EMBL Seminars

At EMBL, experts from institutes throughout the world speak on a wide range of scientific and technical topics

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19 April 2024, 10:00

“Prodding the Subcellular World with Light”

19 April 20242024Company RepresentativeEMBL Heidelberg

Abstract In this seminar an overview of photomanipulation applications possible with Rapp OptoElectronics devices will be presented Examples of photomanipulation applications already performed in the ALMF will be presented afterwards... Abstract[In this seminar an overview of photomanipulation applications possible with Rapp OptoElectronics devices will be presented. Examples of photomanipulation applications already performed in the ALMF will be presented afterwards]. 

Speaker(s): Simona Stelea, Rapp OptoElectronics, Wedel, Germany | Stefan Terjung, ALMF,
Host: Stefan Terjung, ALMF

Place: Room 13-518 a + b

Company Representative

EMBL Heidelberg

Additional information

Abstract
[In this seminar an overview of photomanipulation applications possible with Rapp OptoElectronics devices will be presented. Examples of photomanipulation applications already performed in the ALMF will be presented afterwards].

 


25 April 2024, 11:00

The Wonders of Small Molecule Transport

25 April 20242024PSB SeminarEMBL Grenoble

AbstractTransporting small molecules across cell membranes is an essential process in cell physiology The uptake of glucose and the maintenance of intracellular pH are two fundamental processes carried out by most cells Here I will present our multidisciplinary approach that has revealed important insights into the mechanism of glucose GLUT uptake and Na H exchange which are important... AbstractTransporting small molecules across cell membranes is an essential process in cell physiology. The uptake of glucose and the maintenance of intracellular pH are two fundamental processes carried out by most cells. Here, I will present our multidisciplinary approach that has revealed important insights into the mechanism of glucose (GLUT) uptake and Na+/H+ exchange, which are important transport systems for our cells to utilize glucose as an energy source and for the regulation cytoplasmic and organellar pH. I will also present our recent structural insights into a sperm-specific Na+/H+ exchanger regulated by voltage – transforming the transporter into a signaling cascade that is essential in animals (metazoa) for sperm motility and fertilization. Nature (2023). 623:193–201; Nature. (2020) 578 (7794):321-325; Nature (2015) 526(7573):397-401; Nature (2013) 501(7468):573-7.About the...

Speaker(s): David Drew, Stockholm University, Sweden
Host: Andrew McCarthy

Place: IBS Seminar Room

PSB Seminar

EMBL Grenoble

Additional information

Abstract
Transporting small molecules across cell membranes is an essential process in cell physiology. The uptake of glucose and the maintenance of intracellular pH are two fundamental processes carried out by most cells. Here, I will present our multidisciplinary approach that has revealed important insights into the mechanism of glucose (GLUT) uptake and Na+/H+ exchange, which are important transport systems for our cells to utilize glucose as an energy source and for the regulation cytoplasmic and organellar pH. I will also present our recent structural insights into a sperm-specific Na+/H+ exchanger regulated by voltage – transforming the transporter into a signaling cascade that is essential in animals (metazoa) for sperm motility and fertilization. Nature (2023). 623:193–201; Nature. (2020) 578 (7794):321-325; Nature (2015) 526(7573):397-401; Nature (2013) 501(7468):573-7.

About the speaker
Prof. David Drew hails from New Zealand where he obtained a MSc in Chemistry from Auckland University. He joined the lab of Prof. de Gier at Stockholm University for his PhD thesis research where he developed a technique of using GFP to monitor membrane protein topology and over expression in E. coli. After a EMBO post-doc fellowship at Imperial College London, he started his own research group as a University Royal Society (URF) Fellow at Imperial, focusing on structural studies of glucose (GLUT) transporters. In 2013, Drew returned to Stockholm University where he currently resides as a Wallenberg Scholar. Drew is internationally recognized by his pioneering structural studies of glucose transporters and Na+/H+ exchangers, membrane protein GFP-based methods, and influential reviews on small molecule transport. Drew has been acknowledged with several prizes, including the Göran Gustafsson Prize in Chemistry from the Swedish Royal Academy of Science, the Arrhenius medal from the Swedish Chemistry Society and EMBO membership.

