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19 August 2020 An embryo of the fruit fly Drosophila.

An embryo of the fruit fly Drosophila.

Predicting how gene expression varies

15 July 2019

The pyramids represent chromatin domains in the wild-type situation. The reflection in the water below represents the rearrangements in the mutant fruit fly chromosomes. At first glance the (regulatory) landscapes look very similar, but there are lots of changes to the topology, and yet these have little impact on the nature of the landscape (gene expression). IMAGE: Beata Edyta Mierzwa in collaboration with EMBL.

Rearranging chromosomes

14 March 2018 Information (arrows) emanating out of chromatin to give rise to different cell types. IMAGE: Campbell Medical Illustration

Information (arrows) emanating out of chromatin to give rise to different cell types. IMAGE: Campbell Medical Illustration

Chromatin usage reveals developmental trajectories

30 January 2018 Enhancer activity (green) and promoter activity (purple) in the same regulatory element. IMAGE: EMBL / Eileen Furlong

Enhancer activity (green) and promoter activity (purple) in the same regulatory element. IMAGE: EMBL / Eileen Furlong

Multipurpose enhancers and promoters in embryonic development

13 March 2017

Futures: Genome regulation

13 February 2017

Genetic switches can change shape

12 January 2017 Drosophila embryo over sea of noncoding RNA

Drosophila embryo over sea of noncoding RNA

Buffering mechanism protects embryonic development

4 November 2009

These fluorescence microscopy images of fruit fly embryos demonstrate that the scientists’ computer predictions were correct. As predicted, during the early stages of development (top) a CRM called 1070 is active (red) in the mesoderm (green) – the tissue which will give rise to all muscle types. At a later developmental stage (middle), the same CRM is active (red/pink) in the embryo’s body wall muscle (blue), but not in its gut muscle (green). At the same time (bottom), another CRM, called 5570 (red), drives development in the gut muscle (green) but not in the body wall muscle (blue). Image credit: Furlong/EMBL

Deciphering the regulatory code

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