6 June 2023, 11:00
Dynamics and self-organization of confluent cellular systems: a numerical investigation
AbstractOrganization of cells within a tissue is fundamental to its biological functioning and mechanical properties How a reproducible spatial organization emerges in such a system in spite of the intrinsic stochasticity of cell activity is a question that has attracted the attention of many physicists During this talk I will show some numerical investigation of self organization in cell... AbstractOrganization of cells within a tissue is fundamental to its biological functioning and mechanical properties. How a reproducible spatial organization emerges in such a system in spite of the intrinsic stochasticity of cell activity is a question that has attracted the attention of many physicists. During this talk, I will show some numerical investigation of self-organization in cell monolayers, using the Cellular Potts Model, a widely used numerical modelling tool of multicellular systems. I will show in particular how cell activity can drive an order-disorder transition in epithelial tissues, and compare this transition with the standard defect-mediated theories for melting of two-dimensional materials.About the speakerhttps://marcdurand.netMeet the speakerTo meet with the speaker informally after the talks,sign up here...
Speaker(s): Marc Durand, Laboratory of Materials and Complex Systems, Université Paris Cité, CNRS, France
Host: Roman Belousov
Place: Large Operon
External Faculty Speaker
EMBL Heidelberg, Virtual
Additional information
Abstract
Organization of cells within a tissue is fundamental to its biological functioning and mechanical properties. How a reproducible spatial organization emerges in such a system in spite of the intrinsic stochasticity of cell activity is a question that has attracted the attention of many physicists. During this talk, I will show some numerical investigation of self-organization in cell monolayers, using the Cellular Potts Model, a widely used numerical modelling tool of multicellular systems. I will show in particular how cell activity can drive an order-disorder transition in epithelial tissues, and compare this transition with the standard defect-mediated theories for melting of two-dimensional materials.
About the speaker
https://marcdurand.net
Meet the speaker
To meet with the speaker informally after the talks,sign up here [https://docs.google.com/document/d/1DUO-JcsFC-Uq6PgVIlByZtxNAj8tOxy3FudBom7bpdA/edit?usp=sharing]. We especially encourage predocs and postdocs to take advantage of this opportunity.
Connection details
Zoom*: https://embl-org.zoom.us/j/94618809202?pwd=U1hsZ1MxZFN5M3BocDBhd0wwWVlCUT09 (Meeting ID: 946 1880 9202, Password: 886185)
Please note that the talk will be recorded.
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