Connection details
Zoom*: https://embl-org.zoom.us/j/96262723506?pwd=L1BNci9CcFNkREU5ZEpqUXZ1YTR1dz09

(Meeting ID: [962 6272 3506], Password: [753770])

Please note that the talk will not be recorded.
*For the FAQ section, as a zoom participant, please use either the chat function (the host will read out your question) or the “raise your hand” function and turn on your microphone.


25 April 2024, 13:00

Genetic conflicts during meiosis drive the rapid evolution of chromatin proteins

25 April 20242024External Faculty SpeakerEMBL Heidelberg

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Speaker(s): Harmit Malik, Fred Hutchinson Cancer Center, USA, USA
Host: Gautam Dey/Justin Crocker

Place: IC Lecture Hall

External Faculty Speaker

EMBL Heidelberg


26 April 2024, 11:00

Careers in industry R&D: big pharma vs biotech start-ups

26 April 20242024Career EventEMBL Heidelberg

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Speaker(s): Carina Hasenöhrl, Principal Scientist, Boehringer Ingelheim, Austria, Austria | Sylwia Gawrzak, Translational Scientist, Silence Therapeutics

Place: Virtual seminar (Join the VC)

Career Event

EMBL Heidelberg


2 May 2024, 11:00

TBC

2 May 20242024Human Ecosystems EMBL Heidelberg

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Speaker(s): Chirag Patel, Harvard Medical School, USA
Host: Oliver Stegle

Place: Large Operon

Human Ecosystems

EMBL Heidelberg


3 May 2024, 13:00

To be announced

3 May 20242024Hamburg SpeakerEMBL Hamburg

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Speaker(s): Wolfgang Hoyer, Heinrich Heine University, Duesseldorf, Germany
Host: Meytal Landau

Place: Seminar Room 48e

Hamburg Speaker

EMBL Hamburg


10 May 2024, 11:00

Axonal transport disfunctions in neurodegenerative diseases

10 May 20242024EMBL - Sapienza LectureEMBL Rome

AbstractThe molecular mechanisms causing neuronal death in many neurodegenerative diseases such as amyotrophic lateral sclerosis ALS frontotemporal dementia FTD and Charcot Marie Tooth CMT disease are poorly understood The key consequence of our incomplete understanding of disease pathogenesis is that there is a complete dearth of effective symptomatic treatments for these widespread... AbstractThe molecular mechanisms causing neuronal death in many neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Charcot Marie Tooth (CMT) disease, are poorly understood. The key consequence of our incomplete understanding of disease pathogenesis is that there is a complete dearth of effective symptomatic treatments for these widespread global disorders, prompting the necessity for a step-change in treatment strategies to fight these pathologies.In this view, we are investigating ALS and CMT as disease paradigms to identify new, common targets for pharmacological intervention in these devastating pathologies. Recently, we uncovered alterations in axonal transport of several cytoplasmic organelles, such as mitochondria and signalling endosomes, at pre-symptomatic stages of ALS and CMT pathogenesis, suggesting that these...

Speaker(s): Giampietro Schiavo, UK Dementia Research Institute, University College London, United Kingdom

Place: Sapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma

EMBL - Sapienza Lecture

EMBL Rome

Additional information

Abstract
The molecular mechanisms causing neuronal death in many neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Charcot Marie Tooth (CMT) disease, are poorly understood. The key consequence of our incomplete understanding of disease pathogenesis is that there is a complete dearth of effective symptomatic treatments for these widespread global disorders, prompting the necessity for a step-change in treatment strategies to fight these pathologies.

In this view, we are investigating ALS and CMT as disease paradigms to identify new, common targets for pharmacological intervention in these devastating pathologies. Recently, we uncovered alterations in axonal transport of several cytoplasmic organelles, such as mitochondria and signalling endosomes, at pre-symptomatic stages of ALS and CMT pathogenesis, suggesting that these impairments may play a causative role in disease onset and progression. Crucially, we have restored axonal transport to physiological levels at early symptomatic stages of disease, thus demonstrating that these pathological changes are fully reversible. 

In light of these promising results, our main goal is identifying novel signalling nodes that modulate axonal transport in healthy and diseased neurons. This will allow us to test the hypothesis that counteracting axonal transport deficits observed in ALS, CMT and other neurodegenerative diseases, represents a novel, effective therapeutic strategy towards treating these pathologies.

