The World of Molecular Biology exhibit

Combining light and electron microscopy

Correlative light-electron microscopy (CLEM) employs light microscopes to guide electron microscopes, which have a higher resolution but much more limited field of view. This can reveal the precise site and context of transient molecular processes in the cells and tissues of organisms, building understanding across the scales of molecules and cells.

Cancer

Using the CLEM technology, scientists at EMBL imaged in great detail the brief moment when a cancer cell breaks into the brain from a blood vessel. The images show how cells change their shape, extending arm like structures to help them cross the blood vessel wall. This is one of the processes by which cancers spread to the brain from other areas. 

Big Data

CLEM-images and many other images are available in the EMBL European Bioinformatics Institute (EMBL-EBI) BioImage Archive as part of a wider initiative to improve access to imaging technology and data worldwide. Researchers can register and contribute to the archive images that range from molecules to whole organisms.

EMBL research groups developing CLEM technologies and novel approaches and service facilities providing access and support

Mahamid Group

In-cell structural analysis of phase separation and molecular crowding

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The World of Molecular Biology exhibit

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