Furlong Archives

The pyramids represent chromatin domains in the wild-type situation. The reflection in the water below represents the rearrangements in the mutant fruit fly chromosomes. At first glance the (regulatory) landscapes look very similar, but there are lots of changes to the topology, and yet these have little impact on the nature of the landscape (gene expression). IMAGE: Beata Edyta Mierzwa in collaboration with EMBL.

Rearranging chromosomes

Does rearranging chromosomes affect their function? EMBL scientists reveal uncoupling of 3D chromatin organisation and gene expression.

15 July 2019

By Iris Kruijen

Science

Information (arrows) emanating out of chromatin to give rise to different cell types. IMAGE: Campbell Medical Illustration

Chromatin usage reveals developmental trajectories

EMBL scientists show how chromatin usage in individual cells reveals developmental trajectories

14 March 2018

By Iris Kruijen

Science

Enhancer activity (green) and promoter activity (purple) in the same regulatory element. IMAGE: EMBL / Eileen Furlong

Multipurpose enhancers and promoters in embryonic development

EMBL scientists show that some promoters can act as enhancers and vice versa

30 January 2018

By Iris Kruijen

Science

Futures: Genome regulation

ERC grantee Eileen Furlong shares her vision for the next ten years

13 March 2017

By Edward Dadswell

Science

Genetic switches can change shape

EMBL scientists discovered that common mutations can change the shape of gene promoters

13 February 2017

By Sonia Furtado Neves

Science

Drosophila embryo over sea of noncoding RNA

Buffering mechanism protects embryonic development

New mechanism revealed

12 January 2017

By Mary Todd Bergman

Science

EMBL News