 


17 May 2024, 13:00

Mechanisms of ROS and antiROS generation

17 May 20242024Hamburg SpeakerEMBL Hamburg

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Speaker(s): Andrea Mattevi, University of Pavia, Italy
Host: Matthias Wilmanns

Place: Seminar Room 48e

Hamburg Speaker

EMBL Hamburg


23 May 2024, 13:00

To be announced

23 May 20242024External Faculty SpeakerEMBL Heidelberg

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Speaker(s): Tobias Warnecke, Imperial College, United Kingdom

Place: Room 202

External Faculty Speaker

EMBL Heidelberg


24 May 2024, 13:00

To be announced

24 May 20242024Hamburg SpeakerEMBL Hamburg

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Speaker(s): Giuliana Tromba, Elettra - Sincrotrone Trieste, Italy
Host: Elizabeth Duke

Place: Seminar Room 48e

Hamburg Speaker

EMBL Hamburg


31 May 2024, 11:00

To be announced

31 May 20242024External Faculty SpeakerEMBL Rome

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Speaker(s): Michael Weber, Biotechnology and Cell Signalling | BSC - CNRS - Université de Strasbourg, France
Host: Mathieu Boulard

Place: Conf Room/Building 14

External Faculty Speaker

EMBL Rome


7 June 2024, 10:00

To be announced

7 June 20242024EMBL Distinguished Visitor LectureEMBL Rome

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Speaker(s): David McCormick, University of Oregon, USA
Host: Hiroki Asari

Place: Conf Room/Building 14

EMBL Distinguished Visitor Lecture

EMBL Rome


11 June 2024, 11:00

Motors and MAPs in mitosis

11 June 20242024External Faculty SpeakerEMBL Heidelberg

Abstract Chromosome segregation is performed by the spindle a dynamic machine composed of microtubules motors and other associated proteins MAPs We currently know a lot about the protein components what constitute the spindle However evolution has tuned these components differently in different organisms I will present different strategies that yeast insect and human cells have evolved... Abstract Chromosome segregation is performed by the spindle, a dynamic machine composed of microtubules, motors, and other associated proteins (MAPs). We currently know a lot about the protein components what constitute the spindle. However, evolution has tuned these components differently in different organisms. I will present different strategies that yeast, insect, and human cells have evolved to assemble the spindle for chromosome segregation. Understanding these different modes of spindle assembly may help fight cancer.About the speaker[Biographical information about the speaker].Meet the speakerTo meet with the speaker informally after the talks,sign up here [add link]. We especially encourage predocs and postdocs to take advantage of this opportunity.Attachments[Link to a file (for example a pdf of the seminar’s programme) - the file can be uploaded on the intranet]Connection...

Speaker(s): Phong Tran , Curie Institute , France
Host: Gautam Dey

Place: IC Lecture Hall

External Faculty Speaker

EMBL Heidelberg

Additional information

Abstract
 

Chromosome segregation is performed by the spindle, a dynamic machine composed of microtubules, motors, and other associated proteins (MAPs). We currently know a lot about the protein components what constitute the spindle. However, evolution has tuned these components differently in different organisms. I will present different strategies that yeast, insect, and human cells have evolved to assemble the spindle for chromosome segregation. Understanding these different modes of spindle assembly may help fight cancer.

About the speaker
[Biographical information about the speaker].

Meet the speaker
To meet with the speaker informally after the talks,sign up here [add link]. We especially encourage predocs and postdocs to take advantage of this opportunity.

Attachments
[Link to a file (for example a pdf of the seminar’s programme) - the file can be uploaded on the intranet]

Connection details
Zoom*: [link] (Meeting ID: [XXXXXXXXX], Password: [XXXXXXX])

Please note that the talk will yes/not be recorded.
*For the FAQ section, as a zoom participant, please use either the chat function (the host will read out your question) or the “raise your hand” function and turn on your microphone.


20 June 2024, 11:00

Expansion microscopy for structural cell biology: from centriole architecture to human diseases.

