and yoga videos. You can find these under ‘resources’ on the conference platform.

How to ask questions

Please use the Q&A function. It is possible to send a direct message to participants, poster presenters, and speakers within the conference platform.

If you have any other questions, you can go to the Help Desk on the conference platform. Click on ‘more’ on the top menu and click Help Desk. 

Time zone

The programme is planned based on Central European Time (CET) or Central European Summer Time (CEST) unless otherwise stated. As many virtual participants are attending from around the world, we do our best to accommodate as many timezones as possible when creating the programme. Please take your time zone into consideration when planning your attendance. Remember to set your time zone in your account. 

Virtual event platforms

We are using a virtual event platform for this conference. More information about the platform will be shared ahead of the conference.

Zoom: The virtual event platform will use Zoom for live sessions and we recommend you download the Zoom app in advance of the conference to ensure you get full interactivity.


Gold Sponsors

Silver Sponsor

Event Sponsor

Media Partners

EMBO Journal, an EMBO Press journal

Journal of Cell Science, a The Company of Biologists journal

Open Biology, a Royal Society journal


Sponsorship Opportunities

We offer a variety of event sponsoring possibilities, with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget. Discounts are available for companies sponsoring multiple events at EMBL Heidelberg. View other conferences, or contact sponsorship@embl.de for further information.

If you are interested in becoming a media partner of this event, please visit our media partnerships webpage.

Pre-Conference Webinars

Concurrent industry webinars will be hosted by sponsoring companies prior to the virtual EMBL Conference: Chromatin and Epigenetics

on Monday, 17 May at 12:45 – 13:45 (CEST, Berlin).

To find out the equivalent time zone in your location, enter Berlin, the CEST programme time and your city into the Time Zone Converter.

Participation in this webinar is free of charge for registered conference attendees. The number of available places is limited (first come, first served). All registered conference attendees will receive an email with a registration link.

Click on the list below to read the abstracts and find out more about the webinars

10x Genomics: Simultaneous profiling of the epigenome and transcriptome at a single cell level

Simultaneous profiling of the epigenome and transcriptome at a single cell level

Hannes Arnold, Senior Science and Technology Advisor, 10x Genomics
Tune H Pers, Associate Professor, Novo Nordisk Foundation, Center for Basic Metabolic Research, Denmark

Deep insights into tumor biology, developmental biology, and other biological processes and disease states require a comprehensive view of gene expression patterns and their corresponding epigenetic regulation at single cell resolution. Leverage two modalities at once in single cells to more deeply characterize complex cell populations and capture cellular heterogeneity, and discover gene regulatory interactions driving cell differentiation, development, and disease. Join our workshop to explore how you can multiply your power of discovery with Chromium Single Cell Multiome ATAC + Gene Expression, our first commercial product enabling you to simultaneously profile RNA-seq and ATAC-seq from the same single cells.

Arima Genomics: Catch Them All: Leveraging Capture Hi-C to Characterize Chromatin Landscapes

Catch Them All: Leveraging Capture Hi-C to Characterize Chromatin Landscapes


It’s easy to get lost in the wide range of chromatin conformation techniques today. Arima HiC+ for Capture Hi-C technology enables researchers to tailor their conformation studies to specific regions of interest. Much like whole genome sequencing versus targeted approaches, the Arima Promoter Capture panel is the gene regulation analog to exome capture, covering promoters genome-wide at a significantly higher resolution and with fewer reads.

What will you learn?

1. Learn about the latest development in chromatin conformation capture. Specifically, we will introduce you to capture Hi-C, including region, promoter & variant capture.

2. How are researchers using capture Hi-C today, and what discoveries have they made? Learn how capture Hi-C can help you:

  1. Understand gene regulatory mechanisms by assigning distal regulatory elements to promoter regions across the genome
  2. Characterize regulatory differences between samples by assessing genome-wide promoter contacts
  3. Identify novel therapeutic, diagnostic or prognostic markers by linking human disease-associated variants to their target genes

3. Deep dive into promoter capture. Learn how your lab can start using capture Hi-C.

Who should attend?

This webinar is for epigenetics researchers interested in applying the latest techniques in 3D genomics. Whether you’re working on translational applications or discovery research, there are many new developments in the chromatin conformation space that can take your research to new levels. Come learn about the latest development in capture Hi-C in this webinar from Arima Genomics.  

Dovetail Genomics: MCM complexes are barriers that restrict cohesin-mediated loop extrusion

MCM complexes are barriers that restrict cohesin-mediated loop extrusion

Bart Dequeker, Kikuë Tachibana Lab, Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA)

Eukaryotic genomes are compacted into loops and topologically associating domains (TADs), which contribute to transcription, recombination and genomic stability. Cohesin extrudes DNA into loops that are thought to lengthen until CTCF boundaries are encountered. Little is known about whether loop extrusion is impeded by DNA-bound macromolecular machines. We demonstrate that the replicative helicase MCM is a barrier that restricts loop extrusion in G1 phase. Single-nucleus Hi-C of one-cell embryos revealed that MCM loading reduces CTCF-anchored loops and decreases TAD boundary insulation, suggesting loop extrusion is impeded before reaching CTCF. Single-molecule imaging shows that MCMs are physical barriers that frequently constrain cohesin translocation in vitro. Simulations are consistent with MCMs as abundant, random barriers. We conclude that distinct loop extrusion barriers contribute to shaping 3D genomes.

Date: 17 - 20 May 2021

Location: Virtual


Abstract submission: Closed

Registration: Closed

Contact: Tim Nürnberger

Download event poster

Chromatin and Epigenetics poster

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