Development

How single cells give rise to complex organisms

All the essential information on how a whole multicellular organism develops from a single cell is stored in that organism's genome and epigenome. Thousands of genes are switched on and off in a precisely coordinated manner.

A four-day-old mouse embryo
A four-day-old mouse embryo before it embeds itself in the womb. The cells that will make the connection to the womb are marked in blue. The cells that will give rise to the embryo are marked in orange, and the cells’ membranes are labeled in purple.

This enables individual cells to specialise in particular tasks and to arrange themselves into tissues and organs in the right locations. The developmental process is also influenced by environmental factors, such as the availability of nutrients.

Scientists at EMBL investigate the processes associated with embryo and organism development. They try to understand how embryos transition from a ball of identical cells to structured organisms with highly specialised tissues. The influence of mechanical stimuli and environmental factors on development are also investigated. EMBL scientists try to understand how biological rhythms create waves of activity of genes or signalling molecules, which helps to establish regular structures and tells organs where to form. Alongside traditional lab methods, bioinformatics approaches are also used to explore the processes of development.


EMBL units researching development

Developmental biology

Scientists in the Developmental biology unit seek to understand the fundamental principles that govern multicellular development.

Genome biology

The Genome biology unit uses and develops cutting-edge methods to study how the information in our genome is regulated, processed, and utilised, and how its alteration leads to disease.

Tissue biology and disease modelling

Scientists at EMBL Barcelona use advanced technologies to observe, manipulate, and model how changes in genes percolate through cells, tissues, and organs, in health and disease.

View all EMBL research units


Postdoc - Therapeutic Epigenetic Editing in vivo

Science, research and training in Rome, Italy

Your groupHackettYour supervisorJamie HackettYour role You will lead an in vivo epigenome editing programme focused on the delivery of epigenetic editors in mouse liver to modulate target gene expression. Based at EMBL, and working jointly with biotech partners, you will be responsible for the imple...

Closes on 12th March. Posted 11th February 2026

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Genomics Technology Infrastructure Team Leader

Technology in EMBL-EBI Hinxton

Are you interested in a leading role to shape the infrastructure and systems of one of the world’s most widely used scientific data resources? Ensembl is the leading resource for exploring and analysing genomes, used by researchers globally on a daily basis.  In recent years, Ensembl has seen a subs...

Closes on 26th March. Posted 11th February 2026

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Postdoc / Research Scientist Computational Precision Oncology – Huber group

Science, research and training in EMBL Heidelberg

Your groupThe Huber group develop statistical and machine learning methods for multi-modal single cell and spatial omics data. They collaborate with biomedical researchers on clinical studies to translate basic science into new diagnostic, stratification and treatment options. They contribute to ope...

Closes on 10th March. Posted 9th February 2026

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Postdoctoral Fellow - Haase/Dayton Groups

Science, research and training in Barcelona, Spain

About the team/jobWe are looking for a postdoc to join our groups at EMBL Barcelona. In particular, Haase and Dayton labs, have expertise in 3D vascularized models and human alveolar and airway organoids, respectively. The project aim is to develop patient-specific healthy and disease (chronic obstr...

Closes on 8th March. Posted 6th February 2026

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From microscopy to mycology, from development to disease modelling, EMBL researchers cover a wide range of topics in the biological sciences.