20 June 20242024External Faculty SpeakerEMBL Grenoble

AbstractThe centriole is an evolutionary conserved organelle coordinating fundamental biological processes including cell division cellular signaling and cell motility This organelle of 500 nm long and 250 nm in diameter is composed of about 200 different proteins some of which have been associated with human diseases How these proteins are organized at the level of the centriole architecture... AbstractThe centriole is an evolutionary conserved organelle coordinating fundamental biological processes including cell division, cellular signaling and cell motility. This organelle, of 500 nm long and 250 nm in diameter is composed of about 200 different proteins, some of which have been associated with human diseases. How these proteins are organized at the level of the centriole architecture and how associated mutations could be involved in pathologies is still poorly understood. In this seminar, I will present the latest work from my laboratory, which tackle these fundamental structural cell biology questions using cryo-tomography, cell biology and our newly developed ultrastructure expansion microscopy (U-ExM) method.About the speakerVirginie Hamel (previously Hachet) is an expert in Cell Biology and Biochemistry. She completed her PhD under the supervision of Iain Mattaj at EMBL...

Speaker(s): Virginie Hamel, University of Geneva, Switzerland
Host: Kristina Djinovic Carugo

Place: EMBL Grenoble Seminar Room

External Faculty Speaker

EMBL Grenoble

Additional information

Abstract
The centriole is an evolutionary conserved organelle coordinating fundamental biological processes including cell division, cellular signaling and cell motility. This organelle, of 500 nm long and 250 nm in diameter is composed of about 200 different proteins, some of which have been associated with human diseases. How these proteins are organized at the level of the centriole architecture and how associated mutations could be involved in pathologies is still poorly understood. In this seminar, I will present the latest work from my laboratory, which tackle these fundamental structural cell biology questions using cryo-tomography, cell biology and our newly developed ultrastructure expansion microscopy (U-ExM) method.

About the speaker
Virginie Hamel (previously Hachet) is an expert in Cell Biology and Biochemistry. She completed her PhD under the supervision of Iain Mattaj at EMBL (Heidelberg, Germany, 2004) working on the role of importin alpha in nuclear envelope re-assembly in vitro using Xenopus laevis egg extracts. From 2005 to 2015, she worked as a post-doctoral fellow and then scientist collaborator in the laboratory of Prof. Gönczy at EPFL (Lausanne, Switzerland) where she first studied timing of mitotic entry in C. elegans embryos followed by dissecting the mechanisms of centriole assembly both in vitro and in vivo. Since 2015, she is co-heading the Centriole architecture lab with Prof Paul Guichard in the Molecular and Cellular Biology Department at the University of Geneva. Their lab focuses on deciphering the structural mechanisms governing centriole assembly combining the use of cell biology methods, in vitro reconstitution assays, cryo-microscopy/cryo-tomography and expansion microscopy.

Meet the speaker
To meet with the speaker informally after the talks, please contact administration@embl.fr. We especially encourage predocs and postdocs to take advantage of this opportunity.

Attachments
[Link to a file (for example a pdf of the seminar’s programme) - the file can be uploaded on the intranet]

Connection details
Zoom*: https://embl-org.zoom.us/j/95432724854?pwd=NnJvUWU5dzU0L1NheEM2SFlQM3FPQT09(Meeting ID: 954 3272 4854, Password: Passcode: 765338)

Please note that the talk will yes/not be recorded.
*For the FAQ section, as a zoom participant, please use either the chat function (the host will read out your question) or the “raise your hand” function and turn on your microphone.


12 July 2024, 11:00

Using mouse and human stem cell models to identify neural circuit deficits in neurodevelopmental disorders

12 July 20242024External Faculty SpeakerEMBL Rome

About the speakerDr Singh is a Senior Scientist in the Donald K Johnson Eye Institute and Krembil Research Institute located with University Health Network UHN since 2020 He is an Associate Professor in the Departments of Ophthalmology and Vision Sciences and Laboratory Medicine and Pathobiology LMP at the Faculty of Medicine University of Toronto Prior to this he was at McMaster... About the speakerDr. Singh is a Senior Scientist in the Donald K. Johnson Eye Institute and Krembil Research Institute, located with University Health Network (UHN) since 2020. He is an Associate Professor in the Departments of Ophthalmology and Vision Sciences, and Laboratory Medicine and Pathobiology (LMP) at the Faculty of Medicine, University of Toronto. Prior to this, he was at McMaster University from 2012-2020 where he was a Scientist and Neural Program Lead at the Stem Cell and Cancer Research Institute, The David Braley Chair in Stem Cell Research, and an Associate Professor in the Department of Biochemistry and Biomedical Sciences at McMaster University. His lab utilizes mouse and patient-derived neural 3D organoid/assembloid models, in combination with multi-omic approaches, to study neurodevelopmental and adult neurological and vision disorders. His program focuses on...

