Understanding the causes of disease to find new treatments
To understand what causes a disease, scientists often create a disease model – a biological system in the lab that mirrors a disease or shows some of the same disease processes.
Such a model could be cells growing in a Petri dish, or organisms that lack a certain cell type, tissue, or organ structure. Studying these cells or organisms under controlled lab conditions removes the randomness of the environmental influences that affect humans. Disease processes can also be studied using computer models or statistical approaches.
EMBL scientists study models for several common human diseases. By letting cells grow into spherical assemblies called organoids, they can study the role of individual genes in processes such as cancer development, or investigate how cancerous cells react to drug treatment. Bioinformaticians develop computer models to simulate the processes by which viruses infect their host cells and multiply within them. Other researchers engineer specialised scaffolds on which they can grow cells into defined layers, similar to tissues found in the body. These cells can be used to study biological processes associated with vascular disease or malaria. All of these systems help us to better understand human diseases and may lead to new approaches for their treatment.
Scientists in the Genome Biology Unit use and develop cutting-edge methods to study how information across different molecular layers (DNA, RNA, Proteins, metabolites) are regulated, processed, and utilised, and how their variation leads to different phenotypes, including disease.
Scientists in this unit use integrated structural and computational techniques to study biology at scales from molecular structures to organismal communities.
At its sites in Hamburg and Grenoble, EMBL provides its researchers and hundreds of external users each year with access to world-leading sources of X-ray and neutron radiation, enabling them to study the structures of biological molecules.
Scientists at EMBL Barcelona use advanced technologies to observe, manipulate, and model how changes in genes percolate through cells, tissues, and organs, in health and disease.
Your groupHackettYour supervisorJamie HackettYour role You will lead an in vivo epigenome editing programme focused on the delivery of epigenetic editors in mouse liver to modulate target gene expression. Based at EMBL, and working jointly with biotech partners, you will be responsible for the imple...
Closes on 12th March. Posted 11th February 2026
EditAre you interested in a leading role to shape the infrastructure and systems of one of the world’s most widely used scientific data resources? Ensembl is the leading resource for exploring and analysing genomes, used by researchers globally on a daily basis. In recent years, Ensembl has seen a subs...
Closes on 26th March. Posted 11th February 2026
EditYour groupThe Huber group develop statistical and machine learning methods for multi-modal single cell and spatial omics data. They collaborate with biomedical researchers on clinical studies to translate basic science into new diagnostic, stratification and treatment options. They contribute to ope...
Closes on 10th March. Posted 9th February 2026
EditAbout the team/jobWe are looking for a postdoc to join our groups at EMBL Barcelona. In particular, Haase and Dayton labs, have expertise in 3D vascularized models and human alveolar and airway organoids, respectively. The project aim is to develop patient-specific healthy and disease (chronic obstr...
Closes on 8th March. Posted 6th February 2026
EditFrom microscopy to mycology, from development to disease modelling, EMBL researchers cover a wide range of topics in the biological sciences.