Genome biology beta

The genome encodes the genetic blueprint that coordinates all cellular processes, which ultimately give rise to phenotype. The expression of genetic information is tightly regulated in both time and space at multiple stages, including transcriptional, post-transcriptional and post-translational.

The Genome Biology Unit takes an integrated systems-level approach to unravel these complex processes at all scales, integrating cutting-edge experimental and computational approaches.

In eukaryotes, many steps of gene expression, such as transcription and RNA processing, take place in the structurally complex environment of the nucleus and often involve remodelling of chromatin into active and inactive states. Messenger RNAs, once exported from the nucleus, undergo additional regulatory steps.

Their translation results in the production of proteins, whose functions define the characteristics of different cell types, or cellular phenotypes. Not all RNAs are translated, however. In recent years, multiple types of non-coding RNAs have been discovered that display diverse functionality. Genetic variation in non-coding and protein-coding genes alike, as well as the regulatory elements that govern their expression, can adversely affect the function of these genes, leading to diseases such as cancer. Groups within the Unit are investigating various aspects of genome biology in order to understand these processes leading from genotype to phenotype.

A notable strength of the Unit is its ability to address questions at different scales, ranging from detailed mechanistic studies (using biochemistry, genetics, microfluidics and chemistry) to genome-wide studies (using functional genomic, proteomic and computational approaches), often by developing new enabling technologies. For example, the development and integration of chemistry and microfluidic devices with the recent advances in next-generation sequencing will facilitate major advances in these areas in the coming years. Global, dynamic and quantitative measurements of biological molecules at all levels (DNA, RNA, proteins, cells, organisms, etc) as well as the integration of hypothesis and discovery-driven research characterise the Unit. The synergy between computational and wet-lab groups provides a very interactive and collaborative environment to yield unprecedented insights into how genetic information is ‘read’ and mediates phenotype through molecular networks.

Groups in this unit

Furlong group

Genome regulation and topology during embryonic development

Korbel group

From genomic variation to molecular mechanism

Krebs team

Decoding gene regulation using single molecule genomics

Noh group

Epigenetic mechanisms of neurodevelopment and diseases

Savitski team

Stability proteomics for assessing the state of the proteome

Unit members


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Research units at EMBL

Bioinformatics research

Researchers at EMBL-EBI make sense of vast, complex biological datasets produced using new and emerging technologies in molecular biology.

Cell biology and biophysics

Scientists in this unit use multidisciplinary approaches to investigate the molecular and biophysical mechanisms that enable cells to function.

Developmental biology

Scientists in the Developmental biology unit seek to understand the fundamental principles that govern multicellular development.

Directors' research

This unit covers thematically distinct research groups, headed by EMBL and EMBO leadership.

Structural and computational biology

Scientists in this unit use integrated structural and computational techniques to study biology at scales from molecular structures to organismal communities.

Structural biology

At its sites in Hamburg and Grenoble, EMBL provides its researchers and hundreds of external users each year with access to world-leading sources of X-ray and neutron radiation, enabling them to study the structures of biological molecules.

Tissue biology and disease modelling

Scientists at EMBL Barcelona use advanced technologies to observe, manipulate, and model how changes in genes percolate through cells, tissues, and organs, in health and disease.

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