The University of Chicago
The regulation of the transcriptome is key to cellular processes that underpin cell biology, development and tissue function. All classes of cellular RNA are subject to post-transcriptional modification, be it by direct chemical modification, editing or non-templated nucleotide additions. It is now emerging that the modification status of the transcriptome is dynamic and responsive to environmental/developmental cues. Together, this has elicited the realisation of an ‘epitranscriptome’ where post-transcriptional RNA modification coupled with recruitment of effector RNA binding proteins dynamically regulates genomic output. Importantly, mutations in setting or reading RNA modifications are causative of many human diseases or congenital disorders. This meeting aims to explore all aspects of this emerging topic, from methods development to molecular mechanism. Most importantly, the meeting will place an emphasis on the contribution of RNA modification to mammalian development, tissue homeostasis and disease.
“The Epitranscriptome EMBL conference rapidly became a must in the field.” – Mattia Pelizzola, Istituto Italiano di Tecnologia, Italy.
“The conference provided an excellent opportunity to get the latest insights in the field of epitranscriptomics, presented by the world-leading academic groups.” – Gerhard Müller, Gotham Therapeutics, New York, USA.
“This conference was really good for me. I have learnt about new RNA regulatory mechanisms, especially m6A and how it’s an important target for RNA processing.” – Opeyemi Olotu, University of Turku, Finland.
International Institute of Molecular and Cell Biology
University of Dundee
German Cancer Research Centre (DKFZ)
Boston Children’s Hospital
Weill Cornell Medicine
Goethe University Frankfurt
Barts Cancer Institute, Queen Mary University of London
The University of Texas Southwestern Medical Center
National Cancer Institute
University of Geneva
Weizmann Institute of Science
German Cancer Research Centre
MRC Centre for Regenerative Medicine
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The following time is used in the programme below:
To find out the equivalent time zone in your location, enter Berlin, the programme time and your city into the Time Zone Converter.
|14:00-14:15||Opening remarks by Scientific Organisers|
|Session 1: RNA modification I|
|14:15-15:15||Keynote lecture: RNA methylation in gene expression regulation|
Chuan He – The University of Chicago, USA
|15:15-15:30||Selected short talk 1|
|15:30-16:00||Deciphering the specificity and regulation of the m6A writer complex|
Samie Jaffrey – Weill Cornell Medicine, USA
|16:00-16:15||Selected short talk 2|
|16:30-17:00||Biochemical characterization of the mouse piRNA methyltransferase mHEN1|
Ramesh Pillai – University of Geneva, Switzerland
|17:00-17:15||Selected short talk 3|
|17:15-17:30||Selected short talk 4|
|17:30-18:00||Meet the Speakers of Session 1|
|18:00-19:00||Poster session 1|
|19:00-19:30||Optional Social Programme: Speed networking|
|Session 2: RNA modifications in stem cells and development|
|14:00-14:30||Role of the ‘Epitranscriptome’ in gene regulation and cancer|
Richard Gregory – Boston Children’s Hospital, USA
|14:30-14:45||Selected short talk 5|
|14:45-15:15||Selective translation control by pseudouridine-modified tRNA fragments in stem and cancer cells|
Cristian Bellodi – Lund University, Sweden
|15:30-16:00||Is m6A dynamic?|
Schraga Schwartz – Weizmann Institute of Science, Israel
|16:00-16:15||Selected short talk 6|
|16:15-16:45||Meet the speakers of Session 2|
|16:45-17:45||Poster session 2|
|Session 3: RNA modification II|
|17:45-18:15||RNA modifications and RNA 3D structure|
Janusz Bujnicki – International Institute of Molecular and Cell Biology, Poland
|18:15-18:30||Selected short talk 7|
|18:30-19:00||Talk title to be announced|
Yunsun Nam, The University of Texas Southwestern Medical Center, USA
|19:15-19:45||Talk title to be announced|
Shalini Oberdoerffer – National Cancer Institute, USA
|19:45-20:00||Selected short talk 8|
|20:00-20:30||What spatial interactions can tell us about the function of m6A and m6Am factors|
Štěpánka Vaňáčová – CEITEC, Czech Republic
|20:30-21:00||Meet the speakers of Session 3|
| Time |
|Session 4: RNA modification pathways in physiology and pathology|
|14:00-14:30||The impact of uridylation and m6A modification of RNA on normal and malignant haematopoiesis|
Kamil Kranc – Barts Cancer Institute, Queen Mary University of London, UK
|14:30-14:45||Short talk 9|
|14:45-15:15||How does RNA cap regulation direct gene-specific expression?|
Victoria Cowling – University of Dundee, UK
|15:15-15:30||Short talk 10|
|15:30-16:00||Meet the speakers of Session 4|
|Session 5 – Emerging concepts|
|16:15-16:45||Talk title to be announced|
Michaela Frye – German Cancer Research Centre (DKFZ), Germany
|16:45-17:00||Selected short talk 11|
|17:00-17:30||Exploring canonical and non-canonical functions of cancer-linked dihydrouridine synthase enzymes|
Wendy Gilbert – Yale University, USA
|17:30-18:00||Talk title to be announced|
Stefanie Kellner-Kaiser, Goethe University Frankfurt, Germany
|18:00-18:30||Talk title to be announced|
V. Narry Kim – Seoul National University, South Korea
|18:45-19:45||Panel discussion on emerging therapies|
|20:00-20:30||Meet the speakers of Session 5|
Registration Fees (include access to all of the talks, digital poster sessions and online group discussions, and help us cover our costs to run the event. For further information please refer to the FAQ page):
|EMBL Staff||Intranet access|
Accredited journalists may be eligible to register for a complimentary registration. Registrants may be required to provide accreditation or equivalent proof of press membership after registration. Please contact Aline Schnieder for more information.
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Abstract submission deadline: 10 January 2022 (23:59 Europe/Berlin)
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