"The shapes of life: modelling how cells self-organise" by Dr. James Sharpe
The EMBL Insight Lecture 2013 “From Code to Function – Observing Protein Synthesis Through the Electron Microscope” was presented by EMBL group leader Dr. Christiane Schaffitzel on 31st January 2014.
Christiane Schaffitzel and her team study the function and three-dimensional structure of ribosomes using a combination of molecular biology, biochemistry and cryo-electron microscopy. In her talk, Christiane gives an overview of the steps involved in protein synthesis and the role ribosomes play in the process. She then illustrates how her research group uses cryo-electron microscopy to study the structures of these fascinating molecules. Christiane’s central research questions are: what we can learn from the make up of these fascinating molecules and how are synthesised proteins targeted to their destinations?
• The central dogma of molecular biology
• Protein synthesis
• Molecular structures of the ribosomes
• Ribosomal RNA as an enzyme
• The function of ribosome subunits’ function
• What determines whether a protein is exported or not
• Principals of electron microscopy
• Sample preparation for cryo-electron microscopy and image analysis
The EMBL Insight Lecture is available via on-demand-streaming from this website. You can watch it directly in the window below. Alternatively, you can open the EMBL Insight Lecture here.
Topic area: Microscopy & Imaging, Structural & Computational biology
Age group: 16-19