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mutation

Artist's impression of DNA lesions. Credit: Petra Korlevic

Unpicking the complexity of DNA mutations

DNA damage caused by chemical mutagens is not repaired immediately and can create more genetic diversity in tumours.…

By Oana Stroe

Science

DNA damage and repair jointly leave mutational signatures in the genome.

DNA damage and faulty repair jointly cause mutations

DNA mutations are caused by a combination of DNA damage and repair, shows study by EMBL-EBI and collaborators.…

By Mehdi Khadraoui

Science

The Pan-Cancer project

EMBL co-leads most comprehensive study of genetic causes of cancer…

By Mathias Jäger

Science

Potential new drug target for cystic fibrosis

Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg and Regensburg University, both in Germany, and the University of Lisboa, in Portugal, have discovered a promising potential drug target for cystic fibrosis. Their work, published online today in Cell, also uncovers a…

By Guest author(s)

Science

The mutation police

Scientists at the EMBL-European Bioinformatics Institute (EMBL-EBI) and the MRC Laboratory of Molecular Biology in the UK have discovered how our genome keeps the effects of mutations in check. The discovery, published in the journal Cell, will help in the study of diseases such as cancer and…

By Guest author(s)

Science

Abstract image showing DNA code

A matter of priorities

Just as banks store away only the most valuable possessions in the most secure safes, cells prioritise which genes they guard most closely, researchers at the European Molecular Biology Laboratory’s European Bioinformatics Institute (EMBL-EBI) have found. The study, published online today…

By Oana Stroe

Science

Artist's impression of a chromosome exploding

Rigged to explode?

An inherited mutation in a gene known as the guardian of the genome is likely the link between exploding chromosomes and some particularly aggressive types of cancer, scientists at the European Molecular Biology Laboratory (EMBL), the German Cancer Research Centre (DKFZ) and the University…

By Guest author(s)

Science

An unexpected way to cause leukaemia

Leukaemia – cancer of blood or bone marrow – is caused by mutations that allow defective blood cells to accumulate and displace healthy blood. To devise effective therapies it is crucial to know which mutations cause leukaemia and which cell type gives rise to leukaemic cells. Researchers from…

By Guest author(s)

Science

A gene that protects from kidney disease

Researchers from the European Molecular Biology Laboratory (EMBL) and the University of Michigan have discovered a gene that protects us against a serious kidney disease. In the current online issue of Nature Genetics they report that mutations in the gene cause nephronopthisis (NPHP) in humans and…

By Guest author(s)

Science

A first glimpse of the influenza replication machine

In 1918, 50 million people died during a worldwide influenza pandemic caused by mutation of a bird-specific strain of the influenza virus. Recently H5N1, another highly infectious avian strain has caused outbreaks of bird flu around the world. There is great concern that this virus might also…

By Guest author(s)

Science

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