The Opto-inflammasome in zebrafish as a tool to study cell and tissue responses to speck formation and cell death.

Hasel de Carvalho E, Dharmadhikari SS, Shkarina K, Xiong JR, Reversade B, Broz P, Leptin M

eLife, 2023

doi:10.7554/eLife.86373.

High-resolution line-scan Brillouin microscopy for live imaging of mechanical properties during embryo development.

Bevilacqua C, Gomez JM, Fiuza UM, Chan CJ, Wang L, Hambura S, Eguren M, Ellenberg J, Diz-Muñoz A, Leptin M, Prevedel R

Nature methods, 2023

doi:10.1038/s41592-023-01822-1.

Revisiting the origin of interleukin 1 in anamniotes and sub-functionalization of interleukin 1 in amniotes.

Hasel de Carvalho E, Bartok E, Stölting H, Bajoghli B, Leptin M

Open biology, 2022

doi:10.1098/rsob.220049.

Optogenetic activators of apoptosis, necroptosis, and pyroptosis.

Shkarina K, Hasel de Carvalho E, Santos JC, Ramos S, Leptin M, Broz P

The Journal of cell biology, 2022

doi:10.1083/jcb.202109038.

High-resolution line-scan Brillouin microscopy for live-imaging of mechanical properties during embryo development.

Bevilacqua C, Gomez JM, Fiuza UM, Chan CJ, Wang L, Hambura S, Eguren M, Ellenberg J, Diz-Muñoz A, Leptin M, Prevedel R

bioRxiv, 2022

doi:10.1101/2022.04.25.489364.

Autophagy-mediated plasma membrane removal promotes the formation of epithelial syncytia.

Kakanj P, Bhide S, Moussian B, Leptin M

The EMBO journal, 2022

doi:10.15252/embj.2021109992.

An endosome-associated actin network involved in directed apical plasma membrane growth.

Ríos-Barrera LD, Leptin M

The Journal of cell biology, 2022

doi:10.1083/jcb.202106124.

Notch1 deficiency alters the migratory behavior of developing T cells and calcium signaling in the thymus of medaka.

Aghaallaei N, Inoue D, de Carvalho EH, Dick AM, Wittbrodt J, Leptin M, Bajoghli B

European journal of immunology, 2021

doi:10.1002/eji.202149512.

Mechanical competition alters the cellular interpretation of an endogenous genetic program.

Bhide S, Gombalova D, Mönke G, Stegmaier J, Zinchenko V, Kreshuk A, Belmonte JM, Leptin M

The Journal of cell biology, 2021

doi:10.1083/jcb.202104107.

High-precision targeting workflow for volume electron microscopy.

Ronchi P, Mizzon G, Machado P, D'Imprima E, Best BT, Cassella L, Schnorrenberg S, Montero MG, Jechlinger M, Ephrussi A, Leptin M, Mahamid J, Schwab Y

The Journal of cell biology, 2021

doi:10.1083/jcb.202104069.

αβ/γδ T cell lineage outcome is regulated by intrathymic cell localization and environmental signals.

Aghaallaei N, Dick AM, Tsingos E, Inoue D, Hasel E, Thumberger T, Toyoda A, Leptin M, Wittbrodt J, Bajoghli B

Science advances, 2021

doi:10.1126/sciadv.abg3613.

Regulation of the wound healing response during aging.

Ding X, Kakanj P, Leptin M, Eming SA

The Journal of investigative dermatology, 2021

doi:10.1016/j.jid.2020.11.014.

Fluorescence-based 3D targeting of FIB-SEM acquisition of small volumes in large samples.

Ronchi P, Machado P, D’Imprima E, Mizzon G, Best BT, Cassella L, Schnorrenberg S, Montero MG, Jechlinger M, Ephrussi A, Leptin M, Mahamid J, Schwab Y

bioRxiv, 2021

doi:10.1101/2021.01.18.427072.

Transcytosis via the late endocytic pathway as a cell morphogenetic mechanism.

Mathew R, Rios-Barrera LD, Machado P, Schwab Y, Leptin M

The EMBO journal, 2020

doi:10.15252/embj.2020105332.

Long-term in vivo imaging of Drosophila larvae.

Kakanj P, Eming SA, Partridge L, Leptin M

Nature protocols, 2020

doi:10.1038/s41596-019-0282-z.

Cell and tissue manipulation with ultrashort infrared laser pulses in light-sheet microscopy.

de Medeiros G, Kromm D, Balazs B, Norlin N, Günther S, Izquierdo E, Ronchi P, Komoto S, Krzic U, Schwab Y, Peri F, de Renzis S, Leptin M, Rauzi M, Hufnagel L

Scientific reports, 2020

doi:10.1038/s41598-019-54349-x.

Multiple requirements for Rab GTPases in the development of Drosophila tracheal dorsal branches and terminal cells.

Best BT, Leptin M

G3 (Bethesda, Md.), 2020

doi:10.1534/g3.119.400967.

Polarity sorting drives remodeling of actin-myosin networks.