Speaker(s): Karun Singh, University of Toronto, Canada
Host: Hiroki Asari - EMBL Rome

Place: Conf Room/Building 14

External Faculty Speaker

EMBL Rome

Additional information

About the speaker
Dr. Singh is a Senior Scientist in the Donald K. Johnson Eye Institute and Krembil Research Institute, located with University Health Network (UHN) since 2020. He is an Associate Professor in the Departments of Ophthalmology and Vision Sciences, and Laboratory Medicine and Pathobiology (LMP) at the Faculty of Medicine, University of Toronto. Prior to this, he was at McMaster University from 2012-2020 where he was a Scientist and Neural Program Lead at the Stem Cell and Cancer Research Institute, The David Braley Chair in Stem Cell Research, and an Associate Professor in the Department of Biochemistry and Biomedical Sciences at McMaster University. 

His lab utilizes mouse and patient-derived neural 3D organoid/assembloid models, in combination with multi-omic approaches, to study neurodevelopmental and adult neurological and vision disorders. His program focuses on studying genetic risk factors for neurological and vision disorders, and identifying molecular/cellular mechanisms of disease. The long-term goal is to utilize these platforms to study disease etiology, and develop regenerative medicine approaches such as genetic therapies. 


25 July 2024, 14:30

tbc

25 July 20242024External Faculty SpeakerEMBL Heidelberg

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Speaker(s): Brady Weissbourd, MIT, USA
Host: Levin Riedel

Place: Large Operon

External Faculty Speaker

EMBL Heidelberg


12 September 2024, 14:30

tbc

12 September 20242024External Faculty SpeakerEMBL Heidelberg

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Speaker(s): Nick Foulkes, Karlsruhe Institute of Technology, Germany
Host: Jona Rada

Place: Large Operon

External Faculty Speaker

EMBL Heidelberg


17 October 2024, 14:30

tbc

17 October 20242024External Faculty SpeakerEMBL Heidelberg

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Speaker(s): Hassan Salem, Max Planck Institute for Biology, Tübingen, Germany
Host: Mohannad Dardiry

Place: Large Operon

External Faculty Speaker

EMBL Heidelberg


14 November 2024, 11:00

To be announced

14 November 20242024EMBL - Sapienza LectureEMBL Rome

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Speaker(s): John Cryan, University College Cork, Ireland
Host: Cornelius Gross

Place: Sapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma

EMBL - Sapienza Lecture

EMBL Rome


28 November 2024, 14:30

tba

28 November 20242024External Faculty SpeakerEMBL Heidelberg

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Speaker(s): Sylvie Retaux, Paris‑Saclay Institute of Neuroscience, France
Host: idoia quintana Urzainqui

Place: Large Operon

External Faculty Speaker

EMBL Heidelberg


16 January 2025, 14:30

tba

16 January 20252025External Faculty SpeakerEMBL Heidelberg

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Speaker(s): Barbara Treutlein, ETH, Zurich, Switzerland
Host: Hanh Vu

Place: Large Operon

External Faculty Speaker

EMBL Heidelberg


20 February 2025, 14:30

tba

20 February 20252025External Faculty SpeakerEMBL Heidelberg

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Speaker(s): Allyson Sgro, Boston University College of Engineering, USA
Host: Jordi van Gestel

Place: Large Operon

External Faculty Speaker

EMBL Heidelberg


15 May 2025, 14:30

tba

15 May 20252025External Faculty SpeakerEMBL Heidelberg

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Speaker(s): Michel Milinkovitch, University of Geneva, Switzerland
Host: Aissam Ikmi

Place: Large Operon

External Faculty Speaker

EMBL Heidelberg