Jonathon Howard
Yale University
USA
EMBO | EMBL Symposium
This conference will take place at EMBL Heidelberg, with the option to attend virtually. Proof of COVID-19 vaccination or recovery is required for on-site attendance. Please see EMBL’s COVID-19 terms and conditions.
The microtubule cytoskeleton is essential for a wide variety of cellular functions, such as chromosome segregation, directed vesicle and organelle transport, cell motility and cell polarity. Impaired microtubule function can lead to human diseases including cancer and neurodegenerative disorders, where microtubules serve as important therapeutic targets. In recent years, interdisciplinary approaches embracing cell biology, genetics, molecular biology, biochemistry, biophysics, structural biology and mathematical modelling have made a tremendous impact on microtubule research.
The progressive diversification of the microtubule field has created the need for a strong meeting that unifies the community and brings together researchers from different disciplines interested in microtubule research. This role has been played by this conference series, which was initiated in 2010. Our meetings bring together early-career and established researchers from all over the world who are interested in fundamental microtubule biology and its impact on organism development, homeostasis and disease. As in our previous meetings, this new symposium will feature inspirational keynote and landmark lectures, a large number of short talk opportunities selected from the submitted abstracts, and lively poster sessions, as well as special activities for networking and advancing EMBO global initiatives.
Warwick Medical School
UK
Heidelberg University Hospital
Germany
Ludwig Cancer Research
USA
ETH Zürich
Switzerland
Dartmouth College
USA
(Virtual Speaker)
University of California, San Francisco
USA
(Virtual Speaker)
Stanford University
USA
Cancer Research UK Barts Centre
UK
University of Pennsylvania
USA
Hokkaido University
Japan
Center for Molecular Neurobiology Hamburg (ZMNH)
Germany
Czech Academy of Sciences
Czech Republic
Colorado State University
USA
Harvard University
USA
University of California, Davis
USA
Vrije Universiteit Amsterdam
The Netherlands
Human Technopole
Italy
University of Tübingen
Germany
Stanford University
USA
Yale School of Medicine
USA
Institute for Stem Cell Science and Regenerative Medicine
India
Utrecht University
The Netherlands
Institut Curie
France
University of California, Davis
USA
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Please find the poster listing here.
Time | Speaker |
---|---|
12:00-14:00 | Registration & Lunch |
12:40-13:30 | Pre-conference workshop – registration required Studying Cytoskeletal Processes with Optical Tweezers Correlated to IRM and Fluorescence Microscopy |
14:00-14:10 | Opening remarks |
14:10-15:45 | Session 1: Patterning of microtubule arrays Chair: Jens Lüders – Institute for Research in Biomedicine, Spain |
14:10-14:35 | Mechanisms underlying the functional specification of individual aster microtubules during yeast mitosis Yves Barral – ETH Zürich, Switzerland AVAILABLE ON DEMAND AFTER LIVE STREAM |
14:35-14:50 | Short talk: Control of microtubule release from gamma-TuRC by CAMSAPs and nucleation-promoting factors Dipti Rai – Utrecht University, the Netherlands |
14:50-15:05 | Short talk: Ana1/CEP295 is an essential player in the centrosome maintenance program regulated by Polo kinase Ana Pimenta-Marques – NOVA Medical School, CEDOC, Portugal |
15:05-15:20 | Short talk: The γ-TuRC puzzle: from structure to function Martin Würtz – University of Heidelberg, Germany |
15:20-15:45 | Motorised organisation of microtubule arrays Anne Straube – Warwick Medical School, UK AVAILABLE ON DEMAND AFTER LIVE STREAM |
15:45-16:15 | Coffee break |
16:15-17:45 | Session 2: Microtubule-based control of cell architecture Chair: Mónica Bettencourt-Dias – Instituto Gulbenkian de Ciência, Portugal |
16:15-16:40 | Virtual talk: TON1-dependent microtubules control placement of the cell division plane Magdalena Bezanilla – Dartmouth College, USA AVAILABLE ON DEMAND AFTER LIVE STREAM |