Wollrab V, Belmonte JM, Baldauf L, Leptin M, Nédeléc F, Koenderink GH

Journal of cell science, 2018

doi:10.1242/jcs.219717.

Dual function for Tango1 in secretion of bulky cargo and in ER-Golgi morphology.

Ríos-Barrera LD, Sigurbjörnsdóttir S, Baer M, Leptin M

Proceedings of the National Academy of Sciences of the United States of America, 2017

doi:10.1073/pnas.1711408114.

A Theory that Predicts Behaviors of Disordered Cytoskeletal Networks

Belmonte JM, Leptin M, Nédélec F

2017

doi:10.15252/msb.20177796.

Correction: dynamics of in vivo ASC speck formation.

Kuri P, Schieber NL, Thumberger T, Wittbrodt J, Schwab Y, Leptin M

The Journal of cell biology, 2017

doi:10.1083/jcb.20170310308302017c.

Dynamics of in vivo ASC speck formation.

Kuri P, Schieber NL, Thumberger T, Wittbrodt J, Schwab Y, Leptin M

The Journal of cell biology, 2017

doi:10.1083/jcb.201703103.

A high-sensitivity, bi-directional reporter to monitor NF-κB activity in cell culture and zebrafish in real-time.

Kuri P, Ellwanger K, Kufer TA, Leptin M, Bajoghli B

Journal of cell science, 2016

doi:10.1242/jcs.196485.

From morphogen to morphogenesis and back

Gilmour D, Rembold M, Leptin M

2017

doi:10.1038/nature21348.

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation.

Ding X, Bloch W, Iden S, Rüegg MA, Hall MN, Leptin M, Partridge L, Eming SA

Nature communications, 2016

doi:10.1038/ncomms13226.

Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing.

Kakanj P, Moussian B, Grönke S, Bustos V, Eming SA, Partridge L, Leptin M

Nature communications, 2016

doi:10.1038/ncomms12972.

A Genome-Wide Screen for Dendritically Localized RNAs Identifies Genes Required for Dendrite Morphogenesis.

Misra M, Edmund H, Ennis D, Schlueter MA, Marot JE, Tambasco J, Barlow I, Sigurbjornsdottir S, Mathew R, Vallés AM, Davis I, Leptin M, Gavis ER

G3 (Bethesda, Md.), 2016

doi:10.1534/g3.116.030353.

Preprints for the life sciences

Berg JM, Bhalla N, Bourne PE, Chalfie M, Drubin DG, Fraser JS, Greider CW, Hendricks M, Jones C, Kiley R, King S, Kirschner MW, Krumholz HM, Lehmann R, Leptin M, Pulverer B, Rosenzweig B, Spiro JE, Stebbins M, Strasser C, Swaminathan S, Turner P, Vale RD, VijayRaghavan K, Wolberger C

SCIENCE, 2016

doi:10.1126/science.aaf9133.

Structure and evolutionary history of a large family of NLR proteins in the zebrafish.

Howe K, Schiffer PH, Zielinski J, Wiehe T, Laird GK, Marioni JC, Soylemez O, Kondrashov F, Leptin M

2016

doi:10.1098/rsob.160009.

Embryo-scale tissue mechanics during Drosophila gastrulation movements.

Rauzi M, Krzic U, Saunders TE, Krajnc M, Ziherl P, Hufnagel L, Leptin M

Nature communications, 2015

doi:10.1038/ncomms9677.

Noninvasive In Toto Imaging of the Thymus Reveals Heterogeneous Migratory Behavior of Developing T Cells

Bajoghli B, Kuri P, Inoue D, Aghaallaei N, Hanelt M, Thumberger T, Rauzi M, Wittbrodt J, Leptin M

JOURNAL OF IMMUNOLOGY, 2015

doi:10.4049/jimmunol.1500361.

Molecular mechanisms of de novo lumen formation

Sigurbjörnsdóttir S, Mathew R, Leptin M

Nature reviews. Molecular cell biology, 2014

doi:10.1038/nrm3871.

Systemic Response to Ultraviolet Radiation Involves Induction of Leukocytic IL-1β and Inflammation in Zebrafish

Banerjee S, Leptin M

Journal of immunology (Baltimore, Md. : 1950), 2014

doi:10.4049/jimmunol.1400232.

Slik and the Receptor Tyrosine Kinase Breathless Mediate Localized Activation of Moesin in Terminal Tracheal Cells

Ukken FP, Aprill I, Nair JN, Leptin M

PloS one, 2014

doi:10.1371/journal.pone.0103323.

Cadherin switching during the formation and differentiation of the Drosophila mesoderm - implications for epithelial-to-mesenchymal transitions

Schafer G, Narasimha M, Vogelsang E, Leptin M

JOURNAL OF CELL SCIENCE, 2014

doi:10.1242/jcs.139485.

A conserved role for Snail as a potentiator of active transcription

Rembold M, Ciglar L, Yáñez-Cuna JO, Zinzen RP, Girardot C, Jain A, Welte MA, Stark A, Leptin M, Furlong EE

Genes & development, 2014

doi:10.1101/gad.230953.113.

