An embryo of the fruit fly Drosophila.

Predicting how gene expression varies

Discoveries at EMBL will help researchers to interpret one of the most common types of experiments in genomics and medical…

By Fabian Oswald


The pyramids represent chromatin domains in the wild-type situation. The reflection in the water below represents the rearrangements in the mutant fruit fly chromosomes. At first glance the (regulatory) landscapes look very similar, but there are lots of changes to the topology, and yet these have little impact on the nature of the landscape (gene expression). IMAGE: Beata Edyta Mierzwa in collaboration with EMBL.

Rearranging chromosomes

Does rearranging chromosomes affect their function? EMBL scientists reveal uncoupling of 3D chromatin organisation and gene…

By Iris Kruijen


Information (arrows) emanating out of chromatin to give rise to different cell types. IMAGE: Campbell Medical Illustration

Chromatin usage reveals developmental trajectories

EMBL scientists show how chromatin usage in individual cells reveals developmental…

By Iris Kruijen


Enhancer activity (green) and promoter activity (purple) in the same regulatory element. IMAGE: EMBL / Eileen Furlong

Multipurpose enhancers and promoters in embryonic development

EMBL scientists show that some promoters can act as enhancers and vice…

By Iris Kruijen


Futures: Genome regulation

ERC grantee Eileen Furlong shares her vision for the next ten…

By Edward Dadswell


Genetic switches can change shape

EMBL scientists discovered that common mutations can change the shape of gene…

By Sonia Furtado Neves


These fluorescence microscopy images of fruit fly embryos demonstrate that the scientists’ computer predictions were correct. As predicted, during the early stages of development (top) a CRM called 1070 is active (red) in the mesoderm (green) – the tissue which will give rise to all muscle types. At a later developmental stage (middle), the same CRM is active (red/pink) in the embryo’s body wall muscle (blue), but not in its gut muscle (green). At the same time (bottom), another CRM, called 5570 (red), drives development in the gut muscle (green) but not in the body wall muscle (blue). Image credit: Furlong/EMBL

Deciphering the regulatory code

Embryonic development is like a well-organised building project, with the embryo’s DNA serving as the blueprint from which all construction details…

By Guest author(s)



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