16:40-16:55 | Short talk: Microtubules network dynamic in myonuclei positioning in muscle fibers Alireza Ghasemizadeh – PGNM-INMG, France |
16:55-17:20 | CLASP2 stabilizes GDP-associated terminal tubulins to prevent microtubule catastrophe Ekaterina L. Grishchuk – University of Pennsylvania, USA AVAILABLE ON DEMAND AFTER LIVE STREAM |
17:20-17:45 | Patterning the microtubule cytoskeleton during development Jessica Feldman – Stanford University, USA AVAILABLE ON DEMAND AFTER LIVE STREAM |
17:45-18:45 | Networking session |
18:45-20:15 | Dinner |
20:15-22:00 | Welcome reception with preview of all posters |
Time | Speaker |
---|---|
09:15-10:15 | Keynote lecture: Mechanical stability of microtubules Jonathon Howard – Yale University, USA Chair: Manuel Thery – CEA, IUH/Hopital Saint-Louis, France LIVE STREAM ONLY |
10:15-10:45 | Coffee break |
10:45-12:30 | Session 3: Microtubule motors and their regulation Chair: Vaishnavi Ananthanarayanan – University of New South Wales, Australia LIVE STREAM ONLY |
10:45-11:10 | Capturing kinesin and microtubule dynamics by cryo-electron microscopy Charles Sindelar – Yale School of Medicine, USA AVAILABLE ON DEMAND AFTER LIVE STREAM |
11:10-11:25 | Short talk: Mechanism by which the kinesin-8 Kip3 combines motility and microtubule depolymerization activities Matthieu Benoit – Albert Einstein College of Medicine, USA LIVE STREAM ONLY |
11:25-11:50 | Intraflagellar transport and microtubule dynamics in C. elegans chemosensory cilia Erwin Peterman – Vrije Universiteit Amsterdam, The Netherlands AVAILABLE ON DEMAND AFTER LIVE STREAM |
11:50-12:15 | Microtubule binding-induced allostery promotes Pac1/LIS1 dissociation from dynein prior to cargo transport Steven Markus – Colorado State University, USA AVAILABLE ON DEMAND AFTER LIVE STREAM |
12:15-12:30 | Short talk: The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor Morgan DeSantis – University of Michigan, USA LIVE STREAM ONLY |
12:30-14:00 | Lunch & Meet the speakers of Day 1 and Day 2 Yves Barral, Anne Straube, Ekaterina L. Grishchuk, Jessica Feldman, Jonathon Howard, Charles Sindelar, Erwin Peterman, Steven Markus, Robert Cross |
14:00-15:00 | Session 4: Emerging topics 1 Chair: Stephanie Redemann – University of Virginia, USA |
14:00-14:15 | Virtual short talk: Microtubule deacetylation at the onset of collective migration in vivo Elias Barriga – Instituto Gulbenkian de Ciência, Portugal |
14:15-14:30 | Short talk: Synthetic reconstitution of cortical polarity to study cytoskeleton symmetry breaking Emmanuel Derivery – MRC Laboratory of Molecular Biology, UK |
14:30-14:45 | Short talk: Todalam: A rationally designed tubulin inhibitor with a unique molecular mechanism of action Andrea Prota – Paul Scherrer Institute, Switzerland |
14:45-15:00 | Short talk: Lateral interactions between beta-tubulins determine the temperature dependence of microtubule dynamics Jeffrey Moore – University of Colorado, USA |
15:00-15:25 | Poster flash talks (2 minutes / 1 slide per talk) #51 – Liza Ammar-Khodja, #55 – Sreya Basu, #70 – Liliana Correia, #77 – Ashwin Dsouza, #81 – Veronica Farmer; #85 – Mariya Genova, #96 – Gil Henkin, #98 – Kristýna Holanová, #114 – Hanjin Liu, #122 – Véronique Marthiens |
15:25-15:55 | Coffee break |
15:55-18:35 | Poster session 1 (odd) |
18:35-20:05 | Dinner |
20:05-20:45 | 1st Landmark lecture: Interlocking mechanics of kinesins and tubulins Robert Cross – Warwick Medical School, UK Chair: Kassandra Ori-McKenney – University of California, Davis, USA AVAILABLE ON DEMAND AFTER LIVE STREAM |
20:45-22:30 | Wine & beer session with the possibility to continue poster session |
Time | Speaker |
---|---|
09:15-11:00 | Session 5: Microtubule biophysics Chair: Gary Brouhard – McGill University, Canada |
09:15-09:40 | Microtubule lattice spacing governs tau envelope formation Zdeněk Lánský – Czech Academy of Sciences, Czech Republic AVAILABLE ON DEMAND AFTER LIVE STREAM |
09:40-10:05 | Ultraresolution picotensiometry of kinesin motors Erik Schäffer – University of Tübingen, Germany AVAILABLE ON DEMAND AFTER LIVE STREAM |