Guidance of subcellular tubulogenesis by actin under the control of a synaptotagmin-like protein and Moesin

Jayanandanan N, Mathew R, Leptin M

Nature communications, 2014

doi:10.1038/ncomms4036.

Physical models of mesoderm invagination in Drosophila embryo

Rauzi M, Hočevar Brezavšček A, Ziherl P, Leptin M

Biophysical journal, 2013

doi:10.1016/j.bpj.2013.05.039.

Microsomal triacylglycerol transfer protein (MTP) is required to expand tracheal lumen in Drosophila in a cell-autonomous manner

Baer MM, Palm W, Eaton S, Leptin M, Affolter M

Journal of cell science, 2012

doi:10.1242/jcs.110452.

A model of epithelial invagination driven by collective mechanics of identical cells

Hočevar Brezavšček A, Rauzi M, Leptin M, Ziherl P

Biophysical journal, 2012

doi:10.1016/j.bpj.2012.07.018.

Open access--pass the buck

Leptin M

Science (New York, N.Y.), 2012

doi:10.1126/science.1220395.

Role for Traf4 in polarizing adherens junctions as a prerequisite for efficient cell shape changes

Mathew SJ, Rembold M, Leptin M

Molecular and cellular biology, 2011

doi:10.1128/mcb.05542-11.

A genetic in vivo system to detect asymmetrically distributed RNA

JayaNandanan N, Gavis ER, Riechmann V, Leptin M

EMBO reports, 2011

doi:10.1038/embor.2011.178.

Fibroblast growth factor signalling controls successive cell behaviours during mesoderm layer formation in Drosophila

Clark IB, Muha V, Klingseisen A, Leptin M, Müller HA

Development (Cambridge, England), 2011

doi:10.1242/dev.060277.

In vivo analysis of Ifn-γ1 and Ifn-γ2 signaling in zebrafish

Aggad D, Stein C, Sieger D, Mazel M, Boudinot P, Herbomel P, Levraud JP, Lutfalla G, Leptin M

Journal of immunology (Baltimore, Md. : 1950), 2010

doi:10.4049/jimmunol.1000549.

A novel conserved phosphotyrosine motif in the Drosophila fibroblast growth factor signaling adaptor Dof with a redundant role in signal transmission

Csiszar A, Vogelsang E, Beug H, Leptin M

Molecular and cellular biology, 2010

doi:10.1128/mcb.01436-09.

The role of apoptosis in shaping the tracheal system in the Drosophila embryo

Baer MM, Bilstein A, Caussinus E, Csiszar A, Affolter M, Leptin M

Mechanisms of development, 2010

doi:10.1016/j.mod.2009.11.003.

Looking beyond death: a morphogenetic role for the TNF signalling pathway

Mathew SJ, Haubert D, Krönke M, Leptin M

Journal of cell science, 2009

doi:10.1242/jcs.044487.

A small genomic region containing several loci required for gastrulation in Drosophila

Mathew SJ, Kerridge S, Leptin M

PloS one, 2009

doi:10.1371/journal.pone.0007437.

The role of gamma interferon in innate immunity in the zebrafish embryo

Sieger D, Stein C, Neifer D, van der Sar AM, Leptin M

Disease models & mechanisms, 2009

doi:10.1242/dmm.003509.

A clonal genetic screen for mutants causing defects in larval tracheal morphogenesis in Drosophila

Baer MM, Bilstein A, Leptin M

Genetics, 2007

doi:10.1534/genetics.107.074088.

A genetic mosaic analysis with a repressible cell marker screen to identify genes involved in tracheal cell migration during Drosophila air sac morphogenesis

Chanut-Delalande H, Jung AC, Lin L, Baer MM, Bilstein A, Cabernard C, Leptin M, Affolter M

Genetics, 2007

doi:10.1534/genetics.107.073890.

Analysis and reconstitution of the genetic cascade controlling early mesoderm morphogenesis in the Drosophila embryo

Seher TC, Narasimha M, Vogelsang E, Leptin M

Mechanisms of development, 2007

doi:10.1016/j.mod.2006.12.004.

Control of Drosophila gastrulation by apical localization of adherens junctions and RhoGEF2

Kölsch V, Seher T, Fernandez-Ballester GJ, Serrano L, Leptin M

Science (New York, N.Y.), 2007

doi:10.1126/science.1134833.

Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish

Stein C, Caccamo M, Laird G, Leptin M

Genome biology, 2007

doi:10.1186/gb-2007-8-11-r251.

A screen for genes that influence fibroblast growth factor signal transduction in Drosophila

Zhu MY, Wilson R, Leptin M

Genetics, 2005

doi:10.1534/genetics.104.039750.

Gastrulation movements: the logic and the nuts and bolts

Leptin M

Developmental cell, 2005

doi:10.1016/j.devcel.2005.02.007.

The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage

Bekpen C, Hunn JP, Rohde C, Parvanova I, Guethlein L, Dunn DM, Glowalla E, Leptin M, Howard JC

Genome biology, 2005

doi:10.1186/gb-2005-6-11-r92.