Understanding the causes of disease to find new treatments
To understand what causes a disease, scientists often create a disease model – a biological system in the lab that mirrors a disease or shows some of the same disease processes.
Such a model could be cells growing in a Petri dish, or organisms that lack a certain cell type, tissue, or organ structure. Studying these cells or organisms under controlled lab conditions removes the randomness of the environmental influences that affect humans. Disease processes can also be studied using computer models or statistical approaches.
EMBL scientists study models for several common human diseases. By letting cells grow into spherical assemblies called organoids, they can study the role of individual genes in processes such as cancer development, or investigate how cancerous cells react to drug treatment. Bioinformaticians develop computer models to simulate the processes by which viruses infect their host cells and multiply within them. Other researchers engineer specialised scaffolds on which they can grow cells into defined layers, similar to tissues found in the body. These cells can be used to study biological processes associated with vascular disease or malaria. All of these systems help us to better understand human diseases and may lead to new approaches for their treatment.
Scientists in the Genome Biology Unit use and develop cutting-edge methods to study how information across different molecular layers (DNA, RNA, Proteins, metabolites) are regulated, processed, and utilised, and how their variation leads to different phenotypes, including disease.
Scientists in this unit use integrated structural and computational techniques to study biology at scales from molecular structures to organismal communities.
At its sites in Hamburg and Grenoble, EMBL provides its researchers and hundreds of external users each year with access to world-leading sources of X-ray and neutron radiation, enabling them to study the structures of biological molecules.
Scientists at EMBL Barcelona use advanced technologies to observe, manipulate, and model how changes in genes percolate through cells, tissues, and organs, in health and disease.
About the team and roleWe are seeking an experienced and highly motivated software developer to join the Ensembl team at EMBL-EBI and contribute to the development of the Ensembl Variant Effect Predictor (VEP). Ensembl provides open-access, high-quality genome data for a wide range of species. We of...
Closes on 15th February. Posted 22nd January 2026
EditYour groupThe Vu group at EMBL Heidelberg is seeking a highly motivated bioinformatician or computational biologist to join the lab as a Laboratory Officer. The Vu group investigates the control principles and evolution of animal body size, using planarian flatworms as a model system and an interdis...
Closes on 25th February. Posted 21st January 2026
EditAre you a motivated computational scientist passionate about developing algorithms for cutting-edge proteomics? We are looking for an enthusiastic Computational Proteomics Scientist to join the Proteomics and Metabolomics Team at the European Bioinformatics Institute (EMBL-EBI). The successful candi...
Closes on 4th February. Posted 20th January 2026
EditThe European Molecular Biology Laboratory (EMBL) is Europe’s life sciences laboratory – an intergovernmental organisation with more than 110 independent research groups and service teams covering the spectrum of molecular biology. It operates across six sites in Heidelberg (headquarters), Barcelona,...
Closes on 16th February. Posted 14th January 2026
EditFrom microscopy to mycology, from development to disease modelling, EMBL researchers cover a wide range of topics in the biological sciences.