10:05-10:20 | Short talk: Bending-torsional elasticity and energetics of the plus-end microtubule tip Maxim Igaev – Max Planck Institute for Multidisciplinary Sciences, Germany |
10:20-10:45 | Microtubules function as mechanosensor to regulate intracellular transport Akira Kakugo – Hokkaido University, Japan AVAILABLE ON DEMAND AFTER LIVE STREAM |
10:45-11:00 | Short talk: Measurements and simulations of microtubule growth imply strong longitudinal interactions and reveal a role for GDP on the elongating end Luke Rice – University of Texas, USA |
11:00-11:30 | Coffee break |
11:30-13:15 | Session 6: Microtubules in neurons Chair: Shaul Yogev – Yale University, USA |
11:30-11:55 | Mechanisms for in vivo microtubule polarity in neurons Kang Shen – Stanford University, USA AVAILABLE ON DEMAND AFTER LIVE STREAM |
11:55-12:10 | Short talk: Novel molecular mechanisms in reactivation of quiescent neural stem cells Mahekta Gujar – Duke-NUS Medical School, Singapore LIVE STREAM ONLY |
12:10-12:35 | Substrate-specific loss of Tubulin-alpha4a polyglutamylation in mice Matthias Kneussel – Center for Molecular Neurobiology Hamburg (ZMNH), Germany AVAILABLE ON DEMAND AFTER LIVE STREAM |
12:35-12:50 | Short talk: Microtubules as a determinant of DRG axon asymmetry and regenerative capacity Ana Catarina Costa – University of Porto, Portugal LIVE STREAM ONLY |
12:50-13:15 | Injury induced tau pathology in Drosophila melanogaster Kassandra Ori-McKenney – University of California, Davis, USA AVAILABLE ON DEMAND AFTER LIVE STREAM |
13:15-14:45 | Lunch & Meet the speakers of Day 3 and Day 4 Zdeněk Lánský, Erik Schäffer, Akira Kakugo, Kang Shen, Matthias Kneussel, Kassandra Ori-McKenney, Karen Oegema, Freddy Frischknecht, Minhaj Sirajuddin, Susana Godinho, Gaia Pigino, Iva Tolic, Tim Mitchison |
14:45-15:25 | 2nd Landmark lecture: Mitotic centrosomes: assembly & functions Karen Oegema – Ludwig Cancer Research, USA Chair: Carsten Janke – Institut Curie, France AVAILABLE ON DEMAND AFTER LIVE STREAM |
15:25-15:50 | Poster flash talks (2 minutes / 1 slide per talk) #146 – Priyanka Sasmal, #148 – Harriet Saunders, #150 – Muriel Sebastien, #151 – Sahana Shankar, #155 – Virginie Stoppin-Mellet, #157 – Sameedha Thale, #163 – Monika Trupinic, #164 – Nataliya Trushina, #177 – Mari Yoshida, #179 – Vitaly Zimyanin |
15:50-16:20 | Coffee break |
16:20-18:30 | Poster session 2 (even) |
18:30-19:10 | 3rd Landmark lecture: Microtubules of protozoan parasites: from curious assemblies to exciting biology Freddy Frischknecht – Heidelberg University Hospital, Germany Chair: Anna Akhmanova – Utrecht University, The Netherlands AVAILABLE ON DEMAND AFTER LIVE STREAM |
19:10-21:10 | BBQ dinner |
21:10-23:00 | After-dinner drinks & live music by Lazy Fur |
Time | Speaker |
---|---|
09:15-11:00 | Session 7: The tubulin code Chair: Marija Zanic – Vanderbilt University, USA |
09:15-09:40 | Live cell markers for microtubule PTMs Minhaj Sirajuddin – Institute for Stem Cell Science and Regenerative Medicine, India LIVE STREAM ONLY |
09:40-09:55 | Short talk: One machinery, two codes: Extended “read-write” activities of chromatin remodelers on microtubules Cheryl Walker – Baylor College of Medicine, USA |
09:55-10:20 | Changes in microtubule PTMs drive organelle displacement in cells with amplified centrosomes Susana Godinho – Cancer Research UK Barts Centre, UK AVAILABLE ON DEMAND AFTER LIVE STREAM |
10:20-10:35 | Short talk: TTLL12 is a novel alpha-tubulin methyltransferase that regulates microtubule stability during epithelia polarization and cilia formation Julia Ceglowski – University of Colorado, USA |
10:35-11:00 | From nanopattern to function: the role of the tubulin code in ciliary mechanics Gaia Pigino – Human Technopole, Italy LIVE STREAM ONLY |
11:00-11:30 | Coffee break |
11:30-12:45 | Session 8: Emerging topics 2 Chair: Susanne Bechstedt – McGill University, Canada |
11:30-11:45 | Short talk: Together till the end: what stabilizes microtubule end-bound protein oligomers? Vladimir Volkov – Queen Mary University of London, UK |
11:45-12:00 | Short talk: Semi-synthetic tubulin reveals: Polyglutamylation of tubulin increases detyrosination by controlling vasohibin activity Charlotte Aumeier – University of Geneva, Switzerland |
