Structural Biology services at EMBL Grenoble beta

EMBL Grenoble provides research services including access to its high throughput crystallisation facility (HTX), the fourth-generation synchrotron beamlines for macromolecular crystallography at the ESRF, and the PSB-run Titan Krios cryo-electron microscope at the ESRF.

EMBL Grenoble provides a number of research services to in-house and external users as well as having access to the services provided by other units of EMBL.

Access to services

Instruments for neutron crystallography on the high flux neutron source of the ILL

Neutron protein crystallography provides a powerful complement to X-ray diffraction by enabling key details of the hydrogen atom and water structure in protein crystal structures to be revealed. Applications include direct visualization of hydrogen atoms at catalytic sites in enzymes and the location of lipids, detergents and other disordered groups in crystals that often cannot be seen by X-ray analysis alone.
EMBL Grenoble collaborates with the ILL to provide access to the neutron crystallography beamline:


Partnership for Structural Biology platforms

In the context of the Partnership for Structural Biology (PSB), EMBL Grenoble provides the following services, at present mainly for in-house users:

High-throughput crystallisation

Our high-throughput crystallisation platform, based on a Cartesin nanodrop dispensing robot and Rigaku storage and visualization system, is one of the core technical platforms of the Partnership for Structural Biology (PSB). We also try to bridge the gap between high-throughput crystallisation and automated synchrotron data collection systems.

High-throughput screening for soluble protein expression

In the context of the Partnership for Structural Biology (PSB), combinatorial approaches, screening and robotics are applied to develop novel methods to solve challenging problems of protein expression for structural biology.


Other services

Library

The EMBL Grenoble Library's main responsibility is to use the resources available to the fullest. We aim to give our researchers what they need in the shortest delay.

Christian Boulin Fellowships

The Christian Boulin Fellowships support travel and accommodation costs for young scientists visiting facilities at the EMBL sites, so they can learn and use the latest scientific techniques and advance their research projects

Services and facilities

EMBL serves a community of millions of life scientists worldwide. We provide services covering the whole of molecular biology from genome sequencing to synchrotrons, and EMBL-EBI maintains the world’s most comprehensive range of freely available molecular data resources.