Research Team

The Advanced Light Microscopy Facility (ALMF) offers a collection of state-of-the-art light microscopy equipment and image processing tools. The facility was set up as a cooperation between EMBL and industry to improve communication between users and producers of high-end microscopy technology and to support in-house scientists and visitors in using light microscopy methods for their research. The ALMF also organises regular international courses to teach advanced light microscopy methods.

Relevant publications

  1. Ritzerfeld, J., Remmele, S., Wang, T., Temmerman, K., Brugger, B., Wegehingel, S., Tournaviti, S., Strating, J.R., Wieland, F.T., Neumann, B., Ellenberg, J., Lawerenz, C., Hesser, J., Erfle, H., Pepperkok, R. & Nickel, W. Phenotypic profiling of the human genome reveals gene products involved in plasma membrane targeting of Src kinases. Genome Res. 2011 Jul 27.
  2. Conrad, C., Wunsche, A., Tan, 2. T.H., Bulkescher, J., Sieckmann, F., Verissimo, F., Edelstein, A., Walter, T., Liebel, U., Pepperkok, R. & Ellenberg, J. Micropilot: automation of fluorescence microscopy-based imaging for systems biology. Nat Methods. 2011 Jan 23.
  3. Neumann, B., Walter, T., Heriche, J.K., Bulkescher, J., Erfle, H., Conrad, C., Rogers, P., Poser, I., Held, M., Liebel, U., Cetin, C., Sieckmann, F., Pau, G., Kabbe, R., W√ľnsche, A., Satagopam, V., Schmitz, M.H., Chapuis, C., Gerlich, D.W., Schneider, R., Eils, R., Huber, W., Peters, J.M., Hyman, A.A., Durbin, R., Pepperkok, R. & Ellenberg, J. Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature. 2010 Apr 1;464(7289):721-7.
  4. Gilbert, D.F., Meinhof, T., Pepperkok, R. & Runz, H. DetecTiff(C): A Novel Image Analysis Routine for High-Content Screening Microscopy. J Biomol Screen. 2009 Jul 29.
  5. Starkuviene, V., Pepperkok, R. & Erfle, H. Transfected cell microarrays: an efficient tool for high-throughput functional analysis. Expert Rev Proteomics. 2007 Aug;4(4):479-89.

The scientific activities of the Tara Oceans expedition, led by EMBL senior scientist Eric Karsenti, present an unprecedented effort that resulted in 35,000 samples containing millions of small organism collected in more than 210 ocean stations, chosen for their climatic significance or biodiversity.