12:00-12:15 | Short talk: Microtubules are intrinsically disordered Charlotte Guyomar – University of Rennes, France |
12:15-12:30 | Short talk: A kinesin-1 variant reveals motor-induced microtubule damage in cells Kristen Verhey – University of Michigan, USA |
12:30-12:45 | Short talk: Understanding dynein-mediated neuronal trafficking Alex Fellows – Medical Research Council Laboratory of Molecular Biology, UK |
12:45-14:15 | Lunch |
14:15-16:00 | Session 9: Microtubules in cell division Chair: Patrick Meraldi – University of Geneva, Switzerland |
14:15-14:40 | Virtual talk: The Astrin/SKAP Complex Reduces Friction at the Kinetochore-Microtubule Interface Sophie Dumont – University of California, San Francisco, USA AVAILABLE ON DEMAND AFTER LIVE STREAM |
14:40-14:55 | Short talk: High-throughput analysis of k-fiber ultrastructure in 3D-reconstructed mammalian spindles Robert Kiewisz – New York Structural Biology Center, USA |
14:55-15:20 | How chromosome location determines its fate in mitosis Iva Tolic – Ruđer Bošković Institute, Croatia AVAILABLE ON DEMAND AFTER LIVE STREAM |
15:20-15:35 | Short talk: Plasticity of mitotic spindle architecture and nuclear remodelling in Ichthyosporea Hiral Shah – EMBL Heidelberg, Germany |
15:35-16:00 | Cleavage plane determination in frog eggs Tim Mitchison – Harvard University, USA AVAILABLE ON DEMAND AFTER LIVE STREAM |
16:00-16:25 | Closing remarks & Poster prize |
Departure |
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English | German |
---|---|
Hello | Hallo |
Goodbye | Auf Wiedersehen |
Good morning | Guten Morgen |
Good afternoon | Guten Tag |
Good evening | Guten Abend |
Good night | Gute Nacht |
I’m sorry | Tut mir leid |
Excuse me… | Entschuldigen Sie |
How are you? | Wie geht’s? |
I’m fine thanks. And you? | Mir geht es gut , danke, und dir/Ihnen? |
What is your name | Wie heisst du? Wie heissen Sie? |
My name is | Ich heisse |
Do you speak English | Sprechen Sie Englisch? |
I don’t understand | Ich verstehe nicht |
Please speak more slowly | Können Sie bitte langsamer sprechen |
Thank you | Danke schön |
Where is the toilet? | Wo ist die Toilette? |
Please call me a taxi | Bitte rufen Sie mir ein Taxi |
How do I get to….? | Wie komme ich zum/zur…..? |
A beer/two beers, please | Ein Bier/zwei Bier bitte |
A glass of red/white wine please | Ein Glas Rot/Weisswein bitte |
The menu, please | Die Speisekarte, bitte |
Is there a local speciality? | Gibt es eine Spezialität aus dieser Gegend? |
I’m Vegetarian | Ich bin Vegetarier |
It was delicious | Es war hervorragend |
The bill, please | Die Rechnung, bitte |
I have a headache | Ich habe Kopfschmerzen |
I have a sore throat | Ich habe Halsschmerzen |
My stomach hurts | Ich habe Magenschmerzen |
I’m allergic to | Ich bin allergisch gegen |
I need a doctor who speaks English | Gibt es einen Arzt, der Englisch spricht? |
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Bronze sponsor
Media partners
EMBO Journal, an EMBO Press journal
FEBS Open Bio, a FEBS Press journal
International Union of Biochemistry and Molecular Biology
Journal of Cell Biology, a Rockefeller University Press journal
Journal of Cell Science, a The Company of Biologists journal
Open Biology, a Royal Society journal
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EMBO | EMBL Symposia promote scientific communication and collaboration in the European research area. They provide scientists with a platform to discuss and exchange ideas on forward-looking topics and new developments in the life sciences.
Topics emphasise upcoming developments and the interdisciplinary nature of related fields. Jointly funded and organised by EMBO and EMBL – and complementary to their respective courses, workshops, and conference programmes – the symposia promote scientific communication and collaboration.
All symposia are held in the EMBL Advanced Training Centre (ATC) in Heidelberg, Germany, or virtually.
Date: 8 - 11 Jun 2022
Location: EMBL Heidelberg and Virtual
Deadline(s):
Abstract submission: Closed
Registration (On-site): Closed
Registration (Virtual): Closed
Organisers:
Contact: Lina Nikolajeva